74
Views
28
CrossRef citations to date
0
Altmetric
Original

Feasibility Trial of Methotrexate–Paclitaxel as a Second Line Therapy in Advanced Urothelial Cancer

, M.D., , M.S., , M.S., , Ph.D., , M.D., , M.D., , M.D., , M.D. & , M.D. show all
Pages 673-685 | Published online: 17 Jul 2002

REFERENCES

  • Harker W.G., Meyers F.J., Freiha F.S., Palmer J.M., Shortliffe L.D., Hannigan J.F., McWhirter K.M., Torti F.M. Cisplatin, Methotrexate, and Vinblastine (CMV): An Effective Chemotherapy Regimen for Metastatic Transitional Cell Carcinoma of the Urinary Tract: A Northern California Oncology Group Study. J. Clin. Oncol. 1985; 3: 1463–1470
  • Sternberg C.N., Yagoda A., Scher H.I., Watson R.C., Herr H.W., Morse M.J., Sogani P.C., Vaughan E.D., Bander N., Weiselberg L.R. M-VAC (Methotrexate, Vinblastine, Doxorubicin and Cisplatin) for Advanced Transitional Cell Carcinoma of the Urothelium. J. Urol. 1988; 139: 461–469
  • Sternberg C.N., Yagoda A., Scher H.I., Watson R.C., Geller N., Herr H.W., Morse M.J., Sogani P.C., Vaughan K.D., Bander N. Methotrexate, Vinblastine, Doxorubicin, and Cisplatin for Advanced Transitional Cell Carcinoma of the Urothelium: Efficacy and Patterns of Response and Relapse. Cancer 1989; 64: 2448–2458
  • Bellmunt J., Ribas A., Eres N., Albanell J., Almanz C., Bermejo B., Sole L.A., Baselga J. Carboplatin Versus Cisplatin-Based Chemotherapy in the Treatment of Surgically Incurable Advanced Bladder Carcinoma. Cancer 1997; 80: 1966–1972
  • Loehrer P.J., Einhorn L.H., Elson P.J., Crawford E.D., Kubler P., Tannock I., Regharam D., Stuart-Harris R., Sarosdy M.F., Lowe B.A. A Randomized Comparison of Cisplatin Alone or in Combination with Methotrexate, Vinblastine, and Doxorubicin in Patients with Metastatic Urothelial Carcinoma: A Cooperative Group Study. J. Clin. Oncol. 1992; 10: 1066–1073
  • Logothetis C.J., Dexeus F.H., Finn L., Sella A., Amato R.J., Ayala A.G., Kilbourn R.G. A Prospective Randomized Trial Comparing MVAC and CISCA Chemotherapy for Patients with Metastatic Urothelial Tumors. J. Clin. Oncol. 1990; 8: 1050–1055
  • Seidman A.D., Scher H.I., Heinemann M.H., Bajorin D.F., Sternberg C.N., Dershaw D.D., Silverberg M., Bosl G.I. Continuous Infusion Gallium Nitrate for Patients with Advanced Refractory Urothelial Tract Tumors. Cancer 1991; 68: 2561–2565
  • Witte R.S., Elson P., Bono B., Knop R., Richardson R.R., Dreicer R., Loehrer PJ. Eastern Cooperative Oncology Group Phase II Trial of Ifosfamide in the Treatment of Previously Treated Advanced Urothelial Carcinoma. J. Clin. Oncol. 1997; 15(2)589–593
  • Witte R.S., Elson P., Khandaker J., Trump D.L. Eastern Cooperative Oncology Group Phase II Trial of Trimetrexate in Treatment of Advanced Urothelial Carcinoma. Cancer 1994; 73(3)688–691
  • Pollera C.F., Ceribelli A., Grecco M., Calabresi F. Weekly Gemcitabine in Advanced Bladder Cancer. A Preliminary Report from a Phase I Study. Ann. Oncol. 1994; 5: 182–184
