AGE-DEPENDENT CHANGES OF THE CIRCADIAN SYSTEM

REFERENCES

• Aschoff J. Zeitgeber der tierischen Tagesperiodik. Naturwiss 1954; 41: 49–56
   Web of Science ®Google Scholar
• Aschoff J. Exogenous and endogenous components in circadian rhythms. Cold Spring Harb Symp Quant Biol. 1960; 25: 11–28
   PubMedGoogle Scholar
• Aschoff J. On the aging of circadian systems. Evolution of circadian clock, T Hiroshige, K Honma. Hokkaido University Press, SapporoJapan 1994; 23–44
   Google Scholar
• Aschoff J, Figala J, Poöppel E. Circadian rhythms of locomotor activity in the golden hamster (Mesocricetus auratus) measured with two different techniques. J Comp Physiol Psychol. 1973; 85: 20–28
   PubMed Web of Science ®Google Scholar
• Aschoff J, Hoffmann K, Pohl H, et al. Re-entrainment of circadian rhythms after phase-shifts of the zeitgeber. Chronobiologia 1975; 1: 23–78
   Google Scholar
• Aschoff J, von Saint Paul U, Wever R. Die Lebensdauer von Fliegen unter dem Einfluβ von Zeitverschiebungen. Naturwiss 1971; 58: 574
   PubMedGoogle Scholar
• Baerensprung Fv. Untersuchungen über die Temperaturverhaältnisse des Foetus und des erwachsenen Menschen im gesunden und kranken Zustand. Arch Anat Physiol wiss Med. 1851; 126–75
   Google Scholar
• Balsalobre A, Damiola F, Schibler U. A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell 1998; 93: 929–37
   PubMed Web of Science ®Google Scholar
• Benloucif S, Masana M I, Dubocovich M L. Light-induced phase shifts of circadian activity rhythms and immediate early gene expression in the suprachiasmatic nucleus are attenuated in old C3H/HeN mice. Brain Res. 1997; 747: 34–42
   PubMed Web of Science ®Google Scholar
• Borbély A A. Effects of light on sleep and activity rhythms. Prog Neurobiol. 1978; 10: 1–31
   PubMed Web of Science ®Google Scholar
• Brock M A. Chronobiology and aging. J Am Geriatric Soc. 1991; 39: 74–91
   PubMed Web of Science ®Google Scholar
• Buresova M, Benesova O, Illnerova H. Aging alters resynchronization of the circadian system in rats after a shift of the light-dark cycle. Experientia. 1990; 46: 75–77
   PubMedGoogle Scholar
• Cai A H, Scarbrough K, Hinkle D A, et al. Fetal grafts containing suprachiasmatic nuclei restore the diurnal rhythm of CRH and POMC mRNA in aging rats. Am J Physiol. 1997; 42: R1764–70
   Google Scholar
• Cai A H, Wise P M. Age-related changes in the diurnal rhythms of CRH gene expression in the paraventricular nuclei. Am J Physiol. 1996a; 33: E238–43
   Google Scholar
• Cai A H, Wise P M. Age-related changes in light-induced Jun-B and Jun-D expression: effects of transplantation of fetal tissue containing the suprachiasmatic nucleus. J Biol Rhythms 1996b; 11: 284–90
   PubMed Web of Science ®Google Scholar
• Campbell S S, Dawson D, Anderson M W. Alleviation of sleep maintenance insomnia with timed exposure to bright light. J Am Geriatr Soc. 1993; 41: 829–36
   PubMed Web of Science ®Google Scholar
• Campbell S S, Murphy P J. Relationships between sleep and body temperature in middle-aged and older subjects. J Am Geriatr Soc. 1998; 46: 458–62
   PubMed Web of Science ®Google Scholar
• Carrier J, Monk T H, Buysse D J, et al. Amplitude reduction of the circadian temperature and sleep rhythms in the elderly. Chronobiol Int. 1996; 13: 373–86
   PubMed Web of Science ®Google Scholar
• Carrier J, Monk T H, Reynolds C F, et al. Are age differences in sleep due to phase differences in the output of the circadian timing system. Chronobiol Int. 1999; 16: 79–91
   PubMed Web of Science ®Google Scholar
