Chronobiology of the mammalian response to ionizing radiation potential applications in oncology

REFERENCES

• Breus T.K., Halberg F., Cornelissen G. Influence of Solar Activity on the Physiological Rhythms of Biological Systems. Biophysics 1995; 40: 719–730
   Google Scholar
• Butler G.C., Nicholas J., Lackland D.T., Friedberg W. Perspectives of Those Impacted: Airline Pilots Perspective. Health Phys. 2000; 79: 602–607
   PubMedGoogle Scholar
• Friedberg W., Duke F.E., Snyder L., Faultner D.N., O'Brien K., Darden E.B., Jr, Parker D.E. The Cosmic Radiation Environment at Air Carrier Flight Altitudes and Possible Associated Health Risks. Radiat. Prot. Dosim. 1993; 48: 21–25
   Google Scholar
• Nicholas J.S., Lackland D.T., Butler G.C., Mohr L.C., Jr, Dunbar J.B., Kaune W.T., Grosche B., Hoel D.G. Cosmic Radiation and Magnetic Field Exposure to Airline Flight Crews. Am. J. Ind. Med. 1998; 34: 574–580
   PubMed Web of Science ®Google Scholar
• Rafnsson V., Tulinius H., Jonasson J.G., Hrafnkelsson J. Risk of Breast Cancer in Female Flight Attendants: A Population-Based Study (Iceland). Cancer Causes Control 2001; 12: 95–101
   PubMed Web of Science ®Google Scholar
• Space Radiation Biology and Related Topics, C.A. Tobias, P. Todd. Academic Press, New York 1974; 590
   Google Scholar
• Parker R.G., Withers R.H. Principles of Radiation Oncology. Cancer Treatment, C.M. Haskell. W.B. Saunders, Philadelphia 2001; 52–62
   Google Scholar
• Puck T.T. Effect of Radiation on Mammalian Cells. The Mammalian Cell as a Microorganism, T.T. Puck. Holden-Day, San Francisco 1972
   Google Scholar
• Puck T.T., Marcus P.I. Action of X-Rays on Mammalian Cells. J. Exp. Med. 1956; 103: 653–666
   PubMed Web of Science ®Google Scholar
• Sinclair W.K. Cyclic X-Ray Responses in Mammalian Cells In Vitro. Radiat. Res. 1968; 33: 620–643
   PubMed Web of Science ®Google Scholar
• Anderson R.E., Berthrong M., Fajardo L.F. Radiation Injury. Anderson's Pathology, I. Damjanov, J. Linder. 10th Ed., Mosby, St. Louis 1996; 484–512
   Google Scholar
• Geske F.J., Gerschenson L.E. The Biology of Apoptosis. Hum. Pathol. 2001; 32(10)1029–1038
   PubMed Web of Science ®Google Scholar
• Rubin N.H. Influence of the Circadian Rhythm in Cell Division on Radiation-Induced Mitotic Delay In Vivo. Radiat. Res. 1982; 89: 65–76
   PubMed Web of Science ®Google Scholar
• Radiology of Cultured Mammalian Cells, M.M. Elkind, G.F. Whitmore. Gordon and Breach, New York 1967
   Google Scholar
• Warren S. Histopathology of Radiation Lesions. Physiol. Rev. 1944; 24: 225–238
   Google Scholar
• White D.C. An Atlas of Radiation Histopathology. ERDA Rep TID-26676. Technical Information Center, Office of Public Affairs, US Energy Research and Development Administration, Washington, DC 1975
   Google Scholar
• The Effects on Populations of Exposure to Low Levels of Ionizing Radiation (BEIR Report). National Academy of Sciences—National Research Council, Washington, DC 1990
   Google Scholar
• Radiation Carcinogenesis: Epidemiology and Biological Significance. Progress in Cancer Research and Therapy, J.D. Boice, J.F. Fraumeni. Raven Press, New York 1984; Vol. 26
