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Research Article

CLODRONATE LIPOSOMES: PERSPECTIVES IN RESEARCH AND THERAPEUTICS

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Pages 81-94 | Published online: 15 Jul 2002

REFERENCES

  • Van Rooijen N., Bakker J., Sanders A. Transient Suppression of Macrophage Functions by Liposome-Encapsulated Drugs. Trends Biotechnol. 1997; 15: 178–185
  • Honing H., Van Rooijen N., Van Den Berg T.K. Manipulation of Macrophage Activities Using Liposomes. J. Liposome Res. 2000; 10: 359–389
  • Van Rooijen N., Sanders A. Liposome Mediated Depletion of Macrophages: Mechanism of Action, Preparation of Liposomes and Applications. J. Immunol. Meth. 1994; 174: 83–93
  • Van Rooijen N., Sanders A., Van den Berg T. Apoptosis of Macrophages Induced by Liposome-Mediated Intracellular Delivery of Drugs. J. Immunol. Meth. 1996; 193: 93–99
  • Fleisch H. Bisphosphonates in Bone Disease: From the Laboratory to the Patient. BerneSwitzerland 1993
  • Van Rooijen N., Kors N., Kraal G. Macrophage Subset Repopulation in the Spleen: Differential Kinetics after Liposome-Mediated Elimination. J. Leuk. Biol. 1989; 45: 97–104
  • Van Rooijen N., Kors N., Van den Ende M., Dijkstra C.D. Depletion and Repopulation of Macrophages in Spleen and Liver of Rat After Intravenous Treatment with Liposome Encapsulated Dichloromethylene Diphosphonate. Cell Tissue Res. 1990; 260: 215–222
  • Thepen T., Van Rooijen N., Kraal G. Alveolar Macrophage Elimination In Vivo is Associated with an Increase in Pulmonary Immune Responses in Mice. J. Exp. Med. 1989; 170: 499–509
  • Van Lent P.L.E.M., Holthuyzen A.E.M., Van Den Bersselaar L.A.M., Van Rooijen N., Joosten L.A.B., Van De Loo F.A.J., Van De Putte L.B.A., Van Den Berg W.B. Phagocytic Lining Cells Determine Local Expression of Inflammation in Collagen Type II Arthritis. Arthritis Rheum. 1996; 39: 1545–1555
  • Biewenga J., Van der Ende B., Krist L.F.G., Borst A., Ghufron M., Van Rooijen N. Macrophage Depletion and Repopulation in the Rat After i.p. Administration of Cl2MBP- Liposomes: Depletion Kinetics and Accelerated Repopulation of Peritoneal and Omental Macrophages by Administration of Freund's Adjuvant. Cell Tissue Res. 1995; 280: 189–196
  • Bergh A., Damber J.-E., Van Rooijen N. Liposome-Mediated Macrophage Depletion: An Experimental Approach to Study the Role of Testicular Macrophages. J. Endocrinol. 1993; 136: 407–413
  • Polfliet M.M.J., Goede P.H., Van Kesteren-Hendrikx E.M.L., Van Rooijen N., Dijkstra C.D., Van den Berg T.K. A Method for the Selective Depletion of Perivascular and Meningeal Macrophages in the Central Nervous System. J. Neuroimmunol. 2001; 116: 188–195
  • Delemarre F.G.A., Kors N., Kraal G., Van Rooijen N. Repopulation of Macrophages in Popliteal Lymph Nodes of Mice After Liposome Mediated Depletion. J. Leuk. Biol. 1990; 47: 251–257
  • Salkowski C.A., Neta R., Wynn T.A., Strassmann G., Van Rooijen N., Vogel S.N. Effect of Liposome-Mediated Macrophage Depletion on LPS-Induced Cytokine Gene Expression and Radioprotection. J. Immunol. 1995; 155: 3168–3179
