INTRACELLULAR SIGNAL TRANSDUCTION IN EOSINOPHILS AND ITS CLINICAL SIGNIFICANCE

REFERENCES

• Weller P.F. Eosinophils: Structure and Functions. Curr. Opin. Immunol 1994; 6: 85–90
   PubMed Web of Science ®Google Scholar
• Walsh G.M. Advances in the Immunobiology of Eosinophils and Their Role in Disease. Crit. Rev. Clin. Lab. Sci. 1999; 36: 453–496
   PubMed Web of Science ®Google Scholar
• Gleich G.J. Mechanisms of Eosinophil-associated Inflammation. J. Allergy Clin. Immunol. 2000; 105: 651–663
   PubMed Web of Science ®Google Scholar
• Woerly G., Roger N., Loiseau S., Capron M. Expression of Th1 and Th2 Immunoregulatory Cytokines by Human Eosinophils. Int. Arch. Allergy Immunol. 1999; 118: 95–97
   PubMed Web of Science ®Google Scholar
• Wang W., Tanaka T., Okamura H., Sugita M., Higa S., Kishimoto T., Suemura M. Interleukin-18 Enhances the Production of Interleukin-8 by Eosinophils. Eur. J. Immunol. 2001; 4: 1010–1016
   Web of Science ®Google Scholar
• Kroegel C., Yukawa T., Dent G., Venge P., Chung K.F., Barnes P.J. Stimulation of Degranulation From Human Eosinophils by Platelet-activating Factor. J. Immunol. 1989; 142: 3518–3526
   PubMed Web of Science ®Google Scholar
• Koenderman L., Tool A.T., Roos D., Verhoeven A.J. Priming of the Respiratory Burst in Human Eosinophils is Accompanied by Changes in Signal Transduction. J. Immunol. 1990; 145: 3883–3888
   PubMed Web of Science ®Google Scholar
• Miyamasu M., Hirai K., Takahashi Y., Iida M., Yamaguchi M., Koshino T., Takaishi T., Morita Y., Ohta K., Kasahara T. Chemotactic Agonists Induce Cytokine Generation in Eosinophils. J. Immunol. 1995; 154: 1339–1349
   PubMed Web of Science ®Google Scholar
• Murphy P.M. The Molecular Biology of Leukocyte Chemoattractant Receptors. Annu. Rev. Immunol. 1994; 12: 593–633
   PubMed Web of Science ®Google Scholar
• Tavernier J., Van Der Heyden J., Verhee A., Brusselle G., Van Ostade X., Vandekerckhove J., North J., Rankin S.M., Kay A.B., Robinson D.S. Interleukin 5 Regulates the Isoform Expression of its Own Receptor Alpha-subunit. Blood 2000; 95: 1600–1607
   PubMed Web of Science ®Google Scholar
• Bruggen T.V.D., Koenderman L. Signal Transduction in Eosinophils. Clin. Exp. Allergy 1996; 26: 880–891
   PubMed Web of Science ®Google Scholar
• Neer E.J. Heterotrimeric G proteins: Organizers of Transmembrane Signals. Cell 1995; 80: 249–257
   PubMed Web of Science ®Google Scholar
• Bokoch G.M. Chemoattractant Signaling and Leukocyte Activation. Blood 1995; 86: 1649–1660
   PubMed Web of Science ®Google Scholar
• Agrawal D.K., Ali N., Numao T. PAF Receptors and G-proteins in Human Blood Eosinophils and Neutrophils. J. Lipid Mediat. 1992; 5: 101–104
   PubMedGoogle Scholar
• Koenderman L., Coffer P.J. Controlling Allergic Inflammation by Signaling Regulation of Eosinophils. Allergy 2001; 56: 204–214
   PubMed Web of Science ®Google Scholar
• Rankin S.M., Conroy D.M., Williams T.J. Eotaxin and Eosinophil Recruitment: Implications for Human Disease. Mol. Med. Today 2000; 6: 20–27
   PubMedGoogle Scholar
• Nakajima T., Yamada H., Iikura M., Miyamasu M., Izumi S., Shida H., Ohta K., Imai T., Yoshie O., Mochizuki M., Schroder J.M., Morita Y., Yamamoto K., Hirai K. Intracellular Localization and Release of Eotaxin from Normal Eosinophils. FEBS Lett. 1998; 434: 226–230
   PubMed Web of Science ®Google Scholar
• Garcia-Zepeda E.A., Rothenberg M.E., Ownbey R.T., Celestin J., Leder P., Luster A.D. Human Eotaxin is a Specific Chemoattractant for Eosinophil Cells and Provides a New Mechanism to Explain Tissue Eosinophilia. Nat. Med. 1996; 2: 449–456
   PubMed Web of Science ®Google Scholar
• Fujisawa T., Kato Y., Nagase H., Atsuta J., Terada A., Iguchi K., Kamiya H., Morita Y., Kitaura M., Kawasaki H., Yoshie O., Hirai K. Chemokines Induce Eosinophil Degranulation Through CCR-3. J. Allergy Clin. Immunol. 2000; 106: 507–513
   PubMed Web of Science ®Google Scholar