   Google Scholar
• Reinhold H.S., Fajardo L.F., Hopewell J.W. The Vascular System. Adv. Radiat. Biol. 1990; 14: 177–225
   Google Scholar
• Pena L.A., Fuks Z., Kolesnick R.N. Radiation-Induced Apoptosis of Endothelial Cells in the Murine Central Nervous System: Protection by Fibroblast Growth Factor and Sphingomyelinase Deficiency. Cancer Res. 2000; 60: 321–327
   PubMed Web of Science ®Google Scholar
• Santana P., Pena L.A., Haimovitz-Friedman A., Martin S., Green D., McLoughlin M., Cordon-Cardo C., Schuchman E.H., Fuks Z., Kolesnick R. Acid Sphingomyelinase-Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis. Cell 1996; 86: 189–199
   PubMed Web of Science ®Google Scholar
• Paris F., Fuks Z., Kang A., Capodieci P., Juan G., Ehleiter D., Haimovitz-Friedman A., Cordon-Cardo C., Kolesnick R. Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice. Science 2001; 293: 293–297
   PubMed Web of Science ®Google Scholar
• Houchen C.W., George R.J., Sturmoski M.A., Cohn S.M. FGF-2 Enhances Intestinal Stem Cell Survival and Its Expression Is Induced After Radiation Injury. Am. J. Physiol. 1999; 276: G249–G258
   Google Scholar
• Okunieff P., Mester M., Wang J., Maddox T., Gong X., Tang D., Coffee M., Ding I. In Vivo Radioprotective Effects of Angiogenic Growth Factors on the Small Bowel of C3H Mice. Radiat. Res. 1998; 150: 204–211
   PubMed Web of Science ®Google Scholar
• Khan W.B., Shui C., Ning S., Knox S.J. Enhancement of Murine Intestinal Stem Cell Survival After Irradiation by Keratinocyte Growth Factor. Radiat. Res. 1997; 148: 248–253
   PubMed Web of Science ®Google Scholar
• Scheving L.E., Tsai T.H., Sothern R.B., Hrushesky W.J.M. Circadian Susceptibility-Resistance Cycles to Radiation and Their Manipulability by Methylene Blue. Pharmacol. Ther. 1988; 19: 397–402
   Google Scholar
• Marathe S., Schissel S.L., Yellin M.J., Beatini N., Mintzer R., Williams K.J., Tabas I. Human Vascular Endothelial Cells Are a Rich and Regulatable Source of Secretory Sphingomyelinase. J. Biol. Chem. 1998; 273(7)4081–4088
   PubMedGoogle Scholar
• Cordon-Cardo C., Vlodavsky I., Haimovitz-Friedman A., Hicklin D., Fuks Z. Expression of Basic Fibroblast Growth Factor in Normal Human Tissues. Lab. Invest. 1990; 63: 832–840
   PubMed Web of Science ®Google Scholar
• Lushbaugh C.C. Human Radiation Tolerance. Space Radiation Biology and Related Topics, C.A. Tobias, P. Todd. Academic Press, New York 1974; 476–521
   Google Scholar
• Haus E., Halberg F., Loken M.K., Kim Y.S. Circadian Rhythmometry of Mammalian Radiosensitivity. Space Radiation Biology and Related Topics, C.A. Tobias, P. Todd. Academic Press, New York 1974; 435–474
   Google Scholar
• Scheving L.E. Circadian Rhythms in Cell Proliferation: Their Importance When Investigating the Basic Mechanism of Normal Versus Abnormal Growth. Biological Rhythms in Structure and Function, H. von Meyersbach, L.E. Scheving, J.E. Pauly. Alan R. Liss, New York 1981; 39–79
   Google Scholar
• Scheving L.E., Tsai T.H., Scheving L.A., Feuers R.J. The Potential of Using the Natural Rhythmicity of Cell Proliferation in Improving Cancer Chemotherapy in Rodents. Ann. NY Acad. Sci. 1991; 618: 182–227