• Cassone V M. Melatonin's role in vertebrate circadian rhythms. Chronobiol Int. 1998; 15: 457–73
   PubMed Web of Science ®Google Scholar
• Cassone V M, Warren W S, Brooks D S, et al. Melatonin, the pineal gland, and circadian rhythms. J Biol Rhythms 1993; 73–81
   Web of Science ®Google Scholar
• Chee C A, Roozendaal B, Swaab D F, et al. Vasoactive intestinal polypeptide neuron changes in the senile rat suprachiasmatic nucleus. Neurobiol Aging 1988; 9: 307–12
   PubMed Web of Science ®Google Scholar
• Czeisler C A, Dumont M, Duffy J F, et al. Association of sleep-wake habits in older people with changes in output of circadian pacemaker. Lancet 1992; 340: 933–36
   PubMed Web of Science ®Google Scholar
• Davis F C, Menaker M. Development of the mouse circadian pacemaker: independence from environmental cycles. J Comp Physiol A 1981; 143: 527–39
   PubMed Web of Science ®Google Scholar
• Davis F C, Viswanathan N. Stability of circadian timing with age in Syrian hamsters. Am J Physiol. 1998; 44: R960–68
   Google Scholar
• Delagrange P, Guardiola-Lemaitre B. Melatonin, its receptors, and relationships with biological rhythm disorders. Clin Neuropharmacol. 1997; 20: 482–10
   PubMed Web of Science ®Google Scholar
• Duffy J F, Dijk D J, Klerman E B, et al. Later endogenous circadian temperature nadir relative to an earlier wake time in older people. Am J Physiol. 1998; 275: R1478–R87
   PubMed Web of Science ®Google Scholar
• Edgar D M, Dement W C, Fuller C A. Effect of SCN lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep-wake regulation. J Neurosci. 1993; 13: 1065–79
   PubMed Web of Science ®Google Scholar
• Edgar D M, Kilduff T S, Martin C E, et al. Influence of running wheel activity on free-running sleep/wake and drinking circadian rhythms in mice. Physiol Behav. 1991; 50: 373–78
   PubMed Web of Science ®Google Scholar
• Edgar D M, Martin C E, Dement W C. Activity feedback to the mammalian circadian pacemaker: influence of observed measures of rhythm period length. J Biol Rhythms 1991; 6: 185–99
   PubMed Web of Science ®Google Scholar
• Erkert H G. Characteristics of the circadian activity rhythm in common marmosets (Callithrix j. jacchus). Am J Primatol. 1989; 17: 271–86
   PubMed Web of Science ®Google Scholar
• Freedman M S, Lucas R J, Soni B, et al. Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors. Science 1999; 284: 502–4
   PubMed Web of Science ®Google Scholar
• Gattermann R, Weinandy R. Lack of social entrainment of circadian activity rhythms in the solitary golden hamster and the highly social Mongolian gerbil. Biol Rhythm Res. 1997; 28: 85–93
   Web of Science ®Google Scholar
• Gubin G D, Weinert D. Biorhythms and age [in Russian]. Usp Fiziol Nauk 1991; 22: 77–96
   PubMedGoogle Scholar
• Halberg F, Nelson W, Cadotte L. Increased mortality in mice exposed to weekly 180° shifts of lighting regimen LD 12:12 beginning at 1 year of age. Chronobiologia 1975, Suppl. 1: 26
   Google Scholar
• Halberg J, Halberg E, Regal P, et al. Changes with age characterize circadian rhythm in telemetered core temperature of stroke-prone rats. J Gerontol. 1981; 36: 28–30
   PubMedGoogle Scholar
• Hastings M H, Duffiel G E, Smith E JD, et al. Entrainment of the circadian system of mammals by nonphotic cues. Chronobiol Int. 1998; 15: 425–45
   PubMed Web of Science ®Google Scholar
• Hofman M A, Zhou J N, Swaab D F. Suprachiasmatic nucleus of the human brain: an immunocytochemical and morphometric analysis. Anat Rec. 1996; 244: 552–62
   PubMedGoogle Scholar
