PHARMACOLOGY OF TETRODOTOXIN

REFERENCES

• Cheng C. A., Hwang D. F., Tsai Y. H., Chen H. C., Jeng S. S., Noguchi T., Ohwada K., Hasimoto K. Microflora and tetrodotoxin-producing bacteria in a gastropod, Niotha clathrata. Food Chem. Toxicol 1995; 33: 929–934
   PubMed Web of Science ®Google Scholar
• Lee M. J., Jeong D. Y., Kim W. S., Kim H. D., Kim C. H., Park W. W., Park Y. H., Kim K. S., Kim H. M., Kim D. S. A tetrodotoxin-producing Vibrio strain, LM-1, from the puffer fish Fugu vermicularis radiatus. Appl. Env. Microbiol. 2000; 66: 1698–1701
   PubMed Web of Science ®Google Scholar
• Ritchie K. B., Nagelkerken I., James S., Smith G. W. Environmental microbiology: A tetrodotoxin-producing marine pathogen. Nature 2000; 404: 354
   PubMed Web of Science ®Google Scholar
• Simidu U., Kita-Tsukamoto K., Yasumoto T., Yostu M. Taxonomy of four marine bacterial strains that produce tetrodotoxin. Internal. J. System. Bacteriol. 1990; 40: 331–336
   PubMedGoogle Scholar
• Yasumoto T., Nagai H., Yasumura D., Michishita T., Endo A., Yotsu M., Kotaki Y. Interspecies distribution and possible origin of tetrodotoxin. Ann. New York Acad. Sci. 1986; 479: 44–51
   PubMed Web of Science ®Google Scholar
• Yotsu M., Yamazaki T., Meguro Y., Endo A., Murata M., Naoki H., Yasumoto T. Production of tetrodotoxin and its derivatives by Pseudomonas sp. isolated from the skin of a pufferfish. Toxicon 1987; 25: 226–228
   Web of Science ®Google Scholar
• Matsumura K. Reexamination of tetrodotoxin production by bacteria. Appl. Env. Microbiol. 1995c; 61: 3468–3470
   PubMed Web of Science ®Google Scholar
• Daly J. W., Padgett W. L., Saunders R. L., Cover J. F., Jr. Absence of tetrodotoxins in a captive-raised riparian frog, Atelopus varius. Toxicon 1997; 35: 705–709
   PubMed Web of Science ®Google Scholar
• Kao C. Y. Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena. Pharmacol. Rev. 1966; 18: 997–1049
   PubMed Web of Science ®Google Scholar
• Schantz E. J., Lynch J. M., Vayvada G., Matsumoto K., Rapoport H. The purification and characterization of the poison produced by Gonyaulax catenella in axenic culture. Biochemistry 1966; 5: 1191–1195
   PubMed Web of Science ®Google Scholar
• Arakawa O., Noguchi T., Shida Y., Onoue Y. Occurrence of car-bamoyl-N-hydroxy derivatives of xanitoxin and neosaxitoxin in a xanthid crab Zosimus aeneus. Toxicon 1994; 32: 175–183
   PubMed Web of Science ®Google Scholar
• Daigo K., Uzu A., Arakawa O., Noguchi T., Seto H., Hashimoto K. Isolation and some properties of neosaxitoxin from a xanthid crab Zosimus aeneus. Nippon Suis. Gakk 1985; 51: 309–313
   Google Scholar
• Harada T., Oshima Y, Yasumoto T. Natural occurrence of decarbamoylsaxitoxin in tropical dinoflagellate and bivalves. Agric. Biol. Chem. 1983; 47: 191–193
   Web of Science ®Google Scholar
• Koyama K., Noguchi T., Ueda Y., Hashimoto K. Occurrence of neosaxitoxin and other paralytic shellfish poisons in toxic crabs belonging to the family Xanthidae. Nippon Suis. Gakk 1981; 47: 965
   Google Scholar
• Noguchi T., Konosu S., Hashimoto Y. Identity of the crab toxin with saxitoxin. Toxicon 1969; 7: 325–326
   PubMed Web of Science ®Google Scholar
• Noguchi T., Uzu A., Koyama K., Maruyama J., Nagashima Y., Hashimoto K. Occurrence of tetrodotoxin as the major toxin in a xanthid crab Atergatis floridus. Nippon Suis. Gak 1983; 49: 1887–1892
   Google Scholar
• Yasusmoto T., Oshima Y., Hosaka M., Miyakoshi M. Analysis of paralytic shellfish toxins of xanthid crabs in Okinawa. Nippon Suis. Gakk 1981; 47: 957–959