   PubMedGoogle Scholar
• Scheving L.E., Feures R.J., Tsai T.H., Scheving L.A. Experimental Background for Cancer Chronotherapy. Circadian Cancer Therapy, W.J.M. Hrushesky. CRC Press, Boca Raton, FL 1994; 19–40
   Google Scholar
• Halberg F., Halberg E., Barnum C.P., Bittner J.J. Physiologic 24-hour Periodicity in Human Beings and Mice, the Lighting Regimen and Daily Routine. Photoperiodism and Related Phenomena in Plants and Animals, R. Withrow. American Association for the Advancement of Science, Washington, DC 1959; 803–878
   Google Scholar
• Mayersbach H. von. Cellular Aspects of Bioryhthms, Symposium on Biorhythms. Springer-Verlag, Berlin 1967
   Google Scholar
• Haus E., Halberg F., Loken M.K. Circadian Susceptibility–Resistance Cycle of Bone Marrow Cells to Whole Body X-Irradiation in Balb/c Mice. Chronobiologia 1974; 1: 115–122
   Google Scholar
• Pizzarello D.J., Witcofski R.L., Lyons E.A. Variations in Survival Time After Whole-Body Radiation at Two Times of the Day. Science 1963; 139: 349–365
   PubMed Web of Science ®Google Scholar
• Pizzarello D.J., Isaak D., Kian Eng C., Rhyn A.L. Circadian Rhythmicity in the Sensitivity of Two Strains of Mice to Whole-Body Radiation. Science 1964; 145: 286–291
   PubMed Web of Science ®Google Scholar
• Nelson R.F. Variation in Radiosensitivity of Mice with Time of Day. Acta Radiol. Ther. 1965; 64: 91–96
   Google Scholar
• Kortländer F. Untersuchungen über die Strahlensensitivität der Weissen Maus in Abhängigkeit vom Tagersrhythmus. Medizinische Fakultät der Westfälischen Wilhelms-Universität zu Münster, Germany
   Google Scholar
• Hellwig G., Rosenkranz J. Uber Circadiane Schwankungen der Strahlensensibilität von Ratten. Strahlentherapie 1968; 135: 220–222
   PubMedGoogle Scholar
• Scheving L.E., Tsai T.H., Scheving L.A. Chronobiology of the Intestinal Tract of the Mouse. Am. J. Anat. 1983; 168: 433–465
   PubMedGoogle Scholar
• Gerbes A.L., Arbogast B.J. The Influence of Timeshift on Circadian Rhythm of Sensitivity to X-Irradiation in Mice. Chronobiol. Int. 1984; 1(3)177–184
   PubMedGoogle Scholar
• Gerbes A.L., Arbogast B., Schick P., Messerschmidt O. Acute Radiation Injury of Mice and the Influence of Sudden Time Shift. Radiat. Res. 1984; 99: 285–293
   PubMedGoogle Scholar
• Garcia-Sainz M., Halberg F., Moore V. Periodicidad en la Respuesta Biologica a la Radiacion Bio-ensayo en Roedores. Rev. Mex. Radiol. 1968; 19: 676–681
   Google Scholar
• Kallman R.F., Silini G., Taylor H.M., III. Recuperation from Lethal Injury by Whole Body Irradiation. II. Kinetic Aspects in Radiosensitive Balb/c Mice and Cyclic Fine Structure During the Four Days After Conditioning Irradiation. Radiat. Res. 1966; 29: 362–394
   PubMed Web of Science ®Google Scholar
• Kallman R.F., Silini G. Recuperation from Lethal Injury by Whole Body Irradiation. I. Kinetic Aspects and the Relationship with Conditioning Dose in C57B1 Mice. Radiat. Res. 1964; 22: 622–642
   PubMedGoogle Scholar
• Peters K. Verländerung der Überlebenszeit von Ratten nach Ganzkörperbestrahlung zu Verschiedenen Tageszeiten. Strahlentherapie 1963; 122: 554–557
