Pulmonary embolism: current and new treatment options

References

• Lapner ST, Kearon C. Diagnosis and management of pulmonary embolism. Br Med J 2013;346:f757
   PubMed Web of Science ®Google Scholar
• Goldhaber SZ. Venous thromboembolism: epidemiology and magnitude of the problem. Best Pract Res Clin Haematol 2012;25:235-42
   PubMed Web of Science ®Google Scholar
• Muñoz FJ, Mismetti P, Poggio R, et al. Clinical outcome of patients with upper-extremity deep vein thrombosis: results from the RIETE Registry. Chest 2008;133:143-8
   PubMed Web of Science ®Google Scholar
• Hall D. Perioperative pulmonary embolism: detection, treatment, and outcomes. Am J Ther 2013;20:67-72
   PubMed Web of Science ®Google Scholar
• Tapson VF. Acute pulmonary embolism. N Engl J Med 2008;358:1037-52
   PubMed Web of Science ®Google Scholar
• den Exter PL, van Es J, Erkens PM, et al. Impact of delay in clinical presentation on the diagnostic management and prognosis of patients with suspected pulmonary embolism. Am J Respir Crit Care Med 2013;187:1369-73
   PubMed Web of Science ®Google Scholar
• Goldhaber SZ, Visani L, De Rosa M. Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER). Lancet 1999;353:1386-9
   PubMed Web of Science ®Google Scholar
• Torbicki A, Perrier A, Konstantinides S, et al. Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Eur Heart J 2008;29:2276-315
   PubMed Web of Science ®Google Scholar
• Kearon C, Akl EA, Comerota AJ, et al. Antithrombotic therapy for VTE disease: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2012;141:e419-4S
   Web of Science ®Google Scholar
• Franchini M, Mannucci PM. New anticoagulants for treatment of venous thromboembolism. Eur J Intern Med 2012;23:692-5
   PubMed Web of Science ®Google Scholar
• Huisman MV, Klok FA. How I diagnose acute pulmonary embolism. Blood 2013;121:4443-8
   PubMed Web of Science ®Google Scholar
• Tilyou S. PIOPED study compares lung scans and pulmonary arteriography. J Nucl Med 1989;30:279-80
   PubMed Web of Science ®Google Scholar
• Wells PS, Anderson DR, Rodger M, et al. Derivation of a simple clinical model to categorize patients' probability of pulmonary embolism: increasing the model's utility with the SimpliRED D-dimer. Thromb Haemost 2000;83:416-20
   PubMed Web of Science ®Google Scholar
• Wicki J, Perneger TV, Junod AF, et al. Assessing clinical probability of pulmonary embolism in the emergency ward: a simple score. Arch Intern Med 2001;161:92-7
   PubMed Web of Science ®Google Scholar
• Klok FA, Mos IC, Nijkeuter M, et al. Simplification of the revised Geneva score for assessing clinical probability of pulmonary embolism. Arch Intern Med 2008;168:2131-6
   PubMed Web of Science ®Google Scholar
• Miniati M, Bottai M, Monti S, et al. Simple and accurate prediction of the clinical probability of pulmonary embolism. Am J Respir Crit Care Med 2008;178:290-4
   PubMed Web of Science ®Google Scholar
• Kline JA, Mitchell AM, Kabrhel C, et al. Clinical criteria to prevent unnecessary diagnostic testing in emergency department patients with suspected pulmonary embolism. J Thromb Haemost 2004;2:1247-55
   PubMed Web of Science ®Google Scholar
• Le Gal G, Righini M, Roy PM, et al. Prediction of pulmonary embolism in the emergency department: the revised Geneva score. Ann Intern Med 2006;144:165-71
   PubMed Web of Science ®Google Scholar
• van Belle A, Büller HR, Huisman MV, et al. Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography. JAMA 2006;295:172-9
   PubMed Web of Science ®Google Scholar