   Google Scholar
• Yasumura D., Oshima Y., Yasumoto T., Alcala A. C., Alcala L. C. Tetrodotoxin and paralytic shellfish toxins in Philippine crabs. Agric. Biol. Chem. 1986; 50: 593–598
   Web of Science ®Google Scholar
• Narahashi T. Chemicals as tools in the study of excitable membranes. Physiol. Rev. 1974; 54: 813–889
   PubMed Web of Science ®Google Scholar
• Narahashi T., Deguchi T., Urakawa N., Ohkubo Y. Stabilization and rectification of muscle fiber membrane by tetrodotoxin. Amer. J. Physiol. 1960; 198: 934–938
   PubMedGoogle Scholar
• Narahashi T., Moore J. W., Scott W. R. Tetrodotoxin blockage of sodium conductance increase in lobster giant axons. J. Gen. Physiol. 1964; 47: 965–974
   PubMed Web of Science ®Google Scholar
• Agnew W. S. Voltage-regulated sodium channel molecules. Annu. Rev. Physiol. 1984; 46: 517–530
   PubMed Web of Science ®Google Scholar
• Catterall W. A. Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Annu. Rev. Pharmacol. Toxicol 1980; 20: 15–43
   PubMed Web of Science ®Google Scholar
• Catterall W. A. Cellular and molecular biology of voltage-gated sodium channels. Physiol. Rev. 1992; 72: S15–S48
   PubMed Web of Science ®Google Scholar
• Catterall W. A. From ionic currents to molecular mechanisms: The struc-ture and function of voltage-gated sodium channels. Neuron 2000; 26: 13–25
   PubMed Web of Science ®Google Scholar
• Narahashi T. Mechanism of tetrodotoxin and saxitoxin action. Hand-book of Natural Toxins, A. T. Tu. Marine Toxins and Venoms, Marcell Dekker, Inc., New York 1988; 3: 185–210
   Google Scholar
• Narahashi T. Chemical modulation of sodium channels. Ion Channel Pharmacology, V. Ceña, B. Soria. Oxford University Press, Oxford 1998; 23–73
   Google Scholar
• Narahashi T., Roy M. L., Ginsburg K. S. Recent advances in the study of mechanism of action of marine neurotoxins. Neuro Toxicology 1994; 15(3)545–554
   Google Scholar
• Pappone P. A, Cahalan M. D. Ion permeation in cell membranes. In Physiology of Membrane Disorders, T. E. Adreoli, J. F. Hoffman, D. D. Fanestil, S. G. Schultz. Plenum Press, New York 1986; 249–272
   Google Scholar
• Ritchie J. M., Rogart R. B. The binding of sanitoxin and tetrodotoxin to excitable tissue. Rev. Physiol Biochem. Pharmacol. 1997; 79: 1–49
   Google Scholar
• Isom L. L., De Jongh K. S., Patton E. E., Reber B. F.X., Offord J., Charbonneau H., Walsh K., Goldin A. L., Catterall W. A. Primary struc-ture and functional expression of the β1 subunit of the rat brain sodium channel. Science 1992; 256: 839–842
   PubMed Web of Science ®Google Scholar
• Isom L. L., Ragsdale D. S., De Jongh K. S., Westenbroek R. E., Reber B. F.X., Scheuer T., Catterall W. A. Structure and function of the β2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM-motif. Cell 1995; 83: 433–442
   PubMed Web of Science ®Google Scholar
• Schreibmayer W., Wallner M, Lotan I. Mechanism of modulation of single sodium channels from skeletal muscle by the β1-subunit from rat brain. Pflügers Arch 1994; 426: 360–362
   PubMed Web of Science ®Google Scholar
• Guy H. R., Seetharamulu P. Molecular model of the action potential sodium channel. Proc. Natl. Acad. Sci. USA 1986; 508: 508–512
   Google Scholar
• Cohen C. J., Bean B. P., Colatsky T. J, Tsien R. W. Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. J. Gen. Physiol. 1981; 78: 383–411
   PubMed Web of Science ®Google Scholar
• Matsuki N., Hermsmeyer K. Tetrodotoxin-sensitive Na+ channels in isolated single cultured rat myocardial cells. Am. J. Physiol. 1983; 245: C381–C387