   PubMedGoogle Scholar
• Fochem K., Michalia W., Picha E. Über die Pharmakologische Beeinflussung der Tagersrhythmischen Unterschiede in der Strahlenwirkung und zur Frage der Jahreszeitlich Bedingten Unterschiede der Strahlensensibilitaet bei Ratten und Mäussen. Strahlentherapie 1967; 133: 356–361
   Google Scholar
• Fochem K., Michalia W., Picha E. Über tages- und Jahreszeitliche Unterschiede der Strahlenwirkung bei Versuchstieren und die Möglichkeiten einer Pharmakologischen Beeinflussung. Strahlentherapie 1968; 135: 223–226
   PubMedGoogle Scholar
• Haus E., Lakatua D.J., Sackett-Lundeen L. Circannual Variation of Cell Proliferation in Lymphoid Organs and Bone Marrow of BDF1 Male Mice on Three Lighting Regimens. Chronobiol. Int. 1997; 14(4)347–362
   PubMed Web of Science ®Google Scholar
• Smaaland R., Sothern R.B., Laerum O.D., Abrahamsen J.F. Rhythms in Human Bone Marrow and Blood Cells. Chronobiol. Int. 2002; 19(1)101–127
   PubMed Web of Science ®Google Scholar
• Dethmers J.K., Meister A. Glutathione Export by Human Lymphoid Cells: Depletion of Gluthione by Inhibition of Its Synthesis Decreases Export and Increases Sensitivity to Irradiation. Proc. Natl Acad. Sci. USA 1981; 78: 7492–7496
   PubMed Web of Science ®Google Scholar
• Biaglow J.E., Varnes M.E., Clark E.P., Epp E.P. The Role of Thiols in Cellular Response to Radiation and Drugs. Radiat. Res. 1983; 94: 437–455
   Google Scholar
• Smaaland R., Svardal A.M., Lote K., Ueland P.M., Laerum O.D. Glutathione Content in Human Bone Marrow and Circadian Stage Relation to DNA Synthesis. J. Natl Cancer Inst. 1991; 83: 1092–1098
   PubMed Web of Science ®Google Scholar
• Ueno Y. Diurnal Rhythmicity in the Sensitivity of Hematopoietic Cells to Whole-Body Irradiation of Mice. Int. J. Radiat. Biol. 1968; 14: 301–312
   Google Scholar
• Vacek A., Davidova E., Druzhinin Yu., Hosek B., Chlumecky J. Circadian Rhythmicity in the Effect of Irradiation on the Endogenous Colony Formation in the Spleen of Irradiated Mice. Int. J. Radiat. Biol. 1968; 13: 539–548
   Google Scholar
• Vacek A., Rotkovska D. Circadian Variations in the Effect of X-Irradiation on the Hematopoietic Stem Cells of Mice. Strahlentherapie 1970; 140: 302–306
   PubMedGoogle Scholar
• Newsome-Tabatabai R., Rushton P.S. Daily Variations in Radiosensitivity of Circulating Blood Cells and Bone Marrow Cellularity in Mice. Comp. Biochem. Physiol. 1984; 78A: 779–783
   Google Scholar
• Bernabei P.A., Balzi M., Saccardi R., Becciolini A., Ferrini P.R. Time-Dependent Sensitivity of Rat CFU-GM to Total Body Irradiation. Haematologica 1992; 77: 21–24
   PubMedGoogle Scholar
• Vriesendorp H.M., Quadri S.M., Andersson B.S., Dicke K.A. Hematologic Side Effects of Radiolabeled Immunoglobulin Therapy. Exp. Hematol. 1996; 24: 1183–1190
   PubMedGoogle Scholar
• Blumenthal R.D., Reising A., Lew W., Dunn R., Ying Z., Goldenberg D.M. Chronotolerance of Experimental Radioimmunotherapy: Clearance, Toxicity, and Maximal Tolerated Dose of 131I-Anti-carcinoembryonic Antigen (CEA) IgG as a Function of Time of Day of Dosing in a Murine Model. Eur. J. Cancer 1999; 35(5)815–824
