Role of Epidermal Growth Factor (EGF) in Oesophageal Mucosal Integrity

References

• Li L., Yu Z., Piascik R., Hetzel D. P., Rourk R. M., Namiot Z., Sarosiek J., McCallum R. W. Effect of esophageal intraluminal mechanical and chemical stressors on salivary epidermal growth factor in humans. Am. J. Gastroenterol 1993; 88: 1749–17551. Li L., Yu Z., Piascik R., Hetzel D. P., Rourk R. M., Namiot Z., Sarosiek J., McCallum R. W. Effect of esophageal intraluminal mechanical and chemical stressors on salivary epidermal growth factor in humans. Am. J. Gastroenterol 1993; 88: 1749–1755
   PubMed Web of Science ®Google Scholar
• Rourk R. M., Namiot Z., Sarosiek J., Yu Z., McCallum R. W. Impairment of salivary epidermal growth factor secretory response to esophageal mechanical and chemical stimulation in patients with reflux esophagitis. Am. J. Gastroenterol 1994; 89: 237–2442. Rourk R. M., Namiot Z., Sarosiek J., Yu Z., McCallum R. W. Impairment of salivary epidermal growth factor secretory response to esophageal mechanical and chemical stimulation in patients with reflux esophagitis. Am. J. Gastroenterol 1994; 89: 237–244
   PubMed Web of Science ®Google Scholar
• Namiot Z., Rourk R. M., Piascik R., Hetzel D. P., Sarosiek J., McCallum R. W. Interrelationship between esophageal challenge with mechanical and chemical stimuli and salivary protective mechanisms. Am. J. Gastroenterol 1994; 89: 581–5873. Namiot Z., Rourk R. M., Piascik R., Hetzel D. P., Sarosiek J., McCallum R. W. Interrelationship between esophageal challenge with mechanical and chemical stimuli and salivary protective mechanisms. Am. J. Gastroenterol 1994; 89: 581–587
   PubMed Web of Science ®Google Scholar
• Sarosiek J., Rourk R. M., Piascik R., Namiot Z., Hetzel D. P., McCallum R. W. The effect of esophageal mechanical and chemical stimuli on salivary mucin secretion in healthy individuals. Am. J. Med. Sci. 1994; 308: 23–314. Sarosiek J., Rourk R. M., Piascik R., Namiot Z., Hetzel D. P., McCallum R. W. The effect of esophageal mechanical and chemical stimuli on salivary mucin secretion in healthy individuals. Am. J. Med. Sci. 1994; 308: 23–31
   PubMed Web of Science ®Google Scholar
• Korsten M. A., Rosman A. S., Fishbein S., Shlein R. D., Goldberg H. E., Biener A. Chronic xerostomia increases esophageal acid exposure and is associated with esophageal injury. Am. J. Med. 1991; 90: 701–7065. Korsten M. A., Rosman A. S., Fishbein S., Shlein R. D., Goldberg H. E., Biener A. Chronic xerostomia increases esophageal acid exposure and is associated with esophageal injury. Am. J. Med. 1991; 90: 701–706
   PubMed Web of Science ®Google Scholar
• Marcinkiewicz M., Sarosiek J., Edmunds M. C., Namiot Z., McCallum R. W. Detrimental impact of acid and pepsin on the rate of luminal release of transforming growth factor alpha: Its potential pathogenetic role in the development of reflux esophagitis. J. Clin. Gastroenterol 1996; 22: 261–2696. Marcinkiewicz M., Sarosiek J., Edmunds M. C., Namiot Z., McCallum R. W. Detrimental impact of acid and pepsin on the rate of luminal release of transforming growth factor alpha: Its potential pathogenetic role in the development of reflux esophagitis. J. Clin. Gastroenterol 1996; 22: 261–269
   PubMedGoogle Scholar
• Marti U., Burwen S. J., Jones A. L. Biological effects of epidermal growth factor with emphasis on the gastrointestinal tract and liver: An update. Hepatology 1989; 9: 126–1387. Marti U., Burwen S. J., Jones A. L. Biological effects of epidermal growth factor with emphasis on the gastrointestinal tract and liver: An update. Hepatology 1989; 9: 126–138
   PubMed Web of Science ®Google Scholar