• Kay A.B., Corrigan C.J. Asthma, Eosinophils and Neutrophils. Br. Med. Bull. 1992; 48: 51–64
   PubMed Web of Science ®Google Scholar
• Heath H., Qin S., Rao P., Wu L., LaRosa G., Kassam N., Ponath P.D., Mackay C.R. Chemokine Receptor Usage by Human Eosinophils. The Importance of CCR3 Demonstrated Using an Antagonistic Monoclonal Antibody. J. Clin. Invest. 1997; 99: 178–184
   PubMed Web of Science ®Google Scholar
• Boehme S.A., Sullivan S.K., Crowe P.D., Santos M., Conlon P.J., Sriramarao P., Bacon K.B. Activation of Mitogen-activated Protein Kinase Regulates Eotaxin-induced Eosinophil Migration. J. Immunol. 1999; 163: 1611–1618
   PubMed Web of Science ®Google Scholar
• Kampen G.T., Stafford S., Adachi T., Jinquan T., Quan S., Grant J.A., Skov P.S., Poulsen L.K., Alam R. Eotaxin Induces Degranulation and Chemotaxis of Eosinophils Through the Activation of ERK2 and p38 Mitogen-Activated Protein Kinases. Blood 2000; 95: 1911–1917
   PubMed Web of Science ®Google Scholar
• Bertrand C.P., Ponath P.D. CCR3 Blockade as a New Therapy for Asthma. Exp. Opin. Invest. Drugs 2000; 9: 43–52
   PubMed Web of Science ®Google Scholar
• Miyajima A., Mui A.L., Ogorochi T., Sakamaki K. Receptors for Granulocyte-macrophage Colony-stimulating Factor, Interleukin-3, and Interleukin-5. Blood 1993; 82: 1960–1974
   PubMed Web of Science ®Google Scholar
• Takaki S., Kanazawa H., Shiiba M., Takatsu K. A Critical Cytoplasmic Domain of the Interleukin 5 (IL-5) Receptor Alpha Chain and its Function in IL-5-mediated Growth Signal Transduction. Mol. Cell Biol. 1994; 14: 7404–7413
   PubMed Web of Science ®Google Scholar
• Bates M.E., Bertics P.J., Busse W.W. IL-5 Activates a 45-kilodalton Mitogen-activated Protein (MAP) Kinase and Jak-2 Tyrosine Kinase in Human Eosinophils. J. Immunol. 1996; 156: 711–718
   PubMed Web of Science ®Google Scholar
• Pazdrak K., Stafford S., Alam R. The Activation of the Jak-STAT 1 Signaling Pathway by IL-5 in Eosinophils. J. Immunol. 1995; 155: 397–402
   PubMed Web of Science ®Google Scholar
• Bruggen T.V.D., Caldenhoven E., Kanters D., Coffer P., Raaijmakers J.A., Lammers J.W., Koenderman L. Interleukin-5 Signaling in Human Eosinophils Involves JAK2 Tyrosine Kinase and STAT1α. Blood 1995; 85: 1442–1448
   PubMed Web of Science ®Google Scholar
• de Groot R.P., Coffer P.J., Koenderman L. Regulation of Proliferation, Differentiation and Survival by the IL-3/IL-5/GM-CSF Receptor Family. Cell Signal. 1998; 10: 619–628
   PubMed Web of Science ®Google Scholar
• Bates M.E., Green V.L., Bertics P.J. ERK1 and ERK2 Activation by Chemotactic Factors in Human Eosinophils is Interleukin 5-dependent and Contributes to Leukotriene C(4) Biosynthesis. J. Biol. Chem. 2000; 275: 10,968–10,975
   Web of Science ®Google Scholar
• Raingeaud J., Gupta S., Rogers J.S., Dickens M., Han J., Ulevitch R.J., Davis R.J. Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen- Activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine. J. Biol. Chem. 1995; 270: 7420–7426
   PubMed Web of Science ®Google Scholar
• Derijard B., Hibi M., Wu I.H., Barrett T., Su B., Deng T., Karin M., Davis R.J. JNK1: a Protein Kinase Stimulated by UV Light and Ha-Ras that Binds and Phosphorylates the c-Jun Activation Domain. Cell 1994; 76: 1025–1037
   PubMed Web of Science ®Google Scholar
• Herlaar E., Brown Z. p38 MAPK Signalling Cascades in Inflammatory Disease. Mol. Med. Today 1999; 5: 439–447
   PubMedGoogle Scholar
• Davis R.J. The Mitogen-activated Protein Kinase Signal Transduction Pathway. J. Biol. Chem. 1993; 268: 14,553–14,556
   Web of Science ®Google Scholar
• Mary E.B., Paul J.B., William W.B. IL-5 Activates a 45-kilodalton Mitogen-activated Protein (MAP) Kinase and Jak-2 Tyrosine Kinase in Human Eosinophils. J. Immunol. 1996; 156: 711–718
   PubMed Web of Science ®Google Scholar
• Adachi T., Alam R. The Mechanism of IL-5 Signal Transduction. Am. J. Physiol. 1998; 275: C623–C633
   PubMed Web of Science ®Google Scholar