   PubMedGoogle Scholar
• Bond V.P., Fliedner T.M., Archambeau J.O. Mammalian Radiation Lethality, a Disturbance in Cellular Kinetics. Academic Press, New York 1965
   Google Scholar
• Scheving L.E., Tsai T.H., Scheving L.A., Feures R.J., Kanabrocki E.L. Normal and Abnormal Cell Proliferation in Mice Especially as It Relates to Cancer. Biological Rhythms in Clinical and Laboratory Medicine, Y. Touitou, E. Haus. Springer-Verlag, Berlin 1992; 566–599
   Google Scholar
• Moore J.G. Circadian Cytokinetics of Murine and Human Gut: Implications for Colon Cancer Chemotherapy. Circadian Cancer Therapy, W.J.M. Hrushesky. CRC Press, Boca Raton, FL 1994; 105–116
   Google Scholar
• Moore J.G. Chronobiology of the Gastrointestinal System. Biological Rhythms in Clinical and Laboratory Medicine, Y. Touitou, E. Haus. Springer-Verlag, Berlin 1992; 410–417
   Google Scholar
• Bjarnason G.A., Jordan R. Circadian Variation of Cell Proliferation and Cell Cycle Protein Expression in Man: Clinical Implications. Prog. Cell Cycle Res. 2000; 4: 193–206
   PubMedGoogle Scholar
• Bjarnason G.A., Jordan R. Rhythms in Human Gastrointestinal Mucosa and Skin. Chronobiol. Int. 2002; 19(1)129–140
   PubMed Web of Science ®Google Scholar
• Scheving L.E., Tsai T.H., Powell E.W., Pasley J.N., Halberg F. Bilateral Lesions of Suprachiasmatic Nuclei Effect on Circadian Rhythms in [3H]-Thymidine Incorporation into Deoxyribonucleic Acid in Mouse Intestinal Tract, in Mitotic Index of Corneal Epithelium, and in Serum Corticosterone. Anat. Res. 1983; 205: 239–249
   PubMedGoogle Scholar
• Scheving L.E., Burns E.R., Pauly J.E., Tsai T.H., Betterton H.O., Halberg F. Meal Scheduling, Cellular Rhythms and the Chronotherapy of Cancer. Nutrition, H. Kioshi. Victory-sha, Kyoto 1976; 141–175
   Google Scholar
• Scheving L.A., Scheving L.E., Tsai T.H., Pauly J.E. Circadian Stage-Dependent Effects of Insulin and Glucagon on Deoxyribonucleic Acid Synthesis in the Esophagus, Stomach, Duodenum, Jejunum, Ileum, Caccum, Rectum and Spleen of the Adult Female Mouse. Endocrine 1982; 111: 308–315
   Google Scholar
• Buchi K.N., Moore J.G., Hrushesky W.J.M., Sothern R.B., Rubin N.R. Circadian Rhythm of Cellular Proliferation in the Human Rectal Mucosa. Gastroenterology 1991; 101: 410–415
   PubMed Web of Science ®Google Scholar
• Marra G., Anti M., Percesepe A., Armelao F., Ficarelli R., Coco C., Rinelli A., Vecchio F.M., D'Arcangelo E. Circadian Variations of Epithelial Cell Proliferation in Human Rectal Crypts. Gastroenterology 1994; 106: 982–987
   PubMed Web of Science ®Google Scholar
• Warnakulasuriya K.A.A.S., MacDonald D.G. Diurnal Variation in Labelling Index in Human Buccal Epithelium. Arch. Oral Biol. 1993; 38: 1107–1111
   PubMed Web of Science ®Google Scholar
• Bjarnason G.A., Jordan R., Sothern R.B. Circadian Variation in the Expression of Cell-Cycle Proteins in Human Oral Epithelium. Am. J. Pathol. 1999; 154(2)613–622
   PubMed Web of Science ®Google Scholar
• Bjarnason G.A., Jordan R.C.K., Wood P.A., Li Q., Lincoln D.W., Sothern R.B., Hrushesky W.J.M., Ben-David Y. Circadian Expression of Clock Genes in Human Oral Mucosa and Skin. Association with Specific Cell Cycle Phases. Am. J. Pathol. 2001; 158(5)1793–1801
