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Additional Commentary

Reduced Toxicity of Acetaminophen in Children: It's the Liver

, M.D.
Pages 149-152 | Received 11 May 2003, Accepted 18 Dec 2003, Published online: 05 Nov 2004

References

  • Tenenbein M. Acetaminophen the 150 mg/kg myth. J Toxicol, Clin Toxicol 2004; 42: xx
  • Bond G R, Krenzelok E P, Normann S A, Morris C L, McCoy D J, Thompson M W, McCarthy T, Roblez J, Taylor C, Dolan M A, Requa R K, Curry S C. Acetaminophen ingestion in childhood: cost and relative risk of alternative referral strategies. J Toxicol, Clin Toxicol 1994; 32(5)513–525
  • Caravati E M. Unintentional acetaminophen ingestion in children and the potential for hepatotoxicity. J Toxicol, Clin Toxicol 2000; 38: 291–296
  • Hamilton R J, Goldfrank L R. Poison center data and the Pollyanna phenomenon. J Toxicol, Clin Toxicol 1997; 35: 21–23
  • Rumack B H. Acetaminophen hepatotoxicity: the first 35 years. J Toxicol, Clin Toxicol 2002; 40: 3–20
  • Smilkstein M J, Bronstein A C, Linden C, et al. Acetaminophen overdose: a 48‐hour intravenous N‐acetylcysteine treatment protocol. Ann Emerg Med 1991; 20: 1058–1063
  • Smilkstein M F, Knapp G L, Kulig D W, et al. Efficacy of oral N‐acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). N Engl J Med 1988; 319: 1557–1562
  • Brown R D, Wilson J T, Kearns G L, et al. Single‐dose pharmacokinetics of ibuprofen and acetaminophen in febrile children. J Clin Pharmacol 1992; 32: 231–241
  • Miller R P, Roberts R J, Fisher L J. Acetaminophen elimination kinetics in neonates, children and adults. Clin Pharmacol Ther 1976; 19: 284–294
  • Nash R M, Stein L, Penno M B, et al. Sources of interindividual variation in acetaminophen and antipyrine metabolism. Clin Pharmacol Ther 1984; 36: 417–430
  • Critchley J AJH, Nimmo G R, Gregson C A, et al. Inter‐subject and ethnic differences in paracetamol metabolism. Br J Pharmacol 1986; 22: 649–657
  • Rumore M M, Blaiklock R G. Influence of age dependent pharmacokinetics and metabolism on acetaminophen hepatotoxicity. J Pharm Sci 1992; 81: 203–207
  • de Wildt S N, Kearns G L, Leeder J S, van den Anker J N. Glucuronidation in humans: pharmacogenetic and developmental aspects. Clin Pharmacokinet 1999; 36: 439–452
  • Al‐Obaidy S S, McKiernan P J, Po A WL, et al. Metabolism of paracetamol in children with chronic liver disease. Eur J Pharmacol 1996; 50: 69–76
  • Manyike P T, Kharasch E D, Kalhorn T F, Slattery J T. Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation. Clin Pharmacol Ther 2000; 67: 275–282
  • Lauterburg B H, Vaishnav Y, Stillwell W G, et al. The effects of age and glutathione depletion on hepatic glutathione turnover in vivo determined by acetaminophen probe analysis. J Pharmacol Exp Ther 1980; 213: 54–58
  • Edwards D A, Fish S F, Lamson M J, et al. Prediction of acetaminophen level from clinical history of overdose using a pharmacokinetic model. Ann Emerg Med 1986; 15(11)1314–1319
  • Peterson R G, Rumack B H. Age as a variable in acetaminophen overdose. Arch Intern Med 1981; 141: 390–393
  • Wilson J T, Brown R D, Bocchini J A, et al. Efficacy, disposition, and pharmacodynamics of aspirin, acetaminophen and choline salicylate in young febrile children. Ther Drug Monit 1982; 4: 147–180
  • Kelley M T, Walson P D, Edge J H, et al. Pharmacokinetics and pharmacodynamics of ibuprofen isomers and acetaminophen in febrile children. Clin Pharmacol Ther 1992; 52: 181–189
  • Bond G R, Requa R K, Krenzelok E P, et al. Influence of time until emesis on the efficacy of decontamination using acetaminophen as a marker in a pediatric population. Ann Emerg Med 1993; 22: 1403–1407
  • Mohler C R, Nordt S P, Williams S R, Manoguerra A, Clark R F. Prospective evaluation of home treatment of mild to moderate pediatric acetaminophen exposures. Ann Emerg Med 2000; 35: 239–244

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