  • Roth B., Dreicer R., Einhorn L.H., Neuberg D., Johnson D.H., Smith J.L., Hudes G.R., Schultz S.M., Loehrer P.J. Significant Activity of Paclitaxel in Advanced Transitional-Cell Carcinoma of the Urothelium: A Phase II Trial of the ECOG. J. Clin. Oncol. 1994; 12: 2264–2270
  • Edelman M.J., Meyers F., Houston J., Lauder I. Phase I Trial of Paclitaxel, Carboplatin and Methotrexate (MTX) with Granulocyte Colony-Stimulating Factor and Leucovorin in Advanced Transitional Cell Carcinoma. Semin. Oncol. 1997; 24(5 Suppl. 1)S15-68–S15-71
  • Bajorin D.F., McCaffrey J.A., Hilton S., Mazmudar M., Kelly W.K., Scher H.I., Spicer J., Herr H., Higgins G. Treatment of Patients with Transitional-Cell Carcinoma of the Urothelial Tract with Ifosfamide, Paclitaxel and Cisplatin: A Phase II Trial. J. Clin. Oncol. 1998; 16: 2722–2727
  • Redman B.G., Smith D.C., Flaherty L., Du W., Hussain M. Phase II Trial of Paclitaxel and Carboplatin in the Treatment of Advanced Urothelial Carcinoma. J. Clin. Oncol. 1998; 16: 1844–1848
  • Burch P.A., Richardson R.L., Cha S.S., Sargent D.J., Pitot H.C., Kaur J.S., Camoriano J.K. Phase II Study of Paclitaxel and Cisplatin for Advanced Urothelial Cancer. J. Urol. 2000; 164(5)1538–1542
  • Von der Maase H., Andersen L., Crino L., Weinknecht S., Dogliotti L. Weekly Gemcitabine and Cisplatin Combination Therapy in Patients with Transitional Cell Carcinoma of the Urothelium: A Phase II Clinical Trial. Ann. Oncol. 1999; 10: 1461–1465
  • Stadler W.M., Kuzel T., Roth B., Raghavan D., Dorr F.A. Phase II Study of Single-Agent Gemcitabine in Previously Untreated Patients with Metastatic Urothelial Cancer. J. Clin. Oncol. 1997; 15: 3441–3445
  • Marini L., Sternberg C.N., Sella A., et al. A New Regimen of Gemcitabine and Paclitaxel in Previously Treated Patients with Advanced Transitional Cell Carcinoma. Proc. Am. Soc. Clin. Oncol. 1999; 18: 1335
  • Meluch A.A., Greco F.A., Burris H.A., Hainsworth J.D. Gemcitabine and Paclitaxel Combination Therapy in Transitional Cell Carcinoma of the Urothelium. Eur. J. Cancer 2000; 36: S30–S33
  • Huber M.H., Lee J.S., Newman R.A., Fosella F.V., Wester M., Hong W.K., Lippman S.M. A Phase I Investigation of the Sequential Use of Methotrexate and Paclitaxel with and without G-CSF for the Treatment of Solid Tumors. Ann. Oncol. 1996; 7: 59–63
  • Fuchs D.A., Johnson R.K. Cytologic Evidence that Taxol, an Antineoplastic Agent from Taxus Brevifolia, Acts as a Mitotic Spindle Poison. Cancer Treat. Rep. 1978; 62: 1219–1222
  • Niell H.B., Rangel C., Miller A., Cox C. The Activity of Antimicrotubular Agents in Human Bladder Tumor Cell Lines (HBTCL). Proc. Am. Assoc. Cancer Res. 1993; 34: 1025
  • Rangel C., Niell H., Miller A., Cox C. Taxol and Taxotere in Bladder Cancer: In Vitro Activity and Urine Stability. Cancer Chemother. Pharmacol. 1994; 33: 460–464
  • Allegra C.J., Fine R.L., Drake J.C., Chabner B.A. The Effect of Methotrexate on Intracellular Folate Pools in Human MCF-7 Breast Cancer Cells: Evidence for Direct Inhibition of Purine Synthesis. J. Biol. Chem. 1986; 26: 6478–6485