   Google Scholar
• Baer M., Best P. M., Reuter H. Voltage-dependent action of tetrodotoxin in mammalian cardiac muscle. Nature 1976; 263: 344–345
   PubMed Web of Science ®Google Scholar
• Campbell D. T. Differential expression of Na channel subtypes in two populations of sensory neurons. Biophys. J. 1988; 53: 15a
   Web of Science ®Google Scholar
• Guo X., Strichartz G. Differential gating of TTX-sensitive and -resistant Na currents in bullfrog sensory neurons. Biophys. J. 1990; 57: 107a
   Web of Science ®Google Scholar
• Jones S. W. Two sodium currents in dissociated bullfrog sympathetic neurons. Soc. Neurosci. Abstr. 1986; 12: 1512
   Google Scholar
• Bossu J. L., Feltz A. Patch-clamp study of the tetrodotoxin-resistant sodium current in group C sensory neurones. Neurosci. Lett 1984; 51: 241–246
   PubMed Web of Science ®Google Scholar
• Ikeda S. R., Schofield G. G. Tetrodotoxin-resistant sodium current of rat nodose neurones: monovalent cation selectivity and divalent cation block. J. Physiol. 1987; 389: 255–270
   PubMed Web of Science ®Google Scholar
• Ikeda S. R., Schofield G. G., Weight F. F. Na + and Ca2+currents of acutely isolated adult rat nodose ganglion cells. J. Neurophysiol. 1986; 55: 527–539
   PubMed Web of Science ®Google Scholar
• Kostyuk P. G., Veselovsky N. S., Tsyndrenko A. Y. Ionic currents in the somatic membrane of rat dorsal root ganglion neurons-I. Sodium currents. Neuroscience 1981; 6: 2423–2430
   PubMed Web of Science ®Google Scholar
• Matsuda Y., Yoshida S., Yonezawa T. Tetrodotoxin sensitivity and Ca component of action potentials of mouse dorsal root ganglion cells cultured in vitro. Brain Res 1978; 154: 69–82
   PubMed Web of Science ®Google Scholar
• McLean M. J., Bennett P. B., Thomas R. M. Subtypes of dorsal root ganglion neurons based on different inward currents as measured by whole-cell voltage clamp. Mol. Cell. Biochem. 1988; 80: 97–107
   Web of Science ®Google Scholar
• Schwartz A., Palti Y., Meiri H. Structural and developmental differences between three types of Na channels in dorsal root ganglion cells of newborn rats. J. Membrane Biol. 1990; 116: 117–128
   PubMed Web of Science ®Google Scholar
• Yoshida S, Matsuda Y., Samejima A. Tetrodotoxin-resistant sodium and calcium components of action potentials in dorsal root ganglion cells of the adult mouse. J. Neurophysiol. 1978; 41: 1096–1106
   PubMed Web of Science ®Google Scholar
• Grosskreutz J., Quasthoff S., Kuhn M., Grafe P. Capsaicin blocks tetrodotoxin-resistant sodium potentials and calcium potentials in unmy-elinated C fibres of biopsied human sural nerve in vitro. Neurosci. Letts 1996; 208: 49–52
   PubMed Web of Science ®Google Scholar
• Ogata N., Tatebayashi H. Slow inactivation of tetrodotoxin-insensitive Na + channels in neurons of rat dorsal root ganglia. J. Membrane Biol. 1992; 129: 71–80
   PubMed Web of Science ®Google Scholar
• Roy M. L., Narahashi T. Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons. J. Neuroscience 1992; 12: 2104–2111
   PubMed Web of Science ®Google Scholar
• Ginsburg K. S., Narahashi T. Differential sensitivity of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels to the insecticide allethrin in rat dorsal root ganglion neurons. Brain Res 1993; 627: 239–248
   PubMed Web of Science ®Google Scholar
• Tatebayashi H., Narahashi T. Differential mechanism of actin of the pyrethroid tetramethrin on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. J. Pharmacol. Exp. Ther. 1994; 270: 595–603
   PubMed Web of Science ®Google Scholar
