32
Views
10
CrossRef citations to date
0
Altmetric
Original

Selective Induction of Colon Cancer Cell Apoptosis by 5-Fluorouracil in Humans

, M.D., , M.D., , M.D., , M.D., , M.D. & , M.D.
Pages 657-665 | Published online: 17 Jul 2002

REFERENCES

  • Peeters M., Haller D.G. Therapy for Early-Stage Colorectal Cancer. Oncology (Huntingt) 1999; 13: 307–314
  • Gunderson L.L. Indications for and Results of Combined Modality Treatment of Colorectal Cancer. Acta Oncol. 1999; 38: 7–21
  • Sakamoto J., Hamada C., Kodaira S., Nakazato H., Ohashi Y. Adjuvant Therapy with Oral Fluoropyrimidines as Main Chemotherapeutic Agents After Curative Resection for Colorectal Cancer: Individual Patient Data Meta-analysis of Randomized Trials. Jpn. J. Clin. Oncol. 1999; 29: 78–86
  • Spears C.P., Gustavsson B.G., Mitchell M.S., Spicer D., Berne M., Bernstein L., Danenberg P.V. Thymidylate Synthetase Inhibition in Malignant Tumors and Normal Liver of Patients Given Intravenous 5-Fluorouracil. Cancer Res. 1984; 44: 4144–4150
  • Spears C.P., Shani J., Shahinian A.H., Wolf W., Heidelberger C., Danenberg P.V. Assay and Time Course of 5-Fluorouracil Incorporation into RNA of L1210/0 Ascites Cells In Vivo. Mol. Pharmacol. 1985; 27: 302–307
  • Matsuoka H., Ueo H., Sugimachi K., Akiyoshi T. Preliminary Evidence that Incorporation of 5-Fluorouracil into RNA Correlates with Antitumor Response. Cancer Investig. 1992; 10: 265–269
  • Pritchard D.M., Watson A.J., Potten C.S., Jackman A.L., Hickman J.A. Inhibition by Uridine but not Thymidine of p53-Dependent Intestinal Apoptosis Initiated by 5-Fluorouracil: Evidence for the Involvement of RNA Perturbation. Proc. Natl. Acad. Sci. USA 1997; 94: 1795–1799
  • Staunton M.J., Gaffney E.F. Apoptosis: Basic Concepts and Potential Significance in Human Cancer. Arch. Pathol. Lab. Med. 1998; 122: 310–319
  • Thompson C.B. Apoptosis in the Pathogenesis and Treatment of Disease. Science 1995; 267: 1456–1462
  • Bedi A., Pasricha P.J., Akhtar A.J., Barber J.P., Bedi G.C., Giardiello F.M., Zehnbauer B.A., Hamilton S.R., Jones R.J. Inhibition of Apoptosis During Development of Colorectal Cancer. Cancer Res. 1995; 55: 1811–1816
  • Pasricha P.J., Bedi A., O’ Connor K., Rashid A., Akhtar A.J., Zahurak M.L., Piantadosi S., Hamilton S.R., Giardiello F.M. The Effects of Sulindac on Colorectal Proliferation and Apoptosis in Familial Adenomatous Polyposis. Gastroenterology 1995; 109: 994–998
  • Shchepotin I.B., Soldatenkov V., Buras R.R., Nauta R.J., Shabahang M., Evans S.R. Apoptosis of Human Primary and Metastatic Colon Adenocarcinoma Cell Lines In Vitro Induced by 5-Fluorouracil, Verapamil, and Hyperthermia. Anticancer Res. 1994; 14: 1027–1031
  • Barry M.A., Behnke C.A., Eastman A. Activation of Programmed Cell Death (Apoptosis) by Cis-Platin, Other Anticancer Drugs, Toxins and Hyperthermia. Biochem. Pharmacol. 1990; 40: 2353–2362
  • Sakaguchi Y., Stephens L.C., Makino M., Kaneko T., Strebel F.R., Danhauser L.L., Jenkins G.N., Bull J.M. Apoptosis in Normal Tissues Induced by 5-Fluorouracil: Comparison Between Bolus Injection and Prolonged Infusion. Anticancer Res. 1994; 14: 1489–1492
  • Inada T., Ichikawa A., Igarashi S., et al. Effect of Preoperative 5-Fluorouracil on Apoptosis of Advanced Gastric Cancer. J. Surg. Oncol. 1997; 65: 106–110
  • Yamane N., Makino M., Kaibara N. S-Phase Accumulation Precedes Apoptosis Induced by Preoperative Treatment with 5-Fluorouracil in Human Colorectal Carcinoma Cells. Cancer 1999; 85: 309–317
  • Yamane N., Makino M., Taniguchi T., Kurayoshi K., Kaibara N. Increased Induction of Apoptosis of Human Colorectal Cancer Cells After Preoperative Treatment with 5-Fluorouracil. Gan To Kagaku Ryoho 1998; 25((Suppl 3))404–409
  • Qiao L., Shiff S.J., Rigas B. Sulindac Sulfide Inhibits the Proliferation of Colon Cancer Cells: Diminished Expression of the Proliferation Markers PCNA and Ki-67. Cancer Lett. 1997; 115: 229–234
  • Qiao L., Hanif R., Sphicas E., Shiff S.J., Rigas B. Effect of Aspirin on Induction of Apoptosis in HT-29 Human Colon Adenocarcinoma Cells. Biochem. Pharmacol. 1998; 55: 53–64
  • Sugamura K., Makino M., Shirai H., Kimura O., Maeta M., Itoh H., Kaibara N. Enhanced Induction of Apoptosis of Human Gastric Carcinoma Cells After Preoperative Treatment with 5-Fluorouracil. Cancer 1997; 79: 12–17
  • Ueda M., Kumagai K., Ueki K., Inoki C., Orino I., Ueki M. Growth Inhibition and Apoptotic Cell Death in Uterine Cervical Carcinoma Cells Induced by 5-Fluorouracil. Int. J. Cancer 1997; 71: 668–674
  • Nita M.E., Nagawa H., Tominaga O., Tsuno N., Fujii S., Sasaki S., Fu C.G., Takenoue T., Tsuruo T., Muto T. 5-Fluorouracil Induces Apoptosis in Human Colon Cancer Cell Lines with Modulation of Bcl-2 Family Proteins. Br. J. Cancer 1998; 78: 986–992
  • Yoneda K., Yamamoto T., Osaki T. p53- and p21-Independent Apoptosis of Squamous Cell Carcinoma Cells Induced by 5-Fluorouracil and Radiation. Oral Oncol. 1998; 34: 529–537
  • Pritchard D.M., Jackman A., Potten C.S., Hickman J.A. Chemically-Induced Apoptosis: p21 and p53 as Determinants of Enterotoxin Activity. Toxicol. Lett. 1998; 102–103: 19–27
  • Shiff S.J., Qiao L., Tsai L.-L., Rigas B. Sulindac Sulfide, an Aspirin-Like Compound, Inhibits Proliferation, Causes Cell Cycle Quiescence, and Induces Apoptosis in HT-29 Colon Adenocarcinoma Cells. J. Clin. Investig. 1995; 96: 491–503
  • Shiff J.S., Rigas B. Nonsteroidal Antiinflammatory Drugs and Colorectal Cancer: Evolving Concepts of Their Chemopreventive Actions. Gastroenterology 1997; 113: 1992–1998

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.