• Kawakami F, Okamura H, Tamada Y, et al. Loss of day-night differences in VIP mRNA levels in the suprachiasmatic nucleus of aged rats. Neurosci Lett. 1997; 222: 99–102
   PubMed Web of Science ®Google Scholar
• Kort W J, Weijma J M. Effect of chronic light-dark shift stress on the immune response of the rat. Physiol Behav. 1982; 29: 1083–87
   PubMed Web of Science ®Google Scholar
• Koster-Van Hoffen GC, Mirmiran M, Bos N PA, et al. Effects of a novel melatonin analog on circadian rhythms of body temperature and activity in young, middle-aged, and old rats. Neurobiol Aging 1993; 14: 565–69
   PubMed Web of Science ®Google Scholar
• Krajnak K, Kashon M L, Rosewell K L, et al. Aging alters the rhythmic expression of vasoactive intestinal polypeptide mRNA but not arginine vasopressin mRNA in the suprachiasmatic nuclei of female rats. J Neurosci. 1998; 18: 4767–74
   PubMed Web of Science ®Google Scholar
• Labyak S E, Turek F W, Wallen E P, et al. Effects of bright light on age-related changes in the locomotor activity of Syrian hamsters. Am J Physiol. 1998; R830–39
   PubMedGoogle Scholar
• LeSauter J, Silver R. Output signals of the SCN. Chronobiol Int. 1998; 15: 535–50
   PubMed Web of Science ®Google Scholar
• Li H, Satinoff E. Fetal tissue containing the suprachiasmatic nucleus restores multiple circadian rhythms in old rats. Am J Physiol. 1998; 44: R1735–44
   Google Scholar
• Lucassen P J, Hofmann M A, Swaab D F. Increased light intensity prevents the age related loss of vasopressin-expressing neurons in the rat suprachiasmatic nucleus. Brain Res. 1995; 693: 261–66
   PubMed Web of Science ®Google Scholar
• Madeira M D, Sousa N, Santer R M, et al. Age and sex do not affect the volume, cell numbers, or cell size of the suprachiasmatic nucleus of the rat: an unbiased stereological study. J Comp Neurol. 1995; 361: 585–601
   PubMed Web of Science ®Google Scholar
• Magri F, Locatelli M, Balza G, et al. Changes in endocrine circadian rhythms as markers of physiological and pathological brain aging. Chronobiol Int. 1997; 14: 385–96
   PubMed Web of Science ®Google Scholar
• Mayeda A R, Hofstetter J R, Possidente B. Aging lengthens TauDD in C57BL/6J, DBA/2J, and outbred SWR male mice (Mus musclus). Chronobiol Int. 1997; 14: 19–23
   PubMed Web of Science ®Google Scholar
• McDonald R B, Hoban-Higgins T M, Ruhe R C, et al. Alterations in endogenous circadian rhythm of core temperature in senescent Fischer 344 rats. Am J Physiol. 1999; 45: R824–30
   Google Scholar
• Miller J D. The SCN is comprised of a population of coupled oscillators. Chronobiol Int. 1998; 15: 489–511
   PubMed Web of Science ®Google Scholar
• Monk T H. Circadian rhythms. Clin Geriatr Med. 1989; 5: 331–46
   PubMedGoogle Scholar
• Monk T H, Buysse D J, Reynolds C F, III, et al. Circadian temperature rhythms of older people. Exp Gerontol. 1995; 30: 455–74
   PubMed Web of Science ®Google Scholar
• Moore R Y. Organization of the mammalian circadian system, D J Chadwick, K Ackrill. Circadian clocks and their adjustment, ChichesterEngland 1995; 88–100, John Wiley and Sons
   Google Scholar
• Moore-Ede M C, Sulzman F M. Internal temporal order, J Aschoff. Handbook of behavioral neurobiology, New York, Plenum 1981; 5: 215–44, biological rhythms
   Google Scholar
• Morin L P. Age related changes in hamster circadian period, entrainment, and rhythm splitting. J Biol Rhythms 1988; 3: 237–48
   Web of Science ®Google Scholar
• Morin L P. Age, but not pineal status, modulates circadian periodicity of golden hamsters. J Biol Rhythms 1993; 8: 189–97
   PubMed Web of Science ®Google Scholar