  • Salkowski C.A., Detore G., McNally R., Van Rooijen N., Vogel S.N. Regulation of Inducible Nitric Oxide Synthase Messenger RNA Expression and Nitric Oxide Production by Lipopolysaccharide In Vivo: The Roles of Macrophages, Endogenous IFN-ηo and TNF Receptor-1-Mediated Signaling. J. Immunol. 1997; 158: 905–912
  • Kopydlowski K.M., Salkowski C.A., Cody M.J., Van Rooijen N., Major J., Hamilton T.A., Vogel S.N. Regulation of Macrophage Chemokine Expression by Lipopolysaccharide In Vitro and In Vivo. J. Immunol. 1999; 163: 1537–1544
  • Van Lent P.L.E.M., Holthuyzen A.E.M., Van Rooijen N., Van De Putte L.B.A., Van Den Berg W.B. Local Removal of Phagocytic Synovial Lining Cells by Clodronate-Liposomes Decreases Cartilage Destruction During Collagen Type II Arthritis. Ann. Rheum. Dis. 1998; 57: 408–413
  • Van Lent P.L.E.M., Holthuyzen A.E.M., Van Rooijen N., Van De Loo F.A.J., Van De Putte L.B.A., Van Den Berg W.B. Phagocytic Synovial Lining Cells Regulate Acute and Chronic Joint Inflammation After Antigenic Exacerbation of Smouldering Experimental Murine Arthritis. J. Rheumatol. 1998; 25: 1135–1145
  • Barrera P., Blom A., Van Lent P.L.E.M., Van Bloois L., Storm G., Beijnen J., Van Rooijen N., Van De Putte L.B.A., Van Den Berg W.B. Synovial Macrophage Depletion with Clodronate Containing Liposomes in Rheumatoid Arthritis. Arthritis Rheum. 2000; 43: 1951–1959
  • Van Der Veen G., Broersma L., Dijkstra C.D., Van Rooijen N., Van Rij G., Van Der Gaag R. Prevention of Corneal Allograft Rejection in Rats Treated with Subconjunctival Injections of Liposomes Containing Dichloromethylene Diphosphonate. Invest. Ophthalmol. 1994; 35: 3505–3515
  • Slegers T.P.A.M., Torres P.F., Broersma L., Van Rooijen N., Van Rij G., Van der Gaag R. Effect of Macrophage Depletion on Immune Effector Mechanisms During Corneal Allograft Rejection in Rats. Invest. Ophthalmol. Vis. Res. 2000; 41: 2239–2247
  • Hoch J.R., Stark V.K., Van Rooijen N., Kim J.l., Nutt M.P., Warner T.F. Macrophage Depletion Alters Vein Graft Intimal Hyperplasia. Surgery 1999; 126: 428–437
  • Wu G., Korsgren O., Zhang J., Song Z., Van Rooijen N., Tibell A. Pig Islet Xenograft Rejection is Markedly Delayed in Macrophage-Depleted Mice: A Study in Streptozotocin Diabetic Animals. Xenotransplantation 2000; 7: 214–220
  • Fox A., Koulmanda M., Mandel T.E., Van Rooijen N., Harrison L.C. Evidence that Macrophages are Required for T-cell Infiltration and Rejection of Fetal Pig Pancreas Xenografts in Nonobese Diabetic Mice. Transplantation 1998; 66: 1407–1416
  • Jun H.S., Yoon C.S., Zbytnuik L., Van Rooijen N., Yoon J.W. The Role of Macrophages in T Cell-Mediated Autoimmune Diabetes in Nonobese Diabetic Mice. J. Exp. Med. 1999; 189: 347–358
  • Schumann J., Wolf D., Pahl A., Brune K., Papadopoulos T., Van Rooijen N., Tiegs G. Importance of Kupffer Cells for T Cell-Dependent Liver Injury in Mice. Am. J. Pathol. 2000; 157: 1671–1683
  • Huitinga I., Van Rooijen N., De Groot C.J.A., Uitdehaag B.M.J., Dijkstra C.D. Suppression of Experimental Allergic Encephalomyelitis in Lewis Rats after Elimination of Macrophages. J. Exp. Med. 1990; 172: 1025–1033