• Penaloza A, Verschuren F, Meyer G, et al. Comparison of the unstructured clinician gestalt, the wells score, and the revised Geneva score to estimate pretest probability for suspected pulmonary embolism. Ann Emerg Med 2013;62:117-24
   PubMed Web of Science ®Google Scholar
• Ceriani E, Combescure C, Le Gal G, et al. Clinical prediction rules for pulmonary embolism: a systematic review and meta-analysis. J Thromb Haemost 2010;8:957-70
   PubMed Web of Science ®Google Scholar
• Chagnon I, Bounameaux H, Aujesky D, et al. Comparison of two clinical prediction rules and implicit assessment among patients with suspected pulmonary embolism. Am J Med 2002;113:269-75
   PubMed Web of Science ®Google Scholar
• Moores LK, Collen JF, Woods KM, et al. Practical utility of clinical prediction rules for suspected acute pulmonary embolism in a large academic institution. Thromb Res 2004;113:1-6
   PubMed Web of Science ®Google Scholar
• Tsimogianni AM, Rovina N, Porfyridis I, et al. Clinical prediction of pulmonary embolism in respiratory emergencies. Thromb Res 2011;127:411-17
   PubMed Web of Science ®Google Scholar
• Miniati M, Bottai M, Monti S. Comparison of 3 clinical models for predicting the probability of pulmonary embolism. Medicine (Baltimore) 2005;84:107-14
   PubMed Web of Science ®Google Scholar
• Calisir C, Yavas US, Ozkan IR, et al. Performance of the Wells and Revised Geneva scores for predicting pulmonary embolism. Eur J Emerg Med 2009;16:49-52
   PubMed Web of Science ®Google Scholar
• Arslan ED, Yesilaras SA, Kavalci C, et al. Prediction of pretest probability scoring systems in pulmonary embolism: Wells, Kline and Geneva. Int J Clin Med 2012;3:731-5
   Google Scholar
• Righini M, Bounameaux H. External validation and comparison of recently described prediction rules for suspected pulmonary embolism. Curr Opin Pulm Med 2004;10:345-9
   PubMed Web of Science ®Google Scholar
• Miniati M, Pistolesi M. Assessing the clinical probability of pulmonary embolism. Q J Nucl Med 2001;45:287-93
   PubMedGoogle Scholar
• Sharif-Kashani B, Bikdeli B, Ehteshami-Afshar S, et al. Wells' prediction rules for pulmonary embolism: valid in all clinical subgroups? Blood Coagul Fibrinolysis 2012;23:614-18
   PubMed Web of Science ®Google Scholar
• Posadas-Martinez ML, Vazquez FJ, Giunta DH, et al. Performance of the Wells score in patients with suspected pulmonary embolism during hospitalization: a delayed-type cross sectional study in a community hospital. Thromb Res 2014;133:177-81
   PubMed Web of Science ®Google Scholar
• Miniati M, Monti S, Bottai M. A structured clinical model for predicting the probability of pulmonary embolism. Am J Med 2003;114:173-9
   PubMed Web of Science ®Google Scholar
• Wolf SJ, McCubbin TR, Feldhaus KM, et al. Prospective validation of Wells criteria in the evaluation of patients with suspected pulmonary embolism. Ann Emerg Med 2004;44:503-10
   PubMed Web of Science ®Google Scholar
• Wells PS, Anderson DR, Rodger M, et al. Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and D-dimer. Ann Intern Med 2001;135:98-107
   PubMed Web of Science ®Google Scholar
• Yap KS, Kalff V, Turlakow A, et al. A prospective reassessment of the utility of the Wells score in identifying pulmonary embolism. Med J Aust 2007;187:333-6
   PubMed Web of Science ®Google Scholar
• Righini M, Aujesky D, Roy PM, et al. Clinical usefulness of D-dimer depending on clinical probability and cutoff value in outpatients with suspected pulmonary embolism. Arch Intern Med 2004;164:2483-7
   PubMed Web of Science ®Google Scholar
