The mechanism of action of gefarnate in the light of the latest data on digestive physiopathlogy

References

• Adami, E., Marazzi-Uberti, E., and Turba, C., (1964). Pharmacological research on gefarnate, a new synthetic isoprenoid with an anti-ulcer action. Arch. Int. Pharmacodyn. Ther., 147, 113.1. Adami, E., Marazzi-Uberti, E., and Turba, C., (1964). Pharmacological research on gefarnate, a new synthetic isoprenoid with an anti-ulcer action. Arch. Int. Pharmacodyn. Ther., 147, 113.
   PubMedGoogle Scholar
• Adam, E., and Giorgi-Conciato, M., (1971). Farmacologia e clinica del gefarnato. “Aggiornamenti di “Gastroenterologia”, Edizioni Scientifiche, p.629. Istituto De Angeli, Milano.2. Adam, E., and Giorgi-Conciato, M., (1971). Farmacologia e clinica del gefarnato. In ”Aggiornamenti di Gastroenterologia”, Edizioni Scientifiche, p.629. Istituto De Angeli, Milano.
   Google Scholar
• Baron, J. H., (1963). Studies of basal and peak acid output with an augmented histamine test. Gut, 4, 243.3. Baron, J. H., (1963). Studies of basal and peak acid output with an augmented histamine test. Gut, 4, 243.
   PubMed Web of Science ®Google Scholar
• Baron, J. H., (1970). The clinical use of gastric function test. Scand. J. Gastroent., Suppl., 6, 9.4. Baron, J. H., (1970). The clinical use of gastric function test. Scand. J. Gastroent., Suppl., 6, 9.
   PubMedGoogle Scholar
• Boas, N. F., (1953). Method for the determination of hexosamines in tissues. J. Biol. Chem., 204, 553.5. Boas, N. F., (1953). Method for the determination of hexosamines in tissues. J. Biol. Chem., 204, 553.
   PubMed Web of Science ®Google Scholar
• Celli, L., (1972). Regurgitation gastropathy. Proceedings of 2nd Congress of Jugoslavian Gastroenterologists, OhridMay 28th-31st, 1972.6. Celli, L., (1972). Regurgitation gastropathy. Proceedings of 2nd Congress of Jugoslavian Gastroenterologists, Ohrid, May 28th-31st, 1972.
   Google Scholar
• Cesco, G., (1967). 11 farnesilacetato di geranile come preventivo e curativo dei disturbi da cortisonici sull'apparato digerente. Minerva Gastroenterol., 13, 152.7. Cesco, G., (1967). 11 farnesilacetato di geranile come preventivo e curativo dei disturbi da cortisonici sull'apparato digerente. Minerva Gastroenterol., 13, 152.
   PubMedGoogle Scholar
• von Cieciura, L., Himmel, A., and Trief, H., (1968). Histochemische Untersuchungen der Mucopolysaccharide der Magenschleimhaut des Menschen. Acta Histocheni. Bd., 30, 31.8. von Cieciura, L., Himmel, A., and Trief, H., (1968). Histochemische Untersuchungen der Mucopolysaccharide der Magenschleimhaut des Menschen. Acta Histocheni. Bd., 30, 31.
   PubMedGoogle Scholar
• Coppi, G., Bonardi, G., and Martinelli, E., (1969). On the metabolic fate of gefarnate in rats. Arzneim.-forsch., 19, 1519.9. Coppi, G., Bonardi, G., and Martinelli, E., (1969). On the metabolic fate of gefarnate in rats. Arzneim.-forsch., 19, 1519.
   PubMed Web of Science ®Google Scholar
• Davenport, H. W., (1964). Gastric mucosal injury by fatty and acetylsalicyclic acids. Gustroenterology, 46, 245.10. Davenport, H. W., (1964). Gastric mucosal injury by fatty and acetylsalicyclic acids. Gustroenterology, 46, 245.
