Nursing home-acquired pneumonia: a review of risk factors and therapeutic approaches

References

• Muder RR, Aghababian RV, Loeb MR, et al. Nursing home-acquired pneumonia: an emergency department treatment algorithm. Curr Med Res Opin 2004;20:1309-20
   PubMed Web of Science ®Google Scholar
• El Solh AA, Akinnusi ME, Alfarah Z, et al. Effect of antibiotic guidelines on outcomes of hospitalized patients with nursing home-acquired pneumonia. J Am Geriatr Soc 2009;57:1030-5
   PubMed Web of Science ®Google Scholar
• Marrie TJ. Pneumonia in the long-term-care facility. Infect Control Hosp Epidemiol 2002;23:159-64
   PubMed Web of Science ®Google Scholar
• Marrie TJ, Blanchard W. A comparison of nursing home-acquired pneumonia patients with patients with community-acquired pneumonia and nursing home patients without pneumonia. J Am Geriatr Soc 1997;45:50-5
   PubMed Web of Science ®Google Scholar
• Loeb M. Epidemiology of community- and nursing home-acquired pneumonia in older adults. Expert Rev Anti Infect Ther 2005;3:263-70
   PubMedGoogle Scholar
• Brito V, Niederman MS. How can we improve the management and outcome of pneumonia in the elderly? Eur Respir J 2008;32:12-14
   PubMed Web of Science ®Google Scholar
• Hutt E, Ruscin JM, Corbett K, et al. A multifaceted intervention to implement guidelines improved treatment of nursing home-acquired pneumonia in a state veterans home. J Am Geriatr Soc 2006;54:1694-700
   PubMed Web of Science ®Google Scholar
• Hutt E, Reznickova N, Morgenstern N, et al. Improving care for nursing home-acquired pneumonia in a managed care environment. Am J Manag Care 2004;10:681-6
   PubMed Web of Science ®Google Scholar
• Loeb M, McGeer A, McArthur M, et al. Risk factors for pneumonia and other lower respiratory tract infections in elderly residents of long-term care facilities. Arch Intern Med 1999;159:2058-64
   PubMed Web of Science ®Google Scholar
• Vergis EN, Brennen C, Wagener M, et al. Pneumonia in long-term care: a prospective case-control study of risk factors and impact on survival. Arch Intern Med 2001;161:2378-81
   PubMed Web of Science ®Google Scholar
• Beck-Sague C, Banerjee S, Jarvis WR. Infectious diseases and mortality among nursing home residents. Am J Public Health 1993;83:1739-42
   PubMed Web of Science ®Google Scholar
• Magaziner J, Tenney JH, DeForge B, et al. Prevalence and characteristics of nursing-home acquired infections in the aged. J Am Geriatr Soc 1991;39:1071-8
   PubMed Web of Science ®Google Scholar
• Jacobson C, Strausbaugh LJ. Incidence and impact of infection in the nursing home care unit. Am J Infect Control 1990;18:151-9
   PubMed Web of Science ®Google Scholar
• Setia U, Serventi I, Lorenz P. Nosocomial infections among patients in the long-term care facility: spectrum, prevalence, and risk factors. Am J Infect Control 1998;13:57-62
   Google Scholar
• Rantanen TK, Salo JA. Gastroesophogeal reflux disease as a cause of death: analysis of fatal cases under conservative treatment. Scand J Gastroenterol 1999;34:229-33
   PubMed Web of Science ®Google Scholar
• Quagliarello V, Ginter S, Han L, et al. Modifiable risk factors for nursing home-acquired pneumonia. Clin Infect Dis 2005;40:1-6
   PubMed Web of Science ®Google Scholar
• Knol W, van Marum R, Jansen P, et al. Antipsychotic drug use and risk of pneumonia in elderly people. J Am Geriatr Soc 2008; 56:661-6
   PubMed Web of Science ®Google Scholar
• Sarkar M, Hennessy S, Yang YX. Proton-pump inhibitor use and the risk for community-acquired pneumonia. Ann Intern Med 2008;149:391-8
   PubMed Web of Science ®Google Scholar
• Eurich D, Sadowski C, Simpson S, et al. Recurrent community-acquired pneumonia in patients starting acid-suppressing drugs. Am J Med 2010;123:47-53
   PubMed Web of Science ®Google Scholar
• Mylotte JM. Nursing home-acquired pneumonia: update on treatment options. Drugs Aging 2006;23:377-90
   PubMed Web of Science ®Google Scholar
• Loeb M. Pneumonia in older persons. Clin Infect Dis 2003;37:1335-9
   PubMed Web of Science ®Google Scholar
• Medina-Walpole AM, Katz PR. Nursing home-acquired pneumonia. J Am Geriatr Soc 1999;47:1005-15
   PubMed Web of Science ®Google Scholar
• Kothe H, Bauer T, Marre R, et al. Outcome of community-acquired pneumonia: influence of age, residence status and antimicrobial treatment. Eur Respir J 2008;32:139-46
   PubMed Web of Science ®Google Scholar
• Lim WS, Macfarlane JT. A prospective comparison of nursing home acquired pneumonia with community acquired pneumonia. Eur Respir J 2001;18:362-8
