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ORIGINAL ARTICLE

Leukotriene Synthesis Is Increased by Transcriptional Up-Regulation of 5-Lipoxygenase, Leukotriene A4 Hydrolase, and Leukotriene C4 Synthase in Asthmatic Children

, M.D., , M.D., , M.D., , M.D., , M.D. & , M.D.
Pages 147-154 | Published online: 22 Apr 2003

References

  • O'Byrne PM. Leukotrienes in the pathogenesis of asthma. Chest 1997; 111(suppl 2)27S–34S
  • Schramek H, Wang Y, Konieczkowski M, Simonson MS, Dunn MJ. Endothelin-1 stimulates cytosolic phospholipase A2 activity and gene expression in rat glomerular mesangial cells. Kidney Int 1994; 46(6)1644–1652
  • Murakami M, Penrose JF, Urade Y, Austen KF, Arm JP. Interleukin 4 suppresses c-kit ligand-induced expression of cytosolic phospholipase A2 and prostaglandin endoperoxide synthase 2 and their roles in separate pathways of eicosanoid synthesis in mouse bone marrow-derived mast cells. Proc Natl Acad Sci USA 1995; 92(13)6107–6111
  • Zaitsu M, Hamasaki Y, Matsuo M, Hayasaki R, Muro E, Yamamoto S, Kobayashi I, Ichimaru T, Miyazaki S. Induction of cytosolic phospholipase A2 and prostaglandin H2 synthase-2 by lipopolysaccharide in human polymorphonuclear leukocytes. Eur J Haematol 1999; 63(2)94–102
  • Pouliot M, McDonald PP, Khamzina L, Borgeat P, McColl SR. Granulocyte–macrophage colony-stimulating factor enhances 5-lipoxygenase levels in human polymorphonuclear leukocytes. J Immunol 1994; 152(2)851–858
  • Stankova J, Rola-Pleszczynski M, Dubois CM. Granulocyte–macrophage colony-stimulating factor increases 5-lipoxygenase gene transcription and protein expression in human neutrophils. Blood 1995; 85(12)3719–3726
  • Pouliot M, McDonald PP, Borgeat P, McColl SR. Granulocyte/Macrophage colony- stimulating factor stimulates the expression of the 5-lipoxygenase-activating protein (FLAP) in human neutrophils. J Exp Med 1994; 179(2)1225–1232
  • Cowburn AS, Holgate ST, Sampson AP. IL-5 increases expression of 5-lipoxygenase-activating protein and translocates 5-lipoxygenase to the nucleus in human blood eosinophils. J Immunol 1999; 163(1)456–465
  • Hamasaki Y, Abe M, Matsumoto S, Ichimaru T, Kobayashi I, Tanaka E, Matsuo M, Hara N, Miyazaki S. Inhibition by dexamethasone of retinoic acid-induced enhancement of leukotriene C4 synthesis in rat basophilic leukemia-1 cells. Am J Respir Cell Mol Biol 1994; 11(1)49–56
  • Riddick CA, Serio KJ, Hodulik CR, Ring WL, Regan MS, Bigby TD. TGF-beta increases leukotriene C4 synthase expression in the monocyte-like cell line, THP-1. J Immunol 1999; 162(2)1101–1107
  • Hsieh FH, Lam BK, Penrose JF, Austen KF, Boyce JA. T helper cell type 2 cytokines coordinately regulate immunoglobulin E-dependent cysteinyl leukotriene production by human cord blood-derived mast cells: profound induction of leukotriene C4 synthase expression by interleukin 4. J Exp Med 2000; 193(1)123–133
  • Zaitsu M, Hamasaki Y, Matsuo M, Kukita A, Tsuji K, Miyazaki M, Hayasaki R, Muro E, Yamamoto S, Kobayashi I, Ichimaru T, Kohashi O, Miyazaki S. New induction of leukotriene A4 hydrolase by interleukin-4 and interleukin-13 in human polymorphonuclear leukocytes. Blood 2000; 96(2)601–609
  • Metzger WJ, Richerson HB, Worden K, Monick M, Hunninghake GW. Bronchoalveolar lavage of allergic asthmatic patients following allergen bronchoprovocation. Chest 1986; 89(4)477–483