  • Fernandes D.J., Sur P., Kute T.E., Capizzi R.L. Proliferation-Dependent Cytotoxicity of Methotrexate in Murine L5718Y Leukemia. Cancer Res. 1988; 48: 5638–5644
  • Cos J., Bellmunt J., Soler C., Ribas A., Liuis J.M., Murio J.E., Margarit C. Comparative Study of Sequential Combinations of Paclitaxel and Methotrexate on a Human Bladder Cancer Cell Line. Cancer Investig. 2000; 18(5)429–435
  • Chou T.C. The Median Effect Principle and the Combination Index for Quantitation of Synergism and Antagonism. Synergism and Antagonism in Chemotherapy, T.C. Chou, D. Rideout. Academic Press, New York 1991; 62–89
  • Dreicer R., Gustin D., See W.A., Williams R.D. Paclitaxel in Advanced Urothelial Carcinoma: Its Role in Patients with Renal Insufficiency and as Salvage Therapy. Proc. Am. Soc. Clin. Oncol. 1996; 15: 242–243, Abstract 607
  • Gehan E.A. The Determination of the Number of Patients Required in a Preliminary and Follow-Up Trial of a New Chemotherapeutic Agent. J. Chronic Dis. 1961; 13: 346–353
  • Kaplan E.L., Meier P. Nonparametric Estimation from Incomplete Observations. J. Am. Stat. Assoc. 1958; 53: 457–481
  • Kaufmann S.H., Peereboom D., Buckwalter C.A., Svingen P.A., Grochow L.B., Donehower R.C., Rowinsky E.K. Cytotoxic Effects of Topotecan Combined with Various Anticancer Agents in Human Cancer Cell Lines. J. Natl Cancer Inst. 1996; 88: 734–741
  • User's Guide. SAS, Cary, NC 1995
  • Tu S.M., Hossan E., Amato R., Kilbourn R., Logothetis C.J. Paclitaxel, Cisplatin and Methotrexate Combination Chemotherapy is Active in the Treatment of Refractory Urothelial Malignancies. J. Urol. 1995; 154: 1719–1722
  • Otto T., Bex A., Krege S., Walz P.H., Rubben H. Paclitaxel-Based Second-Line Therapy for Patients with Advanced Chemotherapy-Resistant Bladder Carcinoma (M1): A Clinical Phase II Study. Cancer 1997; 80: 465–470
  • McCaffrey J.A., Hilton S., Mazumdar M., Sadan S., Kelly W.K., Scher H.L., Bajorin D.F. Phase II Trial of Docetaxel in Patients with Advanced or Metastatic Transitional Cell Carcinoma. J. Clin. Oncol. 1997; 15: 1853–1857
  • Chou T.C., Otter G.M., Sirotnak F.M. Combined Effects of Edatrexate with Taxol or Taxotere Against Breast Cancer Cell Growth. Proc. Am. Assoc. Cancer Res. 1993; 34: 300, Abstract 789
  • Berenbaum M.C. What Is Synergy?. Pharmacol. Rev. 1989; 41: 93–141
  • Machado S.G., Robinson G.A. A Direct, General Approach Based on Isobolograms for Assessing the Joint Action of Drugs in Pre-Clinical Experiments. Stat. Med. 1994; 13: 2289–2309
  • Laska E.M., Meisner M., Tang D.I. Classification of the Effectiveness of Combination Treatments. Stat. Med. 1997; 16: 2211–2228
  • Chou T.C., Talalay P. Quantitative Analysis of Dose–Effect Relationships: The Combined Effects of Multiple Drugs or Enzyme Inhibitors. Adv. Enzyme Regul. 1987; 22: 27–55

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.