Advanced search
Publication Cover
Pharmaceutical Development and Technology Volume 5, 2000 - Issue 4
Submit an article Journal homepage
205
Views
15
CrossRef citations to date
0
Altmetric
Research Article

The Influence of Varying Precompaction and Main Compaction Profile Parameters on the Mechanical Strength of Compacts

Colleen E. Ruegger Novartis Pharmaceutical Corporation, East Hanover, New Jersey, U.S.A.
&
Metin Çelik Pharmaceutical Technologies International, Inc., Belle Mead, New Jersey, U.S.A.; PTI, Inc., P.O. Box 186, Belle Mead, NJ, 08502, U.S.A.
Pages 495-505 | Received 16 Jun 1999, Accepted 08 Feb 2000, Published online: 21 Nov 2000

REFERENCES

  • Vezin W. R., Khan K. A., Pang H. M. Adjustment of precompression force to reduce mixing-time dependence of tablet tensile strength. J. Pharm. Pharmacol. 1983; 35: 555–558
  • Rees J. E., Malamataris S. Can creep analysis be used to predict optimal conditions for tablet precompression. Pharm. Technol. 1993; 17: 60–66
  • Bateman S. D., Rubinstein M. H., Thacker H. S. Properties of paracetamol tablets produced using high precompression pressures. J. Pharm. Pharmacol. 1989; 41(suppl.)32P
  • Bateman S. D., Rubinstein M. H., Thacker H. S. Pre- and main compression in tableting. Pharm. Technol. Int. 1990; 2(6)30–36
  • Vezin W. R., Pang H. M., Khan K. A., Malkowska S. The effect of precompression in a rotary machine on tablet strength. Drug Dev. Ind. Pharm. 1983; 9(8)1465–1474
  • Armstrong N. A., Abourida N. M. A. H., Gough A. M. A proposed consolidation parameter for powders. J. Pharm. Pharmacol. 1982; 35: 320–321
  • Çelik M., Lordi N. The Pharmaceutical Compaction Research Laboratory and Information Center. Pharm. Technol. 1991; 15(3)112–116
  • Fell J. T., Newton J. M. The tensile strength of lactose tablets. J. Pharm. Pharmacol. 1968; 20: 657–659
  • Akande A. F., Rubinstein M. H., Ford J. L. Examination of the compaction properties of a 1:1 acetaminophen:microcrystalline cellulose mixture using precompression and main compression. J. Pharm. Sci. 1997; 86(8)900–907
  • Doelker E., Shotton E. The effect of some binding agents on the mechanical properties of granules and their compression characteristics. J. Pharm. Pharmacol. 1977; 29: 193–198
  • Humbert-Droz P., Gurny R., Mordier D., Doelker E. Densification behaviour of drugs presenting availability problems. Int. J. Pharm. Technol. Prod. Manuf. 1983; 4: 29–35
  • Roberts R. J., Rowe R. C. The effect of punch velocity on the compaction of a variety of materials. J. Pharm. Pharmacol. 1985; 37: 377–384
  • Çelik M., Okutgen E. Feasibility study for the development of a prospective compaction functionality test and establishment of a compaction data bank. Drug Dev. Ind. Pharm. 1993; 19(17 and 18)2304–2334

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.