• Bracke M., Coffer P.J., Lammers J.W., Koenderman L. Analysis of Signal Transduction Pathways Regulating Cytokine-mediated Fc Receptor Activation on Human Eosinophils. J. Immunol. 1998; 161: 6768–6774
   PubMed Web of Science ®Google Scholar
• Wong C.K., Ho C.Y., Lam C.W.K., Zhang J.P., Hjelm N.M. Differentiation of a Human Eosinophilic Leukemic Cell Line, EoL-1: Characterization by the Expression of Cytokine Receptors, Adhesion Molecules, CD95 and Eosinophilic Cationic Protein (ECP). Immunol. Lett. 1999; 68: 317–323
   PubMed Web of Science ®Google Scholar
• Wong C.K., Zhang J.P., Lam W.K., Ho C.Y., Hjelm N.M. Sodium Salicylate-induced Apoptosis of Human Peripheral Blood Eosinophils is Independent of the Activation of C-Jun N-terminal Kinase and p38 Mitogen-Activated Protein Kinase. Int. Arch. Allergy Immunol. 2000; 121: 44–52
   PubMed Web of Science ®Google Scholar
• Johnson N.L., Gardner A.M., Diener K.M., Lange-Carter C.A., Gleavy J., Jarpe M.B., Minden A., Karin M., Zon L.I., Johnson G.L. Signal Transduction Pathways Regulated by Mitogen-activated/extracellular Response Kinase Kinase Kinase Induce Cell Death. J. Biol. Chem. 1996; 271: 3229–3237
   PubMed Web of Science ®Google Scholar
• Xia Z., Dickens M., Raingeaud J., Davis R.J., Greenberg M.E. Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis. Science 1995; 270: 1326–1331
   PubMed Web of Science ®Google Scholar
• Kankaanranta H., De Souza P.M., Barnes P.J., Salmon M., Giembycz M.A., Lindsay M.A. SB 203580, An Inhibitor of p38 Mitogen-activated Protein Kinase, Enhances Constitutive Apoptosis of Cytokine-deprived Human Eosinophils. J. Pharmacol. Exp. Ther. 1999; 290: 621–628
   PubMed Web of Science ®Google Scholar
• Tsukahara K., Nakao A., Hiraguri M., Miike S., Mamura M., Saito Y., Iwamoto I. Tumor Necrosis Factor-alpha Mediate Antiapoptotic Signals Partially Via p38 MAP Kinase Activation in Human Eosinophils. Int. Arch. Allergy Immunol. 1999; 120(Suppl 1)54–59
   PubMedGoogle Scholar
• Zhang J.P., Wong C.K., Lam C.W.K. Role of Caspase in Dexamethasone-Induced Apoptosis and Activation of c-Jun NH2-terminal Kinase and p38 Mitogen-activated Protein Kinase in Human Eosinophils. Clin. Exp. Immunol. 2000; 122: 20–27
   PubMed Web of Science ®Google Scholar
• Shida Y., Daniel C.H., Kurt B. Requirement of Lyn and Syk Tyrosine Kinase for the Prevention of Apoptosis by Cytokines in Human Eosinophils. J. Exp. Med. 1996; 183: 1407–1414
   PubMed Web of Science ®Google Scholar
• Pazdrak K., Olszewska-Pazdrak B., Stafford S., Garofalo R.P., Alam R. Lyn, Jak2, and Raf-1 Kinases are Critical for the Antiapoptotic Effect of Interleukin 5, Whereas only Raf-1 Kinase is Essential for Eosinophil Activation and Degranulation. J. Exp. Med. 1998; 188: 421–429
   PubMed Web of Science ®Google Scholar
• Yousefi S., Green D.R., Blaser K., Simon H.U. Protein-tyrosine Phosphorylation Regulates Apoptosis in Human Eosinophils and Neutrophils. Proc. Natl. Acad. Sci. 1994; 91: 10,868–10,872, USA
   Web of Science ®Google Scholar
• Pazdrak K., Schreiber D., Forsythe P., Justement L., Alam R. The Intracellular Signal Transduction Mechanism of Interleukin 5 in Eosinophils: The Involvement of Lyn Tyrosine Kinase and the Ras-Raf-1-MEK-microtubule-associated Protein Kinase Pathway. J. Exp. Med. 1995; 181: 1827–1834
   PubMed Web of Science ®Google Scholar
• Machide M., Mano H., Todokoro K. Interleukin 3 and Erythropoietin Induce Association of Vav with Tec Kinase Through Tec Homology Domain. Oncogene 1995; 11: 619–625
   PubMed Web of Science ®Google Scholar
• Li Y., Shen B.F., Karanes C., Sensenbrenner L., Chen B. Association between Lyn Protein Tyrosine Kinase (p53/56lyn) and the Beta Subunit of the Granulocyte-macrophage Colony-stimulating Factor (GM-CSF) Receptors in a GM-CSF-dependent Human Megakaryocytic Leukemia Cell Line (M-07e). J. Immunol. 1995; 155: 2165–2174
   PubMed Web of Science ®Google Scholar
