Different IL‐5 and IFN‐γ Production from Peripheral Blood T‐Cell Subsets in Atopic and Nonatopic Asthmatic Children

References

• Romagnani S. Lymphokine production by human T cells in disease states. Ann Rev Immunol 1994; 12: 227–257
   PubMed Web of Science ®Google Scholar
• Umetsu D T, DeKruyff R H. TH1 and TH2 CD4+ cells in human allergic disease. J Allergy Clin Immunol 1997; 100(1)1–6
   PubMedGoogle Scholar
• Krug N, Madden J, Redington A E, Lackie P, Djukanovic R, Schauer U, Holgate S T, Frew A J, Howarth P H. T cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. Am J Respir Cell Mol Biol 1996; 14(4)319–326
   PubMedGoogle Scholar
• Cembrzynska‐Nowak M, Szklarz E, Inglot A D, Teodorczyk‐Injeyan J A. Elevated release of tumor necrosis factor‐alpha and interferon‐gamma by bronchoalveolar leukocytes from patients with asthma. Am Rev Respir Dis 1993; 14(2)291–295
   Google Scholar
• Brown V, Warke T J, Shields M D, Ennis M. T cell cytokine profiles in childhood asthma. Thorax 2003; 58(4)311–316
   PubMedGoogle Scholar
• O'Brien R M, Xu H, Rolland J M, Byron K A, Thomas W R. Allergen‐specific production of interferon‐γ by peripheral blood mononuclear cells and CD8 T cells in allergic disease and following immunotherapy. Clin Exp Allergy 2000; 30(3)333–340
   PubMedGoogle Scholar
• Suzuki M, Maghni K, Molet S, Shimbara A, Hamid Q A, Martin J G. IFN‐γ secretion by CD8+ T cells inhibits allergen‐induced airway eosinophilia but not late airway responses. J Allergy Clin Immunol 2002; 109(5)803–809
   PubMedGoogle Scholar
• Magnan A O, Mely L G, Camilla C A, Badier M M, Montero‐Julian F A, Guillot C M, Casano B B, Prato S J, Fert V, Bongrand P, Vervloet D. Assessment of the Th1/Th2 paradigm in whole blood in atopy and asthma. Am J Respir Crit Care Med 2000; 161(6)1790–1796
   PubMed Web of Science ®Google Scholar
• Humbert M, Durham S R, Ying S, Kimmitt P, Barkans J, Assoufi E, Pfister R, Menz G, Robinson D S, Kay A B, Corrigan C J. IL‐4 and IL‐5 mRNA and protein expression in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against “intrinsic” asthma being a distinct immunopathologic entity. Am J Respir Crit Care Med 1996; 154(5)1497–1504
   PubMed Web of Science ®Google Scholar
• Ying S, Durham S R, Corrigan C J, Hamid Q, Kay A B. Phenotype of cells expressing mRNA for Th2‐type (interkeukin 4 and interleukin 5) and Th1‐type (interleukin 2 and interferon‐γ) cytokine in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects. Am J Respir Cell Mol Biol 1995; 12(5)477–478
   PubMed Web of Science ®Google Scholar
• Kotsimbos T C, Ghaffar O, Minshall E M, Humbert M, Durham S R, Pfister R, Menz G, Kay A B, Hamid Q A. Expression of the IL‐4 receptor α‐subunit is increased in bronchial biopsy specimens from atopic and nonatopic asthmaitc subjects. J Allergy Clin Immunol 1998; 102(5)859–866
   PubMedGoogle Scholar
• Tang M L, Coleman J, Kemp A S. Interleukin‐4 and interferon‐gamma production in atopic and nonatopic children with asthma. Clin Exp Allergy 1995; 25(6)515–521
   PubMedGoogle Scholar
• Bettiol J, Bartsch P, Louis R, De Groote D, Gevaerts Y, Louis E, Malaise M. Cytokine production from the peripheral whole blood in atopic and nonatopic asthmatics: relationship with blood and sputum eosinophilia and serum IgE levels. Allergy 2000; 55(12)1134–1141
   PubMedGoogle Scholar
• American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulomonary disease (COPD) and asthma. Am Rev Respir Dis 1987; 136(1)225–244
   PubMed Web of Science ®Google Scholar
