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Review

The key role of adult stem cells: therapeutic perspectives

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Pages 2287-2300 | Accepted 25 Sep 2006, Published online: 16 Oct 2006

References

  • Camargo FD, Finegold M, Goodell MA. Haematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners. J Clin Invest 2004;113:1266–70
  • Andrade J, Lam JT, Zamora M, et al. Predominant fusion of bone marrow-derived cardiomyocytes. Cardiovasc Res 2005;68: 387–93
  • Thomson JA, Itskovitz-Eldor J, Shapiro SS, et al. Embryonic stem cell lines derived from human blastocysts. Science 1998,282:1145–7
  • Rodda DJ, Chew JL, Lim LH, et al. Transcriptional regulation of nanog by OCT4 and SOX2. J Biol Chem 2005;280: 24731–7
  • Gilbert SF. Developmental biology, 6th ed. Sinauer Ass Sunderland, MA, USA 2000
  • Pesce M, Anastassiadis K, Scholer HR. Oct-4: lessons of totipotency from embryonic stem cells. Cells Tissue Organs 1999;165: 144–52
  • Pesce M, Scholer HR. Oct-4: control of totipotency and germline determination. Mol Reprod Dev 2000;55:452–7
  • Hansis C, Grifo JA, Krey LC. Oct-4 expression in inner cell mass and trophectoderm of human blastocysts. Mol Hum Reprod 2000;6: 999–1004
  • Tsunoda Y, Kato Y. Not only inner cell mass nuclei but also trophectoderm nuclei of mouse blastocysts have a developmental totipotency. J Reprod Fertil 1998;113:181–4
  • Zheng YL, Jiang MX, OuYang YC, et al. Production of mouse by inter-strain inner cell mass replacement. Zygote 2005;13: 73–7
  • Do JT, Scholer HR. Nuclei of embryonic stem cells reprogram somatic cells. Stem Cells 2004;22:941–9
  • Wolpert L, et al. Principles of development. Oxford: Oxford Univ. Press; 1993
  • Zwaka TP, Thomson JA. Differentiation of human embryonic stem cells occurs through symmetric cell division. Stem Cells 2005;23:146–9
  • Kawaguchi A, Ogawa M, Saito K, et al. T. Differential expression of Pax6 and Ngn2 between pair- generated cortical neurons. J Neurosci Res 2004;78: 784–95
  • Arun CP. The importance of being asymmetric: the physiology of digesta propulsion on earth and in space. Ann NY Acad Sci 2004;1027:74–84
  • Tai MH, Chang CC, Olson LK, Trosko JE. Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis. Carcinogenesis 2005;26:495–502
  • Mintz B, Illmensee K. Normal genetically mosaic mice produced from malignant teratocarcinoma cells. PNAS 1975;72:3585–89
  • Erdo F, Buhrle C, Blunk J, et al. Host-dependent tumouri-genesis of embryonic stem cell transplantation in experimental stroke. J Cereb Blood Flow Metab 2003;23:780–5
  • Minchiotti G. Nodal-dependant Cripto signalling in ES cells: from stem cells to tumour biology. Oncogene 2005;24: 5668–75
  • Riggi N, Cironi L, Provero P, et al. Development of Ewing’s sarcoma from primary bone marrow-derived mesenchymal progenitor cells. Cancer Res 2005;65:11459–68
  • Andrews PW, Martin MM, Bahrami AR, et al. Embryonic stem (ES) cells and embryonal carcinoma (EC) cells: opposite sides of the same coin. Biochem Soc Trans 2005;33:1526–30
  • Almstrup K, Sonne SB, Hoei-Hansen CE, et al. From embryonic stem cells to testicular germ cell cancer – should we be concerned? Int J Androl 2006;29:211–8
  • Hochedlinger K, Yamada Y, Beard C, et al. Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell 2005;121:465–77
  • Greally JM, Matthew W. Genetics and childhood disorders: XIII. Genomic imprinting: the indelible mark of the gamete. J Am Acad Child Adolesc Psychiatry 2000;39:432–535
  • Reik W, Walter J. Genomic imprinting: parental influence on the genome. Nat Rev Gen 2001;2:21–32
  • Feinberg AP. The epigenetics of cancer aetiology. Semin Cancer Biol 2004;14:427–32
  • Maitra A, Arking DE, Shivapurkar N, et al. Genomic alterations in cultured human embryonic stem cells. Nature Genetics 2005;37:1099–103
  • Rubio D, Garcia-Castro J, Martin MC, et al. Spontaneous human adult stem cell transformation. Cancer Res 2005;65:3035–9
