36
Views
47
CrossRef citations to date
0
Altmetric
Research Article

Structural analysis of the actions of amphetamine and fenfluramine on food intake and feeding behaviour in animals and in man

, , , &
Pages 34-54 | Accepted 19 Oct 1978, Published online: 21 Aug 2008

References

  • Ashley D. V. M., Anderson G. H. Correlation between the plasma tryptophan to neutral amino acid ratio and protein intake in the self-selecting weanling rat. J. Nutr. 1975; 105: 14121. Ashley D. V. M., Anderson G. H. Correlation between the plasma tryptophan to neutral amino acid ratio and protein intake in the self-selecting weanling rat. J. Nutr. 1975; 105: 1412
  • Bernier A., Sicot N., Le Douarec J. C. Action compared de la fenfluramine et de l'amph6tamine chez les rats obèses hypothalmiques. Rev. Fr. Etud. Clin. Biol. 1969; 14: 7622. Bernier A., Sicot N., Le Douarec J. C. Action compared de la fenfluramine et de l'amph6tamine chez les rats obèses hypothalmiques. Rev. Fr. Etud. Clin. Biol. 1969; 14: 762
  • Blundell J. E. Possible mechanism for the effects of anorectic agents on feeding and hoarding behaviour. Psychopharmacol. 1971; 22: 2243. Blundell J. E. Possible mechanism for the effects of anorectic agents on feeding and hoarding behaviour. Psychopharmacol. 1971; 22: 224
  • Blundell J. E. Physiological Psychology. Methuen, London 19754. Blundell J. E. Physiological Psychology. Methuen, London 1975
  • Blundell J. E. Anorexic drugs, food intake and the study of obesity. Nutrition 1975; 29: 55. Blundell J. E. Anorexic drugs, food intake and the study of obesity. Nutrition 1975; 29: 5
  • Blundell J. E. The CNS and feeding - group report. Appetite and Food Intake, T. Silverstone. Dahlem Konferenzen, Berlin 1976; 109–1286. Blundell J. E. The CNS and feeding - group report. Appetite and Food Intake, T. Silverstone. Dahlem Konferenzen, Berlin 1976; 109–128
  • Blundell J. E. Strategies and tactics in the use of anti-obesity drugs. Lancet 1976; 1: 8047. Blundell J. E. Strategies and tactics in the use of anti-obesity drugs. Lancet 1976; 1: 804
  • Blundell J. E. Is there a role for serotonin (5-hydroxytryptamine) in feeding?. Int. J. Obesity 1977; 1: 158. Blundell J. E. Is there a role for serotonin (5-hydroxytryptamine) in feeding?. Int. J. Obesity 1977; 1: 15
  • Blundell J. E. Hunger and satiety in the control of food intake: implications for the treatment of obesity. Clin. Dietet. 1977; 23: 2579. Blundell J. E. Hunger and satiety in the control of food intake: implications for the treatment of obesity. Clin. Dietet. 1977; 23: 257
  • Blundell J. E. Serotonin and feeding. Serotonin in Health and Disease, Vol. 5 Clinical Applications, W. B. Essman. Spectrum, New York 1979, In press.10. Blundell J. E. Serotonin and feeding. Serotonin in Health and Disease, Vol. 5 Clinical Applications, W. B. Essman. Spectrum, New York 1979, In press.
  • Blundell J. E., Burridge S. L. Control of feeding and the psychopharmacology of anorectic drugs. “Obesity”, J. Munro. M.T.P. Press, Lancaster 1979, In press.11. Blundell J. E., Burridge S. L. Control of feeding and the psychopharmacology of anorectic drugs. “Obesity”, J. Munro. M.T.P. Press, Lancaster 1979, In press.
  • Blundell J. E., Latham C. J. Pharmacology of food and water intake. Chemical Influences on Behaviour, S. Cooper, K. Brown. Academic Press, London 1978, In press.12. Blundell J. E., Latham C. J. Pharmacology of food and water intake. Chemical Influences on Behaviour, S. Cooper, K. Brown. Academic Press, London 1978, In press.
