Advanced search
Publication Cover
Journal of Liposome Research Volume 12, 2002 - Issue 1-2
Submit an article Journal homepage
602
Views
166
CrossRef citations to date
0
Altmetric
Research Article

ROLE OF COMPLEMENT ACTIVATION IN HYPERSENSITIVITY REACTIONS TO DOXIL AND HYNIC PEG LIPOSOMES: EXPERIMENTAL AND CLINICAL STUDIES

J. Szebeni Walter Reed Army Institute of Research, Silver Spring, MD, U.S.A.
,
L. Baranyi Walter Reed Army Institute of Research, Silver Spring, MD, U.S.A.
,
S. Savay Walter Reed Army Institute of Research, Silver Spring, MD, U.S.A.
,
J. Milosevits Walter Reed Army Institute of Research, Silver Spring, MD, U.S.A.
,
R. Bunger Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, U.S.A.
,
P. Laverman Department of Nuclear Medicine, University Medical Center, Nijmegen, The Netherlands
,
J. M. Metselaar Utrecht Institute for Pharmaceutical Science, Utrecht University, Utrecht, The Netherlands
,
G. Storm Utrecht Institute for Pharmaceutical Science, Utrecht University, Utrecht, The Netherlands
,
A. Chanan-Khan Kaplan Comprehensive Cancer Center, New York University Medical Center, New YorkUSA
,
L. Liebes Kaplan Comprehensive Cancer Center, New York University Medical Center, New YorkUSA
,
F. M. Muggia Kaplan Comprehensive Cancer Center, New York University Medical Center, New YorkUSA
,
R. Cohen Laboratory of Membrane and Liposome Research, Hebrew University-Hadassah Medical School, Jerusalem, Israel
,
Y. Barenholz Laboratory of Membrane and Liposome Research, Hebrew University-Hadassah Medical School, Jerusalem, Israel
&
C. R. Alving Walter Reed Army Institute of Research, Silver Spring, MD, U.S.A.
 show all
Pages 165-172 | Published online: 15 Jul 2002

REFERENCES

  • Gabizon A.A., Muggia F.M. Initial Clinical Evaluation of Pegylated-Liposomal Doxorubicin in Solid Tumors. Long Circulating Liposomes: Old Drugs, New Therapeutics, M.C. Woodle, G. Storm. Springer-Verlag and Landes Bioscience. 1998; 155–174
  • Gabizon A.A. Pegylated Liposomal Doxorubicin: Metamorphosis of an Old Drug into a New Form of Chemotherapy. Cancer Invest. 2001; 19: 424–436
  • Muggia F.M. Liposomal Encapsulated Anthracyclines: New Therapeutic Horizons. Curr. Oncol. Rep. 2001; 3: 156–162
  • Lyass O., Hubert A., Gabizon A.A. Phase I Study of Doxil-Cisplatin Combination Chemotherapy in Patients with Advanced Malignancies. Clin. Cancer Res. 2001; 7: 3040–3046
  • Gabizon A., Isacson R., Libson E., Kaufman B., Uziely B., Catane R., Ben-Dor C.G., Rabello E., Cass Y., Peretz T.al, e. Clinical Studies of Liposome-Encapsulated Doxorubicin. Acta Oncol. 1994; 33: 779–786
  • de Marie S. Liposomal and Lipid-Based Formulations of Amphotericin B. Leukemia 10, Suppl. 1996; 2: S93–S96
  • Dezube B.J. Safety Assessment: DoxilR (Doxorubicin HCl Liposome Injection) in Refractory AIDS-Related Kaposi's Sarcoma. Doxil Clinical Series. Gardiner-Caldwell SynerMed, Califon, NJ 1996; Volume 1: 1–8
  • Alberts D.S., Garcia D.J. Safety Aspects of Pegylated Liposomal Doxorubicin in Patients with Cancer. Drugs 54, Suppl. 1997; 4: 30–45
  • Uziely B., Jeffers S., Isacson R., Kutsch K., Wei-Tsao D., Yehoshua Z., Libson E., Muggia F.M., Gabizon A. Liposomal Doxorubicin: Antitumor Activity and Unique Toxicities During two Complementary Phase I Studies. J. Clin. Oncol. 1995; 13: 1777–1785
  • Gabizon A., Catane R., Uziely B., Kaufman B., Safra T., Cohen R., Martin F., Huang A., Barenholz Y. Prolonged Circulation Time and Enhanced Accumulation in Malignant Exudates of Doxorubicin Encapsulated in Polyethylene-Glycol Coated Liposomes. Cancer Res. 1994; 54: 987–992
  • Koukourakis M.I., Koukouraki S., Giatromanolaki A., Archimandritis S.C., Skarlatos J., Beroukas K., Bizakis J.G., Retalis G., Karkavitsas N., Helidonis E. Liposomal Doxorubicin and Conventionally Fractionated Radiotherapy in the Treatment of Locally Advanced Non-Small-Cell Lung Cancer and Head and Neck Cancer. J. Clin. Oncol. 1999; 17: 3512–3521
  • ALZA Pharmaceuticals Doxil Package Insert. Mountain View, CAUSA 2000
  • Brouwers A.H., De Jong D.J., Dams E.T., Oyen W.J., Boerman O.C., Laverman P., Naber T.H., Storm G., Corstens F.H. Tc-99m-PEG-Liposomes for the Evaluation of Colitis in Crohn's Disease. J. Drug Target 2000; 8: 225–233
  • Szebeni J., Baranyi B., Savay S., Lutz L.U., Jelezarova E., Bunger R., Alving C.R. The Role of Complement Activation in Hypersensitivity to Pegylated Liposomal Doxorubicin (Doxil®). J. Liposome Res. 2000; 10: 347–361
  • Muller-Eberhard H.J. The Membrane Attack Complex. Spring. Sem. Immunopathol. 1984; 7: 93
  • Szebeni J., Fontana J.L., Wassef N.M., Mongan P.D., Morse D.S., Dobbins D.E., Stahl G.L., Bünger R., Alving C.R. Hemodynamic Changes Induced by Liposomes and Liposome-Encapsulated Hemoglobin in Pigs: A Model for Pseudo-Allergic Cardiopulmonary Reactions to Liposomes. Role of Complement and Inhibition by Soluble CR1 and Anti-C5a Antibody. Circulation 1999; 99: 2302–2309
  • Szebeni J., Baranyi B., Savay S., Bodo M., Morse D.S., Basta M., Stahl G.L., Bunger R., Alving C.R. Liposome-Induced Pulmonary Hypertension: Properties and Mechanism of a Complement-Mediated Pseudoallergic Reaction. Am. J. Physiol. 2000; 279: H1319–H1328
  • Szebeni J. Complement Activation-Related Pseudoallergy Caused by Liposomes, Micellar Carriers of Intravenous Drugs and Radiocontrast Agents. Crit. Rev. Ther. Drug Carr. Syst. 2001; 18: 567–606

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.