   PubMed Web of Science ®Google Scholar
• Haus E., Lakatua D.J., Sackett-Lundeen L.L., White M. Circannual Variation of Intestinal Cell Proliferation in BDF1 Mice on Three Lighting Regimens. Chronobiol. Int. 1984; 1(3)185–194
   PubMedGoogle Scholar
• Potten C.S. A Comprehensive Study of the Radiobiological Response of the Murine (BDF1) Small Intestine. Int. J. Radiat. Biol. 1990; 58(6)925–973
   PubMed Web of Science ®Google Scholar
• Ijiri K., Potten C.S. The Circadian Rhythm for the Number and Sensitivity of Radiation-Induced Apoptosis in the Crypts of Mouse Small Intestine. Int. J. Radiat. Biol. 1990; 58(1)165–175
   PubMed Web of Science ®Google Scholar
• Potten C.S., Booth C., Prichard D.M. The Intestinal Epithelial Stem Cell: The Mucosal Governor. Int. J. Exp. Pathol. 1997; 78: 219–243
   PubMed Web of Science ®Google Scholar
• Booth C., Potten C.S. Gut Instincts: Thoughts on Intestinal Epithelial Stem Cells. J. Clin. Invest. 2000; 105: 1493–1499
   PubMed Web of Science ®Google Scholar
• Potten C.S. The Significance of Spontaneous and Induced Apoptosis in the Gastrointestinal Tract of Mice. Cancer Metast. Rev. 1992; 11: 179–195
   PubMed Web of Science ®Google Scholar
• Potten C.S., Al-Barwari S.E., Hume W.J., Searle J. Circadian Rhythms of Presumptive Stem Cells in Three Different Epithelia of the Mouse. Cell Tissue Kinet. 1977; 10: 557–568
   PubMedGoogle Scholar
• Ruifrok A.C.C., Weil M.M., Thames H.D., Mason K.A. Diurnal Variations in the Expression of Radiation-Induced Apoptosis. Radiat. Res. 1998; 149: 360–365
   PubMed Web of Science ®Google Scholar
• Ijiri K., Potten C.S. Circadian Rhythms in the Incidence of Apoptotic Cells and Number of Clonogenic Cells in Intestinal Crypts After Radiation Using Normal and Reversed Light Conditions. Int. J. Radiat. Biol. 1988; 53(5)717–727
   Web of Science ®Google Scholar
• Duncan A.M.V., Ronen A., Blakey D.H. Diurnal Variation in the Response of Gamma-Ray-Induced Apoptosis in the Mouse Intestinal Epithelium. Cancer Lett. 1983; 21: 163–166
   PubMed Web of Science ®Google Scholar
• Ijiri K. Cell Death (Apoptosis) in Mouse Intestine After Continuous Irradiation with γ Rays and with β Rays from Tritiated Water. Radiat. Res. 1989; 118: 180–191
   PubMed Web of Science ®Google Scholar
• Becciolini A., Balzi M., Fabbrica D., Potten C.S. Cell Kinetics in Rat Small Intestine After Exposure to 3 Gy of γ-Rays at Different Times of the Day. Int. J. Radiat. Biol. 1996; 70(3)281–288
   PubMed Web of Science ®Google Scholar
• Thames H.D., Ruifrok A.C.C., Mason K.A. The Effect of Proliferative Status and Clonogen Content on the Response of Mouse Jejunal Crypts to Split-Dose Irradiation. Radiat. Res. 1997; 147: 172–178
   PubMedGoogle Scholar
• Haus E., Dumitriu L., Nicolau G.Y., Bologa S., Sackett-Lundeen L. Circadian Rhythms of Basic Fibroblast Growth Factor (bFGF), Epidermal Growth Factor (EGF), Insulin-like Growth Factor-1 (IGF-1), Insulin-like Growth Factor Binding Protein-3 (IGFBP-3), Cortisol, and Melatonin in Women with Breast Cancer. Chronobiol. Int. 2001; 18(4)709–727
