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(RC) Practice of Medicine

Sex steroids and brain functioning in the aging male

Pages 39-43 | Published online: 06 Jul 2009

References

  • Shaywitz BA, Shaywitz SE, Pugh KR, Constable RT, Skudlarski P, Fulbright RK, et al. Sex differ- ences in the functional organization of the brain for language. Nature (London) 1995;373:607–9
  • Moffat SD, Hampson HE. Salivary testosterone concentration in left-handers: an association with cerebral language lateralization. Neuropsychology 2000;14:71–81
  • Bagatell C, Bremner WJ. Androgens in men – useand abuse. N Engl J Med 1996;334:707–13
  • Gray A, Feldman HA, McKinley JB, Longcope C. Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. J Clin Endocrinol Metab 1991; 72:1016–25
  • Vermeulen A. Andropause. Maturitas 2000; 34:5–15
  • Hutchison JB, Wozniak A, Beyer C, Karolczak M, Hutchison RE. Steroid metabolizing enzymes in the determination of brain gender. J Steroid Biochem Mol Biol 1999;69:85–96
  • Wang C, Swedloff RS, Iranmanesh A, Dobs A, Snyder PJ, Cunningham G, et al. Transdermal testosterone gel improves sexual function, mood, muscle strength and body composition parameters in hypogonadal men. J Clin Endocrinol Metab 2000; 85:2839–53
  • Wisniewski AB, Migeon CJ, Meyer-Bahlburg HFL, Gearhart JP, Berkovitz GD, Brown TR, et al. Complete androgen insensitivity syndrome: long- term medical, surgical and psychosexual outcome. J Clin Endocrinol Metab 2000;85:2664–9
  • Dobs AS, Meikle AW, Arver S, Sanders SW, Caramelli KE, Mazer NA. Pharmacokinetics, effi- cacy and safety of a permeation-enhanced testoster- one transdermal system in comparison with bi-weekly injection of testosterone enanthate of hypogonadal men. J Clin Endocrinol Metab 1999;84:3469–78
  • Snyder PJ, Peachey H, Berlin JA, Hannoush P, Haddad G, Dlewati A, et al. Effects of testosterone replacement in hypogonadal men. J Clin Endocrinol Metab 2000;85:2670–7
  • Tan U, Tan M. Curvelinear correlations between total testosterone levels and fluid intelligence in men and women. Int J Neurosci 1998;95:77–83
  • Steckelbroeck S, Stoffel-Wagner B, Reichelt R, Schramm J, Bidlingmaier F, Siekmann L, et al. Characterization of 17beta-hydroxysteroid de- hydrogenase activity in brain tissue: testosterone formation in the human temporal lobe. J Neuro- endocrinol 1999;11:457–64
  • Rupprecht R, Holsboer F. Neuropsycho- pharmacological properties of neuroactive steroids. Steroids 1999;64:83–91
  • Laughlin GA, Barrett-Conor E. Sexual dimor- phism in the influence of advanced aging on adrenal hormone levels: the Rancho Bernardo Study. J Clin Endocrinol Metab 2000;85:3561–8
  • Van Cauter E, Leproult R, Kupfer DJ. Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol. J Clin Endocrinol Metab 1996;81:2468–73
  • Magri F, Locatelli M, Balza G, et al. Changes in endocrine circadian rhythms as markers of physio- logical and pathological brain aging. Chronobiol Int 1997;14:386–96
  • Yen SSC, Laughlin G. Aging and the adrenal cortex. Exp Gerontol 1998;33:897–910
  • Lupien SJ, Lecours A, Lussier I, Schwartz G, Nair NP, Meaney MJ. Basal cortisol levels and cognitive deficits in human aging. J Neurosci 1994;14:2893–903
  • Lupien SJ, de Leon M, de Santi S, Convit A, Tarshish C, Nair NP, et al. Cortisol levels during human aging predict hippocampal atrophy and memory deficits. Nat Neurosci 1998;1:69–73