• Morin L P. The circadian visual system. Brain Res Rev. 1994; 67: 102–27
   Google Scholar
• Mouton A, Penev P D, Ruth A, et al. The effects of timed bright light exposure on temperature, mood, and performance rhythms in the elderly [abstract]. Sleep 1996; 25: 564
   Google Scholar
• Mrosovsky N. Tau changes after single non-photic events. Chronobiol Int. 1993; 10: 271–76
   PubMed Web of Science ®Google Scholar
• Mrosovsky N. A non-photic gateway to the circadian clock of hamsters, D J Chadwick, K Ackrill. Circadian clocks and their adjustment, ChichesterEngland 1995; 154–67, John Wiley and Sons
   Google Scholar
• Mrosovsky N, Biello S M. Nonphotic phase shifting in the old and the cold. Chronobiol Int. 1994; 11: 232–52
   PubMed Web of Science ®Google Scholar
• Paris A L, Ramaley J A. Adrenal-gonadal relations and fertility: the effects of repeated stress upon the adrenal rhythm. Neuroendocrinology 1974; 15: 126–36
   PubMed Web of Science ®Google Scholar
• Penev P D, Turek F W, Wallen E P, et al. Aging alters the serotonergic modulation of light-induced phase-advances in golden hamsters. Am J Physiol. 1997; 41: R509–13
   Google Scholar
• Penev P D, Zee P C, Turek F W. Quantitative analysis of the age-related fragmentation of hamster 24h activity rhythms. Am J Physiol. 1997; 42: R2132–137
   Google Scholar
• Penev P D, Zee P C, Wallen E P, et al. Aging alters the phase-resetting properties of a serotonin agonist on hamster circadian rhythmicity. Am J Physiol. 1995; 37: R293–98
   Google Scholar
• Peschke E, Peschke D. Evidence for a circadian rhythm of insulin release from perifused rat pancreatic islets. Diabetologia. 1998; 41: 1085–92
   PubMed Web of Science ®Google Scholar
• Peschke E, Peschke D, Hammer T, et al. Influence of melatonin and serotonin on glucose-stimulated insulin release from perifused rat pancreatic islets in vitro. J Pineal Res. 1997; 23: 156–63
   PubMed Web of Science ®Google Scholar
• Pittendrigh C S. Circadian rhythms and the circadian organization of living systems. Cold Spring Harb Symp Quant Biol. 1960; 25: 159–84
   PubMedGoogle Scholar
• Pittendrigh C S. Circadian systems. Entrainment, J Aschoff. Biological rhythms, New York, Plenum 1981a; 95–124
   Google Scholar
• Pittendrigh C S. Circadian systems. General perspective, J Aschoff. Biological rhythms, New York, Plenum 1981b; 57–80
   Google Scholar
• Pittendrigh C S, Daan S. Circadian oscillations in rodents: a systematic increase of their frequency with age. Science 1974; 186: 548–50
   PubMed Web of Science ®Google Scholar
• Pittendrigh C S, Daan S. A functional analysis of circadian pacemakers in nocturnal rodents. I. The stability and lability of spontaneous frequency. J Comp Physiol A 1976a; 106: 223–52
   Web of Science ®Google Scholar
• Pittendrigh C S, Daan S. A functional analysis of circadian pacemakers in nocturnal rodents: II. The variability of phase response curves. J Comp Physiol A 1976b; 106: 253–66
   Web of Science ®Google Scholar
• Pittendrigh C S, Daan S. A functional analysis of circadian pacemakers in nocturnal rodents: IV. Entrainment: pacemaker as clock. J Comp Physiol A 1976c; 106: 333–55
   Web of Science ®Google Scholar
• Pohl H. Differences in response of the circadian system to light in the Syrian hamster. Physiol Zool. 1984; 57: 509–20
   Google Scholar
• Possidente B, McEldowney S, Pabon A. Aging lengthens circadian period for wheel-running activity in C57BL mice. Physiol Behav. 1995; 57: 575–79
   PubMed Web of Science ®Google Scholar
• Pratt B L, Goldmann B D. Environmental influences upon circadian periodicity of Syrian hamsters. Physiol. Behav. 1986; 36: 91–95