   PubMed Web of Science ®Google Scholar
• Davenport, H. W., Warner, H. A., and Code, C. F., (1964). Functional significance of gastric mucosal barrier to sodium. Gastroenterology, 47, 142.11. Davenport, H. W., Warner, H. A., and Code, C. F., (1964). Functional significance of gastric mucosal barrier to sodium. Gastroenterology, 47, 142.
   PubMed Web of Science ®Google Scholar
• Fanteria, E., and Mordini, M., (1971). Azione normalizzatrice del gefarnato sulla funzione gastrica in corso di trattamento cortisonico. Minerva Gastroenterol., 17, 32.12. Fanteria, E., and Mordini, M., (1971). Azione normalizzatrice del gefarnato sulla funzione gastrica in corso di trattamento cortisonico. Minerva Gastroenterol., 17, 32.
   PubMedGoogle Scholar
• Gad, A., (1969). A histochemical study of human alimentary tract mucosubstances in health and disease. Brit. J. Cancer, 1, 52.13. Gad, A., (1969). A histochemical study of human alimentary tract mucosubstances in health and disease. Brit. J. Cancer, 1, 52.
   Google Scholar
• Gasbarrini, G., and Miglio, F., (1971). L'importanza della biopsia perorale nella diagnosi delle malattie non neoplastiche dello stomaco. In “Aggiomamenti di Gastroenterologia”. Edizioni Scientifiche, p.195. Istituto De Angeli, Milano.14. Gasbarrini, G., and Miglio, F., (1971). L'importanza della biopsia perorale nella diagnosi delle malattie non neoplastiche dello stomaco. In “Aggiomamenti di Gastroenterologia”. Edizioni Scientifiche, p.195. Istituto De Angeli, Milano.
   Google Scholar
• Labb, G., Barbara, L., Vezzadini, P., and Corinaldesi, R., (1970). Development of a radio-immunoassay for the measurement of gastrin. 4th World Congress of Gastroenterology. CopenhagenDenmark.15. Labb, G., Barbara, L., Vezzadini, P., and Corinaldesi, R., (1970). Development of a radio-immunoassay for the measurement of gastrin. 4th World Congress of Gastroenterology. CopenhagenDenmark.
   Google Scholar
• Labb, G., Barbara, L., Vezzadini, P., and Bussolati, G., (1973). Rendic. Gastroenterol.. In press.16. Labb, G., Barbara, L., Vezzadini, P., and Bussolati, G., (1973). Rendic. Gastroenterol. In press.
   Google Scholar
• Lambert, R., Granthil, G, and Minaire, Y., (1972). L'exploration de la sécretion acide de I'estomac chez I'homme. Lyon med., 227, 545.17. Lambert, R., Granthil, G, and Minaire, Y., (1972). L'exploration de la sécretion acide de I'estomac chez I'homme. Lyon med., 227, 545.
   PubMedGoogle Scholar
• Lipkin, M., (1971). In “defence” of the gastric mucosa. Gut, 12, 599.18. Lipkin, M., (1971). In “defence” of the gastric mucosa. Gut, 12, 599.
   PubMed Web of Science ®Google Scholar
• McGuigan, J. E., (1968). Radioimmunoassay of gastrin. Gastroenterology., 54, 1005.19. McGuigan, J. E., (1968). Radioimmunoassay of gastrin. Gastroenterology., 54, 1005.
   PubMed Web of Science ®Google Scholar
• McGuigan, J. E., and Trudeau, W. L., (1970). Studies with antibodies to gastrin: radioimmunoassay in human serum and physiological studies. Gastroenterology, 58, 139.20. McGuigan, J. E., and Trudeau, W. L., (1970). Studies with antibodies to gastrin: radioimmunoassay in human serum and physiological studies. Gastroenterology, 58, 139.
   PubMedGoogle Scholar
• Menguy, R., and Desbaillets, L., (1968). The gastric mucous barrier: influence of protein-bound carbohydrate in mucus on the rate of proteolysis of gastric mucus. Ann. Surg., 168, 475.21. Menguy, R., and Desbaillets, L., (1968). The gastric mucous barrier: influence of protein-bound carbohydrate in mucus on the rate of proteolysis of gastric mucus. Ann. Surg., 168, 475.