• Mano H., Yamashita Y., Sato K., Yazaki Y., Hirai H. Tec Protein-tyrosine Kinase is Involved in Interleukin-3 Signaling Pathway. Blood 1995; 85: 343–350
   PubMed Web of Science ®Google Scholar
• Burton E.A., Hunter S., Wu S.C., Anderson S.M. Binding of Src-like Kinases to the Beta-subunit of the Interleukin-3 Receptor. J. Biol. Chem. 1997; 272: 16,189–16,195
   Google Scholar
• Wei S., Liu J.H., Epling-Burnette P.K., Gamero A.M., Ussery D., Pearson E.W., Elkabani M.E., Diaz J.I., Djeu J.Y. Critical Role of Lyn Kinase in Inhibition of Neutrophil Apoptosis by Granulocyte-macrophage Colony-stimulating Factor. J. Immunol. 1996; 157: 5155–5162
   PubMed Web of Science ®Google Scholar
• Yousefi S., Hoessli D.C., Blaser K., Mills G.B., Simon H.U. Requirement of Lyn and Syk Tyrosine Kinases for the Prevention of Apoptosis by Cytokines in Human Eosinophils. J. Exp. Med. 1996; 183: 1407–1414
   PubMed Web of Science ®Google Scholar
• Darnell J.E., Jr. STATs and Gene Regulation. Science 1997; 277: 1630–1635
   PubMed Web of Science ®Google Scholar
• Schindler C., Darnell J.E., Jr. Transcriptional Responses to Polypeptide Ligands: the JAK-STAT Pathway. Annu. Rev. Biochem. 1995; 64: 621–651
   PubMed Web of Science ®Google Scholar
• Watanabe S., Itoh T., Arai K. Roles of JAK Kinases in Human GM-CSF Receptor Signal Transduction. J. Allergy Clin. Immunol. 1996; 98: S183–S191
   PubMed Web of Science ®Google Scholar
• Durstin M., Inhorn R.C., Griffin J.D. Tyrosine Phosphorylation of Shc is not Required for Proliferation or Viability Signaling by Granulocyte-macrophage Colony-stimulating Factor in Hematopoietic Cell Lines. J. Immunol. 1996; 157: 534–540
   PubMed Web of Science ®Google Scholar
• Inhorn R.C., Carlesso N., Durstin M., Frank D.A., Griffin J.D. Identification of a Viability Domain in the Granulocyte/macrophage Colony-stimulating Factor Receptor Beta-chain Involving Tyrosine-750. Proc. Natl. Acad. Sci. 1995; 92: 8665–8669, USA
   PubMed Web of Science ®Google Scholar
• van Dijk T.B., Caldenhoven E., Raaijmakers J.A., Lammers J.W., Koenderman L., de Groot R.P. Multiple Tyrosine Residues in the Intracellular Domain of the Common Beta Subunit of the Interleukin 5 Receptor are Involved in Activation of STAT5. FEBS Lett. 1997; 412: 161–164
   PubMed Web of Science ®Google Scholar
• Pazdrak K., Adachi T., Alam R. Src Homology 2 Protein Tyrosine Phosphatase (SHPTP2)/Src Homology 2 Phosphatase 2 (SHP2) Tyrosine Phosphatase is a Positive Regulator of the Interleukin 5 Receptor Signal Transduction Pathways Leading to the Prolongation of Eosinophil Survival. J. Exp. Med. 1997; 186: 561–568
   PubMed Web of Science ®Google Scholar
• Chin H., Nakamura N., Kamiyama R., Miyasaka N., Ihle J.N., Miura O. Physical and Functional Interactions Between Stat5 and the Tyrosine-phosphorylated Receptors for Erythropoietin and Interleukin-3. Blood 1996; 88: 4415–4425
   PubMed Web of Science ®Google Scholar
• Woodcock J.M., Bagley C.J., Zacharakis B., Lopez A.F. A Single Tyrosine Residue in the Membrane-proximal Domain of the Granulocyte-macrophage Colony-stimulating Factor, Interleukin (IL)-3, and IL-5 Receptor Common Beta-chain is Necessary and Sufficient for High Affinity Binding and Signaling by all Three Ligands. J. Biol. Chem. 1996; 271: 25,999–26,006
   Web of Science ®Google Scholar
• Chin H., Nakamura N., Kamiyama R., Miyasaka N., Ihle J.N., Miura O. Physical and Functional Interactions Between Stat5 and the Tyrosine-Phosphorylated Receptors for Erythropoietin and Interleukin-3. Blood 1996; 88: 4415–4425
   PubMed Web of Science ®Google Scholar
• Woodcock J.M., Bagley C.J., Zacharakis B., Lopez A.F. A Single Tyrosine Residue in the Membrane-proximal Domain of the Granulocyte-macrophage Colony-stimulating Factor, Interleukin (IL)-3, and IL-5 Receptor Common Beta-chain is Necessary and Sufficient for High Affinity Binding and Signaling by all Three Ligands. J. Biol. Chem. 1996; 271: 25,999–26,006