• Moores LK, Jackson WL Jr, Shorr AF, et al. Meta-analysis: outcomes in patients with suspected pulmonary embolism managed with computed tomographic pulmonary angiography. Ann Intern Med 2004;141:866-74
   PubMed Web of Science ®Google Scholar
• Righini M, Le Gal G, Aujesky D, et al. Diagnosis of pulmonary embolism by multidetector CT alone or combined with venous ultrasonography of the leg: a randomised non-inferiority trial. Lancet 2008;371:1343-52
   PubMed Web of Science ®Google Scholar
• Ghuysen A, Ghaye B, Willems V, et al. Computed tomographic pulmonary angiography and prognostic significance in patients with acute pulmonary embolism. Thorax 2005;60:956-61
   PubMed Web of Science ®Google Scholar
• Stein PD, Fowler SE, Goodman LR, et al. Multidetector computed tomography for acute pulmonary embolism. N Engl J Med 2006;354:2317-27
   PubMed Web of Science ®Google Scholar
• Schembri GP, Miller AE, Smart R. Radiation dosimetry and safety issues in the investigation of pulmonary embolism. Semin Nucl Med 2010;40:442-54
   PubMed Web of Science ®Google Scholar
• Miniati M, Pistolesi M, Marini C, et al. Value of perfusion lung scan in the diagnosis of pulmonary embolism: results of the Prospective Investigative Study of Acute Pulmonary Embolism Diagnosis (PISA-PED). Am J Respir Crit Care Med 1996;154:1387-93
   PubMed Web of Science ®Google Scholar
• Astani SA, Davis LC, Harkness BA, et al. Detection of pulmonary embolism during pregnancy: comparing radiation doses of CTPA and pulmonary scintigraphy. Nucl Med Commun 2014;45:704-11
   Google Scholar
• Anderson DR, Kahn SR, Rodger MA, et al. Computed tomographic pulmonary angiography vs ventilation-perfusion lung scanning in patients with suspected pulmonary embolism: a randomized controlled trial. JAMA 2007;298:2743-53
   PubMed Web of Science ®Google Scholar
• Gleeson FV, Turner S, Scarsbrook AF. Improving the diagnostic performance of lung scintigraphy in suspected pulmonary embolic disease. Clin Radiol 2006;61:1010-15
   PubMed Web of Science ®Google Scholar
• Hull RD, Hirsh J, Carter CJ, et al. Pulmonary angiography, ventilation lung scanning, and venography for clinically suspected pulmonary embolism with abnormal perfusion lung scan. Ann Intern Med 1983;98:891-9
   PubMed Web of Science ®Google Scholar
• Jiménez D, Aujesky D, Díaz G, et al. Prognostic significance of deep vein thrombosis in patients presenting with acute symptomatic pulmonary embolism. Am J Respir Crit Care Med 2010;181:983-91
   PubMed Web of Science ®Google Scholar
• Kasper W, Konstantinides S, Geibel A, et al. Management strategies and determinants of outcome in acute major pulmonary embolism: results of a multicenter registry. J Am Coll Cardiol 1997;30:1165-71
   PubMed Web of Science ®Google Scholar
• Torbicki A, Galie N, Covezzoli A, et al. Right heart thrombi in pulmonary embolism: results from the International Cooperative Pulmonary Embolism Registry. J Am Coll Cardiol 2003;41:2245-51
   PubMed Web of Science ®Google Scholar
• Kucher N, Rossi E, De Rosa M, et al. Massive pulmonary embolism. Circulation 2006;113:577-82
   PubMed Web of Science ®Google Scholar
• Aujesky D, Obrosky DS, Stone RA, et al. Derivation and validation of a prognostic model for pulmonary embolism. Am J Respir Crit Care Med 2005;172:1041-6
   PubMed Web of Science ®Google Scholar
• Jiménez D, Aujesky D, Moores L, et al. Simplification of the Pulmonary Embolism Severity Index for prognostication in patients with acute symptomatic pulmonary embolism. Arch Intern Med 2010;170:1383-9
   PubMed Web of Science ®Google Scholar