• Chai H, Farr R S, Froehlich L A, Mathison D A, McLean J A, Rosenthal R R, Sheffer A L, Spector S L, Townley R G. Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol 1975; 56(4)323–327
   PubMed Web of Science ®Google Scholar
• Jung T, Schauer U, Heusser C, Neumann C, Rieger C. Detection of intracellular cytokines by flow cytometry. J Immunol Methods 1993; 159(1–2)197–207
   PubMed Web of Science ®Google Scholar
• Hoekstra M O, Hoekstra Y, De Reus D, Rutgers B, Gerritsen J, Kauffman H F. Interleukin‐4, interferon‐gamma and interleukin‐5 in peripheral blood of children with moderate atopic asthma. Clin Exp Allergy 1997; 27(11)1254–1260
   PubMedGoogle Scholar
• Nurse B, Haus M, Puterman A S, Weinberg E G, Potter P C. Reduced interferon‐γ but normal interleukin 4 and 5 release by peripheral blood mononuclear cells from atopic asthmatic Xhosa children. J Allergy Clin Immunol 1997; 100(5)662–668
   PubMed Web of Science ®Google Scholar
• Jujo K, Renz H, Abe J, Gelfand E W, Leung D Y. Decreased interferon gamma and increased interlukin‐4 production in atopic dermatitis promotes IgE synthesis. J Allergy Clin Immunol 1992; 90(3 Pt 1)323–331
   PubMed Web of Science ®Google Scholar
• Kimura M, Tsuruta S, Yoshida T. Unique profile of IL‐4 and IFN‐γ production by peripheral mononuclear cells in infants with atopic dermatitis. J Allergy Clin Immunol 1998; 102(2)238–244
   PubMedGoogle Scholar
• Chang J H, Chan H, Quirce S, Green T, Noertjojo K, Lam S, Frew A, Keown P, Chan‐Yeung M. In vitro T lymphocyte response and house dust mite‐induced bronchoconstricton. J Allergy Clin Immunol 1996; 98(5)922–931
   PubMedGoogle Scholar
• Cho S H, Stanciu L A, Begishivili T, Bates P J, Holgate S T, Johnston S L. Peripheral blood CD4+ and CD8+ T cell type 1 and type 2 cytokine production in atopic asthmatic and normal subjects. Clin Exp Allergy 2002; 32(3)427–433
   PubMedGoogle Scholar
• Renz H, Lack G, Saloga J, Schwinzer R, Bradley K, Loader J, Kupfer A, Larsen G L, Gelfand E W. Inhibition of IgE production and normalization of airway responsiveness by sensitized CD8 T cells in a mouse models of allergen‐induced sensitization. J Immuol 1994; 152(1)351–360
   PubMedGoogle Scholar
• Hofstra C L, Van Ark I, Hofman G, Nijkamp F P, Jardieu P M, Van Oosterhout A J. Differential effects of endogenous and exogenous interferon‐γ on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma. Am J Respir Cell Mol Biol 1998; 19(5)826–835
   PubMedGoogle Scholar
• Iwamoto I, Nakajima H, Endo H, Yoshida S. Interferon‐γ regulates antigen‐induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells. J Exp Med 1993; 177(2)573–576
   PubMedGoogle Scholar
• Leonard C, Tormey V, Burke C, Poulter L W. Allergen‐induced cytokine production in atopic disease and its relationship to disease severity. Am J Respir Cell Mol Biol 1997; 17(3)368–375
   PubMedGoogle Scholar
• Koh Y I, Choi I S, Lee H C. Relationship between changes in interferon‐γ production by peripheral blood T cells and changes in peak expiratory flow rate in patients with chronic stable asthma. Clin Exp Allergy 2002; 32(12)1734–1738
   PubMedGoogle Scholar
• Walker C, Virchow J C, Bruijnzeel P L, Blaser K. T cell subsets and their soluble products regulate eosinophilia in allergic and nonallergic asthma. J Immunol 1991; 146(6)1829–1835
   PubMedGoogle Scholar
• Walker C, Bode E, Boer L, Hansel T T, Blaser K, Virchow J C, Jr. Allergic and nonallergic asthmaitics have distinct patterns of T‐cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am Rev Respir Dis 1992; 146(1)109–115
   PubMed Web of Science ®Google Scholar