Testosterone supplementation: why and for whom?

References

• Kaufman JM, Vermeulen A. Declining gonadal function in elderly men. Baillieres Clin Endocrinol Metab 1997;11:289–309
   Google Scholar
• Gray A, Feldman HA, McKinlay JB, Longcope C. Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. J Clin Endocrinol Metab 1991; 73:1016–25
   Google Scholar
• Vermeulen A, Kaufman JM, Giagulli VA. Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males. J Clin Endocrinol Metab 1996;81:1821–6
   Google Scholar
• Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab 2001;86:724–31
   Google Scholar
• Morley JE, Kaiser FE, Perry HM, III, Patrick P, Morley PM, Stauber PM, et al. Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism 1997;46:410–13
   Google Scholar
• Meikle AW, Bishop DT, Stringham JD, West DW. Quantitating genetic and nongenetic factors that determine plasma sex steroid variation in normal male twins. Metabolism 1986; 35:1090–5
   Google Scholar
• Handelsman DJ. Testicular dysfunction in systemic disease. Endocrinol Metab Clin North Am 1994;23:839–56
   Google Scholar
• Gooren LJG. Androgen levels and sex functions in testosterone-treated hypogonadal men. Arch Sex Behav 1987;16:463–73
   Google Scholar
• Bagatell CJ, Heiman JR, Rivier JE, Bremner WJ. Effects of endogenous testosterone and estradiol on sexual behavior in normal young men. J Clin Endocrinol Metab 1994;78:711–16
   Google Scholar
• Schiavi RC, White D, Mandeli J, Schreiner- Engel P. Hormones and nocturnal penile tumescence in healthy aging men. Arch Sex Behav 1999;22:207–15
   Google Scholar
• Bhasin S, Storer TW, Berman N, Yarasheski KE, Clevenger B, Phillips J, et al. Testosterone replacement increases fat-free mass and muscle size in hypogonadal men. J Clin Endocrinol Metab 1997;82:407–13
   Google Scholar
• Bhasin S, Woodhouse L, Casaburi R, Singh AB, Bhasin D, Berman N, et al. Testosterone dose- response relationships in healthy young men. Am J Physiol Endocrinol Metab 2001;281:E1172–E1181
   Google Scholar
• Deslypere JP, Kaufman JM, Vermeulen T, Vogelaers D, Vandalem JL, Vermeulen A. Influence of age on pulsatile luteinizing hormone release and responsiveness of the gonadotrophs to sex hormone feedback in men. J Clin Endocrinol Metab 1987; 64:68–73van den Beld AW, Huhtaniemi IT, Pettersson KS, Pols HA, Grobbee DE, de Jong FH, et al. Luteinizing hormone and different genetic variants, as indicators of frailty in healthy elderly men. J Clin Endocrinol Metab 1999;84:1334–9
   Google Scholar
• Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999;84:3666–72
   Google Scholar
• Orwoll ES, Klein RF. Osteoporosis in men. Endocr Rev 1995;16:87–116
   Google Scholar
• Foresta C, Ruzza G, Mioni R, Guarneri G, Gribaldo R, Meneghello A, et al. Osteoporosis and decline of gonadal function in the elderly male. Horm Res 1984;19:18–22
   Google Scholar
• Center JR, Nguyen TV, Sambrook PN, Eisman JA. Hormonal and biochemical parameters in the determination of osteoporosis in elderly men. J Clin Endocrinol Metab 1999;84:3626–35
   Google Scholar
• Rudman D, Drinka PJ, Wilson CR, Mattson DE, Scherman F, Cuisinier MC, et al. Relations of endogenous anabolic hormones and physical activity to bone mineral density and lean body mass in elderly men. Clin Endocrinol (Oxf) 1994; 40:653–61
   Google Scholar
• Murphy S, Khaw KT, Cassidy A, Compston JE. Sex hormones and bone mineral density in elderly men. Bone Miner 1993;20:133–40
   Google Scholar
• Kaufman JM. Androgens, bone metabolism and osteoporosis. In Oddens B, Vermeulen A, eds. Androgens and The Aging Male. Carnforth, UK: Parthenon Publishing, 1996,39–60
   Google Scholar