  • Blundell J. E., Latham C. J. Pharmacological manipulation of feeding: possible influences of serotonin and dopamine on food intake. Central Mechanisms of Anorexic Drugs, S. Garattini, R. Samanin. Raven Press, New York 1978; 83–10913. Blundell J. E., Latham C. J. Pharmacological manipulation of feeding: possible influences of serotonin and dopamine on food intake. Central Mechanisms of Anorexic Drugs, S. Garattini, R. Samanin. Raven Press, New York 1978; 83–109
  • Blundell J. E., Leshem M. B. Dissociation between the anorexic effects of amphetamine and fenfluramine following hypothalamic injections. Br. J. Pharmacol. 1973; 47: 18314. Blundell J. E., Leshem M. B. Dissociation between the anorexic effects of amphetamine and fenfluramine following hypothalamic injections. Br. J. Pharmacol. 1973; 47: 183
  • Blundell J. E., Leshem M. B. Central action of anorexic agents: effects of amphetamine and fenfluramine in rats with lateral hypothalamic lesions. Eur. J. Pharmacol. 1974; 28: 8115. Blundell J. E., Leshem M. B. Central action of anorexic agents: effects of amphetamine and fenfluramine in rats with lateral hypothalamic lesions. Eur. J. Pharmacol. 1974; 28: 81
  • Blundell J. E., Leshem M. B. Temporal changes in amphetamine and fenfluramine anorexia following lateral hypothalamic lesions in rats. I.R.C.S. (Metab., Neurobiol., Pharmacol.) 1974; 2: 108716. Blundell J. E., Leshem M. B. Temporal changes in amphetamine and fenfluramine anorexia following lateral hypothalamic lesions in rats. I.R.C.S. (Metab., Neurobiol., Pharmacol.) 1974; 2: 1087
  • Blundell J. E., Leshem M. B. Hypothalmic lesions and drug-induced anorexia. Postgrad. Med. J. 1975; 51: 45, Suppl. 117. Blundell J. E., Leshem M. B. Hypothalmic lesions and drug-induced anorexia. Postgrad. Med. J. 1975; 51: 45, Suppl. 1
  • Blundell J. E., Leshem M. B. Analysis of the mode of action of anorexic drugs. “Recent Advances in Obesity Research”, A. Howard. Newman, London 1975; 368–37118. Blundell J. E., Leshem M. B. Analysis of the mode of action of anorexic drugs. “Recent Advances in Obesity Research”, A. Howard. Newman, London 1975; 368–371
  • Blundell J. E., McArthur R. A. Psychopharmacology of feeding: theoretical and clinical implications. Paper presented at the Annual Meeting of the British Assoc, for Advancement of Science. University of Bath, 197819. Blundell J. E., McArthur R. A. Psychopharmacology of feeding: theoretical and clinical implications. Paper presented at the Annual Meeting of the British Assoc, for Advancement of Science. University of Bath, 1978
  • Blundell J. E., Rogers P. J. Pharmacological approaches to the understanding of obesity. “Obesity”, A. J. Stunkard. Saunders, Philadelphia 1978, In press.20. Blundell J. E., Rogers P. J. Pharmacological approaches to the understanding of obesity. “Obesity”, A. J. Stunkard. Saunders, Philadelphia 1978, In press.
