REFERENCES
- Lang J. C. Ocular drug delivery: Conventional ocular formulations. Adv. Drug Deliv. Rev. 1995; 16: 39–43
- Prausnitz M. R., Noonan J. S. Permeability of cornea, sclera and conjunctiva: A literature analysis for drug delivery to the eye. J. Pharm. Sci. 1998; 87: 1479–1488
- Willets G. S. Ocular side effects of drugs. Br. J. Ophthalmol. 1969; 53: 252–262
- Fraunfelder F. T., Meyer S. M. Systemic side effects from ophthalmic timolol and their prevention. J. Ocul. Pharmacol. 1987; 3: 177–184
- Kaila T., Salminen L., Huuppoven R. Systemic absorption of topically applied ocular timolol. J. Ocul. Pharmacol. 1985; 1: 79–83
- Passo M., Palmer E., Van Buskirk E. Plasma timolol in glaucoma patients. Ophthalmology 1984; 91: 1361–1363
- Nadal J., De La Fuente V., Abadias M., Torrent J., Jané F. Toxic coma induced by anticholinergic eyedrops [letter]. Br. Med. J. 1987; 295: 1352
- Kumar V., Schoenwald R. D., Chien D. S., Packer A. J., Choi W. W. Systemic absorption and cardiovascular effects of phenylephrine eyedrops. Am. J. Ophthalmol. 1985; 99: 180–184
- Xiao J., Wang Y., Wu W., Li J., Zhang S. Inhibitory effect of tetrandrine on lens proteins-induced ocular inflammation in rabbits. J. Ocul. Pharmacol. 1992; 8(4)309–315
- Ellis P., Pfoff D. S., Bloedow D. C., Riegel M. Intraocular diclofenac and flurbiprofen concentrations in human aqueous humor following topical application. J. Ocul. Pharmacol. 1994; 10(4)677–682
- Calvo P., Alonso M. J., Vila-Jato J. L., Robinson J. R. Improved ocular bioavailability of indomethacin by novel ocular drug carriers. J. Pharm. Pharmacol. 1996; 46(11)1147–1152
- Mochizuki M., Sawa M., Masuda K. Topical indomethacin in intracapsular extraction of senile cataract. Jpn. J. Ophthalmol. 1977; 21: 215–226
- Sanders D. R., Kraff M. C., Liberman H. L. Breakdown and reestablishment of the blood-aqueous barrier following implant surgery. Arch. Ophthalmol. 1982; 100: 558–590
- Palimeri G., Koliopoulos J., Vellisaropoulos P. Ocular side effects of indomethacin. Ophthalmologica 1972; 164: 339–353
- Muchtar S., Abdulrazik M., Frucht-Pery J., Benita S. Ex-vivo permeation study of indomethacin from a submicron emulsion through albino rabbit cornea. J. Controlled Release 1997; 44: 55–64
- Elbaz E., Zeevi A., Klang S., Benita S. Positively-charged submicron emulsions—a new type of colloidal drug carrier. Int. J. Pharm. 1993; 96: R1–R6
- Klang S. H., Frucht-Pery J., Hoffman A., Benita S. Physicochemical characterization and acute toxicity evaluation of a positively-charged submicron emulsion vehicle. J. Pharm. Pharmacol. 1994; 46: 986–993
- Ezra R., Benita S., Ginsburg I., Kohen R. Prevention of oxidative damage in fibroblast cell cultures and rat skin by positively-charged submicron emulsion of α-tocopherol. Eur. J. Pharm. Biopharm. 1996; 42: 291–298
- Gregoriadis G., Neerunjun D. E. Control of the rate of hepatic uptake and metabolism of liposome-entrapped proteins injected into rats. Biochem. J. 1974; 129: 123–133
- Steger D. L., Desnick J. R. Enzyme therapy VI: comparative in vivo fates and effects on lysosomal integrity of enzymes entrapped in negatively- and positively-charged liposomes. Biochem. Biophys. Acta 1977; 464: 530–546
- Meisner D., Pringle J., Mezei M. Liposomal ophthalmic drug delivery. III. Pharmacodynamic and biodisposition studies of atropine. Int. J. Pharm. 1989; 55: 105–113
- Rojanasakul Y., Robinson J. R. Transport mechanisms of the cornea: Characterization of barrier permselectivity. Int. J. Pharm. 1989; 55: 237–246
- Klang S. H., Siganos C. S., Benita S., Frucht-Pery J. Evaluation of a positively-charged submicron emulsion of piroxicam on the rabbit corneum healing process following alkali burn. J. Controlled Release 1999; 57: 19–27
- Benita S., Levy M. Y. Submicron emulsions as colloidal drug carriers for intravenous administration: Comprehensive physicochemical characterization. J. Pharm. Sci. 1993; 82(11)1069–1079
- Tiffany J. M. Measurement of wettability of the corneal epithelium. I. Particle attachment method. Acta Ophthalmol. 1190; 68(78)175–181
- Tiffany J. M. Measurement of wettability of the corneal epithelium. II. Contact angle method. Acta Ophthalmol. 1190; 68(78)182–187
- Masson V., Billardon P., Fessi H., Devissaguet J. P., Puisieux F. Tolerance studies and pharmacokinetic evaluation of Indomethacin-loaded nanocapsules in rabbit eyes. Proc. 9th Int. Symp. Controlled Release Bio- act. Mater, OrlandoFL, July, 26–311992, 423–424
- Lee V. H. L. A. K. MitraPrecorneal, Corneal and Post Corneal Factors in Ophthalmic Drug Delivery Systems, . Marcel Dekker, Inc., New York 1993; 59–81
- Chang S. C., Lee V. H. L. Nasal and conjuctival contributions to the systemic absorption of topical timolol in the pigmented rabbit: Implications in the design of strategies to maximize the ratio of ocular to systemic absorption. J. Ocul. Pharmacol. 1987; 3: 159–169
- Tang-Liu D. D., Liu S. S., Weinkam R. J. Ocular and systemic bioavailability of ophthalmic flurbiprofen. J. Pharmacokinet. Biopharm. 1984; 12: 611–626
- G. K. Mc EvoyDrug Information, . American Hospital Formulatory Service, American Society of Health-System Pharmacists, Inc. Press, BethesdaMD 1996; 1406–1416
- * Affiliated with The David R. Bloom Center for Pharmacy at the Hebrew University of Jerusalem.