   PubMed Web of Science ®Google Scholar
• Provencio I, Wong S Y, Lederman A B, et al. Visual and circadian responses to light in aged retinally degenerate mice. Vision Res. 1994; 34: 1799–1806
   PubMed Web of Science ®Google Scholar
• Quay W B. Pineal homeostatic regulation of shifts in the circadian activity rhythm during maturation and aging. Trans NY Acad Sci. 1972; 34: 239–54
   PubMedGoogle Scholar
• Ralph M, Mrosovsky N. Behavioral inhibition of circadian responses to light. J Biol Rhythms 1992; 7: 353–59
   PubMed Web of Science ®Google Scholar
• Rappold I, Erkert H G. Re-entrainment, phase-response and range of entrainment of circadian rhythms in owl monkeys (Aotus lemurinus g.) of different age. Biol Rhythm Res. 1994; 25: 353–52
   Web of Science ®Google Scholar
• Rea M A. Photic entrainment of circadian rhythms in rodents. Chronobiol Int. 1998; 15: 395–423
   PubMed Web of Science ®Google Scholar
• Refinetti R, Ma H, Satinoff E. Body temperature rhythms, cold tolerance, and fever in young and old rats of both gender. Exp Gerontol. 1990; 25: 533–43
   PubMed Web of Science ®Google Scholar
• Reilly T, Waterhouse J, Atkinson G. Aging, rhythms of physical performance, and adjustment to changes in the sleep-activity cycle. Occup Environ Med. 1997; 54: 812–16
   PubMed Web of Science ®Google Scholar
• Rietveld W J, Ruis J, Buijs P. The effect of ageing in the circadian control of food intake in the rat. J Interdiscipl Cycle Res. 1988; 19: 289–95
   Google Scholar
• Roozendaal B, Van Gool W A, Swaab D F, et al. Changes in vasopressin cells of the rat suprachiasmatic nucleus with aging. Brain Res. 1987; 409: 259–64
   PubMed Web of Science ®Google Scholar
• Rosenberg R S, Zee P C, Turek F W. Phase response curves to light in young and old hamsters. Am J Physiol. 1991; 261: R491–95
   PubMed Web of Science ®Google Scholar
• Ruby N F, Edgar D M, Craig Heller H, et al. The aged suprachiasmatic nucleus is phase-shifted by cAMP in vitro. Brain Res. 1998; 779: 338–41
   PubMed Web of Science ®Google Scholar
• Rusak B. Photic entrainment routes in mammals, M Zatz, J Axelrod. Circadian rhythms. Discussions in neuroscience VIII. Amsterdam: Elsevier Science. 1992; 38–43
   Google Scholar
• Satinoff E. Patterns of circadian body temperature rhythms in aged rats. Clin Exp Pharmacol Physiol. 1998; 25: 135–40
   PubMed Web of Science ®Google Scholar
• Satinoff E, Li H, Tcheng T K, et al. Do the suprachiasmatic nuclei oscillate in old rats as they do in young ones. Am J Physiol. 1993; 265: R1216–22
   PubMedGoogle Scholar
• Scarbrough K, Losee-Olsen S, Wallen E P, et al. Aging and photoperiod affect entrainment and quantitative aspects of locomotor behavior in Syrian hamsters. Am J Physiol. 1997; 272: R1219–25
   PubMed Web of Science ®Google Scholar
• Schuh J, Weinert D, Gubin G D. The time of resynchronizationas an indicator of the adaptive potency. Chronobiology and chronomedicine. Basic research and applications, J Surowiak, H Lewandowski. Frankfurt am Main: Verlag Peter Lang. 1991; 131–35
   Google Scholar
• Schuh J, Weinert D, Gubin G D, et al. Dynamic variation of circadian amplitudes and acrophases depending on age. Chronobiology and chronomedicine. Basic research and applications, Ch Gutenbrunner, G Hildebrandt, R Moog. Frankfurt am Main: Verlag Peter Lang. 1993; 82–87
   Google Scholar
• Sharma V K, Chandrashekaran M K. Age-dependent modulation of circadian parameters in the field mouse Mus booduga. J Exp Zool. 1998; 280: 321–26
   PubMedGoogle Scholar