• Drinka PJ, Olson J, Bauwens S, Voeks SK, Carlson I, Wilson M. Lack of association between free testosterone and bone density separate from age in elderly males. Calcif Tissue Int 1993;52:67–9
   Google Scholar
• Meier DE, Orwoll ES, Keenan EJ, Fagerstrom RM. Marked decline in trabecular bone mineral content in healthy men with age: lack of association with sex steroid levels. J Am Geriatr Soc 1987;35:189–97
   Google Scholar
• Clarke BL, Ebeling PR, Jones JD, Wahner HW, O’Fallon WM, Riggs BL, et al. Changes in quantitative bone histomorphometry in aging healthy men. J Clin Endocrinol Metab 1996;81:2264–70
   Google Scholar
• Greendale GA, Edelstein S, Barrett-Connor E. Endogenous sex steroids and bone mineral density in older women and men: the Rancho Bernardo Study. J Bone Miner Res 1997;12:1833–43
   Google Scholar
• Khosla S, Melton LJ, III, Atkinson EJ, O’Fallon WM, Klee GG, Riggs BL. Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. J Clin Endocrinol Metab 1998; 83:2266–74van den Beld AW, de Jong FH, Grobbee DE, Pols HA, Lamberts SW. Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. J Clin Endocrinol Metab 2000;85:3276–82
   Google Scholar
• Carani C, Qin K, Simoni M, Faustini-Fustini M, Serpente S, Boyd J, et al. Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med 1997;337:91–5
   Google Scholar
• Barrett-Connor E, Mueller JE, von Muhlen DG, Laughlin GA, Schneider DL, Sartoris DJ. Low levels of estradiol are associated with vertebral fractures in older men, but not women: the Rancho Bernardo Study. J Clin Endocrinol Metab 2000;85:219–23
   Google Scholar
• Vermeulen A, Goemaere S, Kaufman JM. Sex hormones, body composition and aging. Aging Male 1999;2:8–15
   Google Scholar
• Seidell JC, Bjorntorp P, Sjostrom L, Kvist H, Sannerstedt R. Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels. Metabolism 1990;39:897–901
   Google Scholar
• Tchernof A, Labrie F, Belanger A, Prud’homme D, Bouchard C, Tremblay A, et al. Relationships between endogenous steroid hormone, sex hormone-binding globulin and lipoprotein levels in men: contribution of visceral obesity, insulin levels and other metabolic variables. Atherosclerosis 1997;133:235–44
   Google Scholar
• Kannel WB, Cupples LA, Ramaswami R, Stokes J, III, Kreger BE, Higgins M. Regional obesity and risk of cardiovascular disease; the Framingham Study. J Clin Epidemiol 1991;44:183–90
   Google Scholar
• Björntorp P. Visceral obesity: a civilisation syndrome. Obes Res 1993;1:206–22
   Google Scholar
• Larsson L. Histochemical characteristics of human skeletal muscle during aging. Acta Physiol Scand 1983;117:469–71
   Google Scholar
• Frontera WR, Hughes VA, Fielding RA, Fiatarone MA, Evans WJ, Roubenoff R. Aging of skeletal muscle: a 12 year longitudinal study. J Appl Physiol 2000;88:1321–6
   Google Scholar
• Reed RL, Pearlmutter L, Yochum K, Meredith KE, Mooradian AD. The relationship between muscle mass and muscle strength in the elderly. J Am Geriatr Soc 1991;39:555–61
   Google Scholar
• Abbasi AA, Drinka PJ, Mattson DE, Rudman D. Low circulating levels of insulin-like growth factors and testosterone in chronically institution- alized elderly men. J Am Geriatr Soc 1993;41:975–82
   Google Scholar
• Baumgartner RN, Waters DL, Gallagher D, Morley JE, Garry PJ. Predictors of skeletal muscle mass in elderly men and women. Mech Ageing Dev 1999;107:123–36
   Google Scholar
• Verhaar HJJ, Samson MM, Aleman A, de Vries WR, de Vreede PL, Koppeschaar HPF. The relationship between indices of muscle function and circulating anabolic hormones in healthy. Aging Male 2000;3:75–80
   Google Scholar
• Kirkland RT, Keenan BS, Probstfield JL, Patsch W, Lin TL, Clayton GW, et al. Decrease in plasma high-density lipoprotein cholesterol levels at puberty in boys with delayed adolescence. Correlation with plasma testosterone levels. J Am Med Assoc 1987;257:502–7
