Budesonide/formoterol maintenance and reliever therapy: a new treatment approach for adult patients with asthma

References

• Global Initiative for Asthma. Global strategy for asthma management and prevention. Available from www.ginasthma. com [last accessed 15 May 2007]
   Google Scholar
• O’Byrne PM, Barnes PJ, Rodriguez-Roisin R, et al. Low dose inhaled budesonide and formoterol in mild persistent asthma: the OPTIMA randomized trial. Am J Respir Crit Care Med 2001;164:1392–7
   Google Scholar
• Shapiro G, Lumry W, Wolfe J, et al. Combined salmeterol 50 µg and fluticasone propionate 250 µg in the diskus device for the treatment of asthma. Am J Respir Crit Care Med 2000;161:527–34
   PubMed Web of Science ®Google Scholar
• Barnes PJ. Scientific rationale for inhaled combination therapy with long-acting beta2-agonists and corticosteroids. Eur Respir J 2002;19:182–91
   PubMed Web of Science ®Google Scholar
• Bateman ED, Boushey HA, Bousquet J, et al. Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study. Am J Respir Crit Care Med 2004;170:836–44
   PubMed Web of Science ®Google Scholar
• O’Byrne PM, Bisgaard H, Godard PP, et al. Budesonide/ formoterol combination therapy as both maintenance and reliever medication in asthma. Am J Respir Crit Care Med 2005;171:129–36
   Google Scholar
• Gibson PG. Teaching old drugs new tricks: asthma therapy adjusted by patient perception or noninvasive markers. Eur Respir J 2005;25:397–9
   PubMed Web of Science ®Google Scholar
• FitzGerald JM, Gibson PG. Asthma exacerbations – 4: prevention. Thorax 2006;61:992–9
   PubMed Web of Science ®Google Scholar
• Rabe KF, Pizzichini E, Stallberg B, et al. Budesonide/formoterol in a single inhaler for maintenance and relief in mild-to-moderate asthma: a randomized, double-blind trial. Chest 2006;129:246–56
   PubMed Web of Science ®Google Scholar
• Kuna P, Peters MJ, Manjra AI, et al. Effect of budesonide/ formoterol maintenance and reliever therapy on asthma exacerbations. Int J Clin Pract 2007;61:725–36
   PubMed Web of Science ®Google Scholar
• Vogelmeier C, D’Urzo A, Pauwels R, et al. Budesonide/ formoterol maintenance and reliever therapy: an effective asthma treatment option? Eur Respir J 2005;26:819–28
   PubMed Web of Science ®Google Scholar
• Stoloff SW, Stempel DA, Meyer J, et al. Improved refill persistence with fluticasone propionate and salmeterol in a single inhaler compared with other controller therapies. J Allergy Clin Immunol 2004;113:245–51
   PubMed Web of Science ®Google Scholar
• Stempel DA, Stoloff SW, Carranza Rosenzweig JR, et al. Adherence to asthma controller medication regimens. Respir Med 2005;99:1263–7
   PubMed Web of Science ®Google Scholar
• O’Connor RD, Rosenzweig JR, Stanford RH, et al. Asthma-related exacerbations, therapy switching, and therapy discontinuation: a comparison of 3 commonly used controller regimens. Ann Allergy Asthma Immunol 2005;95: 535–40
   Google Scholar
• Marceau C, Lemiere C, Berbiche D, et al. Persistence, adherence, and effectiveness of combination therapy among adult patients with asthma. J Allergy Clin Immunol 2006;118:574–81
   PubMed Web of Science ®Google Scholar
• Angus R, Reagon R, Cheesbrough A. Short-acting beta 2-agonist and oral corticosteroid use in asthma patients prescribed either concurrent beclomethasone and long-acting beta 2-agonist or salmeterol/fluticasone propionate combination. Int J Clin Pract 2005;59: 156–62
   Google Scholar
• Partridge MR, Van der MT, Myrseth SE, et al. Attitudes and actions of asthma patients on regular maintenance therapy: the INSPIRE study. BMC Pulm Med 2006;6:13
   PubMedGoogle Scholar
• Scicchitano R, Aalbers R, Ukena D, et al. Efficacy and safety of budesonide/formoterol single inhaler therapy versus a higher dose of budesonide in moderate to severe asthma. Curr Med Res Opin 2004;20:1403–18
   PubMed Web of Science ®Google Scholar
• Sin DD, Man J, Sharpe H, et al. Pharmacological management to reduce exacerbations in adults with asthma: a systematic review and meta-analysis. J Am Med Assoc 2004;292:367–76
   PubMed Web of Science ®Google Scholar
• Gibson PG, Powell H, Ducharme FM. Differential effects of maintenance long-acting beta-agonist and inhaled corticosteroid on asthma control and asthma exacerbations. J Allergy Clin Immunol 2007;119:344–50
   Google Scholar
• Rabe KF, Atienza T, Magyar P, et al. Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations: a randomised controlled, double-blind study. Lancet 2006;368:744–53
   PubMed Web of Science ®Google Scholar
• Juniper EF, O’Byrne PM, Guyatt GH, et al. Development and validation of a questionnaire to measure asthma control. Eur Respir J 1999;14:902–7
   PubMed Web of Science ®Google Scholar