   Web of Science ®Google Scholar
• David M., Petricoin E., 3rd., Benjamin C., Pine R., Weber M.J., Larner A.C. Requirement for MAP Kinase (ERK2) Activity in Interferon Alpha- and Interferon Beta-stimulated Gene Expression Through STAT Proteins. Science 1995; 269: 1721–1723
   PubMed Web of Science ®Google Scholar
• Miike S., Nakao A., Hiraguri M., Kurasawa K., Saito Y., Iwamoto I. Involvement of JAK2, but not PI 3-kinase/Akt and MAP Kinase Pathways, in Anti-apoptotic Signals of GM-CSF in Human Eosinophils. J. Leukoc. Biol. 1999; 65: 700–706
   PubMed Web of Science ®Google Scholar
• Toker A., Cantley L.C. Signalling Through the Lipid Products of Phosphoinositide-3-OH Kinase. Nature 1997; 387: 673–676
   PubMed Web of Science ®Google Scholar
• Coffer P.J., Schweizer R.C., Dubois G.R., Maikoe T., Lammers J.W., Koenderman L. Analysis of Signal Transduction Pathways in Human Eosinophils Activated by Chemoattractants and the T-helper 2-derived Cytokines Interleukin-4 and Interleukin-5. Blood 1998; 91: 2547–2557
   PubMed Web of Science ®Google Scholar
• Hiraguri M., Miike S., Sano H., Kurasawa K., Saito Y., Iwamoto I. Granulocyte-macrophage Colony-stimulating Factor and IL-5 Activate Mitogen-activated Protein Kinase Through Jak2 Kinase and Phosphatidylinositol 3-kinase in Human Eosinophils. J. Allergy Clin. Immunol. 1997; 100: S45–S51
   PubMed Web of Science ®Google Scholar
• Palframan R.T., Collins P.D., Severs N.J., Rothery S., Williams T.J., Rankin S.M. Mechanisms of Acute Eosinophil Mobilization from the Bone Marrow Stimulated by Interleukin 5: the Role of Specific Adhesion Molecules and Phosphatidylinositol 3-kinase. J. Exp. Med. 1998; 188: 1621–1632
   PubMed Web of Science ®Google Scholar
• Miike S., Kurasawa K., Saito Y., Iwamoto I. Platelet-activating Factor Activates Mitogen-activated Protein Kinases Through the Activation of Phosphatidylinositol 3-kinase and Tyrosine Kinase in Human Eosinophils. J. Leukoc. Biol. 2000; 67: 117–126
   PubMed Web of Science ®Google Scholar
• Sotsios Y., Ward S.G. Phosphoinositide 3-kinase: A Key Biochemical Signal for Cell Migration in Response to Chemokines. Immunol. Rev. 2000; 177: 217–235
   PubMed Web of Science ®Google Scholar
• Blackwell T.S., Christman J.W. The Role of Nuclear Factor-κB in Cytokine Gene Regulation. Am. J. Respir. Cell Mol. Biol. 1997; 17: 3–9
   PubMed Web of Science ®Google Scholar
• Schmitz M.L., Baeuerle P.A. The p65 Subunit is Responsible for the Strong Transcription Activating Potential of NF-κB. EMBO J. 1991; 10: 3805–3817
   PubMed Web of Science ®Google Scholar
• Yamashita N., Koizumi H., Murata M., Mano K., Ohta K. Nuclear Factor kappa B Mediates Interleukin-8 Production in Eosinophils. Int. Arch. Allergy Immunol. 1999; 120: 230–236
   PubMed Web of Science ®Google Scholar
• Gilmore T.D. The Rel/NF-kappaB Signal Transduction Pathway: Introduction. Oncogene 1999; 18: 6842–6844
   PubMed Web of Science ®Google Scholar
• Baldwin A.S., Jr. The NF-kappa B and I kappa B Proteins: New Discoveries and Insights. Annu. Rev. Immunol. 1996; 14: 649–683
   PubMed Web of Science ®Google Scholar
• Yamashita N., Koizumi H., Murata M., Mano K., Ohta K. Nuclear Factor kappa B Mediates Interleukin-8 Production in Eosinophils. Int. Arch. Allergy Immunol. 1999; 120: 230–236
   PubMed Web of Science ®Google Scholar
• Fiedler M.A., Wernke-Dollries K., Stark J.M. Inhibition of TNF-alpha-induced NF-kappaB Activation and IL-8 Release in A549 Cells with the Proteasome Inhibitor MG-132. Am. J. Respir. Cell Mol. Biol. 1998; 19: 259–268
   PubMed Web of Science ®Google Scholar
• Yang L., Cohn L., Zhang D.H., Homer R., Ray A., Ray P. Essential Role of Nuclear Factor kappaB in the Induction of Eosinophilia in Allergic Airway Inflammation. J. Exp. Med. 1998; 188: 1739–1750
   PubMed Web of Science ®Google Scholar
