116
Views
25
CrossRef citations to date
0
Altmetric
Research Article

Food-Borne Clenbuterol May Have Potential for Cardiovascular Effects with Chronic Exposure (Commentary)

Pages 345-348 | Published online: 31 Jul 2001

REFERENCES

  • Mitchell G. A., Dunnavan G. Illegal Use of Beta-Adrenergic Agonists in the United States. J. Anim. Sci. 1998; 76: 208–211
  • Kuiper H. A., Noordam M. Y., van Dooren-Flipsen M. M., Schilt R., Roos A. H. Illegal Use of Beta-Adrenergic Agonists: European Community (Review). J. Anim. Sci. 1998; 76: 195–207
  • Chan T. Y.K. Health Hazards Due to Clenbuterol Residues in Food. J. Toxicol. Clin. Toxicol. 1999; 37: 517–519
  • Palmer R. M., Delday M. I., McMillan D. N., Noble B. S., Bain P., Maltin C. A. Effects of the Cyclo-Oxygenase Inhibitor, Fenbufen, on Clenbuterol-Induced Hypertrophy of Cardiac and Skeletal Muscle of Rats. Br. J. Pharmacol. 1990; 101: 835–838
  • Petrou M., Wynne D. G., Boheler K. R., Yacoub M. H. Clenbuterol Induces Hypertrophy of the Latissimus dorsi Muscle and Heart in the Rat with Molecular and Phenotypic Changes. Circulation 1995; 92(9 Suppl)II483–II489
  • Wong K., Boheler K. R., Bishop J., Petrou M., Yacoub M. H. Clenbuterol Induces Cardiac Hypertrophy with Normal Functional, Morphological and Molecular Features. Cardiovasc. Res. 1998; 37: 115–122
  • Cubria J. C., Reguera R., Balana-Fouce R., Ordonez C., Ordonez D. Polyamine-Mediated Hypertrophy Induced by Clenbuterol in the Mouse. J. Pharm. Pharmacol. 1998; 50: 91–96
  • Von Deutsch D. A., Abukahalaf I. K., Wineski L. E., Aboul-Enein H. Y., Pitts S. A., Parks B. A., Oster R. A., Paulsen D. F., Potter D. E. Beta-Agonist Induced Alterations in Organ Weights and Protein Content: Comparison of Racemic Clenbuterol and Its Enantiomers. Chirality 2000; 12: 637–648
  • Yang Y. T., McElligott M. A. Multiple Actions of β- Adrenergic Agonists on Skeletal Muscle and Adipose Tissue. Biochem. J. 1989; 261: 1–10
  • Kennedy M. C. Newer Drugs Used to Enhance Sporting Performance. Med. J. Aust. 2000; 173: 314–317
  • Prather I. D., Brown D. E., North P., Wilson J. R. Clenbuterol: A Substitute for Anabolic Steroids?. Med. Sci. Sports Exercise 1995; 27: 1118–1121
  • Nieminen M. S., Rämo M. P., Viitasalo M., Heikkila P., Karjalainen J., Mantysaari M., Heeikkila J. Serious Cardiovascular Side Effects of Large Doses of Anabolic Steroids in Weight Lifters. Eur. Heart J. 1996; 17: 1576–1583
  • Goldstein D. R., Dobbs T., Krull B., Plumb V. J. Clenbuterol and Anabolic Steroids: A Previously Unreported Cause of Myocardial Infarction with Normal Coronary Arteriograms. South. Med. J. 1998; 91: 780–784
  • Hartung R., Gerth J., Fünfstück R., Gröne H.-J., Stein G. End-Stage Renal Disease in a Bodybuilder: A Multifactorial Process or Simply Doping? Nephrol. Dial. Transplant. 2001; 16: 163–165
  • Dickerman R. D., Schaller F., McConathy W. J. Left Ventricular Wall Thickening Does Occur in Elite Power Athletes with or without Anabolic Steroid Use. Cardiology 1998; 90: 145–148
  • Brown D. W., Giles W. H., Croft J. B. Left Ventricular Hypertrophy as a Predictor of Coronary Heart Disease Mortality and the Effect of Hypertension. Am. Heart J. 2000; 140: 848–856