   PubMed Web of Science ®Google Scholar
• Mori, G., Cova, D., and Ingrami, A., (1969). Fluorimetric evaluation of Schiff-positive gastric mucines in rats treated with gefarnate. VIIIth Intern. Congress of Gastroenterology, July 7th-13th, 1968, Prague, p.67. Ed:Gregor, O. and Riedl, O.,Prague. F.K. . Schattauer Verlag, Stuttgart and New York.22. Mori, G., Cova, D., and Ingrami, A., (1969). Fluorimetric evaluation of Schiff-positive gastric mucines in rats treated with gefarnate. VIIIth Intern. Congress of Gastroenterology, July 7th-13th, 1968, Prague, p.67. Gregor, O. and Riedl, O., Prague. F.K. Schattauer Verlag, Stuttgart and New York.
   Google Scholar
• Murari, G., (1964). Pharmacological investigation on gefarnate, a new synthetic compound against gastric ulcer. Med. Exp., 11, 361.23. Murari, G., (1964). Pharmacological investigation on gefarnate, a new synthetic compound against gastric ulcer. Med. Exp., 11, 361.
   PubMedGoogle Scholar
• Piper, D. W., Griffith, E. M., and Fenton, B. H., (1965). Gastric mucus secretion in normal subjects and patients with gastric ulcer, gastric carcinoma, and pernicious anemia. Amer. J. Dig. Dis., 10, 411.24. Piper, D. W., Griffith, E. M., and Fenton, B. H., (1965). Gastric mucus secretion in normal subjects and patients with gastric ulcer, gastric carcinoma, and pernicious anemia. Amer. J. Dig. Dis., 10, 411.
   Google Scholar
• Robinson, L. A., and White, T. T., (1970). A spectrophotometric method for the analysis of pepsin. Gastroenterology, 58, 798.25. Robinson, L. A., and White, T. T., (1970). A spectrophotometric method for the analysis of pepsin. Gastroenterology, 58, 798.
   PubMed Web of Science ®Google Scholar
• Ruckley, E. V., and Sircus, W., (1970). Tests for gastric secretory function and their clinical application. Progress in Gastroznterology, 2, p.73. G. B. J. Glass. Grum & Stratton, New York.26. Ruckley, E. V., and Sircus, W., (1970). Tests for gastric secretory function and their clinical application. Progress in Gastroznterology, 2, p.73. G. B. J. Glass. Grum & Stratton, New York.
   Google Scholar
• Schrager, J., (1970). The chemical composition and function of gastro-intestinal mucus. Gut, 11, 450.27. Schrager, J., (1970). The chemical composition and function of gastro-intestinal mucus. Gut, 11, 450.
   PubMed Web of Science ®Google Scholar
• Schrager, J., and Oates, M. D. G., (1971). The isolation and partial characterisation of the principal gastric glycoprotein of “visible” mucus. Digestion, 4, 1.28. Schrager, J., and Oates, M. D. G., (1971). The isolation and partial characterisation of the principal gastric glycoprotein of “visible” mucus. Digestion, 4, 1.
   PubMed Web of Science ®Google Scholar
• Takagi, K., and Okabe, S., (1968). The effect of drugs on the production and recovery processes of the stress ulcer. Jap. J. Pharmacol., 18, 9.29. Takagi, K., and Okabe, S., (1968). The effect of drugs on the production and recovery processes of the stress ulcer. Jap. J. Pharmacol., 18, 9.
   PubMedGoogle Scholar
• Takagi, K., and Yano, S., (1972). Effect of anti-ulcer drugs on gastric mucous hexosamine in rats subjected to several ulcerogenic conditions. Chem. Pharm. Bull., 20, 1170.30. Takagi, K., and Yano, S., (1972). Effect of anti-ulcer drugs on gastric mucous hexosamine in rats subjected to several ulcerogenic conditions. Chem. Pharm. Bull., 20, 1170.
   PubMed Web of Science ®Google Scholar