   PubMed Web of Science ®Google Scholar
• Folkman J., Camphausen K. What Does Radiotherapy Do to Endothelial Cells?. Science 2001; 293: 227–228
   PubMedGoogle Scholar
• Teicher B.A., Dupuis N., Kusomoto T., Robinson M.F., Liu F., Menon K., Coleman C.N. Antiangiogenic Agents Can Increase Tumor Oxygenation and Response to Radiation Therapy. Radiat. Oncol. Invest. 1995; 2: 269–276
   Google Scholar
• Mauceri H.J., Hanna N.N., Beckett M.A., Gorski D.H., Staba M.J., Stellato K.A., Bigelow K., Heimann R., Gately S., Dhanabal M., Soff G.A., Sukhatme V.P., Kufe D.W., Weichselbaum R.R. Combined Effects of Angiostatin and Ionizing Radiation in Antitumour Therapy. Nature 1998; 394: 287–291
   PubMed Web of Science ®Google Scholar
• Scheving L.E., Pauly J.E. Daily Mitotic Fluctuations in the Epidermis of the Rat and Their Relation to Variations in Spontaneous Activity and Rectal Temperature. Acta Anat. 1960; 43: 337–345
   PubMedGoogle Scholar
• Clausen O.P.F., Thorud E., Bjerknes R., Elgjo K. Circadian Rhythms in Mouse Epidermal Basal Cell Proliferation. Cell Tissue Kinet. 1979; 12: 319–337
   PubMedGoogle Scholar
• Scheving L.E. Mitotic Activity in the Human Epidermis. Anat. Rec. 1959; 135: 7–19
   PubMedGoogle Scholar
• Fisher L.B. Determination of the Normal Rate and Duration of Mitosis in Human Epidermis. Br. J. Dermatol. 1968; 80(1)24–28
   PubMedGoogle Scholar
• Denekamp J., Fowler J.F. Further Investigations of the Response of Irradiated Mouse Skin. Int. J. Radiat. Biol. 1966; 10(5)435–441
   Google Scholar
• Hirn-Stadler B., Rojas A. Influence of Circadian Rhythms on Radiosensitivity: Single and Fractionated Dose Studies in Mouse Skin. Int. J. Radiat. Biol. 1991; 59(1)185–193
   PubMed Web of Science ®Google Scholar
• Bertalanffy F.A.D. Mitotic Rate Spontaneous Mammary Gland Adenocarcinoma in C3H/HeJ Mice. Nature (London) 1963; 198: 496–497
   Google Scholar
• Halberg F., Haus E., Cardoso S.S., Scheving L.E., Kuhl J.F.W., Shiotsuka R., Rosene G., Pauly J.E., Runge W., Spalding J.F., Lee J.K., Good R.A. Toward a Chronotherapy of Neoplasia: Tolerance of Treatment Depends upon Host Rhythms. Experientia 1973; 29: 909–1044
   PubMedGoogle Scholar
• Echave Llanos J. Ritmo de 24 horas en la Actividad Mitotica de un Carcinoma Mamario Injertado de C3H/mza Hembra. Rev. Soc. Argent. Biol. 1961; 37: 226–239
   Google Scholar
• Haus E., Halberg F. Cronofarmacologia del Cancro e Della Leucemia. Farmacologia Clinica E Terapia, A. Bertelli. Edizioni, C.G. Medico-Scientifiche, Torino, Italy 1978; 29–85
   Google Scholar
• Burns E.R., Scheving L.E., Tsai T.H. Circadian Rhythms in DNA Synthesis and Mitosis in Normal Mice and in Mice Bearing the Lewis Lung Carcinoma. Eur. J. Cancer 1979; 15(2)233–242
   Google Scholar
• Blank M.A., Gushchin V.A., Halberg F., Portela A., Cornélissen G. X-Irradiation Chronosensitivity and Circadian Rhythmic Proliferation in Healthy and Sarcoma-Carrying Rats' Bone Marrow. In Vivo 1995; 9: 395–400
   PubMedGoogle Scholar