• Donze J, Le Gal G, Fine MJ, et al. Prospective validation of the Pulmonary Embolism Severity Index. A clinical prognostic model for pulmonary embolism. Thromb Haemost 2008;100:943-8
   PubMed Web of Science ®Google Scholar
• Righini M, Roy PM, Meyer G, et al. The Simplified Pulmonary Embolism Severity Index (PESI): validation of a clinical prognostic model for pulmonary embolism. J Thromb Haemost 2011;9:2115-17
   PubMed Web of Science ®Google Scholar
• Aujesky D, Roy PM, Verschuren F, et al. Outpatient versus inpatient treatment for patients with acute pulmonary embolism: an international, open-label, randomised, non-inferiority trial. Lancet 2011;378:41-8
   PubMed Web of Science ®Google Scholar
• Burns SK, Haramati LB. Diagnostic imaging and risk stratification of patients with acute pulmonary embolism. Cardiol Rev 2012;20:15-24
   PubMed Web of Science ®Google Scholar
• Becattini C, Vedovati MC, Agnelli G. Prognostic value of troponins in acute pulmonary embolism: a meta-analysis. Circulation 2007;116:427-33
   PubMed Web of Science ®Google Scholar
• Klok FA, Mos IC, Huisman MV. Brain-type natriuretic peptide levels in the prediction of adverse outcome in patients with pulmonary embolism: a systematic review and meta-analysis. Am J Respir Crit Care Med 2008;178:425-30
   PubMed Web of Science ®Google Scholar
• Konstantinides S, Meyer G, Danays T, et al. Pulmonary Embolism Thrombolysis Study: an investigator-initiated, investigator-sponsored trial. American College of Cardiology 2013 62nd Annual Scientific Session. San Francisco, USA, 9–11 March 2013; Oral presentation 304-15
   Google Scholar
• Wan S, Quinlan DJ, Agnelli G, et al. Thrombolysis compared with heparin for the initial treatment of pulmonary embolism: a meta-analysis of the randomized controlled trials. Circulation 2004;110:744-9
   PubMed Web of Science ®Google Scholar
• Tapson VF. Thrombolytic therapy for acute pulmonary embolism. Semin Thromb Hemost 2013;39:452-8
   PubMed Web of Science ®Google Scholar
• Meneveau N, Seronde MF, Blonde MC, et al. Management of unsuccessful thrombolysis in acute massive pulmonary embolism. Chest 2006;129:1043-50
   PubMed Web of Science ®Google Scholar
• Pirmohamed M. Warfarin: almost 60 years old and still causing problems. Br J Clin Pharmacol 2006;62:509-11
   PubMed Web of Science ®Google Scholar
• Scaglione F. New oral anticoagulants: comparative pharmacology with vitamin K antagonists. Clin Pharmacokinet 2013;52:69-82
   PubMed Web of Science ®Google Scholar
• Willey VJ, Bullano MF, Hauch O, et al. Management patterns and outcomes of patients with venous thromboembolism in the usual community practice setting. Clin Ther 2004;26:1149-59
   PubMed Web of Science ®Google Scholar
• The EINSTEIN–PE Investigators. Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. N Engl J Med 2012;366:1287-97
   PubMed Web of Science ®Google Scholar
• Schulman S, Kearon C, Kakkar AK, et al. Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med 2009;361:2342-52
   PubMed Web of Science ®Google Scholar
• Oake N, Fergusson DA, Forster AJ, et al. Frequency of adverse events in patients with poor anticoagulation: a meta-analysis. CMAJ 2007;176:1589-94
   PubMed Web of Science ®Google Scholar
• Poli D, Antonucci E, Testa S, et al. Bleeding risk in very old patients on vitamin K antagonist treatment: results of a prospective collaborative study on elderly patients followed by Italian Centres for Anticoagulation. Circulation 2011;124:824-9
   PubMed Web of Science ®Google Scholar