   Google Scholar
• Barrett-Connor EL. Testosterone and risk factors for cardiovascular disease in men. Diabete Metab 1995;21:156–61
   Google Scholar
• Bagatell CJ, Bremner WJ. Androgen and pro- gestagen effects on plasma lipids. Prog Cardiovasc Dis 1995;38:255–71
   Google Scholar
• Haffner JM. Androgens in relation to cardio- vascular disease and insulin resistance in aging male. In Oddens B, Vermeulen A, eds. Androgens and The Aging Male, Carnforth, UK: Parthenon Publishing, 1996,65–84
   Google Scholar
• Caron P, Bennet A, Camare R, Louvet JP, Boneu B, Sie P. Plasminogen activator inhibitor in plasma is related to testosterone in men. Metabolism 1989;38:1010–15
   Google Scholar
• Phillips GB, Pinkernell BH, Jing TY. The associ- ation of hypotestosteronemia with coronary artery disease in men. Arterioscler Thromb 1994;14:701–6
   Google Scholar
• Swartz CM, Young MA. Low serum testosterone and myocardial infarction in geriatric male inpatients. J Am Geriatr Soc 1987;35:39–44
   Google Scholar
• Haffner JE, Moss SE, Klein BEK, Klein R. Sex hormones and DHEASO4 in relation to ischemic heart disease in diabetic subjects. The WESDR Study. Diabetes Care 1996;19:1045–50
   Google Scholar
• Barrett-Connor E, Khaw KT. Endogenous sex hormones and cardiovascular disease in men. A prospective population-based study. Circulation 1988;78:539–45
   Google Scholar
• Cauley JA, Gutai JP, Kuller LH, Dai WS. Useful- ness of sex steroid hormone levels in predicting coronary artery disease in men. Am J Cardiol 1987;60:771–7
   Google Scholar
• Polderman KH, Stehouwer CD, van Kamp GJ, Dekker GA, Verheugt FW, Gooren LJ. Influence of sex hormones on plasma endothelin levels. Ann Intern Med 1993;118:429–32
   Google Scholar
• Ajayi AA, Mathur R, Halushka PV. Testosterone increases human platelet thromboxane A2 receptor density and aggregation responses. Circulation 1995;91:2742–7
   Google Scholar
• Barrett-Connor E. Lower endogenous androgen levels and dyslipidemia in men with non-insulin- dependent diabetes mellitus. Ann Intern Med 1992;117:807–11
   Google Scholar
• Vermeulen A, Kaufman JM. Androgens and cardiovascular disease in men and women. Aging Male 1998;35–50
   Google Scholar
• Tenover JS. Effects of testosterone supple- mentation in the aging male. J Clin Endocrinol Metab 1992;75:1092–8
   Google Scholar
• Morley JE, Perry HM, III, Kaiser FE, Kraenzle D, Jensen J, Houston K, et al. Effects of testosterone replacement therapy in old hypogonadal males: a preliminary study. J Am Geriatr Soc 1993; 41:149–52
   Google Scholar
• Schiavi RC. Androgens and sexual function in men. In Oddens B, Vermeulen A, eds. Androgens and the Aging Male. Carnforth, UK: Parthenon Publishing, 1996;111–28
   Google Scholar
• Bancroft J. Androgens, sexuality and the aging male. In Labrie F, Proulx L, eds. Endocrinology. Amsterdam: Elsevier 1984;913–16
   Google Scholar
• Schiavi RC, Schreiner-Engel P, White D, Mandeli J. Pituitary-gonadal function during sleep in men with hypoactive sexual desire and in normal controls. Psychosom Med 1988;50:304–18
   Google Scholar
• Pfeilschifter J, Scheidt-Nave C, Leidig-Bruckner G, Woitge HW, Blum WF, Wuster C, et al. Relationship between circulating insulin-like growth factor components and sex hormones in a population-based sample of 50- to 80-year-old men and women. J Clin Endocrinol Metab 1996;81:2534–40
   Google Scholar
• Nilsson PM, Moller L, Solstad K. Adverse effects of psychosocial stress on gonadal function and insulin levels in middle-aged males. J Intern Med 1995;237:479–86
   Google Scholar
