LACK OF DNA BINDING IN THE RAT NASAL MUCOSA AND OTHER TISSUES OF THE NASAL TOXICANTS ROFLUMILAST, A PHOSPHODIESTERASE 4 INHIBITOR, AND A METABOLITE, 4-AMINO-3,5-DICHLOROPYRIDINE, IN CONTRAST TO THE NASAL CARCINOGEN 2,6-DIMETHYLANILINE*

REFERENCES

• Jeffrey A. M., Amin S. G., Kriminski J., Williams G. M., Luo F. Q., Zech K. Organ Specificity of DNA Adduct Formation with Aromatic Amines Carcinogenic for the Rat Nasal Mucosa or Liver. Toxicologist 2001; 60: 153–154
   Google Scholar
• Pino M. V., Valerio M. G., Miller G. K., Larson J. L., Rosolia D. L., Jayyosi Z., Crouch C. N., Trojanowski J. Q., Geiger L. E. Toxicologic and Carcinogenic Effects of the Type IV Phosphodiesterase Inhibitor RP 73401 on the Nasal Olfactory Tissue in Rats. Toxicol. Pathol. 1999; 27: 383–394
   PubMed Web of Science ®Google Scholar
• Haseman J. K., Hailey J. R. An Update of the National Toxicology Program Database on Nasal Carcinogens. Mutat. Res. 1997; 380: 3–11
   PubMed Web of Science ®Google Scholar
• Green T., Lee R., Moore R. B., Ashby J., Willis G. A., Lund V. J., Clapp M. J. Acetochlor-Induced Rat Nasal Tumors: Further Studies on the Mode of Action and Relevance to Humans. Regul. Toxicol. Pharmacol. 2000; 32: 127–133
   PubMed Web of Science ®Google Scholar
• National Toxicology Program. Toxicology and Carcinogenesis Studies of 2,6-Xylidine (2,6-Dimethylaniline) (CAS No. 87-62-7) in Charles River CD Rats (Feed Studies). National Institute of Environmental Health Sciences, Research Triangle Park, NC 1990, 27709http://ntp-server.niehs.nih.gov/htdocs/LT-studies/TR278.html
   Google Scholar
• Feng P. C., Wilson A. G., McClanahan R. H., Patanella J. E., Wratten S. E. Metabolism of Alachlor by Rat and Mouse Liver and Nasal Turbinate Tissues. Drug Metab. Disp. 1990; 18: 373–377
   PubMed Web of Science ®Google Scholar
• Li A. A., Asbury K. J., Hopkins W. E., Feng P. C., Wilson A. G. Metabolism of Alachlor by Rat and Monkey Liver and Nasal Turbinate Tissue. Drug Metab. Disp. 1992; 20: 616–618
   PubMed Web of Science ®Google Scholar
• Short C. R., Joseph M., Hardy M. L. Covalent Binding of [14C]-2,6-Dimethylaniline to DNA of Rat Liver and Ethmoid Turbinate. J. Tox. Environ. Health 1989; 27: 85–94
   PubMed Web of Science ®Google Scholar
• Taningher M., Terranova M. P., Airoldi L., Chiappetta L., Parodi S. Lack of Alachlor Induced DNA Damage as Assayed in Rodent Liver by the Alkaline Elution Test. Toxicology 1993; 85: 117–122
   PubMed Web of Science ®Google Scholar
• Randerath K., Reddy M. V., Gupta R. C. 32P-Postlabeling Test for DNA Damage. Proc. Natl. Acad. Sci., USA 1981; 78: 6126–6129
   PubMed Web of Science ®Google Scholar
• Phillips D. H., Farmer P. B., Beland F. A., Nath R. G., Poirier M. C., Reddy M. V., Turteltaub K. W. Methods of DNA Adduct Determination and Their Application to Testing Compounds for Genotoxicity. Environ. Mol. Mutagen. 2000; 35: 222–233
   PubMed Web of Science ®Google Scholar
• DeBord D. G., Cheever K. L., Werren D. M., Reid T. M., Swearengin T. F., Savage R. E., Jr. Determination of 4,4′-Methylene-bis-(2-chloroaniline)-DNA Adduct Formation in Rat Liver and Human Uroepithelial Cells by the 32P-Postlabeling Assay. Fundam. Appl. Toxicol. 1996; 30: 138–144
   PubMedGoogle Scholar
• Vock E. H., Hoymann H. G., Heinrich U., Lutz W. K. 32P-Postlabeling of a DNA Adduct Derived From 4,4′-Methylenedianiline, in the Olfactory Epithelium of Rats Exposed by Inhalation to 4,4′-Methylenediphenyl Diisocyanate. Carcinogenesis 1996; 17: 1069–1073