  • Tran E.H., Hoekstra K., Van Rooijen N., Dijkstra C.D., Owens T. Immune Invasion of the Central Nervous System Parenchyma and Experimental Allergic Encephalomyelitis, but not Leukocyte Extravasation from Blood, are Prevented in Macrophage-Depleted Mice. J. Immunol. 1998; 161: 3767–3775
  • Polfliet M.M.J., Van de Veerdonk F., Dopp E.A., Van Kesteren-Hendrikx E.M.L., Van Rooijen N., Dijkstra C.D., Van den Berg T.K. Perivascular and Meningeal Macrophages Play a Role During the Onset of Experimental Allergic Encephalomyelitis. J. Neuroimmunol 2001; 122: 1–8
  • Liu T., Van Rooijen N., Tracey D.J. Depletion of Macrophages Reduces Axonal Degeneration and Hyperalgesia Following Nerve Injury. Pain 2000; 86: 25–32
  • Popovich P.G., Guan Z., Wei P., Huitinga I., Van Rooijen N., Stokes B.T. Depletion of Hematogenous Macrophages Promotes Partial Neurologic Recovery and Neuroanatomical Repair after Experimental Spinal Cord Injury. Exp. Neurol. 1999; 158: 351–365
  • Van Rooijen N. Macrophages as Accessory Cells in the “In Vivo” Humoral Immune Response: From Processing of Particulate Antigens to Regulation by Suppression. Semin. Immunol. 1992; 4: 237–245
  • Alves-Rosa F., Stanganelli C., Cabrera J., Van Rooijen N., Palermo M.S., Isturiz M.A. Treatment with Liposome-Encapsulated Clodronate as a New Strategic Approach in the Management of Immune. Thrombocytopenic Purpura in a Mouse Model. Blood 2000; 96: 2834–2840
  • Wolff G., Worgall S., Van Rooijen N., Song W.-R., Harvey B.-G., Crystal R.G. Enhancement of In Vivo Adenovirus-Mediated Gene Transfer and Expression by Prior Depletion of Tissue Macrophages in the Target Organ. J. Virol. 1997; 71: 624–629
  • Worgall S., Leopold P.L., Wolff G., Ferris B., Van Rooijen N., Crystal R.G. Role of Alveolar Macrophages in Rapid Elimination of Adenovirus Vectors Administered to the Epithelial Surface of the Respiratory Tract. Human Gene Therapy 1997; 8: 1675–1684
  • Stein C.S., Pemberton J.L., Van Rooijen N., Davidson B.L. Effects of Macrophage Depletion and Anti-CD40L Ligand on Transgene Expression and Redosing with Recombinant Adenovirus. Gene Therapy 1998; 5: 431–439
  • Schughart K., Bischoff R., Ali Hadji D., Boussif O., Perraud F., Accart N., Rasmussen U.B., Pavirani A., Van Rooijen N., Kolbe H.V.J. Effect of Liposome-Encapsulated Clodronate Pretreatment on Synthetic Vector-Mediated Gene Expression in Mice. Gene Therapy 1999; 6: 448–453
  • Gregoriadis G. Engineering Liposomes for Drug Delivery: Progress and Problems. Trends Biotechn. 1995; 13: 527–537
  • Litzinger D.C., Buiting A.M.J., Van Rooijen N., Huang L. Effect of Liposome Size on the Circulation Time and Intraorgan Distribution of Amphipathic Polyethylene-Glycol Containing Liposomes. Bioch. Bioph. Acta 1994; 1190: 99–107
  • Oussoren C., Velinova M., Scherphof G., Van der Want J.J., Van Rooijen N., Storm G. Lymphatic Uptake and Biodistribution of Liposomes After Subcutaneous Injection. IV. Fate of Liposomes in Regional Lymph Nodes. Bioch. Bioph. Acta 1998; 1370: 259–272
