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Drug and Chemical Toxicology Volume 24, 2001 - Issue 4
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Research Article

TOXICITY OF A SEVOFLURANE DEGRADATION PRODUCT INCUBATED WITH RAT LIVER AND RENAL CORTICAL SLICES

Jeffrey M. Catania Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, U.S.A.
,
Alan R. Parrish Department of Medical Pharmacology and Toxicology, Texas A and M University Health Science Center, College Station, Texas, U.S.A.
&
A. Jay Gandolfi Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, P.O. Box 210207, Tucson, AZ, 85721-0207, U.S.A.; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, U.S.A.
Pages 347-357 | Published online: 30 Nov 2001

REFERENCES

  • Neumann M. A., Laster M. J., Weiskopf R. B., Gong D. H., Dudziak R., Forster H., Eger E. I., II. The Elimination of Sodium and Potassium Hydroxides from Desiccated Soda Lime Diminishes Degradation of Desflurane to Carbon Monoxide and Sevoflurane to Compound A But Does Not Compromise Carbon Dioxide Absorption. Anesth. Analg. 1999; 89(3)768–773
  • Gonsowski C. T., Laster M. J., Eger E. I., II, Ferrel L. D., Kerschmann R. L. Toxicity of Compound A in Rats. Anesthesiology 1994; 80(3)556–573
  • Kharasch E. D., Hoffman G. M., Thorning D., Hankins D. C., Kilty C. G. Role of Renal Cysteine Conjugate Beta-lyase Pathway in Inhaled Compound A Nephrotoxicity in Rats. Anesthesiology 1998; 88(6)1624–1633
  • Iyer R. A., Anders M. W. Cysteine Conjugate Beta-lyase-dependent Biotransformation of the Cysteine S-conjugates of the Sevoflurane Degradation Product 2-(fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (Compound A). Chem. Res. Toxicol. 1997; 10(7)811–819
  • Iyer R. A., Anders M. W. Cysteine Conjugate Beta-lyase-dependent Biotransformation of the Cysteine S-conjugates of the Sevoflurane Degradation Product Compound A in Human, Nonhuman Primate and Rat Kidney Cytosol and Mitochondria. Anesthesiology 1996; 85(6)1454–1461
  • Jin L., Davis M. R., Kharasch E. D., Doss G. A., Baillie T. A. Identification in Rat Bile of Glutathione Conjugates of Fluoromethyl 2,2-Difluoro-1-(trifluoromethyl)vinyl Ether, a Nephrotoxic Degradate of the Anesthetic Agent Sevoflurane. Chem. Res. Toxicol. 1996; 9(2)555–561
  • Iyer R. A., Baggs R. B., Anders M. W. Nephrotoxicity of the Glutathione and Cysteine S-conjugates of the Sevoflurane Degradation Product 2-(Fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (Compound A) in Male Fischer 344 Rats. J. Pharm. Exp. Ther. 1997; 283(3)1544–1551
  • Uttamsingh V., Iyer R. A., Baggs R. B., Anders M. W. Fate and Toxicity of 2-(Fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (Compound A)-derived Mercapturates in Male, Fischer 344 Rats. Anesthesiology 1998; 89(5)1174–1183
  • Spracklin D. K., Kharasch E. D. Evidence for Metabolism of Fluoromethyl 2,2-Difluoro-1-(trifluoromethyl)vinyl Ether (Compound A), a Sevoflurane Degradation Product, by Cysteine-conjugate Beta-lyase. Chem. Res. Toxicol. 1996; 9(4)696–702
  • Goldberg M. E., Cantillo J., Gratz I., Deal E., Vekeman D., McDougall R., Afshar M., Zafeiridis A., Larijani G. Dose of Compound A, not Sevoflurane, Determines Changes in the Biochemical Markers of Renal Injury in Healthy Volunteers. Anesth. Analg. 1999; 88(2)437–445
  • Ebert T. J., Messana L. D., Uhrich T. D., Staacke T. S. Absence of Renal and Hepatic Toxicity after Four Hours of 1.25 Minimum Alveolar Anesthetic Concentration Sevoflurane Anesthesia in Volunteers. Anesth. Analg. 1998; 86(3)662–667
  • Eger E. I., II, Ionescu P., Koblin D. D., Weiskopf R. B. Compound A: Solubility in Saline and Olive Oil; Destruction by Blood. Anest. Analg. 1996; 83(4)849–853
  • Jin L., Baillie T. A., Davis M. R., Kharasch E. D. Nephrotoxicity of Sevoflurane Compound A [Fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl Ether] in Rats: Evidence for Glutathione and Cysteine Conjugate Formation and the Role of Renal Cysteine Conjugate Beta-lyase. Biochem. Biophys. Res. Commun. 1995; 210(2)498–506

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