  • Wenzel SE. Abnormalities of cell and mediator levels in bronchoalveolar lavage fluid of patients with mild asthma. J Allergy Clin Immunol 1996; 98(5 Pt(2))S17–S21
  • Zaitsu M, Hamasaki Y, Ishii K, Kita M, Hayasaki R, Muro E, Yamamoto S, Kobayashi I, Matsuo M, Ichimaru T, Miyazaki S. Direct evidence that LTC4 and LTB4 but not TXA2 are involved in asthma attacks in children. J Asthma 1998; 35(5)445–448
  • Shindo K, Koide K, Fukumura M. Enhancement of leukotriene B4 release in stimulated asthmatic neutrophils by platelet activating factor. Thorax 1997; 52(12)1024–1029
  • Sampson AP, Thomas RU, Costello JF, Piper PJ. Enhanced leukotriene synthesis in leukocytes of atopic and asthmatic subjects. Br J Clin Pharmacol 1992; 33(4)423–430
  • Hood PP, Cotter TP, Costello JF, Sampson AP. Effect of intravenous corticosteroid on ex vivo leukotriene generation by blood leukocytes of normal and asthmatic patients. Thorax 1999; 54(12)1075–1082
  • Kristjansson S, Shimizu T, Wennergren G, Strannegard IL, Strandvik B. Leukotriene B4 and C4 generation by human leukocytes after ex vivo stimulation with Ca-ionophore and opsonized zymosan in children with atopic asthma. Pediatr Allergy Immunol 1995; 6(3)155–160
  • Mitsunobu F, Mifune T, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Harada S, Takata S, Tanizaki Y, Harada M. Enhanced peripheral leukocyte leukotriene production and bronchial hyperresponsiveness in asthmatics. Eur Respir J 2000; 16(3)504–508
  • Kuitert LM, Newton R, Barnes NC, Adcock IM, Barnes PJ. Eicosanoid mediator expression in mononuclear and polymorphonuclear cells in normal subjects and patients with atopic asthma and cystic fibrosis. Thorax 1996; 51(12)1223–1228
  • Koshino T, Takano S, Houjo T, Sano T, Kudo K, Kihara H, Kitani S, Takaishi T, Hirai K, Ito K, Morita Y. Expression of 5-lipoxygenase and 5-lipoxygenase-activating protein mRNAs in the peripheral blood leukocytes of asthmatics. Biochem Biophys Res Commun 1998; 247(2)510–513
  • Sanak M, Simon HU, Szczeklik A. Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma. Lancet 1997; 350(9091)1599–1600
  • Van Sambeek R, Stevenson DD, Baldasaro M, Lam BK, Zhao J, Yoshida S, Yandora C, Drazen JM, Penrose JF. 5′ flanking region polymorphism of the gene encoding leukotriene C4 synthase does not correlate with the aspirin-intolerant asthma phenotype in the United States. J Allergy Clin Immunol 2000; 106(1 pt 1)72–76
  • Drazen JM, Yandava CN, Dube L, Szczerback N, Hippensteel R, Pillari A, Israel E, Schork N, Silverman ES, Katz DA, Drajesk J. Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nat Gemet 1999; 22(2)168–170
  • Clark JD, Lin LL, Kriz RW, Ramesha CS, Sultzman LA, Lin AY, NM., Knopf JL. A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP. Cell 1991; 65(6)1043–1051
  • Dixon RA, Jones RE, Diehl RE, Bennett CD, Kargman S, Rouzer CA. Cloning of the cDNA for human 5-lipoxygenase. Proc Natl Acad Sci USA 1988; 85(2)416–420
  • Dixon RA, Diehl RE, Opas E, Rands E, Vickers PJ, Evans JF, Gillard JW, Miller DK. Requirement of a 5-lipoxygenase activating protein for leukotriene synthesis. Nature 1990; 343(6255)282–284
  • Mancini JA, Evans JF. Cloning and characterization of the human leukotriene A4 hydrolase gene. Eur J Biochem 1995; 231(1)65–71
  • Penrose JF, Spector J, Baldasaro M, Xu K, Boyce J, Arm JP, Austen KF, Lam BK. Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35. J. Biol Chem 1996; 271(19)11356–11361

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