• Chinn K., Narahashi T. Stabilization of sodium channel states by deltamethrin in mouse neuroblastoma cells. J. Physiol. 1986; 380: 191–207
   PubMed Web of Science ®Google Scholar
• Yamamoto D., Quandt F. N., Narahashi T. Modification of single sodium channels by the insecticide tetramethrin. Brain Res 1983; 274: 344–349
   PubMed Web of Science ®Google Scholar
• Catterall W. A. Structure and function of voltage-gated ion channels. Annu. Rev. Biochem. 1995; 64: 493–531
   PubMed Web of Science ®Google Scholar
• Goldin A. L. Diversity of mammalian voltage-gated sodium channels. Ann. N.Y. Acad. Sci. 1999; 868: 38–50
   PubMed Web of Science ®Google Scholar
• Marban E., Yamagishi T., Tomaselli F. Structure and function of voltage-activated sodium channels. J. Physiol. 1998; 508: 647–657
   PubMed Web of Science ®Google Scholar
• Plummer N. W., Meisler M. H. Evolution and diversity of mammalian sodium channel genes. Genomics 1999; 57: 323–331
   PubMed Web of Science ®Google Scholar
• Shiomi K., Yamaguchi S., Kikuchi T., Yamamori K., Matsui T. Occurrence of tetrodotoxin-binding high molecular weight substances in the body fluid of shore crab (Hemigrapsus sanguineus). Toxicon 1992; 30: 1529–1537
   PubMed Web of Science ®Google Scholar
• Ho B., Yeo D. S., Ding J. L. A tetrodotoxin neutralizing system in the haemolymph of the horseshoe crab, Carcinoscorpius rotundicauda. Toxicon 1994; 32: 755–762
   PubMed Web of Science ®Google Scholar
• Hille B. The receptor for tetrodotoxin and saxitoxin. A structural hypothesis. Biophys. J 1975; 15: 615–619
   PubMed Web of Science ®Google Scholar
• Backx P. H., Yue D. T., Lawrence J. H., Marban E., Tomaselli G. F. Molecular localization of an ion-binding site within the pore of mammalian sodium channels. Science 1992; 257: 248–251
   PubMed Web of Science ®Google Scholar
• Heinemann S. H., Terlau H., Imoto K. Molecular basis for pharmaco-logical differences between brain and cardiac sodium channels. Pflügers Arch 1992; 422: 90–92
   PubMed Web of Science ®Google Scholar
• Penzotti J. L., Fozzard H. A., Lipkind G. M., Dudley S. C., Jr. Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na + channel outer vestibule. Biophys. J. 1998; 75: 2647–2657
   PubMed Web of Science ®Google Scholar
• Satin J., Kyle J. W., Chen M., Bell P., Cribbs L. L., Fozzard H. A., Rogart R. B. A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties. Science 1992; 256: 1202–1205
   PubMed Web of Science ®Google Scholar
• Sunami A., Glaaser I. W., Fozzard H. A. A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel. Proc. Natl. Acad. Sci. USA 2000; 97: 2326–2331
   PubMed Web of Science ®Google Scholar
• Sivilotti L., Okuse K., Akopian A. N., Moss S., Wood J. N. A single serine residue confers tetrodotoxin insensitivity on the rat sensory-neuron-specific sodium channel SNS. FEBS Lett 1997; 409: 49–52
   PubMed Web of Science ®Google Scholar
• Koroshetz W. J., Moskowitz M. A. Emerging treatments for stoke in humans. Trends Pharmacol. Sci 1996; 17: 227–233
   PubMed Web of Science ®Google Scholar
• Yamasaki Y., Kogure K., Hara H., Ban H., Akaike N. The possible involvement of tetrodotoxin-sensitive ion channels in ischemic neuronal damage in the rat hippocampus. Neurosci. Letts 1991; 121: 251–254
   PubMed Web of Science ®Google Scholar
• Lysko P. G., Webb C. L., Yue T. L., Gu J. L., Feuerstein G. Neuroprotective effects of tetrodotoxin as a Na + channel modulator and glutamate release inhibitor in cultured rat cerebellar neurons and in gerbil global brain ischemia. Stroke 1994; 25: 2476–2482