• Hart L.A., Krishnan V.L., Adcock I.M., Barnes P.J., Chung K.F. Activation and Localization of Transcription Factor, Nuclear Factor-κB, in Asthma. Am. J. Respir. Crit. Care Med. 1998; 158: 1585–1592
   PubMed Web of Science ®Google Scholar
• Wu M., Lee H., Bellas R.E., Schauer S.L., Arsura M., Katz D., FitzGerald M.J., Rothstein T.L., Sherr D.H., Sonenshein G.E. Inhibition of NF-kappaB/Rel Induces Apoptosis of Murine B Cells. EMBO J. 1996; 15: 4682–4690
   PubMed Web of Science ®Google Scholar
• Grimm S., Bauer M.K., Baeuerle P.A., Schulze-Osthoff K. Bcl-2 Down-regulates the Activity of Transcription Factor NF-kappaB Induced upon Apoptosis. J. Cell Biol. 1996; 134: 13–23
   PubMed Web of Science ®Google Scholar
• Beg A.A., Baltimore D. An Essential Role for NF-kappaB in Preventing TNF-alpha-induced Cell Death. Science 1996; 274: 782–784
   PubMed Web of Science ®Google Scholar
• Feinman R., Koury J., Thames M., Barlogie B., Epstein J., Siegel D.S. Role of NF-kappaB in the Rescue of Multiple Myeloma Cells from Glucocorticoid-induced Apoptosis by bcl-2. Blood 1999; 93: 3044–3052
   PubMed Web of Science ®Google Scholar
• Ward C., Chilvers E.R., Lawson M.F., Pryde J.G., Fujihara S., Farrow S.N., Haslett C., Rossi A.G. NF-kappaB Activation is a Critical Regulator of Human Granulocyte Apoptosis in Vitro. J. Biol. Chem. 1999; 274: 4309–4318
   PubMed Web of Science ®Google Scholar
• Kung T.T., Stelts D.M., Zurcher J.A., Adams G.K., 3rd., Egan R.W., Kreutner W., Watnick A.S., Jones H., Chapman R.W. Involvement of IL-5 in a Murine Model of Allergic Pulmonary Inflammation: Prophylactic and Therapeutic Effect of an Anti-IL-5 Antibody. Am. J. Respir. Cell Mol. Biol. 1995; 13: 360–365
   PubMed Web of Science ®Google Scholar
• Elsner J., Petering H., Hochstetter R., Kimmig D., Wells T.N., Kapp A., Proudfoot A.E. The CC Chemokine Antagonist Met-RANTES Inhibits Eosinophil Effector Functions Through the Chemokine Receptors CCR1 and CCR3. Eur. J. Immunol. 1997; 27: 2892–2898
   PubMed Web of Science ®Google Scholar
• Wilkinson S.E., Parker P.J., Nixon J.S. Isoenzyme Specificity of Bisindolylmaleimides, Selective Inhibitors of Protein Kinase C. Biochem. J. 1993; 294: 335–337
   PubMed Web of Science ®Google Scholar
• Chijiwa T., Mishima A., Hagiwara M., Sano M., Hayashi K., Inoue T., Naito K., Toshioka T., Hidaka H. Inhibition of Forskolin-induced Neurite Outgrowth and Protein Phosphorylation by a Newly Synthesized Selective Inhibitor of Cyclic AMP-dependent Protein Kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D Pheochromocytoma Cells. J. Biol. Chem. 1990; 265: 5267–5272
   PubMed Web of Science ®Google Scholar
• Hart R.C., Bates M.D., Cormier M.J., Rosen G.M., Conn P.M. Synthesis and Characterization of Calmodulin Antagonistic Drugs. Methods Enzymol. 1983; 102: 195–204
   PubMed Web of Science ®Google Scholar
• Alessi D.R., Cuenda A., Cohen P., Dudley D.T., Saltiel AR. PD 098059 is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo. J. Biol. Chem. 1995; 270: 27,489–27,494
   Web of Science ®Google Scholar
• Favata M.F., Horiuchi K.Y., Manos E.J., Daulerio A.J., Stradley D.A., Feeser W.S., Van Dyk D.E., Pitts W.J., Earl R.A., Hobbs F., Copeland R.A., Magolda R.L., Scherle P.A., Trzaskos J.M. Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase. J. Biol. Chem. 1998; 273: 18,623–18,632
   Google Scholar
• Badger A.M., Bradbeer J.N., Votta B., Lee J.C., Adams J.L., Griswold D.E. Pharmacological Profile of SB 203580, A Selective Inhibitor of Cytokine Suppressive Binding Protein/p38 Kinase, in Animal Models of Arthritis, Bone Resorption, Endotoxin Shock and Immune function. J. Pharmacol. Exp. Ther. 1996; 279: 1453–1461
   PubMed Web of Science ®Google Scholar
• Underwood D.C., Osborn R.R., Kotzer C.J., Adams J.L., Lee J.C., Webb E.F., Carpenter D.C., Bochnowicz S., Thomas H.C., Hay D.W., Griswold D.E. SB 239063, A Potent p38 MAP Kinase Inhibitor, Reduces Inflammatory Cytokine Production, Airways Eosinophil Infiltration, and Persistence. J. Pharmacol. Exp. Ther. 2000; 293: 281–288