  • Hu Q., Van Rooijen N., Liu D. Effect of Macrophage Elimination Using Liposome-Encapsulated Dichloromethylene Diphosphonate on Tissue Distribution of Liposomes. J. Liposome Res. 1996; 6: 681–698
  • Laverman P., Brouwers A.H., Oyen W.J.G., Dams E.Th.M., Van Rooijen N., Corstens F.H.M., Storm G., Boerman O.C. Dose Effect of Stealth-Liposomes; Disappearance of Long-circulating Characteristics at Low Lipid Dose. J. Pharm. Exp. Ther. 2000; 293: 996–1001
  • Laverman P., Carstens M.G., Boerman O.C., Dams E.Th.M., Oyen W.J.G., Van Rooijen N., Corstens F.H.M., Storm G. Factors Affecting the Accelerated Blood Clearance of Polyethylene Glycol-Liposomes Upon Repeated Injection. J. Pharm. Exp.Ther. 2001; 298: 607–612
  • Fraser C.C., Chen B.P., Webb S., Van Rooijen N., Kraal G. Circulation of Human Hemopoietic Cells in Severe Combined Immunodeficient Mice Following Cl2MDP-Liposome Mediated Macrophage Depletion. Blood 1995; 86: 183–192
  • Terpstra W., Leenen P.J.M., Van den Bos C., Prins A., Loenen W.A.M., Verstegen M.M.A., Van Wijngaardt S., Van Rooijen N., Wognum A.W., Wagemaker G., Wielenga J.J., Löwenberg B. Facilitated Engraftment of Human Hematopoietic Cells in Severe Combined Immunodeficient Mice Following a Single Injection of Cl2MDP Liposomes. Leukemia 1997; 11: 1049–1054
  • Verstegen M.M.A., Van Hennik P.B., Terpstra W., Van Den Bos C., Wielenga J.J., Van Rooijen N., Ploemacher R.E., Wagemaker G., Wognum A.W. Transplantation of Human Umbilical Cord Blood Cells in Macrophage-Depleted SCID Mice: Evidence for Accessory Cell Involvement in Expansion of Immature CD34 + CD38- cells. Blood 1998; 91: 1966–1976
  • Badell E., Pasquetto V., Van Rooijen N., Druilhe P. A Mouse Model for Human Malaria Erythrocytic Stages. Parasitology Today 1995; 11: 235–237
  • Badell E., Oeuvray C., Moreno A., Soe S., Van Rooijen N., Bouzidi A., Druilhe P. Human Malaria in Immunocompromised Mice: An In Vivo Model to Study Defense Mechanisms Against P. Falciparum. J. Exp. Med. 2000; 192: 1653–1659
  • Moreno A., Badell E., Van Rooijen N., Druilhe P. Human Malaria in Immunocompromised Mice: New In Vivo Model for Chemotherapy Studies. Antimicrob. Agents. Chemother. 2001; 45: 1847–1853
  • Van Rooijen N., Sanders A. Kupffer Cell Depletion by Liposome-Delivered Drugs: Comparative Activity of Intracellular Clodronate, Propamidine and Ethylenediaminetetraacetic Acid (EDTA). Hepatology 1996; 23: 1239–1243
  • Alves-Rosa F., Stanganolli C., Cabrera J., Cymberknop D., Rubel C., Vanzulli S., Van Rooijen N., Palermo M., Isturiz M.A. Rapid Recovery of Platelet Count Following Administration of Liposome-Encapsulated Clodronate in a Mouse Model of Immune Thrombocytopenia. Brit. J Haematol. 2002; 116: 357–366
  • List A. Malignant Hypercalcemia: The Choice of Therapy. Arch Intern. Med. 1991; 151: 471–476
  • Heidenreich A., Hofmann R., Engelmann U.H. The Use of Bisphosphonate for the Palliative Treatment of Painful Bone Metastasis Due to Hormone Refractory Prostate Cancer. J. Urol. 2001; 165: 136–140

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