2,334
Views
67
CrossRef citations to date
0
Altmetric
Diabetes: Review

A systematic literature review of methodologies used to assess medication adherence in patients with diabetes

, , , &
Pages 1071-1085 | Accepted 09 Jan 2014, Published online: 11 Feb 2014

References

  • Kurtz SM. Adherence to diabetes regimens: empirical status and clinical applications. Diabetes Educ 1990;16:50-9
  • Peyrot M, Rubin RR, Lauritzen T, et al. Psychosocial problems and barriers to improved diabetes management: results of the Cross-National Diabetes Attitudes, Wishes and Needs (DAWN) Study. Diabetic Med 2005;22:1379-85
  • World Health Organization. Adherence to long-term therapies: evidence for action. 2003; Available from: http://apps.who.int/medicinedocs/en/d/Js4883e/ [Last accessed 6 December 2012]
  • Cramer JA. A systematic review of adherence with medications for diabetes. Diabetes Care 2004;27:1218-24
  • Gonzalez JS, Schneider HE. Methodological issues in the assessment of diabetes treatment adherence. Curr Diabetes Rep 2011;11:472-9
  • Odegard PS, Capoccia K. Medication taking and diabetes: a systematic review of the literature. Diabetes Educ 2007;33:1014-29
  • Cramer JA, Roy A, Burrell A, et al. Medication compliance and persistence: terminology and definitions. Value Health 2008; 11:44-7
  • Peterson AM, Nau DP, Cramer JA, et al. A checklist for medication compliance and persistence studies using retrospective databases. Value Health 2007;10:3-12
  • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia 2012;55:1577-96
  • NICE. Type 2 diabetes: The management of type 2 diabetes. 2009. Available at: http://www.nice.org.uk/nicemedia/live/12165/44320/44320.pdf [Last accessed 6 December 2012]
  • UKPDS. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998;352:837-53
  • Nathan DM, Buse JB, Davidson MB, et al. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2009;32:193-203
  • Borus JS, Laffel L. Adherence challenges in the management of type 1 diabetes in adolescents: prevention and intervention. Curr Opin Pediatr 2010;22:405-11
  • Polonsky WH, Fisher L, Guzman S, et al. Psychological insulin resistance in patients with type 2 diabetes: the scope of the problem. Diabetes Care 2005;28:2543-5
  • Ho PM, Rumsfeld JS, Masoudi FA, et al. Effect of medication nonadherence on hospitalization and mortality among patients with diabetes mellitus. Arch Intern Med 2006;166:1836-41
  • Lau DT, Nau DP. Oral antihyperglycemic medication nonadherence and subsequent hospitalization among individuals with type 2 diabetes. Diabetes Care 2004;27:2149-53
  • Lee WC, Balu S, Cobden D, et al. Medication adherence and the associated health-economic impact among patients with type 2 diabetes mellitus converting to insulin pen therapy: an analysis of third-party managed care claims data. Clinical Therapeutics 2006;28:1712-25; discussion 10-1
  • Pladevall M, Williams LK, Potts LA, et al. Clinical outcomes and adherence to medications measured by claims data in patients with diabetes. Diabetes Care 2004;27:2800-5
  • Rozenfeld Y, Hunt JS, Plauschinat C, et al. Oral antidiabetic medication adherence and glycemic control in managed care. Am J Manag Care 2008;14:71-5
  • Salas M, Hughes D, Zuluaga A, et al. Costs of medication nonadherence in patients with diabetes mellitus: a systematic review and critical analysis of the literature. Value Health 2009;12:915-22
  • Sokol MC, McGuigan KA, Verbrugge RR, Epstein RS. Impact of medication adherence on hospitalization risk and healthcare cost. Med Care 2005;43:521-30
  • Vervloet M, van Dijk L, Santen-Reestman J, et al. Improving medication adherence in diabetes type 2 patients through Real Time Medication Monitoring: a randomised controlled trial to evaluate the effect of monitoring patients' medication use combined with short message service (SMS) reminders. BMC Health Serv Res 2011;11:5