  • Blundell J. E., Campbell D. B., Leshem M. B., Tozer R. Comparison of the time course of the anorectic effect of fenfluramine and amphetamine with drug levels in blood. J. Pharm. Pharmacol 1975; 27: 18721. Blundell J. E., Campbell D. B., Leshem M. B., Tozer R. Comparison of the time course of the anorectic effect of fenfluramine and amphetamine with drug levels in blood. J. Pharm. Pharmacol 1975; 27: 187
  • Blundell J. E., Latham C. J., Leshem M. B. Differences between the anorexic actions of amphetamine and fenfluramine - possible effects on hunger and satiety. J. Pharm. Pharmacol. 1976; 28: 47122. Blundell J. E., Latham C. J., Leshem M. B. Differences between the anorexic actions of amphetamine and fenfluramine - possible effects on hunger and satiety. J. Pharm. Pharmacol. 1976; 28: 471
  • Blundell J. E., Tombros E., Rogers P. J., Latham C. J. Behavioural analysis of feeding: implications for the pharmacological manipulation of food intake in animals and man. Prog. Neuropharmacol. 1979, In press23. Blundell J. E., Tombros E., Rogers P. J., Latham C. J. Behavioural analysis of feeding: implications for the pharmacological manipulation of food intake in animals and man. Prog. Neuropharmacol. 1979, In press
  • Braun J. J. Neocortex and feeding behaviour in the rat. J. Comp. Physiol. Psychol. 1975; 89: 50724. Braun J. J. Neocortex and feeding behaviour in the rat. J. Comp. Physiol. Psychol. 1975; 89: 507
  • Cabanac M. The physiological role of pleasure. Science 1971; 173: 110325. Cabanac M. The physiological role of pleasure. Science 1971; 173: 1103
  • Cabanac M., Duclaux R. Obesity: absence of satiety aversion to sucrose. Science 1970; 168: 49626. Cabanac M., Duclaux R. Obesity: absence of satiety aversion to sucrose. Science 1970; 168: 496
  • Cole S. O. Increased suppression of food intake by amphetamine in rats with anterior hypothalamic lesions. J. Comp. Physiol. Psychol. 1966; 61: 30227. Cole S. O. Increased suppression of food intake by amphetamine in rats with anterior hypothalamic lesions. J. Comp. Physiol. Psychol. 1966; 61: 302
  • Collier G. H., Hirsch E., Hamlin P. H. The ecological determinants of reinforcement in the rat. Physiol. Behav. 1972; 9: 70528. Collier G. H., Hirsch E., Hamlin P. H. The ecological determinants of reinforcement in the rat. Physiol. Behav. 1972; 9: 705
  • Collier G. H., Kanarek R., Hirsch E., Marwine A. Environmental determinants of feeding behaviour or how to turn a rat into a tiger. “Psychological Research - the Inside Story”, M. H. Siegal, P. Ziegler. Harper and Row, New York 1976; 104–12829. Collier G. H., Kanarek R., Hirsch E., Marwine A. Environmental determinants of feeding behaviour or how to turn a rat into a tiger. “Psychological Research - the Inside Story”, M. H. Siegal, P. Ziegler. Harper and Row, New York 1976; 104–128
  • Curzon G., Joseph M. H., Knott P. J. Effects of immobilization and food deprivation on rat brain tryptophan metabolism. J. Neurochem. 1972; 19: 196730. Curzon G., Joseph M. H., Knott P. J. Effects of immobilization and food deprivation on rat brain tryptophan metabolism. J. Neurochem. 1972; 19: 1967
  • Dobranski S., Doggett N. S. The effects of (+) amphetamine and fenfluramine on feeding in starved and satiated mice. Psychopharmacol. 1976; 48: 28331. Dobranski S., Doggett N. S. The effects of (+) amphetamine and fenfluramine on feeding in starved and satiated mice. Psychopharmacol. 1976; 48: 283
  • Duhault J., Verdavainne C. Modification du taux de sérotonine certbrale chez le rat par les trifluoromethyl-phinyl-2–6thylaminopropane (fenfluramine). Arch. Int. Pharmacodyn. Thér. 1967; 170: 276–28632. Duhault J., Verdavainne C. Modification du taux de sérotonine certbrale chez le rat par les trifluoromethyl-phinyl-2–6thylaminopropane (fenfluramine). Arch. Int. Pharmacodyn. Thér. 1967; 170: 276–286