   PubMed Web of Science ®Google Scholar
• Muder R. Penumonia in residents of long-term care facilities: epidemiology, etiology, management and prevention. Am J Med 1998;105:319-30
   PubMed Web of Science ®Google Scholar
• Troy CJ, Peeling RW, Ellis AG, et al. Chlamydia pneumoniae as a new source of infectious outbreaks in nursing homes. JAMA 1997;277:1214-18
   PubMed Web of Science ®Google Scholar
• Seenivasan MH, Yu VL, Muder RR. Legionnaires' disease in long-term care facilities: overview and proposed solutions. J Am Geriatr Soc 2005;53:875-80
   PubMed Web of Science ®Google Scholar
• Maruyama T, Niederman MS, Kobayashi T, et al. A prospective comparison of nursing home-acquired pneumonia with hospital-acquired pneumonia in non-intubated elderly. Respir Med 2008;102:1287-95
   PubMed Web of Science ®Google Scholar
• Mills K, Graham AC, Winslow BT, et al. Treatment of nursing home-acquired pneumonia. Am Fam Physician 2009;79:976-82
   PubMed Web of Science ®Google Scholar
• Ellis SE, Coffey CS, Mitchel EF Jr, et al. Influenza- and respiratory syncytial virus-associated morbidity and mortality in the nursing home population. J Am Geriatr Soc 2003;51:761-7
   PubMed Web of Science ®Google Scholar
• Falsey AR, Dallal GE, Formica MA, et al. Long-term care facilities: a cornucopia of viral pathogens. J Am Geriatr Soc 2008;56:1281-5
   PubMed Web of Science ®Google Scholar
• Talbot HK, Falsey AR. The diagnosis of viral respiratory disease in older adults. Clin Infect Dis 2010;50:747-51
   PubMed Web of Science ®Google Scholar
• El-Solh AA, Sikka P, Ramadan F, et al. Etiology of severe pneumonia in the very elderly. Am J Respir Crit Care Med 2001;163:645-51
   PubMed Web of Science ®Google Scholar
• El Solh AA, Pietrantoni C, Bhat A, et al. Indicators of potentially drug-resistant bacteria in severe nursing home-acquired pneumonia. Clin Infect Dis 2004;39:474-80
   PubMed Web of Science ®Google Scholar
• Drinka PJ. Long term tracking of methicillin-resistant Staphylococcus aureus in a large skilled nursing facility. J Am Geriatr Soc 2004;52:1968
   PubMed Web of Science ®Google Scholar
• El Solh A, Aquilina A, Dhillon R, et al. Antimicrobial treatment failure in institutionalized elderly with severe pneumonia. Am J Respir Crit Care Med 2002;166:1038-43
   PubMed Web of Science ®Google Scholar
• Polverino E, Dambrava P, Cillóniz C, et al. Nursing home-acquired pneumonia: a 10 year single-centre experience. Thorax 2010;65:354-9. Erratum in: Thorax 2010;65:844
   PubMed Web of Science ®Google Scholar
• Kollef M, Shorr A, Tabak Y, et al. Epidemiology and outcomes of health-care associated pneumonia: results from a large US database of culture positive pneumonia. Chest 2005;128:3854-62
   PubMed Web of Science ®Google Scholar
• Shorr AF, Zilberberg MD, Micek ST, et al. Prediction of infection due to antibiotic-resistant bacteria by select risk factors for health care-associated pneumonia. Arch Intern Med 2008;168:2205-10
   PubMed Web of Science ®Google Scholar
• Hutt E, Kramer AM. Evidence-based guidelines for management of nursing home-acquired pneumonia. J Fam Pract 2002;51:709-16
   PubMed Web of Science ®Google Scholar
• Bentley DW, Bradley S, High K, et al. Practice guidelines for evaluation of fever and infections in long-term care facilities. Clin Infect Dis 2000;31:640-53
   PubMedGoogle Scholar
• El Solh AA. Nursing home-acquired pneumonia. Semin Respir Crit Care Med 2009;30:16-25
   PubMed Web of Science ®Google Scholar
• El Solh A, Niderman M, Drinka P. Management of pneumonia in the nursing home. Chest (In Press)
   Google Scholar
• Dosa D. Should I hospitalize my resident with nursing home-acquired pneumonia? J Am Med Dir Assoc 2006;7(3 Suppl):S74-80, 73
   PubMedGoogle Scholar
• Fried TR, Gillick MR, Lipsitz LA. Whether to transfer? Factors associated with hospitalization and outcome of elderly long-term care patients with pneumonia. J Gen Intern Med 1995;10:246-50
   PubMed Web of Science ®Google Scholar
• Intrator O, Castle NG, Mor V. Facility characteristics associated with hospitalization of nursing home residents: Results of a national study. Med Care 1999;37:228-37
   PubMed Web of Science ®Google Scholar
• Mehr DR, Zweig SC, Kruse RL, et al. Mortality from lower respiratory infection in nursing home residents. A pilot prospective community-based study. J Fam Pract 1998;47:298-304
   PubMed Web of Science ®Google Scholar
• Fine MJ, Auble TE, Yealy DM, et al. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med 1997;336:243-50