  • Hood KK, Peterson CM, Rohan JM, Drotar D. Association between adherence and glycemic control in pediatric type 1 diabetes: a meta-analysis. Pediatrics 2009;124:e1171-9
  • Alvarez Guisasola F, Tofe Povedano S, Krishnarajah G, et al. Hypoglycaemic symptoms, treatment satisfaction, adherence and their associations with glycaemic goal in patients with type 2 diabetes mellitus: findings from the Real-Life Effectiveness and Care Patterns of Diabetes Management (RECAP-DM) Study. Diabetes Obes Metabol 2008;10(Suppl 1):25-32
  • Amsberg S, Anderbro T, Wredling R, et al. A cognitive behavior therapy-based intervention among poorly controlled adult type 1 diabetes patients – a randomized controlled trial. Patient Educ Couns 2009;72-80
  • Babamoto KS, Sey KA, Camilleri AJ, et al. Improving diabetes care and health measures among hispanics using community health workers: results from a randomized controlled trial. Health Educ Behav 2009;113-26
  • Bagner DM, Williams LB, Geffken GR, et al. Type 1 diabetes in youth: The relationship between adherence and executive functioning. Child Health Care 2007;36:169-79
  • Bailey GR, Barner JC, Weems JK, et al. Assessing barriers to medication adherence in underserved patients with diabetes in Texas. Diabetes Educ 2012;38:271-79
  • Billimek J, Sorkin DH. Self-reported neighborhood safety and nonadherence to treatment regimens among patients with type 2 diabetes. J Gen Intern Med 2012;27:292-96
  • Butler JM, Skinner M, Gelfand D, et al. Maternal parenting style and adjustment in adolescents with type I diabetes. J Pediatr Psychol 2007;32:1227-37
  • Cohen HW, Shmukler C, Ullman R, et al. Measurements of medication adherence in diabetic patients with poorly controlled HbA(1c). Diabetic Med 2010;210-6
  • Daly JM, Hartz AJ, Xu Y, et al. An assessment of attitudes, behaviors, and outcomes of patients with type 2 diabetes. Journal of the American Board of Family Medicine: JABFM 2009;22:280-90
  • Delahanty LM, Grant RW, Wittenberg E, et al. Association of diabetes-related emotional distress with diabetes treatment in primary care patients with Type 2 diabetes. Diabetic Med 2007;24:48-54
  • Drew LM, Berg C, Wiebe DJ. The mediating role of extreme peer orientation in the relationships between adolescent-parent relationship and diabetes management. J Fam Psych 2010;24:299-306
  • Ellis DA, Podolski C-L, Frey M, et al. The role of parental monitoring in adolescent health outcomes: Impact on regimen adherence in youth with type 1 diabetes. J Pediatr Psychol 2007;32:907-17
  • Fernandes R, Wales S, Crisp J, Kyngas H. Modification and testing of the Chronic Disease Compliance Instrument to measure treatment compliance in adolescents with diabetes. J Clin Nurs 2011;20:1273-81
  • Gialamas A, Yelland LN, Ryan P, et al. Does point-of-care testing lead to the same or better adherence to medication? A randomised controlled trial: the PoCT in General Practice Trial. Med J of Australia 2009;487-91
  • Gimenes HT, Zanetti ML, Haas VJ. Factors related to patient adherence to antidiabetic drug therapy. Rev Latino-Am Enfermagem 2009;17:46-51
  • Heisler M, Hofer TP, Klamerus ML, et al. Study protocol: the Adherence and Intensification of Medications (AIM) study – a cluster randomized controlled effectiveness study. Trials 2010;11:95
  • Kreyenbuhl J, Leith J, Medoff DR, et al. A comparison of adherence to hypoglycemic medications between Type 2 diabetes patients with and without serious mental illness. Psychiatry Res 2011;188:109-14
  • Lewin AB, Storch EA, Williams LB, et al. Brief report: Normative data on a structured interview for diabetes adherence in childhood. J Pediatr Psychol 2010;35:177-82