  • Novo S., Barbagallo M., Abrignani M. G., Nardi E., Di Maria G. U., Longo B., Mistretta A., Strano A. Increased Prevalence of Cardiac Arrhythmias and Transient Episodes of Myocardial Ischemia in Hypertensives with Left Ventricular Hypertrophy but Without Clinical History of Coronary Heart Disease. Am. J. Hypertens. 1997; 10: 843–851
  • Duncker D. J., Bache R. J. Effect of Chronotropic and Inotropic Stimulation on the Coronary Pressure Flow Relation in Left Ventricular Hypertrophy. Basic Res. Cardiol. 1997; 92: 271–286
  • Bouvy M. L., Heerdink E. R., De Bruin M. L., Herings R. M., Leufkens H. G., Hoes A. W. Use of Sympathomimetic Drugs Leads to Increased Risk of Hospitalization for Arrhythmias in Patients with Congestive Heart Failure. Arch. Intern. Med. 2000; 160: 2477–2480
  • Mogilnicka E., Kilmek V., Nowak G., Czyrak A. Clonidine and Beta-Agonists Induce Hyperthermia in Rats at a High Ambient Temperature. J. Neural. Transm. 1985; 63: 223–235
  • Gonzalez-Alonso J. Separate and Combined Influences of Dehydration and Hyperthermia on Cardiovascular Responses to Exercise. Int. J. Sports Med. 1998; 19(Suppl 2)S111–S114
  • Parssinen M., Kujala U., Vartiainen E., Sarna S., Seppala T. Increased Premature Mortality of Competitive Powerlifters Suspected to Have Used Anabolic Agents. Int. J. Sports Med. 2000; 21: 225–227
  • Sullivan M. L., Martinez C. M., Gennis P., Gallagher E. J. The Cardiac Toxicity of Anabolic Steroids Prog. Cardiovasc. Dis. 1998; 41: 1–15
  • Choo J. J., Horan M. A., Little R. A., Rothewell N. J. Anabolic Effects of Clenbuterol on Skeletal Muscle Are Mediated by Beta-2-Adrenoreceptor Activation. Am. J. Physiol. 1992; 263: E50–E56
  • Meyer H. H., Rinke L. M. The Pharmacokinetics and Residues of Clenbuterol in Veal Calves. J. Anim. Sci. 1991; 69: 4538–4544
  • Sporano V., Grasso L., Esposito M., Oliviero G., Brambilla G., Loizzo A. Clenbuterol Residues in Non-Liver Containing Meat as a Cause of Collective Food Poisoning. Vet. Hum. Toxicol. 1998; 40: 141–143
  • Brambilla G., Cenci T., Franconi F., Galarini R., Macri A., Rondoni F., Strozzi M., Loizzo A. Clinical and Pharmacological Profile in a Clenbuterol Epidemic Poisoning of Contaminated Beef Meat in Italy. Toxicol. Lett. 2000; 114: 47–53
  • Pulce C., Lamaison D., Keck G., Bostvironnois C., Nicolas J., Descotes J. Collective Human Food Poisonings by Clenbuterol Residues in Veal Liver. Vet. Hum. Toxicol. 1991; 33: 480–481
  • Shiu T. C., Chong Y. H. A Cluster of Clenbuterol Poisoning Associated with the Pork and Pig Offal in Hong Kong. Public Health Epidemiol. Bull. (Hong Kong) 2001; 10: 14–17
  • Martinez-Navarro J. F. Food Poisoning Related to Consumption of Illicit β-Agonist in Liver (Letter). Lancet 1990; 336: 1311
  • Elliott C. T., McCaughey W. J., Shortt H. D. Residues of the Beta-Agonist Clenbuterol in Tissues of Medicated Farm Animals. Food Addict. Contam. 1993; 10: 231–244
  • Smith D. J., Paulson G. D. Distribution, Elimination, and Residues of [14C]Clenbuterol HCl in Holstein Calves. J. Anim. Sci. 1997; 75: 454–461
  • Whitsett T. L., Manion C. V., Wilson M. F. Cardiac, Pulmonary and Neuromuscular Effects of Clenbuterol and Terbutaline Compared with Placebo. Br. J. Clin. Pharmacol. 1981; 12: 195–200
  • Su W. J., Perng R. P. Spiropent (Clenbuterol): Another Choice for Patients with Chronic Reversible Airways Obstruction. Chung Hua I Hsueh Tsa Chih 1991; 47: 13–17

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.