• Slonaker J R. The normal activity of the albino rat from birth to natural death, its rate of growth and the duration of life. J Anim Behav. 1912; 2: 20–42
   Google Scholar
• Sturm J, Weinert H, Weinert D. Age-dependent changes in the stability of daily activity rhythms of laboratory mice. Z Saäugetierk, in press 2000
   Google Scholar
• Sutin E L, Dement W C, Heller H C, et al. Light-induced gene expression in the suprachiasmatic nucleus of young and aging rats. Neurobiol Aging 1993; 14: 441–46
   PubMed Web of Science ®Google Scholar
• Swaab D F, Hofman M A. Age, sex and light: variability in the human suprachismatic nucleus in relation to its function. Progr Brain Res. 1994; 100: 261–65
   PubMed Web of Science ®Google Scholar
• Topitz A. Neue Gedanken über Beziehungen biologischer Rhythmen zu Klima und Wetter. Rep 5th Conf Soc Biol Rhythm. Stockholm 1955; 161–62
   Google Scholar
• Touitou Y, Bogdan A, Haus E, et al. Modifications of circadian and circannual rhythms with aging. Exp Gerontol. 1997; 32: 603–14
   PubMed Web of Science ®Google Scholar
• Turek F W, Penev P, Zhang Y, et al. Effects of age on the circadian system. Neurosci Biobehav Rev. 1995; 19: 53–58
   PubMed Web of Science ®Google Scholar
• Ungar F, Halberg F. Circadian rhythm in the in vitro response of mouse adrenal to adrenocorticotropic hormone. Science 1962; 137: 1058–60
   PubMed Web of Science ®Google Scholar
• Valentinuzzi V S, Scarbrough K, Takahashi J S, et al. Effects of aging on the circadian rhythm of wheel-running activity in C57Bl/6 mice. Am J Physiol. 1997; 42: R1957–64
   Google Scholar
• Van Cauter E, Leproult R, Kupfer D J. Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol. J Clin Endocrinol Metab. 1996; 81: 2468–73
   PubMed Web of Science ®Google Scholar
• Van der Zee E A, Jansen K, Gerkema M P. Severe loss of vasopressin-immunoreactive cells in the suprachiasmatic nucleus of aging voles coincides with reduced circadian organization of running wheel activity. Brain Res. 1999; 816: 572–79
   PubMed Web of Science ®Google Scholar
• Van Gool W A, Witting W, Mirmiran M. Age-related changes in circadian sleep-wakefulness rhythms in male rats isolated from time cues. Brain Res. 1987; 413: 384–87
   PubMed Web of Science ®Google Scholar
• Van Reeth O, Zhang Y, Lesourd M, et al. Age-related changes in the hamster's circadian system partially reversed by treatment with Sulbutiamine, a Vit B-1 related compound. Biol Rhythm Res. 1994; 25: 477–79
   Web of Science ®Google Scholar
• Van Reeth O, Zhang Y, Zee P C, et al. Aging alters feedback effects of the activity-rest-cycle on the circadian clock. Am J Physiol. 1992; 263: R981–86
   PubMedGoogle Scholar
• Van Reeth O, Zhang Y, Zee P C, et al. Grafting fetal suprachiasmatic nuclei in the hypothalamus of old hamsters restores responsiveness of the circadian clock to a phase shifting stimulus. Brain Res. 1994; 643: 338–42
   PubMed Web of Science ®Google Scholar
• Van Someren E JW, Lijzenga C, Mirmiran M, et al. Long-term fitness training improves the circadian rest-activity rhythm in healthy elderly males. J Biol Rhythms 1997; 12: 146–56
   PubMed Web of Science ®Google Scholar
• Viswanathan N, Davis F C. Suprachiasmatic nucleus grafts restore circadian function in aged hamsters. Brain Res. 1995; 686: 10–16
   PubMed Web of Science ®Google Scholar
• Vitiello M V, Smallwood R G, Avery D H. Circadian temperature rhythms in young adult and aged men. Neurobiol Aging 1986; 7: 97–100
   PubMed Web of Science ®Google Scholar