  • Kassem M, Burns JS. Adult stem cells and cancer. Cancer Res 2005; 65: 9601–2
  • Nakamizo A, Marini F, Amano T et al. Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Research 2005; 65: 3307–18
  • Sapienza C. Imprinted gene expression, transplantation medicine, and the ‘other’ human embryonic stem cell. PNAS 2002;99:10243–5
  • Lakshmipathy U, Verfaillie C. Stem cell plasticity. Blood 2005;19:29–38
  • Korbling M, Estrov Z. Adult stem cells for tissue repair – a new therapeutic concept? New Engl J Med 2003;349:570–82
  • Pittenger MF, Mackay AM, Beck SC, et al Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143–7
  • Reyes M, Verfaillie CM. Characterization of multipotent adult progenitor cells, a subpopulation of mesenchymal stem cells. Ann NY Acad Sci 2001;938:231–5
  • Friedenstein AJ, Chailakhjan RK, Lalykina KS. The development of fibroblast colonies in monolayer cultures of Guinea-pig bone marrow and spleen cells. Cell Tissue Kinet 1970;3:393–403
  • Sigurjonsson OE, Perreault M-C, Egeland T, Glover JC. Adult human haematopoietic stem cells produce neurons efficiently in the regenerating chicken embryo spinal cord. PNAS 2005;102:5227–32
  • Yoo Y, Wecker A, Heyd L, et al. Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. J Clin Invest 2005;115:326–38
  • Le Blanc K, Gotherstrom C, Ringden O, et al. Foetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta. Transplantation 2005;79:1607–14
  • Lee OC, Kuo TK, Chen WM, et al. Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood 2004;103:1669–75
  • Köegler G, Sensken S, Airey JA, et al. A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med 2004;2:123–35
  • Pessina A, Eletti B, Croera C, et al. Pancreas developing markers expressed on human mononucleated umbilical cord blood cells. Biochem Biophys Res Commun 2004;323:315–22
  • Yoshida S, Ishikawa F, Kawano N, et al. Human cord blood-derived cells generate insulin-producing cells in vivo. Stem Cells 2005;23:1409–16
  • Murrel W, Feron F, Wetzig A, et al. Multipotent stem cells from adult olfactory mucosa. Dev Dyn 2005;233:496–515
  • Polentes J, Gauthier P. Transplantation of olfactory ensheathing cells after spinal injury. Neurochirurgie 2005;51:421–34
  • Marshall CT, Lu C, Winstead W, et al. The therapeutic potential of human olfactory-derived stem cells. Histol Histopathol 2006;21:633–43
  • Coles BLK, Angenieux B, Inoue T, et al. Facile isolation and the characterization of human retinal stem cells. PNAS 2004;101:15772–7
  • Imitola J, Raddassi K, Park KI, et al. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1 alpha/CXC chemokine receptor 4 pathway. PNAS 2004;101:18117–22
  • Sordi V, Malosio ML, Marchesi F, et al. Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets. Blood 2005;15:106:419–27
  • Collas P, Håkelien A-M. Reprogramming somatic cells for therapeutic applications. J Regener Med 2003;4:7–13
  • Håkelien AM, Landsverk HB, Robl JM, et al. Reprogramming fibroblasts to express T-cell functions using cell extracts. Nature Biotech 2002;20:460–6
  • Håkelien AM, Collas P. Novel approaches to transdifferentiation. Cloning and Stem Cells 2002;4:379–87
  • Tang DG, Tokumoto YM, Apperly JA, et al. Lack of replicative senescence in cultured rat oligodendrocyte precursor cells. Science 2001;291:868–71
  • Shen CN, Slack JM, Tosh D. Molecular basis of transdifferentiation of pancreas to liver. Natl Cell Biol 2000;879–87
  • Tsai RVL, Kittappa R, McKay RDG. Plasticity, niches, and the use of stem cells. Develop Cell 2002;2:707–12
  • Odelberg SJ, Kollhoff A, Keating MT. Dedifferentiation of mammalian myotubes induced by msx1. Cell 2000;103: 1099–109
  • Yu Y, Flint A, Dvorin EL, Bischoff J. AC133–2, a novel isoform of human AC133 stem cell antigen. J Biol Chem 2002;277:20711–6
  • Danet GH, Luongo JL, Butler G, et al. C1qRp defines a new human stem cell population with haematopoietic and hepatic potential. PNAS 2002;99:10441–5
  • Ivanova NB, Dimos JT, Schaniel C, et al. A stem cell molecular signature. Science 2002;298:601–4
