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Original

THE COMBINED EFFECT OF CYCLOSPORINE A AND GENTAMICIN ON ENZYMURIA IN THE SPRAGUE-DAWLEY RAT

, B.Sc., Ph.D., , B.Sc., Ph.D. & , B.Sc., Ph.D.
Pages 283-295 | Published online: 07 Jul 2009

REFERENCES

  • Bennett W M. The nephrotoxicity of new and old immunosupprressive drugs. Renal Failure 1998; 20: 687–690
  • Simon N, Brunet P, Roumenov D, et al. Trimethazine does not modify blood levels and immunosuppressant effects of CyA in renal allograft recipients. Br J Clin Pharmacol 1997; 44: 591–594
  • White D JG, Calne R Y. The use of cyclosporine A immunossuppression in organ grafting. Immunol Rev 1982; 65: 115–131
  • Vercauteren S B, Bosmans J L, Elseviers M M, et al. A meta-analysis and morphological review of cyclosporine-induced nephrotoxicity in autoimmune diseases. Kidney Int 1998; 54: 536–545
  • Morris P J. Some experimental and clinical studies of cyclosporine A in renal transplantation. Transplant. Proc 1982; 14: 525–528
  • Mihatsch M J, Thiel G, Basler V, et al. Morphological patterns in cyclosporine-treated renal transplant recipients. Transplant Proc 1984; 17(Supp 1)101–116
  • Termeer A, Hoitsma A J, Koene R AP. Severe nephrotoxicity caused by combine use of gentamicin and cyclosporine in renal allograft recipients. Transplantation 1986; 42: 220–221
  • Whiting P H, Cunningham C, Thomson A W, Simpson J G. Enhancement of high dose cyclosporine A toxicity by frusemide. Biochem Pharmacol 1984; 33: 1075–1079
  • Deray G, Lehoang P, Cacoub P, et al. Oral contraceptive interaction with cyclosporine. Lancet 1980; 1: 158–159
  • Obatomi D K, Plummer D T. Relative sensitivity of two strains of rats to gentamicin nephrotoxicity. Nig J Biochem 1988; 5: 91–94
  • Kaloyanides G J, Pastoriza-Munoz E. Aminoglycoside nephrotoxicity. Kidney Int 1980; 18: 571–582
  • Hows J M, Palmer S, Want S, et al. Serum levels of Cyclosporine A and nephrotoxicity in bone marrow transplant patients. Lancet 1981; 2: 145–146
  • Klintman G BM, Iwatsuki S, Starzl T E. Nephrotoxicity of cyclosporine A in liver and kidney transplant patients. Lancet 1981; 1: 470–471
  • Ryffel B, Muller A M, Mihatsch M J. Experimental cyclosporine nephrotoxicity-risk of concomitant chemotherapy. Clin Nephrol 1986; 25(Suppl 1)S121–125
  • Obatomi D K, Ukoli C O. Increased excretion of urinary enzymes in patients with renal disorders. Med Sci Res 1996; 24: 529–531
  • Obatomi D K. Urinary enzymes as biomarkers of renal damage and disease. Biokemistri 1994; 4: 1–24
  • Fashola T OA, Obatomi D K, Haslam J D, Plummer D T. Early marker of cyclosporine A- induced renal toxicity. Med Sci Res 1999; 27: 753–757
  • Obatomi D K, Plummer D T. Dose-related gentamicin nephrotoxicity in rats: A biochemical correlation. BioSci Res Commun 1990; 2: 1–7
  • Obatomi D K, Plummer D T. The effect of gentamicin and cefuroxime on the excretion of enzymes in rat urine. Med. Sci. Res 1991; 19: 421–423
  • Plummer D T, Noorazar S, Obatomi D K, Haslam J D. The assessment of renal injury by urinary enzymes. Uraemia Invest 1986; 9: 97–102
  • Plummer D T. An introduction to Practical Biochemistry. 2, McGraw Hill, London 1978; 144–145
  • Ryffel B. Toxicology- Experimental studies. Prog Allergy 1986; 38: 181–197
  • Bennett W M. Comparison of cyclosporine nephrotoxicity with aminoglycoside nephrotoxicity. Clin Nephrol 1986; 25(Suppl 1)S126–129
  • Humes A HD, Jackson N M, O'Connor R P, et al. Pathogenic mechanisms of nephrotoxicity: insights into Cyclosporine nephrotoxicity. Transplant Proc 1985; 17(Suppl 1)51–61
  • Sullivan B A, Hak L J, Finn W F. Cyclosporine nephrotoxicity- studies in laboratory animals. Transplant Proc 1984; 17(Suppl 1)45–154
  • Paller M S, Murray B M. Renal dysfunction in animal models of cyclosporine toxicity. Transplant Proc 1984; 17(Suppl 1)155–159
  • Adelman R O, Conzelman G, Spangler W, Ishizaki G. Diagnostic Significance of enzymes and protein in urine, U C Dubach, U Schmidt. Bern Stuttgart, Vienna, Hans Huber Publishers. 1979; 166–180
  • Houghton D C, Lee D, Gilbert D N, Bennett W M. Chronic gentamicin nephrotoxicity-continued tubular injury with preserved glomerular filtration function. Am J Pathol 1986; 123: 183–194
  • Donatsch P, Ryffel B. Pharmacokinetics of cyclosporine in toxicological studies. Transplant Proc 1986; 6(Suppl 1)71–76

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