• Hamby L, Weeks WB, Malikowski C. Complications of warfarin therapy: causes, costs, and the role of the anticoagulation clinic. Eff Clin Pract 2000;3:179-84
   PubMedGoogle Scholar
• Bayer Pharma AG. Xarelto (rivaroxaban) Summary of Product Characteristics. 2013. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000944/WC500057108.pdf [Last accessed 16 May 2014]
   Google Scholar
• Harder S, Graff J. Novel oral anticoagulants: clinical pharmacology, indications and practical considerations. Eur J Clin Pharmacol 2013;69:1617-33
   PubMed Web of Science ®Google Scholar
• Bristol-Myers Squibb, Pfizer EEIG. Eliquis (apixaban) Summary of Product Characteristics. 2013. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002148/WC500107728.pdf [Last accessed 16 May 2014]
   Google Scholar
• Boehringer Ingelheim International GmbH. Pradaxa (dabigatran etexilate) Summary of Product Characteristics. 2014. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000829/WC500041059.pdf [Last accessed 16 May 2014]
   Google Scholar
• Agnelli G, Buller HR, Cohen A, et al. Oral apixaban for the treatment of acute venous thromboembolism. N Engl J Med 2013;369:799-808
   PubMed Web of Science ®Google Scholar
• The Hokusai-VTE Investigators. Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism. N Engl J Med 2013;369:1406-15
   PubMed Web of Science ®Google Scholar
• Schulman S, Kakkar AK, Goldhaber SZ, et al. Treatment of acute venous thromboembolism with dabigatran or warfarin and pooled analysis. Circulation 2014;129:764-72
   PubMed Web of Science ®Google Scholar
• The EINSTEIN Investigators. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med 2010;363:2499-510
   PubMed Web of Science ®Google Scholar
• Agnelli G, Buller HR, Cohen A, et al. Apixaban for extended treatment of venous thromboembolism. N Engl J Med 2013;368:699-708
   PubMed Web of Science ®Google Scholar
• Schulman S, Kearon C, Kakkar AK, et al. Extended use of dabigatran, warfarin, or placebo in venous thromboembolism. N Engl J Med 2013;368:709-18
   PubMed Web of Science ®Google Scholar
• Rivaroxaban for treating pulmonary embolism and preventing recurrent venous thromboembolism; NICE technology appraisal guidance 287. National Institute for Health and Care Excellence, 2013. Available at: http://www.nice.org.uk/nicemedia/live/14192/64274/64274.pdf [Last accessed 20 May 2014]
   Google Scholar
• Boehringer Ingelheim Pharmaceuticals Inc. Pradaxa (dabigatran etexilate) Prescribing Information. 2014. Available at: http://bidocs.boehringer-ingelheim.com/BIWebAccess/ViewServlet.ser?docBase=renetnt&folderPath=/Prescribing%20Information/PIs/Pradaxa/Pradaxa.pdf [Last accessed 16 May 2014]
   Google Scholar
• Kaatz S, Crowther M. Reversal of target-specific oral anticoagulants. J Thromb Thrombolysis 2013;36:195-202
   PubMed Web of Science ®Google Scholar
• Siegal DM, Crowther MA. Acute management of bleeding in patients on novel oral anticoagulants. Eur Heart J 2013;34:489-98
   PubMed Web of Science ®Google Scholar
• Eerenberg ES, Kamphuisen PW, Sijpkens MK, et al. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation 2011;124:1573-9
   PubMed Web of Science ®Google Scholar
• Galan AM, Arellano-Rodrigo E, Sanz V, et al. Effects of rivaroxaban and dabigatran on hemostasis and reversion of their antithrombotic effects by different coagulation factors: evidence raised from a clinical study in healthy volunteers. J Thromb Haemost 2013;11(Suppl 2):1–1322. Abstract PA 3. 10-6
   Google Scholar
• Levi M, Moore T, Castillejos C, et al. Effects of three-factor and four-factor prothrombin complex concentrates on the pharmacodynamics of rivaroxaban. J Thromb Haemost 2013;11:167: Abstract OC 36.5