  • Blau HM, Brazelton TR, Weimann JM. The evolving concept of a stem cell: entity or function? Cell 2001;105:829–41
  • Tsai RY, McKay RD. Cell contact regulates fate choice by cortical stem cells. J Neurosci 2000;20:3725–35
  • Wagers AJ, Sherwood RI, Christensen JL, Weissman IL. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 2002;297:2256–9
  • Krause DS, Theise ND, Collector MI, et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001;105:369–77
  • Castro RF, Jackson KA, Goodell MA, et al. Failure of bone marrow cells to transdifferentiate into neural cells in vivo. Science 2002;297:9
  • Brazelton TR, Rossi FM, Keshet GI, Blau HM. From marrow to brain: expression of neuronal phenotypes in adult mice. Science 2000;290:1775–9
  • Moore BE, Quesenberry PJ. The adult hemopoietic stem cell plasticity debate: idols vs new paradigms. Leukemia 2003;17:1205–10
  • Spees JL, Olson SD, Ylostalo J, et al. Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma. PNAS 2003;100:2397–402
  • Blau HM. A twist of fate. Nature 2002;419:437
  • Tran SD, Pillemer SR, Dutra A, et al. Differentiation of human bone marrow-derived cells into buccal epithelial cells in vivo: a molecular analytical study. Lancet 2003;361:1084–8
  • Newsome PN, Johannessen I, Boyle S, et al. Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion. Gastroenterology 2003;124:1891–900
  • Jiang Y, Jahagirdar BN, Reinhardt RL, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002;418:41–9
  • Mazurier F, Doedens M, Gan OI, Dick JE. Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells. Nat Med 2003;9:959–63
  • Bianco P, Riminucci M, Gronthos S, Robey PG. Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells 2001;19:180–92
  • Sanchez-Ramos J, Song S, Cardozo-Pelaez F, et al. Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol 2000;164:247–56
  • Woodbury D, Schwarz EJ, Prockop DJ, Black IB. Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 2000;61:364–70
  • Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143–7
  • Gronthos S, Zannettino AC, Hay SJ, et al. Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow. J Cell Sci 2003;116: 1827–35
  • Brazelton TR, Rossi FM, Keshet GI, Blau HM. From marrow to brain: expression of neuronal phenotypes in adult mice. Science 2000;290:1775–9
  • Mezey E, Chandross KJ, Harta G, et al. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 2000;290:1779–82
  • Krause DS, Theise N, Collector M, et al. Multi-organ, multilineage engraftment by a single bone marrow derived stem cell. Cell 2001;105:369–77
  • Kabos P, Ehtesham M, Kabosova A, et al. Generation of neural progenitor cells from whole adult bone marrow. Exp Neurol 2002;178:288–93
  • Otani A, Kinder K, Ewalt K, et al. Bone marrow-derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis. Nat Med 2002;8:1004–10
  • Sekiya I, Vuoristo JT, Larson BL, Prockop DJ. In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis. PNAS 2002;99:4397–402
  • Ito T, Suzuki A, Imai E, et al. Bone marrow is a reservoir of repopulating mesangial cells during glomerular remodeling. J Am Soc Nephrol 2001;12:2625–35
  • Masuya M, Drake CJ, Fleming PA, et al. Hematopoietic origin of glomerular mesangial cells. Blood 2003;101:2215–8
  • Miyazaki M, Akiyama I, Sakaguchi M, et al. Improved conditions to induce hepatocytes from rat bone marrow cells in culture. Biochem Biophys Res Commun 2002;298:24–30
  • Fiegel HC, Lioznov MV, Cortes-Dericks L, et al. Liver-specific gene expression in cultured human hematopoietic stem cells. Stem Cells 2003;21:98–104
  • Perin EC, Dohmann HF, Borojevic R, et al. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 2003;107:2294–302
  • Stamm C, Westphal B, Kleine HD, et al. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet 2003;361:45–6
  • Tse HF, Kwong YL, Chan JK, et al. Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet 2003;361:47–9
  • Strauer BE, Brehm M, Zeus T, et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 2002;106:1913–8