  • Mann DM, Ponieman D, Leventhal H, Halm EA. Predictors of adherence to diabetes medications: The role of disease and medication beliefs. J Behav Med 2009;32:278-84
  • Markowitz SM, Carper MM, Gonzalez JS, et al. Cognitive-behavioral therapy for the treatment of depression and adherence in patients with type 1 diabetes: pilot data and feasibility. Prim Care Companion CNS Disord 2012;14
  • Miller VA, Drotar D. Decision-making competence and adherence to treatment in adolescents with diabetes. J Pediatr Psychol 2007;32:178-88
  • Mulvaney SA, Rothman RL, Dietrich MS, et al. Using mobile phones to measure adolescent diabetes adherence. Health Psychol 2012;31:43-50
  • Nau DP, Aikens JE, Pacholski AM. Effects of gender and depression on oral medication adherence in persons with type 2 diabetes mellitus. Gender Medicine 2007;4:205-13
  • Nicklett EJ, Liang J. Diabetes-related support, regimen adherence, and health decline among older adults. J Gerontol B Psychol Sci Soc Sci 2010;65B:390-99
  • Odegard PS, Gray SL. Barriers to medication adherence in poorly controlled diabetes mellitus. Diabetes Educ 2008;34:692-97
  • Rhee MK, Ziemer DC, Caudle J, et al. Use of a uniform treatment algorithm abolishes racial disparities in glycemic control. Diabetes Educ 2008;34:655-63
  • Rothman RL, Mulvaney S, Elasy TA, et al. Self-management behaviors, racial disparities, and glycemic control among adolescents with type 2 diabetes. Pediatrics 2008;121:e912-9
  • Snoek FJ, van der Ven NC, Twisk JW, et al. Cognitive behavioural therapy (CBT) compared with blood glucose awareness training (BGAT) in poorly controlled Type 1 diabetic patients: long-term effects on HbA moderated by depression. A randomized controlled trial. Diabetic Med 2008;25:1337-42
  • Stewart SM, Wang JT, Wang Y-C, White PC. Patient- versus parent-reported psychological symptoms as predictors of type 1 diabetes management in adolescents. Child Health Care 2009;38:200-12
  • Tan MY, Magarey J. Self-care practices of Malaysian adults with diabetes and sub-optimal glycaemic control. Patient Educ Couns 2008;72:252-67
  • Tan MY, Magarey JM, Chee SS, et al. A brief structured education programme enhances self-care practices and improves glycaemic control in Malaysians with poorly controlled diabetes. Health education research 2011;26:896-907
  • Walker EA, Shmukler C, Ullman R, et al. Results of a successful telephonic intervention to improve diabetes control in urban adults: a randomized trial. Diabetes Care 2011;34:2-7
  • Wolever RQ, Dreusicke M, Fikkan J, et al. Integrative health coaching for patients with type 2 diabetes: a randomized clinical trial. Diabetes Educ 2010;36:629-39
  • Wysocki T, Harris MA, Buckloh LM, et al. Randomized trial of behavioral family systems therapy for diabetes: maintenance of effects on diabetes outcomes in adolescents. Diabetes Care 2007;30:555-60
  • Williams GC, Patrick H, Niemiec CP, et al. Reducing the health risks of diabetes: How self-determination theory may help improve medication adherence and quality of life. Diabetes Educ 2009;35:484-92
  • Zhang Y, Lave JR, Donohue JM, et al. The impact of Medicare part D on medication adherence among older adults enrolled in Medicare-advantage products. Medical care 2010;48:409-17
  • Kindmalm L, Melander A, Nilsson JL. Refill adherence of antihyperglycaemic drugs related to glucose control (HbA1c) in patients with type 2 diabetes. Acta Diabetologica 2007;44:209-13
  • Lin EH, Von Korff M, Ciechanowski P, et al. Treatment adjustment and medication adherence for complex patients with diabetes, heart disease, and depression: a randomized controlled trial. Ann Fam Med 2012;10:6-14
  • Rubak S, Sandbaek A, Lauritzen T, et al. Effect of "motivational interviewing" on quality of care measures in screen detected type 2 diabetes patients: a one-year follow-up of an RCT, ADDITION Denmark. Scand J Prim Health Care 2011;29:92-98