   Web of Science ®Google Scholar
• Brighton TA, Eikelboom JW, Mann K, et al. Low-dose aspirin for preventing recurrent venous thromboembolism. N Engl J Med 2012;367:1979-87
   PubMed Web of Science ®Google Scholar
• Becattini C, Agnelli G, Schenone A, et al. Aspirin for preventing the recurrence of venous thromboembolism. N Engl J Med 2012;366:1959-67
   PubMed Web of Science ®Google Scholar
• Warkentin TE. Aspirin for dual prevention of venous and arterial thrombosis. N Engl J Med 2012;367:2039-41
   PubMed Web of Science ®Google Scholar
• Desai SR. Unsuspected pulmonary embolism on CT scanning: yet another headache for clinicians? Thorax 2007;62:470-2
   PubMed Web of Science ®Google Scholar
• Abdel-Razeq HN, Mansour AH, Ismael YM. Incidental pulmonary embolism in cancer patients: clinical characteristics and outcome – a comprehensive cancer center experience. Vasc Health Risk Manag 2011;7:153-8
   PubMedGoogle Scholar
• Goodman LR. Small pulmonary emboli: what do we know? Radiology 2005;234:654-8
   PubMed Web of Science ®Google Scholar
• Stein PD, Goodman LR, Hull RD, et al. Diagnosis and management of isolated subsegmental pulmonary embolism: review and assessment of the options. Clin Appl Thromb Hemost 2012;18:20-6
   PubMed Web of Science ®Google Scholar
• Le Gal G, Righini M, Parent F, et al. Diagnosis and management of subsegmental pulmonary embolism. J Thromb Haemost 2006;4:724-31
   PubMed Web of Science ®Google Scholar
• den Exter PL, van Es J, Klok FA, et al. Risk profile and clinical outcome of symptomatic subsegmental acute pulmonary embolism. Blood 2013;122:1144-9
   PubMed Web of Science ®Google Scholar
• Douketis JD, Spyropoulos AC, Spencer FA, et al. Perioperative management of antithrombotic therapy: antithrombotic therapy and prevention of thrombosis: American College of Chest Physicians evidence-based clinical practice guidelines (9th Edition). Chest 2012;141:e326-50S
   Web of Science ®Google Scholar
• Spyropoulos AC, Douketis JD. How I treat anticoagulated patients undergoing an elective procedure or surgery. Blood 2012;120:2954-62
   PubMed Web of Science ®Google Scholar
• Dunn AS, Spyropoulos AC, Turpie AGG. Bridging therapy in patients on long-term oral anticoagulants who require surgery: the Prospective Peri-operative Enoxaparin Cohort Trial (PROSPECT). J Thromb Haemost 2007;5:2211-18
   PubMed Web of Science ®Google Scholar
• Baron TH, Kamath PS, McBane RD. Management of antithrombotic therapy in patients undergoing invasive procedures. N Engl J Med 2013;368:2113-24
   PubMed Web of Science ®Google Scholar
• Clark SL, Belfort MA, Dildy GA, et al. Maternal death in the 21st century: causes, prevention, and relationship to cesarean delivery. Am J Obstet Gynecol 2008;199:36.e1-5
   PubMed Web of Science ®Google Scholar
• Kayem G, Kurinczuk J, Lewis G, et al. Risk factors for progression from severe maternal morbidity to death: a national cohort study. PLoS One 2011;6:e29077
   PubMed Web of Science ®Google Scholar
• Kline JA, Williams GW, Hernandez-Nino J. D-dimer concentrations in normal pregnancy: new diagnostic thresholds are needed. Clin Chem 2005;51:825-9
   PubMed Web of Science ®Google Scholar
• Ridge CA, McDermott S, Freyne BJ, et al. Pulmonary embolism in pregnancy: comparison of pulmonary CT angiography and lung scintigraphy. Am J Roentgenol 2009;193:1223-7
   PubMed Web of Science ®Google Scholar
• Cahill AG, Stout MJ, Macones GA, et al. Diagnosing pulmonary embolism in pregnancy using computed-tomographic angiography or ventilation-perfusion. Obstet Gynecol 2009;114:124-9
