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Journal of Toxicology: Clinical Toxicology Volume 39, 2001 - Issue 6
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Research Article

Reversal of Severe Methanol-Induced Visual Impairment: No Evidence of Retinal Toxicity Due to Fomepizole

Dr. Marco Sivilotti Department of Emergency Medicine, Queen's University, 76 Stuart Street, Kingston, Ontario, K7L 2V7, Canada
,
Marco L.A. Sivilotti University of Massachusetts Medical School, Worcester, Massachusetts, U.S.A.
,
Michael J. Burns University of Massachusetts Medical School, Worcester, Massachusetts, U.S.A.
,
Cynthia K. Aaron University of Massachusetts Medical School, Worcester, Massachusetts, U.S.A.
,
Kenneth E. McMartin Louisiana State University Medical Center, Shreveport, Louisiana, U.S.A.
&
Jeffrey Brent University of Colorado Health Science Center, Denver, Colorado, U.S.A.
Pages 627-631 | Published online: 31 Oct 2001

REFERENCES

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  • Jacobsen D., Sebastian C. S., Barron S. K., Carriere E. W., McMartin K. E. Effects of 4-Methylpyrazole, Methanol/Ethylene Glycol Antidote, in Healthy humans. J. Emerg. Med. 1990; 8: 455–461
  • Brent J., McMartin K., Phillips S., Burkhart K. K., Donovan J. W., Wells M., Kulig K. Fomepizole for the Treatment of Ethylene Glycol Poisoning. N. Engl. J. Med. 1999; 340(11)832–838
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  • Blomstrand R., Ingelmansson S. O., Jensen M., Hedstrom C. G. Normal Electroretinogram and No Toxicity Signs After Chronic and Acute Administration of the Alcohol Dehydrogenase Inhibitor 4-Methylpyrazole to the Cynomolgus Monkey (Macaca fascicularis)—A Possible New Treatment of Methanol Poisoning. Drug Alcohol Depend 1984; 13: 9–20
  • Blomstrand R., Ingelmansson S. O. Studies on the Effect of 4-Methylpyrazole on Methanol Poisoning Using the Monkey as an Animal Model: With Particular Reference to the Ocular Toxicity. Drug Alcohol Depend 1984; 13: 343–355
  • McMartin K. E., Hedstrom K. G, Tolf B. R., Ostling-Wintzell H., Blomstrand R. Studies on the Metabolic Interactions Between 4-Methylpyrazole and Methanol Using Monkey as an Animal Model. Arch. Biochem. Biophys. 1980; 199(2)606–614
  • , Retinal images available for viewing at http://meds. queensu.ca/medicine/emergency/staff/sivilotti/Methanol Retina Images.htm
  • Palatnick W., Redman L. W., Sitar D. S., Tenenbein M. Methanol Half-Life During Ethanol Administration: Implications for Management of Methanol Poisoning. Ann. Emerg. Med. 1995; 26(2)202–207

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