  • Lingvay I, Legendre JL, Kaloyanova PF, et al. Insulin-based versus triple oral therapy for newly diagnosed type 2 diabetes: which is better? Diabetes Care 2009;1789-95
  • Phumipamorn S, Pongwecharak J, Soorapan S, et al. Effects of the pharmacist's input on glycaemic control and cardiovascular risks in Muslim diabetes. Primary care diabetes 2008;2:31-7
  • Bogner HR, Morales KH, de Vries HF, Cappola AR. Integrated management of type 2 diabetes mellitus and depression treatment to improve medication adherence: a randomized controlled trial. Ann Fam Med 2012;15-22
  • Mulvaney SA, Rothman RL, Wallston KA, et al. An internet-based program to improve self-management in adolescents with type 1 diabetes. Diabetes Care 2010;33:602-4
  • Toussi M, Choleau C, Reach G, et al. A novel method for measuring patients' adherence to insulin dosing guidelines: introducing indicators of adherence. BMC Med Inform Decis Mak 2008;8:55
  • Morisky DE, Ang A, Krousel-Wood M, Ward HJ. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens (Greenwich) 2008;10:348-54
  • Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care 1986;24:67-74
  • French DP, Wade AN, Farmer AJ. Predicting self-care behaviours of patients with type 2 diabetes: the importance of beliefs about behaviour, not just beliefs about illness. J Psychosom Res 2013;74:327-33
  • Heisler M, Faul JD, Hayward RA, et al. Mechanisms for racial and ethnic disparities in glycemic control in middle-aged and older Americans in the health and retirement study. Arch of InternMed 2007;167:1853-60
  • Lu M, Safren SA, Skolnik PR, et al. Optimal recall period and response task for self-reported HIV medication adherence. AIDS Behav 2008;12:86-94
  • Naicker AS, Ohnmar H, Choon SK, et al. A study of risk factors associated with diabetic foot, knowledge and practice of foot care among diabetic patients. Int Med J 2009;16:189-93
  • Grant RW, Devita NG, Singer DE, Meigs JB. Improving adherence and reducing medication discrepancies in patients with diabetes. Ann Pharmacother 2003;37:962-9
  • Brod M, Rana A, Barnett AH. Adherence patterns in patients with type 2 diabetes on basal insulin analogues: missed, mistimed and reduced doses. Curr Med Res Opin 2012;28:1933-46
  • La Greca A, Follansbee D, Skyler J. Developmental and behavioral aspects of diabetes management in youngsters. Child Health Care 1990;19:132-39
  • La Greca AM, Auslander WF, Greco P, et al. I get by with a little help from my family and friends: adolescents' support for diabetes care. J Pediatr Psychol 1995;20:449-76
  • Frey MA, Ellis D, Naar-King S, Greger N. Diabetes management in adolescents in poor metabolic control. Diabetes Educ 2004;30:647-57
  • Kyngas HA, Skaar-Chandler CA, Duffy ME. The development of an instrument to measure the compliance of adolescents with a chronic disease. J Adv Nurs 2000;32:1499-506
  • Delgado AB, Lima ML. Contributo para a validacao concorrente de uma medida de adesao aos tratamentos. Psicologia, Saude & Doenças 2001;2:81-100
  • Svarstad BL, Chewning BA, Sleath BL, Claesson C. The Brief Medication Questionnaire: a tool for screening patient adherence and barriers to adherence. Patient Educ Couns 1999;37:113-24
  • Rhee MK, Slocum W, Ziemer DC, et al. Patient adherence improves glycemic control. Diabetes Educ 2005;31:240-50
  • Littlefield CH, Craven JL, Rodin GM, et al. Relationship of self-efficacy and binging to adherence to diabetes regimen among adolescents. Diabetes Care 1992;15:90-4
  • Levesque CS, Williams GC, Elliot D, et al. Validating the theoretical structure of the Treatment Self-Regulation Questionnaire (TSRQ) across three different health behaviors. Health Educ Res 2007;22:691-702
