References
- Uckun , F. M. , Pendergrass , S. , Maher , D. , Zhu , D. , Tuel‐Ahlgren , L. , Mao , C. and Venkatachalam , T. K. 1999 . N′‐[2‐(2‐Thiophene)ethyl]‐N′‐[2‐(5‐bromopyridyl)] thiourea as a potent inhibitor of NNI‐resistant and multidrug‐reistant human immunodeficiency virus‐1 . Bioorg. Med. Chem. Lett. , 9 : 3411
- U.S. Patent No. 6,124,324 . issued to Uckun et al., 2000
- Kooyman , E. C. 1963 . Halo‐substituted or 2,5‐disubstituted thiophene compounds . Pure Appl. Chem. , 7 : 193
- March , J. 1992 . Advanced Organic Chemistry Edited by: March , J. 515 New York : John Wiley & Sons .
- Marino , G. 1971 . Electrophilic substitution on five membered aromatic heterocycles . Adv. Heterocyclic Chem. , 13 : 235
- Bell , F. W. , Cantrell , A. S. , Hogberg , M. , Jaskunas , S. R. , Johansson , N. G. , Jordan , C. L. , Kinnick , M. D. , Lind , P. , Morin , J. M. Jr. , Noreen , R. , Oberg , B. , Palkowitz , J. A. , Parrish , C. A. , Pranc , P. , Sahlberg , C. , Ternansky , R. T. , Vasileff , R. T. , Vrang , L. , West , S. J. , Zhang , H. and Zhou , X. X. 1995 . Phenethylthiazolylthiourea (PETT) compounds, a new class of HIV‐1 reverse transcriptase inhibitors. 1. Synthesis and basic structure–activity relationship studies of PETT analogs . J. Med. Chem. , 38 : 4929
- Cantrell , A. S. , Engelhardt , P. , Hogberg , M. , Jaskunas , S. R. , Johansson , N. G. , Jordan , C. L. , Kangasmetsa , J. , Kinnick , M. D. , Lind , P. , Morin , J. M. Jr. , Muesing , M. A. , Noreen , R. , Oberg , B. , Pranc , P. , Sahlberg , C. , Ternansky , R. J. , Vasileff , R. T. , Vrang , L. , West , S. J. and Zhang , H. 1996 . Phenethylthiazolylthiourea (PETT) compounds, a new class of HIV‐1 reverse transcriptase inhibitors. 1. Synthesis and further structure–activity relationship studies of PETT analogs . J. Med. Chem. , 39 : 4261
- Vig , R. , Mao , C. , Venkatachalam , T. K. , Tuel‐Ahlgren , L. , Sudbeck , E. A. and Uckun , F. M. 1998 . Rational design and synthesis of phenethyl‐5‐bromopyridyl thiourea derivatives as potent non‐nucleoside inhibitors of HIV reserve transcriptase . Bioorg. Med. Chem. , 6 : 1789
- Mao , C. , Sudbeck , E. A. , Venkatachalam , T. K. and Uckun , F. M. 1999 . Rational design of N‐[2‐(2′,5‐dimethoxyphenylethyl)]‐N′‐[2‐(5‐bromopyridyl)]‐thiourea (HI‐236) as a potent non‐nucleoside inhibitor of drug‐resistant human immunodeficiency virus . Bioorg. Med. Chem. Lett. , 9 : 1593
- Mao , C. , Sudbeck , E. A. , Venkatachalam , T. K. and Uckun , F. M. 1999 . Structure‐based design of non‐nucleoside reverse transcriptase inhibitors of drug‐resistant human immunodeficiency virus . Antivir. Chem. Chemther. , 10 : 233