   PubMed Web of Science ®Google Scholar
• Rosenberg L. J., Teng Y. D., Wrathall J. R. Effects of the sodium channel blocker tetrodotoxin on acute white matter pathology after experimental contusive spinal cord injury. J. Neurosci. 1999; 19: 6122–6133
   PubMed Web of Science ®Google Scholar
• Burack M. A, Stasheff S. F., Wilson W. A. Selective suppression of in vitro electrographic seizures by low-dose tetrodotoxin: a novel anticonvulsant effect. Epilepsy Res 1995; 22: 115–126
   PubMed Web of Science ®Google Scholar
• Graber K. D., Prince D. A. Tetrodotoxin prevents posttraumatic epileptogenesis in rats. Ann. Neurol 1999; 46: 234–242
   PubMed Web of Science ®Google Scholar
• Chang F. C., Bauer R. M., Benton B. J., Keller S. A., Capacio B. R. 4-Aminopyridine antagonizes saxitoxin- and tetrodotoxin-induced cardio-respiratory depression. Toxicon 1996; 34: 671–690
   PubMed Web of Science ®Google Scholar
• Chang F. C.T., Spriggs D. L., Benton B. J., Keller S. A., Capacio B. R. 4-Aminopyridine reverses saxitoxin (STX)- and tetrodotoxin (TTX)-induced cardiorespiratory depression in chronically instrumented guinea pigs. Fundament. Appl. Toxicol. 1997; 38: 75–88
   PubMedGoogle Scholar
• Schwartz D. M., Duncan K. G., Duncan J. L. Experimental use of te-trodotoxin for corneal pain after excimer laser keratectomy. Cornea 1998a; 17: 196–199
   PubMed Web of Science ®Google Scholar
• Schwartz D. M., Fields H. L., Duncan K. G., Duncan J. L., Jones M. R. Experimental study of tetrodotoxin, a long-acting topical anesthetic. Amer. J. Ophthalmol. 1998b; 125: 481–487
   PubMed Web of Science ®Google Scholar
• Kohane D. S., Yieh J., Lu N. T., Langer R., Strichartz G. R., Berde C. B. A reexamination of tetrodotoxin for prolonged duration local anesthesia. Anesthesiology 1998; 89: 119–131
   PubMed Web of Science ®Google Scholar
• Garvin P. J., Niehoff M. L., Robinson S. M. Effects of tetrodotoxin and OKY-046 in renal ischemia reperfusion. J. Surgical Res. 1999; 85: 273–278
   PubMed Web of Science ®Google Scholar
• Li W. J., Bergman S. M., Holmes R. P., Strandhoy J. W., Handa R. K., McCullough D. L. Tetrodotoxin protects against acute ischemic renal fail-ure in the rat. J. Urol 1992; 147: 519–522
   PubMed Web of Science ®Google Scholar
• Matsumura K. In vivo neutralization of tetrodotoxin by a monoclonal anti-body. Toxicon 1995a; 33: 1239–1241
   PubMed Web of Science ®Google Scholar
• Matsumura K. monoclonal antibody against tetrodotoxin that reacts to the active group for the toxicity. A Europ. J. Pharmacol 1995b; 293: 41–45
   PubMed Web of Science ®Google Scholar
• Rivera V. R., Poli M. A., Bignami G. S. Prophylaxis and treatment with a monoclonal antibody of tetrodotoxin poisoning in mice. Toxicon 1995; 33: 1231–1237
   PubMed Web of Science ®Google Scholar
• Narahashi T., Moore J. W., Frazier D. T. Dependence of tetrodotoxin blockage of nerve membrane conductance on external pH. J. Pharmacol. Exper. Therap 1969; 169: 224–228
   PubMed Web of Science ®Google Scholar
• Narahashi T. Mode of action of dinoflagellate toxins on nerve membranes. Proceedings of the First International Conference on Toxic Dinoflagel-late Blooms, Nov. 4–6, 1974, V. R. LoCicero. MA, Science and Technology Foundation, Wakefield, MA 1975; 395–402
   Google Scholar
• Catterall W., Mackie K. Local anesthetics. The Pharmacological Basis of Therapeutics, J. G. Hardman, L. E. Limbird. 9th Edition, McGraw-Hill, New York 1996; 331–347, Chapter 15
   Google Scholar