Advanced search
Publication Cover
Clinical and Experimental Hypertension Volume 24, 2002 - Issue 4
Submit an article Journal homepage
26
Views
5
CrossRef citations to date
0
Altmetric
Original

RED BLOOD CELL Na+/H+ EXCHANGE ACTIVITY IS INSULIN RESISTANT IN HYPERTENSIVE PATIENTS

José R. Romero Endocrinology-Hypertension Division, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA, 02115, U.S.A.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, U.S.A.
,
Alicia Rivera Department of Pathology, Harvard Medical School, Boston, Massachusetts, U.S.A.; Department of Laboratory Medicine, The Children's Hospital, Boston, Massachusetts, U.S.A.
&
Paul R. Conlin Endocrinology-Hypertension Division, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA, 02115, U.S.A.; Medical Service, VA Boston Healthcare System, Boston, Massachusetts, U.S.A.
Pages 277-287 | Received 15 Nov 2001, Published online: 13 May 2002

REFERENCES

  • Siffert W., Dusing R. Sodium-Proton Exchange and Primary Hypertension. An Update. Hypertension 1995; 26: 649–655
  • Orlov S. N., Adragna N. C., Adarichev V. A., Hamet P. Genetic and Biochemical Determinants of Abnormal Monovalent Ion Transport in Primary Hypertension. Am. J. Physiol. 1999; 276 (3 Pt 1): C511–C536
  • Berk B. C., Aronow M. S., Brock T. A., Cragoe E. Jr., Gimbrone M. A. Jr., Alexander R. W. Angiotensin II-Stimulated Na+/H+Exchange in Cultured Vascular Smooth Muscle Cells. Evidence for Protein Kinase C-Dependent and -Independent Pathways. J. Biol. Chem. 1987; 262: 5057–5064
  • Thrombin, EGF and Okadaic Acid Activate the Na+/H+Exchanger, NHE-1, by Phosphorylating a Set of Common Sites. J. Biol. Chem. 1991; 266: 19166–19171
  • Vallega G. A., Canessa M. L., Berk B. C., Brock T. A., Alexander R. W. Vascular Smooth Muscle Na+/H+Exchanger Kinetics and its Activation by Angiotensin II. Am. J. Physiol. 1988; 254: C751–C758
  • Conlin P. R., Kim S. Y., Williams G. H., Canessa M. L. Na+/H+Exchanger Kinetics in Adrenal Glomerulosa Cells and Its Activation by Angiotensin II. Endocrinology 1990; 127: 236–244
  • Mahnensmith R. L., Aronson P. S. The Plasma Membrane Sodium-Hydrogen Exchanger and its Role in Physiological and Pathophysiological Processes. Circ. Res. 1985; 56: 773–788
  • Sardet C., Counillon L., Franchi A., Pouyssegur J. Growth Factors Induce Phosphorylation of the Na+/H+Antiporter, a Glycoprotein of 110 KD. Science 1990; 247: 723–726
  • Klip A. Action of Insulin on Na+/H+Exchange. InNa+/H+Exchange, S. Grinstein, 1988; 285–306
  • Semplicini A., Ceolotto G., Felice M., Bordin L., Monari A., Clari G., Pessina A. C. Posttranslational Effects of Protein Kinase C and Insulin on Red Cell Membrane Phosphorylation and Cation Heteroexchange in Hypertension. Blood Press. 1996; (Suppl. 1): 55–58
  • Pontremoli R., Zerbini G., Rivera A., Canessa M. Insulin Activation of Red Blood Cell Na+/H+Exchange Decreases the Affinity of Sodium Sites. Kidney. Int. 1994; 46(2)365–375
  • Sarangarajan R., Dhabia N., Soliemani M., Baird N., Joiner C. Is the Sodium-Hydrogen Exchanger Isoform Present in Erythroid Cells. Biochim. Biophys. Acta 1998; 1374 (1–2): 56–62NHE-1
  • Moore R. D. Effect of Insulin Upon Ion Transport. Biochim. Biophys. A 1983; 737: 1–49
  • Gambhir K. K., Archer J. A., Bradley C. J. Characteristics of Human Erythrocyte Insulin Receptors. Diabetes 1978; 27: 701–708
  • Grigorescu F., White M. F., Kahn C. R. Insulin Binding and Insulin-Dependent Phosphorylation of the Insulin Receptor Solubilized from Human Erythrocytes. J. Biol. Chem. 1983; 258: 13708–13716
  • Canessa M. Kinetic Properties of the Human Red Blood Cell Na+/H+ Na+/Na+ Na+/Li+Exchanges. Methods in Enzymology 1989; 173: 176–191
  • Zeng G., Quon M. J. Insulin-Stimulated Production of Nitric Oxide Is Inhibited by Wortmannin. Direct Measurement in Vascular Endothelial Cells. J. Clin. Invest. 1996; 98: 894–898
  • Lifton R. P., Hunt S. C., Williams R. R., Pouyssegur J., Lalouel J. M. Exclusion of the Na+/H+Antiporter as a Candidate Gene in Human Essential Hypertension. Hypertension 1991; 17: 8–14
  • Orlov S. N., Adarichev V. A., Devlin A. M., Maximova N. V., Sun Y. L., Tremblay J., Dominiczak A. F., Postnov Y. V., Hamet P. Increased Na+/H+Exchanger Isoform 1 Activity in Spontaneously Hypertensive Rats: Lack of Mutations within the Coding Region of NHE1. Biochim. Biophys. Acta 2000; 1500(2)169–180
  • Canessa M., Manriquez E. Phosphorylation Signals of the Insulin Receptor in Human Red Cells: Activation of Na+/H+Exchange. Nutr. Metab. Cardiovasc. Dis. 1997, 2: 57–62
  • Sauvage M., Maziere P., Fathallah H., Giraud F. Insulin Stimulates NHE1 Activity by Sequential Activation of Phosphatidylinositol 3-Kinase and Protein Kinase C Zeta in Human Erythrocytes. Eur. J. Biochem. 2000; 267(4)955–962
  • Masai M., Fujioka Y., Fujiwara M., Morimoto S., Miyoshi A., Suzuki H., Iwasaki T. Activation of Na+/H+Exchanger Is Associated with Hyperinsulinemia in Borderline Hypertensive Rats. Eur. J. Clin. Invest. 2001; 31(3)193–200
  • Kadowaki T. Insights into Insulin Resistance and Type 2 Diabetes from Knockout Mouse Models. J. Clin. Invest. 2000; 106(4)459–465

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.