  • Sanchez-Ramos JR, Song S, Kamath SG, et al. Expression of neural markers in human umbilical cord blood. Exp Neurol 2001;171:109–15
  • Willing AE, Vendrame M, Mallery J, et al. Mobilised peripheral blood cells administered intravenously produce functional recovery in stroke. Cell Transplant 2003;12:449–54
  • Chen J, Sanberg PR, Li Y, et al. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke 2001;32:2682–8
  • Saporta S, Kim JJ, Willing AE, et al. Human umbilical cord blood stem cells infusion in spinal cord injury: engraftment and beneficial influence on behavior. J Hematother Stem Cell Res 2003;12:271–8
  • Garbuzova-Davis S, Willing AE, Zigova T, et al. Intravenous administration of human umbilical cord blood cells in a mouse model of amyotrophic lateral sclerosis: distribution, migration, and differentiation. J Hematother Stem Cell Res 2003;12: 255–70
  • Buzanska L, Stachowiak E, Stachowiak M, Domanska-Janik K. Neural stem cell line derived from human umbilical cord blood – morphological and functional properties. J Neurochem 2003;85:339
  • Kakinuma S, Tanaka Y, Chinzei R, et al. Human umbilical cord blood as a source of transplantable hepatic progenitor cells. Stem Cells 2003;21:217–27
  • Ishikawa F, Drake CJ, Yang S, et al. Transplanted human cord blood cells give rise to hepatocytes in engrafted mice. Ann NY Acad Sci 2003;996:174–85
  • Wang X, Ge S, McNamara G, et al. Albumin-expressing hepatocyte-like cells develop in the livers of immune-deficient mice that received transplants of highly purified human hematopoietic stem cells. Blood 2003;101:4201–8
  • Kessinger A, Sharp JG. The whys and hows of hematopoietic progenitor and stem cell mobilization. Bone Marrow Transplant 2003;31:319–29
  • Camargo FD, Finegold M, Goodell MA. Hematopoietic myelomonocytic cells are the major source of epatocyte fusion partners. J Clin Invest 2004;113:1266–70
  • Pagano SF, Impagnatiello F, Girelli M, et al. Isolation and characterization of neural stem cells from the adult human olfactory bulb. Stem Cells 2000;18:295–300
  • Shihabuddin LS, Horner PJ, Ray J, Gage FH. Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. J Neurosci 2000;20:8727–35
  • Palmer TD, Schwartz PH, Taupin P, et al. Cell culture. Progenitor cells from human brain after death. Nature 2001;411:42–3
  • Bjornson CR, Rietze RL, Reynolds BA, et al. Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo. Science 1999;283:534–7
  • Galli R, Gritti A, Bonfanti L, Vescovi AL. Neural stem cells: an overview. Circ Res 2003;92:598–608
  • Clarke DL, Johansson CB, Wilbertz J, et al. Generalised potential of adult neural stem cells. Science 2000;288:1660–3
  • Galli R, Borello U, Gritti A, et al. Skeletal myogenic potential of human and mouse neural stem cells. Nat Neurosci 2000;3:986–91
  • Rietze RL, Valcanis H, Brooker GF, et al. Purification of a pluripotent neural stem cell from the adult mouse brain. Nature 2001;412:736–9
  • Englund U, Bjorklund A, Wictorin K, et al. Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry. PNAS 2002;99:17089–94
  • Arvidsson A, Collin T, Kirik D, et al. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med 2002;8:963–70
  • Riess P, Zhang C, Saatman KE, et al. Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injury. Neurosurgery 2002;51:1043–52
  • Chang MY, Son H, Lee YS, Lee SH. Neurons and astrocytes secrete factors that cause stem cells to differentiate into neurons and astrocytes, respectively. Mol Cell Neurosci 2003;23: 414–26
  • Hori J, Ng TF, Shatos M, et al. Neural progenitor cells lack immunogenicity and resist destruction as allografts. Stem Cells 2003;21:405–16
  • Asakura A, Seale P, Girgis-Gabardo A, Rudnicki MA. Myogenic specification of side population cells in skeletal muscle. J Cell Biol 2002;159:123–34
  • Lee JY, Qu-Petersen Z, Cao B, et al. Clonal isolation of muscle-derived cells capable of enhancing muscle regeneration and bone healing. J Cell Biol 2000;150:1085–100