• Buena F, Swerdloff RS, Steiner BS, Lutchman- singh P, Peterson MA, Pandian MR, et al. Sexual function does not change when serum testosterone levels are pharmacologically varied within the normal male range. Fertil Steril 1993;59:1118–23
   Google Scholar
• Kraemer HC, Becker HB, Brodie HK, Doering CH, Moos RH, Hamburg DA. Orgasmic frequency and plasma testosterone levels in normal human males. Arch Sex Behav 1976;5:125–32
   Google Scholar
• Mills TM, Reilly CM, Lewis RW. Androgens and penile erection: a review. J Androl 1996; 17:633–8
   Google Scholar
• Lugg JA, Rajfer J, Gonzalez-Cadavid NF. Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat. Endocrinology 1995;136:1495–501
   Google Scholar
• Janowsky JS, Oviatt SK, Orwoll ES. Testosterone influences spatial cognition in older men. Behav Neurosci 1994;108:325–32
   Google Scholar
• Barrett-Connor E, Goodman-Gruen D, Patay B. Endogenous sex hormones and cognitive function in older men. J Clin Endocrinol Metab 1999;84:3681–5
   Google Scholar
• Christiansen K, Kussmann R. Sex hormones and cognitive functions in men. Neuropsychobiology 1987;18:27–36
   Google Scholar
• McKeever WF, Deyo A. Testosterone, dihydrotestosterone and spatial task perfor- mance of males. Bull Psychonomic Soc 1990;28:305–8
   Google Scholar
• Seidman SN, Walsh BT. Testosterone and depression in aging men. Am J Geriatr Psychiatry 1999;7:18–33
   Google Scholar
• Araujo AB, Durante R, Feldman HA, Goldstein I, McKinlay JB. The relationship between depres- sive symptoms and male erectile dysfunction: cross-sectional results from the Massachusetts Male Aging Study. Psychosom Med 1998;60:458–65
   Google Scholar
• Wang C, Swerdloff RS, Iranmanesh A, Dobs A, Snyder PJ, Cunningham G, et al. Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition para- meters in hypogonadal men. Testosterone Gel Study Group. J Clin Endocrinol Metab 2000;85:2839–53
   Google Scholar
• Brodsky IG, Balagopal P, Nair KS. Effects of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men – a clinical research center study. J Clin Endocrinol Metab 1996;81:3469–75
   Google Scholar
• Sheffield-Moore M, Urban RJ, Wolf SE, Jiang J, Catlin DH, Herndon DN, et al. Short-term oxandrolone administration stimulates net muscle protein synthesis in young men. J Clin Endocrinol Metab 1999;84:2705–11
   Google Scholar
• Urban RJ, Gilkison C, Jiang J, Marcell T, Tipton K, Sheffield-Moore M, et al. Testosterone administration to older men for 6 months increases skeletal muscle strength, net muscle protein balance and the expression of intra- muscular IgF-1 transcription. Presented at the 82nd Annual Meeting of the Endocrine Society, 2000;Abstract 393
   Google Scholar
• Urban RJ, Bodenburg YH, Gilkison C, Foxworth J, Coggan AR, Wolfe RR, et al. Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis. Am J Physiol 1995;269:E820–6
   Google Scholar
• Sih R, Morley JE, Kaiser FE, Perry HM, III, Patrick P, Ross C. Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial. J Clin Endocrinol Metab 1997;82:1661–7
   Google Scholar
• Tenover JS. Androgen administration to aging men. Endocrinol Metab Clin North Am 1994;23:877–92
   Google Scholar
• Snyder PJ, Peachey H, Hannoush P, Berlin JA, Loh L, Lenrow DA, et al. Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age. J Clin Endocrinol Metab 1999;84:2647–53
   Google Scholar
• Clague JE, Wu FC, Horan MA. Difficulties in measuring the effect of testosterone replacement therapy on muscle function in older men. Int J Androl 1999;22:261–5
   Google Scholar
• Bhasin S, Bagatell CJ, Bremner WJ, Plymate SR, Tenover JL, Korenman SG, et al. Issues in testosterone replacement in older men. J Clin Endocrinol Metab 1998;83:3435–48