  • Fernstrom J. D., Wurtman R. J. Brain serotonin content: physiological regulation by plasma neutral amino acids. Science 1972; 178: 41433. Fernstrom J. D., Wurtman R. J. Brain serotonin content: physiological regulation by plasma neutral amino acids. Science 1972; 178: 414
  • Fernstrom J. D., Wurtman R. J. Control of brain 5-HT content by dietary carbohydrates. “Serotonin and Behaviour”, J. Barchas, E. Usdin. Academic Press, New York 1973; 121–12834. Fernstrom J. D., Wurtman R. J. Control of brain 5-HT content by dietary carbohydrates. “Serotonin and Behaviour”, J. Barchas, E. Usdin. Academic Press, New York 1973; 121–128
  • Garattini S., Samanin R. Anorectic drugs and brain neurotransmitters. “Appetite and Food Intake”, T. Silverstone. Dahlem Konferenzen, Berlin 1976; 83–10835. Garattini S., Samanin R. Anorectic drugs and brain neurotransmitters. “Appetite and Food Intake”, T. Silverstone. Dahlem Konferenzen, Berlin 1976; 83–108
  • Garattini S., Buczko W., Jori A., Samanin R. On the mechanism of action of fenfluramine. Postgrad. Med. J. 1975; 51: 27, Suppl. 136. Garattini S., Buczko W., Jori A., Samanin R. On the mechanism of action of fenfluramine. Postgrad. Med. J. 1975; 51: 27, Suppl. 1
  • Glick D. Changes in amphetamine sensitivity following frontal cortical damage in rats and mice. Eur. J. Pharmacol. 1972; 20: 35137. Glick D. Changes in amphetamine sensitivity following frontal cortical damage in rats and mice. Eur. J. Pharmacol. 1972; 20: 351
  • Glick D., Greenstein S. Facilitation of recovery after lateral hypothalamic damage by prior ablation of frontal cortex. Nature New Biol. 1972; 239: 18738. Glick D., Greenstein S. Facilitation of recovery after lateral hypothalamic damage by prior ablation of frontal cortex. Nature New Biol. 1972; 239: 187
  • Hamilton C. L., Brobeck J. R. Hypothalamic hyperphagia in the monkey. J. Comp. Physiol. Psychol. 1964; 57: 27139. Hamilton C. L., Brobeck J. R. Hypothalamic hyperphagia in the monkey. J. Comp. Physiol. Psychol. 1964; 57: 271
  • Kissileff H. R. Free feeding in normal and ‘recovered’ lateral rats monitored by a pellet-detecting eatometer. Physiol. Behav. 1970; 5: 16340. Kissileff H. R. Free feeding in normal and ‘recovered’ lateral rats monitored by a pellet-detecting eatometer. Physiol. Behav. 1970; 5: 163
  • Kolb B., Nonneman A. Prefrontal cortex and the regulation of food intake in the rat. J. Comp. Physiol. Psychol 1975; 88: 80641. Kolb B., Nonneman A. Prefrontal cortex and the regulation of food intake in the rat. J. Comp. Physiol. Psychol 1975; 88: 806
  • Moran G. Severe food deprivation: some thoughts regarding its exclusive use. Psychol. Bull. 1975; 82: 54342. Moran G. Severe food deprivation: some thoughts regarding its exclusive use. Psychol. Bull. 1975; 82: 543
  • Palkovitz M., Saavedra J. M., Jacobowitz D. M., Kizer J. S., Zaborsky L., Brownstein M. J. Serotonergic innervation of the forebrain: effect of lesions on serotonin and tryptophan hydroxylase levels. Brain Res. 1977; 130: 12143. Palkovitz M., Saavedra J. M., Jacobowitz D. M., Kizer J. S., Zaborsky L., Brownstein M. J. Serotonergic innervation of the forebrain: effect of lesions on serotonin and tryptophan hydroxylase levels. Brain Res. 1977; 130: 121
  • Rodin J. The role of perception of internal and external signals on the regulation of feeding in overweight and non-obese individuals. “Appetite and Food Intake”, T. Silverstone. Dahlem Konferenzen, Berlin 1976; 265–28344. Rodin J. The role of perception of internal and external signals on the regulation of feeding in overweight and non-obese individuals. “Appetite and Food Intake”, T. Silverstone. Dahlem Konferenzen, Berlin 1976; 265–283