  • Torrente Y, Tremblay JP, Pisati F, et al. Intraarterial injection of muscle-derived CD34(+)Sca-1(+) stem cells restores dystrophin in mdx mice. J Cell Biol 2001;152:335–48
  • Qu-Petersen Z, Deasy B, Jankowski R, et al. Identification of a novel population of muscle stem cells in mice: potential for muscle regeneration. J Cell Biol 2002;157:851–64
  • Polesskaya A, Seale P, Rudnicki MA. Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration. Cell 2003;113: 841–52
  • Lee JY, Cannon TW, Pruchnic R, et al. The effects of periurethral muscle-derived stem cell injection on leak point pressure in a rat model of stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct 2003;14:31–7
  • Atkins BZ, Lewis CW, Kraus WE, et al. Intracardiac transplantation of skeletal myoblasts yields two populations of striated cells in situ. Ann Thorac Surg 1999;67:124–9
  • Iijima Y, Nagai T, Mizukami M, et al. Beating is necessary for transdifferentiation of skeletal muscle-derived cells into cardiomyocytes. FASEB J 2003;17:1361–3
  • Wang X, Al-Dhalimy M, Lagasse E, et al. Liver repopulation and correction of metabolic liver disease by transplanted adult mouse pancreatic cells. Am J Pathol 2001;158:571–9
  • Ramiya VK, Maraist M, Arfors KE, et al. Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nat Med 2000;6:278–82
  • Bonner-Weir S, Taneja M, Weir GC, et al. In vitro cultivation of human islets from expanded ductal tissue. PNAS 2000;97:7999–8004
  • Gmyr V, Kerr-Conte J, Belaich S, et al. Adult human cytokeratin 19-positive cells reexpress insulin promoter factor 1 in vitro: further evidence for pluripotent pancreatic stem cells in humans. Diabetes 2000;49:1671–80
  • Dufayet de la Tour D, Halvorsen T, Demeterco C, et al. [Beta]-cell differentiation from a human pancreatic cell line in vitro and in vivo. Mol Endocrinol 2001;15:476–83
  • Abraham EJ, Leech CA, Lin JC, et al. Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells. Endocrinology 2002;143:3152–61
  • Ferber S, Halkin A, Cohen H, et al. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 2000;6:568–72
  • Meller D, Pires RT, Tseng SC. Ex vivo preservation and expansion of human limbal epithelial stem cells on amniotic membrane cultures. Br J Ophthalmol 2002;86:463–71
  • Tsai RJ, Li LM, Chen JK. Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells. New Engl J Med 2000;343:86–93
  • Schwab IR, Reyes M, Isseroff RR. Successful transplantation of bioengineered tissue replacements in patients with ocular surface disease. Cornea 2000;19:421–6
  • Tsubota K, Satake Y, Kaido M, et al. Treatment of severe ocular-surface disorders with corneal epithelial stem-cell transplantation. New Engl J Med 1999;340:1697–703
  • Henderson TR, Coster DJ, Williams KA. The long term outcome of limbal allografts: the search for surviving cells. Br J Ophthalmol 2001;85:604–9
  • Seigel GM, Sun W, Salvi R, et al. Human corneal stem cells display functional neuronal properties. Mol Vis 2003;9:159–63
  • Chacko DM, Das AV, Zhao X, et al. Transplantation of ocular stem cells: the role of injury in incorporation and differentiation of grafted cells in the retina. Vision Res 2003;43:937–46
  • Dontu G, Abdallah WM, Foley JM, et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 2003;17:1253–70
  • Alvi AJ, Clayton H, Joshi C, et al. Functional and molecular characterisation of mammary side population cells. Breast Cancer Res 2003;5:R1–R8
  • Okumura K, Nakamura K, Hisatomi Y, et al. Salivary gland progenitor cells induced by duct ligation differentiate into hepatic and pancreatic lineages. Hepatology 2003;38:104–13
  • Toma JG, Akhavan M, Fernandes KJ, et al. Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol 2001;3:778–84
  • Oshima H, Rochat A, Kedzia C, et al. Morphogenesis and renewal of hair follicles from adult multipotent stem cells. Cell 2001;104:233–45
  • Taylor G, Lehrer MS, Jensen PJ, et al. Involvement of follicular stem cells in forming not only the follicle but also the epidermis. Cell 2000;102:451–61