• Wachulec M, Peloso E, Satinoff E. Individual differences in response to LPS and psychological stress in aged rats. Am J Physiol. 1997; 272: R1252–57
   PubMedGoogle Scholar
• Watanabe A, Shibata S, Watanabe S. Circadian rhythm of spontaneous neuronal activity in the suprachiasmatic nucleus of old hamster in vitro. Brain Res. 1995; 695: 237–39
   PubMed Web of Science ®Google Scholar
• Wax T M. Runwheel activity patterns of mature-young and senescent mice: the effect of constant lighting conditions. J Gerontol. 1975; 30: 22–27
   PubMedGoogle Scholar
• Wechselberger E, Erkert H G. Characteristics of the light-induced phase response of circadian activity rhythms in common marmosets, Callithrix j. jacchus (Primates-Cebidae). Chronobiol Int. 1994; 11: 275–84
   PubMed Web of Science ®Google Scholar
• Weinert D. Lower variability in female as compared to male laboratory mice: investigations on circadian rhythms. J Exp Anim Sci. 1996; 37: 121–37
   Google Scholar
• Weinert D, Eimert H, Erkert H G, et al. Resynchronization of the circadian corticosterone rhythm after a light/dark shift in juvenile and adult mice. Chronobiol Int. 1994; 11: 222–31
   PubMed Web of Science ®Google Scholar
• Weinert D, Eimert H, Sturm J, et al. Different rates of resynchronization depending on direction of LD-shift, circadian function and age. Biol Rhythm Res. 1995; 26: 456
   Google Scholar
• Weinert D, Eimert H, Uhlemann S. Effect of various LD-and feeding cycles on the circadian rhythmicity depending on age. J Interdiscipl Cycle Res. 1992; 23: 215–17
   Web of Science ®Google Scholar
• Weinert D, Gubin G D, Durov A M, et al. Changes in amplitudes of circadian rhythms during postnatal ontogenesis. Bull Exp Biol Med (NY) 1990; 110: 1276–78
   Web of Science ®Google Scholar
• Weinert D, Gubin G D, Schuh J. Biological rhythms and postnatal age. Wiss Zeitschr HUB, R Math/Nat Wiss 1990; 39: 404–12
   Google Scholar
• Weinert D, Kompauerova V. Light-induced phase and period responses of circadian activity rhythms in laboratory mice of different age. Zoology 1998; 101: 45–52
   Web of Science ®Google Scholar
• Weinert D, Kompauerova V, Sturm J, et al. Impaired synchronization of circadian activity rhythms in old mice—possible causes. Biol Rhythm Res. 1997; 28: 133, (suppl.)
   Google Scholar
• Weinert D, Schuh J. Investigations on the development of the time-structure of some parameters during the postnatal ontogeny. I. Daily patterns of motor activity, feeding and drinking. Zool Jb Anat. 1984a; 111: 133–46
   Google Scholar
• Weinert D, Schuh J. Investigations on the development of the time-structure of some parameters during the postnatal ontogeny. II. Daily patterns of blood glucose and liver glycogen. Zool Jb Anat. 1984b; 111: 147–53
   Google Scholar
• Weinert D, Schuh J. Frequency and phase correlations of biorhythms of some metabolic parameters during postnatal ontogenesis in mice. Bull Exp Biol Med (NY) 1988; 12: 1764–67
   Web of Science ®Google Scholar
• Weinert D, Sitka U, Minors D, et al. The development of circadian rhythmicity in neonates. Early Hum Dev. 1994; 36: 117–26
   PubMed Web of Science ®Google Scholar
• Weinert D, Ulrich F E, Schuh J. Ontogenetische Änderungen der Tagesmuster der Plasmainsulinkonzentration und ihre Beziehung zur Nahrungsaufnahme. Biomed Biochim Acta. 1987; 46: 387–95
   PubMedGoogle Scholar
• Weinert D, Waterhouse J. Daily activity and body temperature rhythms do not change simultaneously with age in laboratory mice. Physiol Behav. 1999; 66: 605–12
   PubMed Web of Science ®Google Scholar