  • Rogers P. J., Binnes D., McArthur R. A., Blundell J. E. Effect of tryptophan and anorexic drugs on food intake, food selection, motivation and the micro-structure of feeding in man (summary). Int. J. Obesity. 1978, In press45. Rogers P. J., Binnes D., McArthur R. A., Blundell J. E. Effect of tryptophan and anorexic drugs on food intake, food selection, motivation and the micro-structure of feeding in man (summary). Int. J. Obesity. 1978, In press
  • Shoulson I., Chase T. N. Fenfluramine in man: hypophagia associated with diminished serotonin turnover. Clin. Pharmacol. Ther. 1976; 17: 61646. Shoulson I., Chase T. N. Fenfluramine in man: hypophagia associated with diminished serotonin turnover. Clin. Pharmacol. Ther. 1976; 17: 616
  • Silverstone J. T., Stunkard A. J. The anorexic effect of dexamphetamine sulphate. Br. J. Pharmacol. Chemother. 1968; 33: 51347. Silverstone J. T., Stunkard A. J. The anorexic effect of dexamphetamine sulphate. Br. J. Pharmacol. Chemother. 1968; 33: 513
  • Stellar E. The CNS and appetite: historical introduction. “Appetite and Food Intake”, T. Silverstone. Dahlem Konferenzen, Berlin 1976; 15–2048. Stellar E. The CNS and appetite: historical introduction. “Appetite and Food Intake”, T. Silverstone. Dahlem Konferenzen, Berlin 1976; 15–20
  • Strieker E. M., Zigmond M. J. Recovery of function following damage to central catecholamine-containing neurons - a neurochemical model for the lateral hypothalamic syndrome. “Progress in Physiological Psychology, J. M. Sprague, A. N. Epstein. Academic Press, New York 1976; Vol. 6: 121–18849. Strieker E. M., Zigmond M. J. Recovery of function following damage to central catecholamine-containing neurons - a neurochemical model for the lateral hypothalamic syndrome. “Progress in Physiological Psychology, J. M. Sprague, A. N. Epstein. Academic Press, New York 1976; Vol. 6: 121–188
  • Stunkard A. J., Kaplan D. Eating in public places: a review of reports of the direct observation of eating behaviour. Int. J. Obesity 1977; 1: 8950. Stunkard A. J., Kaplan D. Eating in public places: a review of reports of the direct observation of eating behaviour. Int. J. Obesity 1977; 1: 89
  • Wiepkema P. R. Behavioural factors in the regulation of food intake. Proc. Nutr. Soc 1971; 30: 14251. Wiepkema P. R. Behavioural factors in the regulation of food intake. Proc. Nutr. Soc 1971; 30: 142
  • Wiepkema P. R. Positive feedbacks at work during feeding. Behaviour 1971; 39: 26652. Wiepkema P. R. Positive feedbacks at work during feeding. Behaviour 1971; 39: 266
  • Wolgin D. L., Cytawa J., Teitelbaum P. The role of activation in the regulation of food intake. “Hunger - Basic Mechanisms and Clinical Implications”, D. Novin, W. Wyrwicka, G. Bray. Raven Press, New York 1976; 179–19153. Wolgin D. L., Cytawa J., Teitelbaum P. The role of activation in the regulation of food intake. “Hunger - Basic Mechanisms and Clinical Implications”, D. Novin, W. Wyrwicka, G. Bray. Raven Press, New York 1976; 179–191
  • Wooley S. C., Wooley W. Salivation to the sight and thought of food: a new measure of appetite. Psychosom. Med. 1973; 35: 13654. Wooley S. C., Wooley W. Salivation to the sight and thought of food: a new measure of appetite. Psychosom. Med. 1973; 35: 136
  • Wurtman J. J., Wurtman R. J. Fenfluramine and fluoxetine spare protein consumption while suppressing caloric intake by rats. Science 1977; 198: 117855. Wurtman J. J., Wurtman R. J. Fenfluramine and fluoxetine spare protein consumption while suppressing caloric intake by rats. Science 1977; 198: 1178

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.