   PubMed Web of Science ®Google Scholar
• Lim WS, van der Eerden MM, Laing R, et al. Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study. Thorax 2003;58:377-82
   PubMed Web of Science ®Google Scholar
• Mylotte JM, Naughton B, Saludades C, et al. Validation and application of the pneumonia prognosis index to nursing home residents with pneumonia. J Am Geriatr Soc 1998; 46:1538-44
   PubMed Web of Science ®Google Scholar
• Myint PK, Kamath AV, Vowler SL, et al. The CURB (confusion, urea, respiratory rate and blood pressure) criteria in community-acquired pneumonia (CAP) in hospitalized elderly patients aged 65 years and over: a prospective observational cohort study. Age Ageing 2005;34:75-7
   PubMed Web of Science ®Google Scholar
• Myint P, Kamath A, Vowler S, et al. British Thoracic Society. Severity assessment criteria recommended by the British Thoracic Society for community-acquired pneumonia and older patients. Should SOAR criteria be used in older people? A compilation study of two prospective cohorts. Age Ageing 2006;35:286-91
   PubMed Web of Science ®Google Scholar
• El Solh A, Alhajhusain A, Abou Jaoude P, et al. Validity of severity of scores in hospitalized patients with nursing home acquired pneumonia. Chest 2010 (In Press)
   Google Scholar
• Torres OH, Munoz J, Ruiz D, et al. Outcome predictors of pneumonia in elderly patients: importance of functional assessment. J Am Geriatr Soc 2004;52:1603-9
   PubMed Web of Science ®Google Scholar
• van der Steen JT, Mehr DR, Kruse RL, et al. Dementia, lower respiratory tract infection, and mortality. J Am Med Dir Assoc 2007;8:396-403
   PubMed Web of Science ®Google Scholar
• Mandell LA, Bartlett JG, Dowell SF, et al.; for the Infectious Diseases Society of America. Update of practice guidelines for the management of community-acquired pneumonia in immunocompetent adults. Clin Infect Dis 2003;37:1405-33
   PubMed Web of Science ®Google Scholar
• Mandell LA, Marrie TJ, Grossman RF, et al. Canadian guidelines for the initial management of community-acquired pneumonia: an evidence-based update by the Canadian Infectious Diseases Society and the Canadian Thoracic Society: The Canadian Community-Acquired Pneumonia Working Group. Clin Infect Dis 2000;31:383-421
   PubMedGoogle Scholar
• Gleason PP, Meehan TP, Fine JM, et al. Associations between initial antimicrobial therapy and medical outcomes for hospitalized elderly patients with pneumonia. Arch Intern Med 1999;159:2562-72
   PubMed Web of Science ®Google Scholar
• Cunha BA, Domenico PD, Cunha CB. Pharmacodynamics of doxycycline. Clin Microbiol Infect 2000;6:270-3
   PubMed Web of Science ®Google Scholar
• Pettersson E, Vernby A, Molstad S, et al. Infections and antibiotic prescribing in Swedish nursing homes: a cross-sectional study. Scand J Infect Dis 2008;40:393-8
   PubMed Web of Science ®Google Scholar
• American Thoracic Society Documents. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005;171:388-416
   PubMed Web of Science ®Google Scholar
• El-Solh AA, Pietrantoni C, Bhat A, et al. Microbiology of severe aspiration pneumonia in institutionalized elderly. Am J Respir Crit Care Med 2003;167:1650-4
   PubMed Web of Science ®Google Scholar
• Mylotte JM. Treatment of nursing home-acquired pneumonia: dogma vs. data. Am Fam Physician 2009;79:945-8
   PubMed Web of Science ®Google Scholar
• El Solh A, Akinnusi M, Alfarah Z, et al. Effect of antibiotic guidelines on outcomes of hospitalized patients with nursing home acquired pneumonia. J Am Geriatr Soc 2009;57:1030-5
   PubMed Web of Science ®Google Scholar
• Ruf B, Szucs T. Reducing the burden of influenza associated complications with antiviral therapy. Infection 2009;37:186-96
   PubMed Web of Science ®Google Scholar
• Houck PM, Bratzler DW, Nsa W, et al. Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia. Arch Intern Med 2004;164:637-44
   PubMedGoogle Scholar
• Marrie TJ, Wu L. Factors influencing in-hospital mortality in community acquired pneumonia: a prospective study of patients not initially admitted to the ICU. Chest 2005;127:1260-70
   PubMed Web of Science ®Google Scholar
• Frei CR, Restrepo MI, Mortensen EM, et al. Impact of guideline-concordant empiric antibiotic therapy in community-acquired pneumonia. Am J Med 2006;119:865-71
   PubMed Web of Science ®Google Scholar
• Mandell LA, Wunderink RG, Anzueto A, et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 2007;44(Suppl 2):S27-72
   PubMed Web of Science ®Google Scholar