  • Adams AS, Trinacty CM, Zhang F, et al. Medication adherence and racial differences in A1C control. Diabetes Care 2008;31:916-21
  • Cobden D, Lee WC, Balu S, et al. Health outcomes and economic impact of therapy conversion to a biphasic insulin analog pen among privately insured patients with type 2 diabetes mellitus. Pharmacotherapy 2007;27:948-62
  • Colombi AM, Yu-Isenberg K, Priest J. The effects of health plan copayments on adherence to oral diabetes medication and health resource utilization. Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine 2008;50:535-41
  • Donnelly LA, Morris AD, Evans JM, collaboration DM. Adherence to insulin and its association with glycaemic control in patients with type 2 diabetes. QJM 2007;100:345-50
  • Egede LE, Gebregziabher M, Dismuke CE, et al. Medication nonadherence in diabetes: longitudinal effects on costs and potential cost savings from improvement. Diabetes Care 2012;35:2533-9
  • Grant R, Adams AS, Trinacty CM, et al. Relationship between patient medication adherence and subsequent clinical inertia in type 2 diabetes glycemic management. Diabetes Care 2007;30:807-12
  • Kalsekar I, Sheehan C, Peak A. Utilization patterns and medication adherence in patients with type 2 diabetes: Variations based on type of pharmacy (chain vs independent). Res Social Adm Pharm 2007;3:378-91
  • Kleinman NL, Schaneman JL, Lynch WD. The association of insulin medication possession ratio, use of insulin glargine, and health benefit costs in employees and spouses with type 2 diabetes. J Occup Environ Med 2008;50:1386-93
  • Krass I, Hebing R, Mitchell B, et al. Diabetes management in an Australian primary care population. J Clin Pharm Ther 2011;36:664-72
  • Kreyenbuhl J, Dixon LB, McCarthy JF, et al. Does adherence to medications for type 2 diabetes differ between individuals with vs without schizophrenia? Schizophr Bull 2010;36:428-35
  • Neugaard BI, Priest JL, Burch SP, et al. Quality of care for veterans with chronic diseases: Performance on quality indicators, medication use and adherence, and health care utilization. Popul Health Manag 2011;14:99-106
  • Piette JD, Heisler M, Ganoczy D, et al. Differential medication adherence among patients with schizophrenia and comorbid diabetes and hypertension. Psychiatr Serv 2007;58:207-12
  • Greco P, La Greca A, Ireland S, et al. Assessing adherence in IDDM: a comparison of two methods. Diabetes 1990;39:108A
  • La Greca AM, Swales T, Klemp S, Madigan S. Self care behaviors among adolescents with diabetes. 9th Annual Sessions of the Society of Behavioral Medicine. Baltimore, MD, 1988:A42.
  • Toobert DJ, Glasgow RE. Assessing diabetes self-management: the summary of diabetes self-care activities questionnaire. In: Bradley C, ed. Handbook of Psychology and Diabetes. Chur, Switzerland: Harwood Academic, 1994:351-75
  • Harris MA, Wysocki T, Sadler M, et al. Validation of a structured interview for the assessment of diabetes self-management. Diabetes Care 2000;23:1301-4
  • Wysocki T, Harris M, Buckloh L, et al. Randomized trial of behavioral family systems therapy for adolescents with diabetes: effects on diabetes outcomes. Diabetes Care 2004;53:441-6
  • Wysocki T, Harris MA, Wilkinson K, et al. Self-management competence as a predictor of outcomes of intensive therapy or usual care in youth with type 1 diabetes. Diabetes Care 2003;26:2043-7
  • Aikens JE, Piette JD. Longitudinal association between medication adherence and glycaemic control in Type 2 diabetes. Diabetic medicine : a journal of the British Diabetic Association 2013;30:338-44
  • Garber MC, Nau DP, Erickson SR, et al. The concordance of self-report with other measures of medication adherence: a summary of the literature. Medical care 2004;42:649-52

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.