   PubMed Web of Science ®Google Scholar
• McQueen C. A., Williams G. M. Review of the Genotoxicity and Carcinogenicity of 4,4′-Methylene-Dianiline and 4,4′-Methylene-bis-2-Chloroaniline. Mutat. Res. 1990; 239: 133–142
   PubMed Web of Science ®Google Scholar
• Gupta R. C. 32P-Adduct Assay: Short- and Long-Term Persistance of 2-Acetylaminofluorene-DNA Adducts and Other Applications of the Assay. Cell Biol. Toxicol. 1988; 4: 467–474
   PubMed Web of Science ®Google Scholar
• Verna L., Whysner J., Williams G. M. 2-Acetylaminofluorene Mechanistic Data and Risk Assessment: DNA Reactivity, Enhanced Cell Proliferation and Tumor Initiation. Pharmacol. Ther. 1996; 71: 83–105
   PubMed Web of Science ®Google Scholar
• Snyderwine E. G., Roller P. P., Wirth P. J., Adamson R. H., Sato S., Thorgeirsson S. S. Synthesis, Purification and Mutagenicity of 2-Hydroxyamino-3-Methylimidazolo[4,5-f]Quinoline. Carcinogenesis 1987; 8: 1017–1020
   PubMed Web of Science ®Google Scholar
• Marques M. M., Mourato L. L.G., Santos M. A., Beland F. A. Synthesis, Characterization, and Conformational Analysis of DNA Adducts From Methylated Anilines Present in Tobacco Smoke. Chem. Res. Toxicol. 1996; 9: 99–108
   PubMed Web of Science ®Google Scholar
• Beland F. A., Melchior W. B., Mourato L. L.G., Santos M. A., Marques M. M. Arylamine-DNA Adduct Conformation in Relation to Mutagenesis. Mutat. Res. 1997; 376: 13–19
   PubMed Web of Science ®Google Scholar
• Marron D. M., Ames B. N. Revised Methods for the Salmonella typhimurium Mutagenicity Test. Mutat. Res. 1983; 11: 173–215
   Google Scholar
• Reddy M. V., Randerath K. Nuclease P1-Mediated Enhancement of Sensitivity of 32P-Postlabeling Test for Structurally Diverse DNA Adducts. Carcinogenesis 1986; 7: 1543–1551
   PubMed Web of Science ®Google Scholar
• Gupta R. C. Enhanced Sensitivity of 32P-Postlabeling Analysis of Aromatic Carcinogen-DNA Adducts. Cancer Res. 1985; 45: 5656–5662
   PubMed Web of Science ®Google Scholar
• Gonçalves L. L., Beland F. A., Marques M. M. Synthesis, Characterization, and Comparative 32P-Postlabeling Efficiencies of 2,6-dimethylaniline-DNA Adducts. Chem. Res. Toxicol. 2001; 14: 165–174
   PubMed Web of Science ®Google Scholar
• Miller E. C., Miller J. A., Sandin R. B., Brown R. K. The Carcinogenic Activities of Certain Analogues of 2-Acetylaminofluorene in the Rat. Cancer Res. 1949; 9: 504–509
   PubMed Web of Science ®Google Scholar
• Nestmann E. R., Bryant D. W., Carr C. J. Toxicological Significance of DNA Adducts: Summary of Discussion with an Expert Panel. Reg. Toxicol. Pharmacol. 1996; 24: 9–18
   PubMed Web of Science ®Google Scholar
• Williams G. M., Weisburger J. H. Chemical Carcinogens. Casarett and Doull's Toxicology. The Basic Science of Poisons, C. D. Kaassen, M. O. Amdur, J. Doull. Macmillan Pub. Co., New York 1986; 99–173
   Google Scholar
• Baur H., Neumann H. G. Correlation of Nucleic Acid Binding by Metabolites of Trans-4-Aminostilbene Derivatives with Tissue Specific Acute Toxicity and Carcinogenicity in Rats. Carcinogenesis 1980; 1: 877–885
   PubMed Web of Science ®Google Scholar
• Lutz W. K. In Vivo Chemical Binding of Organic Chemicals to DNA as a Quantative Indicator in the Process of Chemical Carcinogenesis. Mutat. Res. 1979; 65: 289–356
   PubMed Web of Science ®Google Scholar