• Weinert D, Weinert H, Sturm J. Multioscillatory nature of the circadian activity rhythm of laboratory mice. Chronobiol Int. 1997; 14(suppl. 1)179
   Google Scholar
• Weinert D, Weiss T. A nonlinear interrelationship between period length and the amount of activity—age-dependent changes. Biol Rhythm Res. 1997; 28: 105–20
   Web of Science ®Google Scholar
• Weinert H, Weinert D. Circadian activity rhythms of laboratory mice during the last weeks of their life. Biol Rhythm Res. 1998; 29: 159–78
   Web of Science ®Google Scholar
• Weitzmann E D, Moline M L, Czeisler Ch A, et al. Chronobiology of aging: temperature, sleep-wake rhythms and entrainment. Neurobiol Aging 1982; 3: 299–309
   PubMed Web of Science ®Google Scholar
• Welsh D K, Richardson G S, Dement W C. Effect of age on the circadian pattern of sleep and wakefulness in the mouse. J Gerontol. 1986; 41: 579–86
   PubMedGoogle Scholar
• Wever R A. Basic principles of human circadian rhythms. Temporal variations of the cardio-vascular system, T FH Schmidt, B T Engel, G Blumchen. Berlin: Springer Verlag. 1992; 15–84
   Google Scholar
• Wise P M, Cohen I R, Weiland N G, et al. Aging alters the circadian rhythm of glucose utilization in the suprachiasmatic nucleus. Proc Natl Acad Sci USA 1988; 85: 5305–9
   PubMed Web of Science ®Google Scholar
• Witting W, Mirmiran M, Bos N PA, et al. Effect of light intensity on diurnal sleep-wake distribution in young and old rats. Brain Res Bull. 1993; 30: 157–62
   PubMed Web of Science ®Google Scholar
• Witting W, Mirmiran M, Bos N PA, et al. The effect of old age on the free-running period of circadian rhythms in rat. Chronobiol Int. 1994; 11: 103–12
   PubMed Web of Science ®Google Scholar
• Wollnik F, Brysch W, Uhlmann E, et al. Block of c-Fos and JunB expression by antisense-oligonucleotide inhibit light-induced phase shifts of the mammalian circadian clock. Eur J Neurosci. 1995; 7: 388–93
   PubMed Web of Science ®Google Scholar
• Yamada N, Shimoda K, Ohi K, et al. Free-access to a running wheel shortens the period of free-running rhythm in blinded rats. Physiol Behav. 1988; 42: 87–91
   PubMed Web of Science ®Google Scholar
• Yamada N, Shimoda K, Takahashi K, et al. Relationship between free-running period and motor activity in blinded rats. Brain Res Bull. 1990; 25: 115–19
   PubMed Web of Science ®Google Scholar
• Yoshimura T, Ebihara S. Decline of circadian photosensitivity associated with retinal degeneration in CBA/J-rd/rd mice. Brain Res. 1998; 779: 188–93
   PubMed Web of Science ®Google Scholar
• Yunis E J, Fernandes G, Nelson W, et al. Circadian temperature rhythms and aging in rodent, L E Scheving, F Halberg, J E Pauly. Chronobiology. Stuttgart: Georg Thieme Publishers. 1974; 358–63
   Google Scholar
• Zee P C, Rosenberg R S, Turek F W. Effects of aging on entrainment and rate of resynchronization of the circadian locomotor activity. Am J Physiol. 1992; 263: 1099–1103
   Google Scholar
• Zhang Y, Brainard G C, Zee P C. Effects of aging on lens transmittance and retinal input to the suprachiasmatic nucleus in golden hamsters. Neurosci Lett. 1998; 258: 167–70
   PubMed Web of Science ®Google Scholar
• Zhang Y, Kornhauser J M, Zee P C, et al. Effects of aging on light induced phase-shifting of circadian behavioral rhythms, fos expression and CREB phosphorylation in the hamster suprachiasmatic nucleus. Neuroscience 1996; 70: 951–61
   PubMed Web of Science ®Google Scholar
• Zylka Mj, Shearman L P, Weaver D R, et al. Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain. Neuron 1998; 20: 1103–10
   PubMed Web of Science ®Google Scholar