• Juniper EF, Svensson K, Mork AC, et al. Measurement properties and interpretation of three shortened versions of the asthma control questionnaire. Respir Med 2005;99:553–8
   PubMed Web of Science ®Google Scholar
• Aalbers R, Backer V, Kava TT, et al. Adjustable maintenance dosing with budesonide/formoterol compared with fixed-dose salmeterol/fluticasone in moderate to severe asthma. Curr Med Res Opin 2004;20:225–40
   PubMed Web of Science ®Google Scholar
• Gibson PG, Saltos N, Fakes K. Acute anti-inflammatory effects of inhaled budesonide in asthma. A randomized controlled trial. Am J Respir Crit Care Med 2001;163:32–6
   Google Scholar
• Barnes PJ. Scientific rationale for using a single inhaler for asthma control. Eur Respir J 2007;29:587–95
   PubMed Web of Science ®Google Scholar
• Tintinger GR, Anderson R, Theron AJ, et al. Comparison of the effects of selective and non-selective beta-adrenoceptor agonists on the pro-inflammatory activities of human neutrophils in vivo. Inflammation 2000;24:239–49
   Web of Science ®Google Scholar
• Palmqvist M, Ibsen T, Mellen A, et al. Comparison of the relative efficacy of formoterol and salmeterol in asthmatic patients. Am J Respir Crit Care Med 1999;160:244–9
   PubMed Web of Science ®Google Scholar
• van Veen A, Weller FR, Wierenga EA, et al. A comparison of salmeterol and formoterol in attenuating airway responses to short-acting beta2-agonists. Pulm Pharmacol Ther 2003;16:153–61
   PubMed Web of Science ®Google Scholar
• Papi A, Canonica GW, Maestrelli P, et al. Rescue use of beclomethasone and albuterol in a single inhaler for mild asthma. New Engl J Med 2007;356:2040–52
   PubMed Web of Science ®Google Scholar
• Rabe KF, Vermeire PA, Soriano JB, et al. Clinical management of asthma in 1999: the Asthma Insights and Reality in Europe (AIRE) study. Eur Respir J 2000;16:802–7
   PubMed Web of Science ®Google Scholar
• Spitzer WO, Suissa S, Ernst P, et al. The use of beta-agonists and the risk of death and near death from asthma. New Engl J Med 1992;326:501–6
   PubMed Web of Science ®Google Scholar
• Anderson HR, Ayres JG, Sturdy PM, et al. Bronchodilator treatment and deaths from asthma: case-control study. Br Med J 2005;330:117
   PubMed Web of Science ®Google Scholar
• O’Byrne PM. Acute asthma intervention: insights from the STAY study. J Allergy Clin Immunol 2007;119:1132–6
   Google Scholar
• Jatakanon A, Lim S, Barnes PJ. Changes in sputum eosinophils predict loss of asthma control. Am J Respir Crit Care Med 2000;161:64–72
   PubMed Web of Science ®Google Scholar
• Miller-Larsson A, Mattsson H, Hjertberg E, et al. Reversible fatty acid conjugation of budesonide. Novel mechanism for prolonged retention of topically applied steroid in airway tissue. Drug Metab Dispos 1998;26:623–30
   Google Scholar
• Jendbro M, Johansson CJ, Strandberg P, et al. Pharmacokinetics of budesonide and its major ester metabolite after inhalation and intravenous administration of budesonide in the rat. Drug Metab Dispos 2001;29:769–76
   PubMed Web of Science ®Google Scholar
• Tattersfield AE, Postma DS, Barnes PJ, et al. Exacerbations of asthma: a descriptive study of 425 severe exacerbations [The FACET International Study Group]. Am J Respir Crit Care Med 1999;160:594–9
   PubMed Web of Science ®Google Scholar
• Barnes PJ. A single inhaler for asthma? Am J Respir Crit Care Med 2005;171:95–6
   PubMed Web of Science ®Google Scholar
• Harrison TW, Oborne J, Newton S, et al. Doubling the dose of inhaled corticosteroid to prevent asthma exacerbations: randomised controlled trial. Lancet 2004;363:271–5
   PubMed Web of Science ®Google Scholar
• FitzGerald JM, Becker A, Sears MR, et al. Doubling the dose of budesonide versus maintenance treatment in asthma exacerbations. Thorax 2004;59:550–6
   PubMed Web of Science ®Google Scholar
• Selroos O. A smarter way to manage asthma with a fixed dose combination of a long-acting β2-agonist and inhaled corticosteroid. Ther Clin Risk Manag 2007;3:[epub]
   Google Scholar
• Salpeter SR, Buckley NS, Ormiston TM, et al. Meta-analysis: effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deaths. Ann Intern Med 2006;144:904–12
   PubMed Web of Science ®Google Scholar
• Ernst P, McIvor A, Ducharme FM, et al. Safety and effectiveness of long-acting inhaled beta-agonist bronchodilators when taken with inhaled corticosteroids. Ann Intern Med 2006;145:692–4
   PubMed Web of Science ®Google Scholar
• Jaeschke R, Mejza F, Lesniak W, et al. The safety of formoterol among patients with asthma using inhaled corticosteroids. Am J Respir Crit Care Med 2007;175:A57
   Google Scholar
• American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1987;136:225–44
   PubMed Web of Science ®Google Scholar