   PubMed Web of Science ®Google Scholar
• Arcaro A., Wymann M.P. Wortmannin is a Potent Phosphatidylinositol 3-kinase Inhibitor: the Role of Phosphatidylinositol 3,4,5-trisphosphate in Neutrophil Responses. Biochem. J. 1993; 296: 297–301
   PubMed Web of Science ®Google Scholar
• Bracke M., Coffer P.J., Lammers J.W., Koenderman L. Analysis of Signal Transduction Pathways Regulating Cytokine-mediated Fc Receptor Activation on Human Eosinophils. J. Immunol. 1998; 161: 6768–6774
   PubMed Web of Science ®Google Scholar
• Barnes P.J., Karin M. Nuclear factor-kappaB: A Pivotal Transcription Factor in Chronic Inflammatory Diseases. N. Engl. J. Med. 1997; 336: 1066–1071
   PubMed Web of Science ®Google Scholar
• Barnes P.J., Adcock I.M. Transcription Factors and Asthma. Eur. Respir. J. 1998; 12: 221–234
   PubMed Web of Science ®Google Scholar
• LeVan T.D., Bloom J.W., Adams D.G., Hensel J.L., Halonen M. Platelet-activating Factor Induction of Activator Protein-1 Signaling in Bronchial Epithelial Cells. Mol. Pharmacol. 1998; 53: 135–140
   PubMed Web of Science ®Google Scholar
• Fiedler M.A., Wernke-Dollries K., Stark J.M. Inhibition of TNF-alpha-induced NF-kappaB Activation and IL-8 Release in A549 Cells with the Proteasome Inhibitor MG-132. Am. J. Respir. Cell Mol. Biol. 1998; 19: 259–268
   PubMed Web of Science ®Google Scholar
• Sallusto F., Mackay C.R., Lanzavecchia A. Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells. Science 1997; 277: 2005–2007
   PubMed Web of Science ®Google Scholar
• Uguccioni M., Mackay C.R., Ochensberger B., Loetscher P., Rhis S., LaRosa G.J., Rao P., Ponath P.D., Baggiolini M., Dahinden C.A. High Expression of the Chemokine Receptor CCR3 in Human Blood Basophils. Role in Activation by Eotaxin, MCP-4, and Other Chemokines. J. Clin. Invest. 1997; 100: 1137–1143
   PubMed Web of Science ®Google Scholar
• Hochstetter R., Dobos G., Kimmig D., Dulkys Y., Kapp A., Elsner J. The CC Chemokine Receptor 3 CCR3 is Functionally Expressed on Eosinophils but not on Neutrophils. Eur. J. Immunol. 2000; 30: 2759–2764
   PubMed Web of Science ®Google Scholar
• Elsner J., Petering H., Kimmig D., Wells T.N., Proudfoot A.E., Kapp A. The CC Chemokine Receptor Antagonist Net-RANTES Inhibits Eosinophil Effector Functions. Int. Arch. Allergy Immunol. 1999; 118: 462–465
   PubMed Web of Science ®Google Scholar
• England B.P., Balasubramanian P., Uings I., Bethell S., Chen M.J., Schatz P.J., Yin Q., Chen Y.F., Whitehorn E.A., Tsavaler A., Martens C.L., Barrett R.W., McKinnon M. A Potent Dimeric Peptide Antagonist of Interleukin-5 that Binds Two Interleukin-5 Receptor Alpha Chains. Proc. Natl. Acad. Sci. 2000; 97: 6862–6867, USA
   PubMed Web of Science ®Google Scholar
• Leckie M.J., ten Brinke A., Khan J., Diamant Z., O'Connor B.J., Walls C.M., Mathur A.K., Cowley H.C., Chung K.F., Djukanovic R., Hansel T.T., Holgate S.T., Sterk P.J., Barnes P.J. Effects of an Interleukin-5 Blocking Monoclonal Antibody on Eosinophils, Airway Hyper-responsiveness, and the Late Asthmatic Response. Lancet 2000; 356: 2114–2116
   PubMed Web of Science ®Google Scholar
• Hart T.K., Cook R.M., Zia-Amirhosseini P., Minthorn E., Sellers T.S., Maleeff B.E., Eustis S., Schwartz L.W., Tsui P., Appelbaum E.R., Martin E.C., Bugelski P.J., Herzyk D.J. Preclinical Efficacy and Safety of Mepolizumab (SB-240563), a Humanized Monoclonal Antibody to IL-5, in Cynomolgus Monkeys. J. Allergy Clin. Immunol. 2001; 108: 250–257
   PubMed Web of Science ®Google Scholar
• Bochner B.S., Schleimer R.P. The Role of Adhesion Molecules in Human Eosinophil and Basophil Recruitment. J. Allergy Clin. Immunol. 1994; 94: 427–438
   PubMed Web of Science ®Google Scholar
• Kumano K., Nakao A., Nakajima H., Miike S., Kurasawa K., Saito Y., Iwamoto I. Blockade of JAK2 by Tyrphostin AG-490 Inhibits Antigen-induced Eosinophil Recruitment into the Mouse Airways. Biochem. Biophys. Res. Commun. 2000; 270: 209–214
