Degradation of a Fluoropyridinyl Drug in capsule Formulation: Degradant Identification, Proposed Degradation Mechanism, and Formulation Optimization

Jian-Ge Chen DuPont Pharmaceuticals Company, Experimental Station, Wilmington, Delaware, 19880, U.S.A.

Jian-Ge (James) Chen Schering-Plough Research Institute, 2000 Galloping Hill Rd., K11-3/L5, Kenilworth, NJ, 07033, U.S.A.

, Ph. D., M.B.A.,

Debbie A. Markovitz DuPont Pharmaceuticals Company, Experimental Station, Wilmington, Delaware, 19880, U.S.A.

Amy Y. Yang DuPont Pharmaceuticals Company, Experimental Station, Wilmington, Delaware, 19880, U.S.A.

Shelley R. Rabel DuPont Pharmaceuticals Company, Experimental Station, Wilmington, Delaware, 19880, U.S.A.

Josephine Pang DuPont Pharmaceuticals Company, Experimental Station, Wilmington, Delaware, 19880, U.S.A.

Olga Dolinsky DuPont Pharmaceuticals Company, Experimental Station, Wilmington, Delaware, 19880, U.S.A.

Lei-Shu Wu DuPont Pharmaceuticals Company, Experimental Station, Wilmington, Delaware, 19880, U.S.A.

Mark Alasandro DuPont Pharmaceuticals Company, Experimental Station, Wilmington, Delaware, 19880, U.S.A.

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Degradation of a Fluoropyridinyl Drug in capsule Formulation: Degradant Identification, Proposed Degradation Mechanism, and Formulation Optimization

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Degradation of a Fluoropyridinyl Drug in capsule Formulation: Degradant Identification, Proposed Degradation Mechanism, and Formulation Optimization

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