  • Kalmijn S, Launer I, Stolk RP, de Jong FH, Pols HA, Hofman A, et al. A prospective study on cortisol, dehydroepiandrosterone sulfate and cog- nitive function in the elderly. J Clin Endocrinol Metab 1998;83:3487–92
  • Seeman TE, McEwan B, Singer BH, Albert MS, Rowe JW. Increase in urinary cortisol excretion and memory declines: MacArthur studies of successful aging. J Clin Endocrinol Metab 1997;82:2458–65
  • Sapolsky R. Glucocorticoid, stress and their adverse neurological effects: relevance of aging. Exp Gerontol 1999;34:721–32
  • Guazzo EP, Kirkpatrick P, Goodyear IM, Shiers HM, Herbert J. Cortisol, dehydroepiandrosterone (DHEA) and DHEA sulfate in the cerebrospinal fluid of man: relationship to blood levels and effects of age. J Clin Endocrinol Metab 1996;81:3951–60
  • Baulieu EE, Robel P. Dehydroepiandrosterone (DHEA) and DHEA sulfate as neuroactive steroids. J Endocrinol 1996;150(Suppl): S221–39
  • Zwain IH, Yen S. Dehydroepiandrosterone: bio- synthesis and metabolism in the brain. Endocrinology 1999;140:880–7
  • Morales AJ, Nolan J, Nelson JC, Yen SS. Effects of replacement dose of DHEA in men and women of advancing age. J Clin Endocrinol Metab 1994;78:1360–7
  • El-Hefnawy T, Huhtaniemi IT. Progesterone and testicular function. Aging Male 1999;2:240–5
  • Baulieu EE, Schumacher M, Koenig H, Jung- Testas I, Akwa Y. Progesterone as a neurosteroid: actions within the central nervous system. Cell Mol Neurobiol 1996;16:143–54
  • Genazzani AR, Petraglia F, Bernardi F, Casarosa E, Salvestroni C, Tonetti A, et al. Circulating levels of allopregnanolone in humans: gender, age and endocrine influences. J Clin Endocrinol Metab 1998; 83:2099–103
  • Rupprecht R, Koch M, Montkowski A, Lancel M, Faulhaber J, Harting J, et al. Assessment of neuroleptic-like properties of progesterone. Psychopharmacology 1999;143:29–38
  • Carlson LE, Sherwin B. Higher levels of plasma estradiol and testosterone in healthy elderly men compared with age-matched women may protect aspects of explicit memory. Menopause 2000;7:168–77
  • Ogawa S, Chester AE, Hewitt SC, Walker VR, Gustafsson JA, Smithies O, et al. From the cover: abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO) Proc Natl Acad Sci USA 2000;97:14737–41
  • Mauras N, O’Brien K, Klein KO, Hayes V. Estro- gen suppression in males: metabolic effects. J Clin Endocrinol Metab 2000;85:2370–7
  • Ryan KJ, Naftolin F, Reddy V, Flores F, Petro Z. Estrogen formation in the brain. Am J Obstet Gynecol 1972;114:454–6
  • Schindler AE, Ebert A, Freidrich E. Conversion of androstenedione to estrone in human tissue. J Clin Endocrinol Metab 1972;35:627–30
  • Osterlund MK, Gustafsson J, Keller E, Hurd YL. Estrogen receptor-beta messenger ribonucleic acid expression within the human forebrain: distinct distribution pattern to ER-alpha mRNA. J Clin Endocrinol Metab 2000;85:3840–6
  • Packard MG. Posttraining estrogen and memory modulation. Horm Behav 1998;34:126–39
  • Luine VN, Richards ST, Wu VY, Beck KD. Estradiol enhances learning and memory in a spatial memory task. Horm Behav 1998;34:149–62
  • Kyomen HH, Satlin A, Hennen J, Wei JY. Estro- gen therapy and aggressive behavior in elderly patients with moderate-to-severe dementia. Am J Geriatr Psychiatry 1999;7:339–48
  • Kyomen HA, Nobel K, Wei JY. The use of estro- gen to reduce aggressive behavior in elderly men with dementia. Geriatr Soc 1991;39:1110–12
  • Kay PAJ, Forman LJ, et al. Transdermal estradiol in the management of aggressive behavior in male patients with dementia. Clin Gerontol 1995;15:54–8

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