   PubMed Web of Science ®Google Scholar
• Wilbur J, Shian B. Diagnosis of deep venous thrombosis and pulmonary embolism. Am Fam Physician 2012;86:913-19
   PubMed Web of Science ®Google Scholar
• Wainwright H, Beighton P. Warfarin embryopathy: fetal manifestations. Virchows Arch 2010;457:735-9
   PubMed Web of Science ®Google Scholar
• Bates SM, Greer IA, Middeldorp S, et al. VTE, thrombophilia, antithrombotic therapy, and pregnancy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2012;141:e691-736S
   Web of Science ®Google Scholar
• Greer I, Hunt BJ. Low molecular weight heparin in pregnancy: current issues. Br J Haematol 2005;128:593-601
   PubMed Web of Science ®Google Scholar
• Kominiarek MA, Angelopoulos SM, Shapiro NL, et al. Low-molecular-weight heparin in pregnancy: peripartum bleeding complications. J Perinatol 2007;27:329-34
   PubMed Web of Science ®Google Scholar
• Horlocker TT, Wedel DJ, Rowlingson JC, et al. Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Third Edition). Reg Anesth Pain Med 2010;35:64-101
   PubMed Web of Science ®Google Scholar
• te Raa GD, Ribbert LS, Snijder RJ, et al. Treatment options in massive pulmonary embolism during pregnancy; a case-report and review of literature. Thromb Res 2009;124:1-5
   PubMed Web of Science ®Google Scholar
• Letai A, Kuter DJ. Cancer, coagulation, and anticoagulation. Oncologist 1999;4:443-9
   PubMedGoogle Scholar
• Agnelli G, Verso M. Management of venous thromboembolism in patients with cancer. J Thromb Haemost 2011;9(Suppl 1):316-24
   PubMed Web of Science ®Google Scholar
• Mandala M, Falanga A, Roila F. Management of venous thromboembolism in cancer patients: ESMO clinical recommendations. Ann Oncol 2009;20(Suppl 4):182-4
   PubMedGoogle Scholar
• Knowlson L, Bacchu S, Paneesha S, et al. Elevated D-dimers are also a marker of underlying malignancy and increased mortality in the absence of venous thromboembolism. J Clin Pathol 2010;63:818-22
   PubMed Web of Science ®Google Scholar
• Lee AY, Levine MN, Baker RI, et al. Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med 2003;349:146-53
   PubMed Web of Science ®Google Scholar
• Meyer G, Marjanovic Z, Valcke J, et al. Comparison of low-molecular-weight heparin and warfarin for the secondary prevention of venous thromboembolism in patients with cancer: a randomized controlled study. Arch Intern Med 2002;162:1729-35
   PubMed Web of Science ®Google Scholar
• Hull RD, Pineo GF, Brant RF, et al. Long-term low-molecular-weight heparin versus usual care in proximal-vein thrombosis patients with cancer. Am J Med 2006;119:1062-72
   PubMed Web of Science ®Google Scholar
• Kakkar AK, Levine MN, Kadziola Z, et al. Low molecular weight heparin, therapy with dalteparin, and survival in advanced cancer: the Fragmin Advanced Malignancy OUtcome Study (FAMOUS). J Clin Oncol 2004;22:1944-8
   PubMed Web of Science ®Google Scholar
• Farge D, Debourdeau P, Beckers M, et al. International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer. J Thromb Haemost 2013;11:56-70
   PubMed Web of Science ®Google Scholar
• den Exter PL, Hooijer J, Dekkers OM, et al. Risk of recurrent venous thromboembolism and mortality in patients with cancer incidentally diagnosed with pulmonary embolism: a comparison with symptomatic patients. J Clin Oncol 2011;29:2405-9
   PubMed Web of Science ®Google Scholar
• Konstantinides S, Goldhaber SZ. Pulmonary embolism: risk assessment and management. Eur Heart J 2012;33:3014-22
   PubMed Web of Science ®Google Scholar