   Google Scholar
• Behre HM, von Eckardstein S, Kliesch S, Nieschlag E. Long-term substitution therapy of hypogonadal men with transscrotal testosterone over 7–10 years. Clin Endocrinol (Oxf) 1999;50:629–35
   Google Scholar
• Katznelson L, Finkelstein JS, Schoenfeld DA, Rosenthal DI, Anderson EJ, Klibanski A. Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. J Clin Endocrinol Metab 1996;81:4358–65
   Google Scholar
• Snyder PJ, Peachey H, Berlin JA, Hannoush P, Haddad G, Dlewati A, et al. Effects of testos- terone replacement in hypogonadal men. J Clin Endocrinol Metab 2000;85:2670–7
   Google Scholar
• Behre HM, Kliesch S, Leifke E, Link TM, Nieschlag E. Long-term effect of testosterone therapy on bone mineral density in hypogonadal men. J Clin Endocrinol Metab 1997;82:2386–90
   Google Scholar
• Saggese G, Bertelloni S, Baroncelli GI. Sex steroids and the acquisition of bone mass. Horm Res 1997;48(Suppl 5):65–71
   Google Scholar
• Vanderschueren D, Boonen S, Bouillon R. Osteoporosis and osteoporotic fractures in men: a clinical perspective. Baillieres Best Pract Res Clin Endocrinol Metab 2000;14:299–315
   Google Scholar
• Snyder PJ, Peachey H, Hannoush P, Berlin JA, Loh L, Holmes JH, et al. Effect of testosterone treatment on bone mineral density in men over 65 zyears of age. J Clin Endocrinol Metab 1999;84:1966–72
   Google Scholar
• Peacock M, Liu G, Carey M, McClintock R, Ambrosius W, Hui S, et al. Effect of calcium or 25OH vitamin D3 dietary supplementation on bone loss at the hip in men and women over the age of 60. J Clin Endocrinol Metab 2000;85:3011–19
   Google Scholar
• Wang C, Eyre DR, Clark R, Kleinberg D, Newman C, Iranmanesh A, et al. Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men – a clinical research center study. J Clin Endocrinol Metab 1996;81:3654–62
   Google Scholar
• Bagatell CJ, Heiman JR, Matsumoto AM, Rivier JE, Bremner WJ. Metabolic and behavioral effects of high-dose, exogenous testosterone in healthy men. J Clin Endocrinol Metab 1994;79:561–7
   Google Scholar
• Anderson RA, Bancroft J, Wu FC. The effects of exogenous testosterone on sexuality and mood of normal men. J Clin Endocrinol Metab 1992;75:1503–7
   Google Scholar
• Hajjar RR, Kaiser FE, Morley JE. Outcomes of long-term testosterone replacement in older hypogonadal males: a retrospective analysis. J Clin Endocrinol Metab 1997;82:3793–6
   Google Scholar
• Wang C, Alexander G, Berman N, Salehian B, Davidson T, McDonald V, et al. Testosterone replacement therapy improves mood in hypo- gonadal men – a clinical research center study. J Clin Endocrinol Metab 1996;81:3578–83
   Google Scholar
• Marin P, Holmäng S, Gustafson C, Jönsson C, Kvist H, Elander A, et al. Androgen treatment of abdominally obese men. Obes Res 1993;1:245–8
   Google Scholar
• Ellyin FM. The long term beneficial effect of low dose testosterone in the aging male. Presented at the 77th Annual Meeting of the Endocrine Society, 1995;P2–P27
   Google Scholar
• Orwoll ES, Oviatt SK, Biddle J, et al. Transdermal testosterone supplementation in normal older men. Presented at the 74th Annual Meeting of the Endocrine Society, 1992:319
   Google Scholar
• Alexander GM, Swerdloff RS, Wang C, Davidson T, McDonald V, Steiner B, et al. Androgen-behavior correlations in hypogonadal men and eugonadal men. II. Cognitive abilities. Horm Behav 1998;33:85–94
   Google Scholar
• Deslypere JP, Vermeulen A. Influence of age on steroid concentrations in skin and striated muscle in women and in cardiac muscle and lung tissue in men. J Clin Endocrinol Metab 1985;61:648–53
   Google Scholar
• Greenstein BD. Androgen receptors in the rat brain, anterior pituitary gland and ventral prostate gland: effects of orchidectomy and ageing. J Endocrinol 1979;81:75–81