• Badran A.F., Echave Llanos J.M. Persistence of Mitotic Circadian Rhythm of a Transplantable Mammary Carcinoma After 35 Generations: Its Bearing on the Success of Treatment with Endoxan. J. Natl Cancer Inst. 1965; 35: 285–290
   PubMedGoogle Scholar
• Klevecz R.R., Braly P.S. Circadian and Ultradian Cytokinetics of Human Cancers. Circadian Cancer Therapy, W.J.M. Hrushesky. CRC Press, Boca Raton, FL 1994; 165–183
   Google Scholar
• Tähti E. Studies of the Effect of X-Irradiation on 24-Hour Variations in the Mitotic Activity in Human Malignant Tumours. Acta Pathol. Microbiol. Scand. 1956; Suppl. 117: 1–61
   Google Scholar
• Voutilainen A. Ueber die 24-Stunden-Rhythmik der Mitosenfrequenz in Malignen Tumoren. Acta Pathol. Microbiol. Scand. 1953; Suppl. 99: 1–104
   Google Scholar
• Garcia-Sainz M., Halberg F. Mitotic Rhythms in Human Cancer, Reevaluated by Electronic Computer Programs—Evidence for Chronopathology. J. Natl Cancer Inst. 1966; 37: 279–292
   PubMedGoogle Scholar
• Howard A. Influence of Radiation on DNA Metabolism. Ciba Foundation Symposium on Ionizing Radiations and Cell Metabolism. J. and A. Churchill, London 1956
   Google Scholar
• Low-Beer B.V.A. 32P Studies in Breast Tumours. Cardologia 1952; 21: 497–505
   PubMedGoogle Scholar
• Bullen M.A., Freundlich H.F., Hale B.T., Marshall D.H., Tudway R.C. The Activity of Malignant Tumours and Response to Therapeutic Agents, Studied by Continuous Records of Radioactive Phosphorus Uptake. Postgrad. Med. J. 1963; 39: 265–277
   PubMedGoogle Scholar
• Stoll B.A., Burch W.M. Surface Detection of Circadian Rhythm in 32P Content of Cancer of the Breast. Cancer 1968; 21: 193–196
   PubMed Web of Science ®Google Scholar
• Klevecz R.R., Braly P.S. Circadian and Ultradian Rhythms of Proliferation in Human Ovarian Cancer. Chronobiol. Int. 1987; 4: 513–522
   PubMed Web of Science ®Google Scholar
• Deka A.C., Chatterjee B., Gupta B.D., Balakrishnan C., Dutta T.K. Temperature Rhythm—an Index of Tumour Regression and Mucositis During the Radiation Treatment of Oral Cancers. Ind. J. Cancer 1976; 13: 44–50
   PubMedGoogle Scholar
• Deka B., Deka A.C., Patil R.B., Halberg F. In Phase Synchronization of Circadian Temperature Rhythm of Cancerous and Healthy Sides of Mouth Documented by 2-Hourly Measurements for 4 Consecutive Days. Int. J. Chronobiol. 1981; 7: 226, Abstract
   Google Scholar
• Halberg, F.; Gupta, B. D.; Haus, E.; Halberg, E.; Deka, A. C.; Nelson, W.; Sothern, R. B.; Cornélissen, G.; Lee, J. K.; Lakatua, D. J.; Scheving, L. E.; Burns, E. R. Steps Toward a Cancer Chronopolytherapy. Proceedings of XIV International Congress on Therapeutics, Montpellier, France, L'Expansion Scientifique Francaise, 1977; 151–196.
   Google Scholar
• Haus E., Halberg F. Circannual Rhythm in Level and Timing of Serum Corticosterone in Standardized Inbred Mature C-Mice. Environ. Res. 1970; 3: 81–106
   PubMed Web of Science ®Google Scholar
• Haus E., Nicolau G.Y., Lakatua D.J., Sackett-Lundeen L. Reference Values for Chronopharmacology. Annu. Rev. Chronopharmacol. 1988; 4: 333–424
   Google Scholar
• Mormont C., Waterhouse J. Contribution of the Rest–Activity Circadian Rhythm to Quality of Life. Chronobiol. Int. 2002; 19((1))313–323
   PubMedGoogle Scholar