   PubMed Web of Science ®Google Scholar
• Wegner C.D., Gundel R.H., Reilly P., Haynes N., Letts L.G., Rothlein R. Intercellular Adhesion Molecule-1 (ICAM-1) in the Pathogenesis of Asthma. Science 1990; 247: 456–459
   PubMed Web of Science ®Google Scholar
• Tohda Y., Kubo H., Nakajima S., Fukuoka M. Effect of Anti-ICAM-1 on Bronchial Response: Bronchoalveolar Lavage Fluid (BALF) and Ultrastructural Changes of Bronchial Epithelium in Guinea Pigs with Dual Phase Bronchial Response. Methods Find Exp. Clin. Pharmacol. 1999; 21: 541–547
   PubMedGoogle Scholar
• Yates D.H. Role of Exhaled Nitric Oxide in Asthma. Immunol. Cell Biol. 2001; 79: 178–190
   PubMed Web of Science ®Google Scholar
• Koarai A., Ichinose M., Sugiura H., Yamagata S., Hattori T., Shirato K. Allergic Airway Hyperresponsiveness and Eosinophil Infiltration is Reduced by a Selective iNOS Inhibitor, 1400W, in mice. Pulm. Pharmacol. Ther. 2000; 13: 267–275
   PubMed Web of Science ®Google Scholar
• Floyd H., Ni J., Cornish A.L., Zeng Z., Liu D., Carter K.C., Steel J., Crocker P.R. Siglec-8. A Novel Eosinophil-specific Member of the Immunoglobulin Superfamily. J. Biol. Chem. 2000; 275: 861–866
   PubMed Web of Science ®Google Scholar
• Kikly K.K., Bochner B.S., Freeman S.D., Tan K.B., Gallagher K.T., D'alessio K.J., Holmes S.D., Abrahamson J.A., Erickson-Miller C.L., Murdock P.R., Tachimoto H., Schleimer R.P., White J.R. Identification of SAF-2, a Novel Siglec Expressed on Eosinophils, Mast Cells, and Basophils. J. Allergy Clin. Immunol. 2000; 105: 1093–1100
   PubMed Web of Science ®Google Scholar
• Brenner V., Lindauer K., Parkar A., Fordham J., Hayes I., Stow M., Gama R., Pollock K., Jupp R. Analysis of Cellular Adhesion by Microarray Expression Profiling. J. Immunol. Methods 2001; 250: 15–28
   PubMed Web of Science ®Google Scholar
• Itoh K., Okubo K., Utiyama H., Hirano T., Yoshii J., Matsubara K. Expression Profile of Active Genes in Granulocytes. Blood 1998; 92: 1432–1441
   PubMed Web of Science ®Google Scholar
• Rothenberg M.E. Eosinophilia. N. Engl. J. Med. 1998; 338: 1592–1600
   PubMed Web of Science ®Google Scholar
• Simon H.U., Yousefi S., Schranz C., Schapowal A., Bachert C., Blaser K. Direct Demonstration of Delayed Eosinophil Apoptosis as a Mechanism Causing Tissue Eosinophilia. J. Immunol. 1997; 158: 3902–3908
   PubMed Web of Science ®Google Scholar
• Mehta H., Busse W.W. Eosinophil as a Therapeutic Target in Allergic Disease. Compr. Ther. 1994; 20: 651–657
   PubMedGoogle Scholar
• Ward I., Dransfield I., Chilvers E.R., Haslett I., Rossi A.G. Pharmacological Manipulation of Granulocyte Apoptosis: Potential Therapeutic Targets. Trends Pharmacol. Sci. 1999; 20: 503–509
   PubMed Web of Science ®Google Scholar
• So H.S., Park R.K., Kim M.S., Lee S.R., Jung B.H., Chung S.Y., Jun C.D., Chung H.T. Nitric Oxide Inhibits c-Jun N-terminal Kinase 2 (JNK2) via S-nitrosylation. Biochem. Biophys. Res. Commun. 1998; 247: 809–813
   PubMed Web of Science ®Google Scholar
• Tsuyuki S., Bertrand C., Erard F., Trifilieff A., Tsuyuki J., Wesp M., Anderson G.P., Coyle A.J. Activation of the Fas Receptor on Lung Eosinophils Leads to Apoptosis and the Resolution of Eosinophilic Inflammation of the Airways. J. Clin. Invest. 1995; 96: 2924–2931
   PubMed Web of Science ®Google Scholar
• Cousin J.M., Haslett C., Rossi A.G. Regulation of Granulocyte Apoptosis by PKC Inhibition and Elevation of [Ca2+]i. Biochem. Soc. Trans. 1997; 25: 243S
   PubMed Web of Science ®Google Scholar
• Ohta K., Yamashita N. Apoptosis of Eosinophils and Lymphocytes in Allergic Inflammation. J. Allergy Clin. Immunol. 1999; 104: 14–21
   PubMed Web of Science ®Google Scholar
• Ward C., Dransfield I., Chilvers E.R., Haslett C., Rossi A.G. Pharmacological Manipulation of Granulocyte Apoptosis: Potential Therapeutic Targets. TIPS 1999; 20: 503–509
   PubMed Web of Science ®Google Scholar