   Google Scholar
• Fischbeck KH, Lieberman A, Bailey CK, Abel A, Merry DE. Androgen receptor mutation in Kennedy’s disease. Philos Trans R Soc Lond B Biol Sci 1999;354:1075–8
   Google Scholar
• Krithivas K, Yurgalevitch SM, Mohr BA, Wilcox CJ, Batter SJ, Brown M, et al. Evidence that the CAG repeat in the androgen receptor gene is associated with the age-related decline in serum androgen levels in men. J Endocrinol 1999;162:137–42
   Google Scholar
• Tincello DG, Saunders PT, Hodgins MB, Simpson NB, Edwards CR, Hargreaves TB, et al. Correlation of clinical, endocrine and molecular abnormalities with in vivo responses to high-dose testosterone in patients with partial androgen insensitivity syndrome. Clin Endocrinol (Oxf) 1997; 46:497–506
   Google Scholar
• Weidemann W, Peters B, Romalo G, Spindler KD, Schweikert HU. Response to androgen treatment in a patient with partial androgen insensitivity and a mutation in the deoxyribo- nucleic acid-binding domain of the androgen receptor. J Clin Endocrinol Metab 1998;83:1173–6
   Google Scholar
• Vermeulen A, Kaufman JM. Ageing of the hypothalamo-pituitary-testicular axis in men. Horm Res 1995;43:25–8
   Google Scholar
• Winters SJ, Sherins RJ, Troen P. The gonado- tropin-suppressive activity of androgen is increased in elderly men. Metabolism 1984;33:1052–9
   Google Scholar
• Winters SJ, Atkinson L. Serum LH concen- trations in hypogonadal men during transdermal testosterone replacement through scrotal skin: further evidence that ageing enhances testos- terone negative feedback. The Testoderm Study Group. Clin Endocrinol (Oxf) 1997;47:317–22
   Google Scholar
• Rajfer J, Namkung PC, Petra PH. Identification, partial characterization and age-related changes of a cytoplasmic androgen receptor in the rat penis. J Steroid Biochem 1980;13:1489–92
   Google Scholar
• Gonzalez-Cadavid NF, Swerdloff RS, Lemmi CA, Rajfer J. Expression of the androgen receptor gene in rat penile tissue and cells during sexual maturation. Endocrinology 1991;129:1671–8
   Google Scholar
• Roehrborn CG, Lange JL, George FW, Wilson JD. Changes in amount and intracellular distribution of androgen receptor in human foreskin as a function of age. J Clin Invest 1987; 79:44–7
   Google Scholar
• Tohgi H, Utsugisawa K, Yamagata M, Yoshimura M. Effects of age on messenger RNA expression of glucocorticoid, thyroid hormone, androgen, and estrogen receptors in postmor- tem human hippocampus. Brain Res 1995;700:245–53
   Google Scholar
• Ono K, Haji M, Nawata H, Maki T, Kato K, Ibayashi H. Age-related changes in gluco- corticoid and androgen receptors of cultured human pubic skin fibroblasts. Gerontology 1988; 34:128–33
   Google Scholar
• Mowszowicz I, Riahi M, Wright F, Bouchard P, Kuttenn F, Mauvais-Jarvis P. Androgen receptor in human skin cytosol. J Clin Endocrinol Metab 1981;52:338–44
   Google Scholar
• Fichman KR, Nyberg LM, Bujnovszky P, Brown TR, Walsh PC. The ontogeny of the androgen receptor in human foreskin. J Clin Endocrinol Metab 1981;52:919–23
   Google Scholar
• Vermeulen A. Androgen replacement therapy in the aging male – a critical evaluation. J Clin Endocrinol Metab 2001;86:2380–90
   Google Scholar
• Morales A, Lunenfeld B. Investigation, treatment and monitoring of late-onset hypogonadism in males. Official Recommendations of ISSAM, International Society for the Study of the Aging Male. Aging Male 2002; 5:74–86van Kesteren P, Lips P, Gooren LJ, Asscheman H, Megens J. Long-term follow-up of bone mineral density and bone metabolism in transsexuals treated with cross-sex hormones. Clin Endocrinol (Oxf) 1998;48:347–54
   Google Scholar