  • Lako M, Armstrong L, Cairns PM, et al. Hair follicle dermal cells repopulate the mouse haematopoietic system. J Cell Sci 2002;115:3967–74
  • Bennett AR, Farley A, Blair NF, et al. Identification and characterization of thymic epithelial progenitor cells. Immunity 2002;16:803–14
  • Gill J, Malin M, Hollander GA, Boyd R. Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells. Nat Immunol 2002;3:635–42
  • Gronthos S, Mankani M, Brahim J, et al. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. PNAS 2000;97:13625–30
  • Miura M, Gronthos S, Zhao M, et al. SHED: stem cells from human exfoliated deciduous teeth. PNAS 2003;100:5807–12
  • Zuk PA, Zhu M, Mizuno H, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 2001;7:211–28
  • Halvorsen YD, Franklin D, Bond AL, et al. Extracellular matrix mineralization and osteoblast gene expression by human adipose tissue-derived stromal cells. Tissue Eng 2001;7:729–41
  • Erickson GR, Gimble JM, Franklin DM, et al. Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo. Biochem Biophys Res Commun 2002;290:763–9
  • Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002;13: 4279–95
  • Safford KM, Hicok KC, Safford SD, et al. Neurogenic differentiation of murine and human adipose-derived stromal cells. Biochem Biophys Res Commun 2002;294:371–9
  • Hong SH, Gang EJ, Jeong JA, et al. In vitro differentiation of human umbilical cord blood-derived mesenchymal stem cells into epatocyte-like cells. Biochem Biophys Res Commun 2005;330:11053–61
  • Alison MR, Poulsom R, Jeffery R, et al. Hepatocytes from nonhepatic adult stem cells. Nature 2000;406:25764
  • Orlic D, Kajstura J, Chimenti S, et al. Mobilised bone marrow cells repair the infarcted heart, improving function and survival. PNAS 2001;98:10344–9
  • Willing AE, Vendrame M, Mallery J, et al. Mobilised peripheral blood cells administered intravenously produce functional recovery in stroke. Cell Transplant 2003;12:449–54
  • Borlongan CV, Hess DC. G-CSF-Mobilised human peripheral blood for transplantation therapy in stroke. Cell Transplant 2003;12:447–8
  • Jensen GS, Drapeau C. The use of in situ bone marrow stem cells for the treatment of various degenerative diseases. Med Hypotheses 2002;59:422–8
  • Ramer MS, Priestley JV, McMahon SB. Functional regeneration of sensory axons into the adult spinal cord. Nature 2000;403: 312–6
  • Fallon J, Reid S, Kinyamu R, et al. In vivo induction of massive proliferation, directed migration, and differentiation of neural cells in the adult mammalian brain. PNAS 2000;97: 14686–91
  • Gill SS, Patel NK, Hotton GR, et al. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nat Med 2003;9:589–95
  • Zeisberg M, Hanai J, Sugimoto H, et al. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 2003;9:964–8
  • Grove JE, Lutzko C, Priller J, et al. Marrow-derived cells as vehicles for delivery of gene therapy to pulmonary epithelium. Am J Respir Cell Mol Biol 2002;27:645–51
  • Steptoe RJ, Ritchie JM, Harrison LC. Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes. J Clin Invest 2003;111:1357–63
  • Ferber S, Halkin A, Cohen H, et al. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 2000;6:568–72
  • McKee JA, Banik SS, Boyer MJ, et al. Human arteries engineered in vitro. EMBO Rep 2003;4:633–8
  • Shi S, Gronthos S, Chen S, et al. Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression. Nat Biotechnol 2002;20:587–91
  • Simonsen JL, Rosada C, Serakinci N, et al. Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells. Nat Biotechnol 2002;20:592–6
  • Cavazzana-Calvo M, Hacein-Bey S, de Saint Basile G, et al. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 2000;288:669–72
  • Hacein-Bey-Abina S, Le Deist F, Carlier F, et al. Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy. New Engl J Med 2002;346:1185–93
  • Aiuti A, Slavin S, Aker M, et al. Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning. Science 2002;296:2410–3

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