Visceral obesity, androgens and the risks of cardiovascular disease and diabetes mellitus

References

• Schwartz MW, Seeley RJ. Neuroendocrine responses to starvation and weight loss. N Engl J Med 1997;336:1802–11
   PubMed Web of Science ®Google Scholar
• Rosenbaum M, Leibl RL, Hirsch J. Obesity. N Engl J Med 1997;337:397–407
   Google Scholar
• Roemmich JN. Alterations in body composition during adolescence. Curr Opin Endocrinol Diabet 1998;5:11–18
   Google Scholar
• Katznelson L, Rosenthal DI, Rosol MS, Anderson EJ, Hayden DL, Schoenfeld DA, et al. Using quantitative CT to assess adipose distribution in adult men with acquitted hypogonadism. Am J Roentgenol 1998;170:423–7
   PubMed Web of Science ®Google Scholar
• Vermeulen A, Goemaere S, Kaufman JM. Sex hormones, body composition and aging. Aging Male 1999;2:8–15
   Google Scholar
• Couillard C, Gagnon J, Bergeron J, Leon AS, Rao DC, Skinner JS, et al. Contribution of body fatness and adipose tissue distribution to the age variation in plasma steroid hormone concentrations in men: the HERITAGE family study. J Clin Endcrinol Metab 2000;85:1026–31
   PubMed Web of Science ®Google Scholar
• Simon D, Charles MA, Nahoul K, Orssaud G,Kremski J, Hully V, et al. Association between plasma total testosterone and cardiovascular risk factors in healthy adult men: the Telecom Study. J Clin Endocrinol Metab 1997;82:682–5
   Google Scholar
• Pritchard J, Despres JP, Gagnon J, Tchernof A,Nadeau A, Tremblay A, et al. Plasma adrenal, gonadal and conjugated steroids before and after long-term overfeeding in identical twins. J Clin Endocrinol Metab 1998;83:3277–84
   Google Scholar
• Vermeulen A, Kaufman JM, Giagulli VA.Influence of some biological indexes on sex hormone-binding-globulin and androgen levels in ageing or obese males. J Clin Endocrinol Metab 1996;81:1821–6
   Google Scholar
• Pritchard J, Despres JP, Gagnon J, Tchernof A,Nadeau A, Tremblay A, et al. Plasma adrenal, gonadal and conjugated steroids before and after long-term exercise induced negative energy balance in identical twins. Metabolism 1999; 48:1120–7
   Google Scholar
• Leenen R, Vander Kooy K, Seidell JC,Deurenberg P, Koppescharr HPF. Visceral fat accumulation in relation to sex hormones in obese men and women undergoing weight loss therapy. J Clin Endocrinol Metab 1994;78:1515–20
   Google Scholar
• Khaw KT, Barrett-Connor E. Lower endogenous androgens predict central adiposity in men. Ann Epidemiol 1992;2:675–82
   PubMedGoogle Scholar
• Zmuda JM, Cauley JA, Kriska A, Glynn NW,Gutai JP, Kuller LH. Longitudinal relation between endogenous testosterone and cardio- vascular risk factors in middle-aged men: a 13-year follow-up of former Multiple Risk Factor Intervention Trial participants. Am J Epidemiol 1997;146:609–17
   Google Scholar
• Tsai EC, Boyko EJ, Leonetti DL, Fujimoto WY.Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men. Int J Obes 2000;24:485–91
   Google Scholar
• Björntorp P. Visceral obesity: a civilization syndrome. Obes Res 1993;1:206–22
   PubMedGoogle Scholar
• Tchernof A, Poehlman ET. Effects of the menopause transition on body fatness and body fat distribution. Obes Res 1998;6:246–54
   PubMedGoogle Scholar
• Kannel WB, Cupples LA, Ramaswami R, Stokes JIII, Kreger BE, Higgins M. Regional obesity and risk of coronary disease: the Framingham Study. J Clin Epidemiol 1991;44:183–90
   Google Scholar
• Björntorp P. The android woman – a risky condition. J Intern Med 1996;239:105–10
   PubMed Web of Science ®Google Scholar
• Després JP, Marette A. Relation of components of insulin resistance syndrome to coronary disease risk. Curr Opin Lipidol 1994;5:274–89
   PubMedGoogle Scholar
• Seidell JC, Björntorp P, Sjöström L, Kvist H, Sannerstedt R. Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels. Metabolism 1990;39:897–901
   PubMed Web of Science ®Google Scholar
• Tchernof A, Labrie F, Belanger A, Prud’homme D,Bouchard C, Tremblay A, et al. Relationships between endogenous sex steroid hormone, sex hormone-binding globulin, and lipoprotein levels in men: contribution of visceral obesity, insulin levels and other metabolic variables. Atherosclerosis 1997;133:235–44
   Google Scholar
• Kaufman JM, Vermeulen A. Declining gonadal function in elderly men. Bailliere’s Clin Endocrinol Metab 1997;11:189–98
   Google Scholar
• Stellato RK, Feldman HA, Hamdy O, Horton ES,McKinlay JB. Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts Male Aging Study. Diabet Care 2000;23:490–4
   Google Scholar
• Vgontzas A, Papanicoaou DA, Bixler EO,Hopper K, Lotsikas A, Lin HM, et al. Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hyper- cytokinemia. J Clin Endocrinol Metab 2000; 85:1151–8
   Google Scholar
• Flier JS. What’s in a name? In search of leptins’s physiological role. J Clin Endocrinol Metab 1998; 83:1407–13
   PubMedGoogle Scholar
• Mantzoros CS. The role of leptin in human obesity and disease: a review of current evidence. Ann Intern Med 1999;130:671–80
   PubMed Web of Science ®Google Scholar
• Isidori AM, Caprio M, Strollo F, Moretti C, FrajeseG, Isidori A, et al. Leptin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels. J Clin Endocrinol Metab 1999;84:3673–80
   Google Scholar
• Van den Saffele JK, Goemaere S, De Bacquer D,Kaufman JM. Serum leptin levels in healthy ageing men: are decreased serum testosterone and increased adiposity the consequence of leptin deficiency? Clin Endocrinol 1999;51:81–8
   Google Scholar
• Doucet E, St-Pierre S, Almeras N, Mauriege P,Despres JP, Richard D, et al. Fasting insulin levels influence plasma leptin levels independently from the contribution of adiposity: evidence from both a cross-sectional and an intervention study. J Clin Endocrinol Metab 2000;85:4231–7
   Google Scholar
• Mantzoros CS, Flier JS. Leptin as a therapeutic agent – trials and tribulations. J Clin Endocrinol Metab 2000;85:4000–2
   PubMed Web of Science ®Google Scholar
• Rebuffe-Scrive CS, Mårin P, Björntorp P. Effect of testosterone on abdominal adipose tissue in men. Int J Obes Res 1991;15:791–5
   PubMed Web of Science ®Google Scholar
• Mårin P, Holmång S, Gustafsson C. Androgen treatment of abdominally obese men. Int J Obes Res 1993;1:245–51
   Google Scholar
• Mårin P, Odén B, Björntorp P. Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men. J Clin Endocrinol Metab 1995;80:239–43
   Google Scholar
• Mårin P, Arver S. Androgens and abdominal obesity. Bailliere’s Clin Endocrinol Metab 1998; 12:441–51
   PubMed Web of Science ®Google Scholar
• Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz WH. The disease burden associated with overweight and obesity. J Am Med Assoc 1999; 282:1523–9
   PubMed Web of Science ®Google Scholar