• Barnard J. A., Beauchamp R. D., Russell W. E., Dubois R. N., Coffey R. J. Epidermal growth factor-related peptides and their relevance to gastrointestinal physiology. Gastroenterology 1995; 108: 564–5808. Barnard J. A., Beauchamp R. D., Russell W. E., Dubois R. N., Coffey R. J. Epidermal growth factor-related peptides and their relevance to gastrointestinal physiology. Gastroenterology 1995; 108: 564–580
   PubMed Web of Science ®Google Scholar
• Sarosiek J., Feng T., McCallum R. W. The interrelationship between salivary epidermal growth factor and the functional integrity of the esophageal mucosal barrier in the rat. Am. J. Med. Sci. 1991; 302: 359–3639. Sarosiek J., Feng T., McCallum R. W. The interrelationship between salivary epidermal growth factor and the functional integrity of the esophageal mucosal barrier in the rat. Am. J. Med. Sci. 1991; 302: 359–363
   PubMed Web of Science ®Google Scholar
• Marcinkiewicz M., Van der Linden B., Peura D. A., Goldin G., Parolisi S., Sarosiek J. Impact of Helicobacter pylori colonization on immunoreactive epidermal growth factor and transforming growth factor-a in gastric juice. Its potential pathogenic implications. Dig. Dis. Sci. 1996; 41: 2150–215510. Marcinkiewicz M., Van der Linden B., Peura D. A., Goldin G., Parolisi S., Sarosiek J. Impact of Helicobacter pylori colonization on immunoreactive epidermal growth factor and transforming growth factor-a in gastric juice. Its potential pathogenic implications. Dig. Dis. Sci. 1996; 41: 2150–2155
   PubMed Web of Science ®Google Scholar
• Konturek P. K., Brzozowski T., Konturek S. J., Dembinski A. Role of epidermal growth factor, prostaglandin, and sulfhydryls in stress induced gastric lesions. Gastroenterology 1990; 99: 1607–161511. Konturek P. K., Brzozowski T., Konturek S. J., Dembinski A. Role of epidermal growth factor, prostaglandin, and sulfhydryls in stress induced gastric lesions. Gastroenterology 1990; 99: 1607–1615
   PubMed Web of Science ®Google Scholar
• Jankowski J., Hopwood D., Wormsley K. G. Expression of epidermal growth factor, transforming growth factor alpha and their receptor in gastro-oesophageal diseases. Dig. Dis. 1993; 11: 1–1112. Jankowski J., Hopwood D., Wormsley K. G. Expression of epidermal growth factor, transforming growth factor alpha and their receptor in gastro-oesophageal diseases. Dig. Dis. 1993; 11: 1–11
   PubMed Web of Science ®Google Scholar
• Carpenter G., Cohen S. Epidermal growth factor. J. Biol. Chem. 1990; 265: 7709–771213. Carpenter G., Cohen S. Epidermal growth factor. J. Biol. Chem. 1990; 265: 7709–7712
   PubMed Web of Science ®Google Scholar
• Cooke R. M., Wilkinson A. J., Baron M., Pastore A., Tappin M. J., Campbell I. D., Gregory H., Sheard B. The solution structure of human epidermal growth factor. Nature 1987; 327: 339–34114. Cooke R. M., Wilkinson A. J., Baron M., Pastore A., Tappin M. J., Campbell I. D., Gregory H., Sheard B. The solution structure of human epidermal growth factor. Nature 1987; 327: 339–341
   PubMed Web of Science ®Google Scholar
• Mayo K. H., Cavalli R. C., Peters A. R., Boelens R., Kaplein R. Sequence-specific ‘H-n.m.r. assignments and peptide backbone conformation in rat epidermal growth factor. Biochem. J. 1989; 257: 197–20515. Mayo K. H., Cavalli R. C., Peters A. R., Boelens R., Kaplein R. Sequence-specific ‘H-n.m.r. assignments and peptide backbone conformation in rat epidermal growth factor. Biochem. J. 1989; 257: 197–205
   PubMed Web of Science ®Google Scholar
• Todderud G., Carpenter G. Epidermal growth factor: The receptor and its function. Biofactors 1989; 2: 11–1516. Todderud G., Carpenter G. Epidermal growth factor: The receptor and its function. Biofactors 1989; 2: 11–15
   PubMedGoogle Scholar
• Laurence D. J. R., Gusterson B. A. The epidermal growth factor. Tumor Biol 1990; 11: 229–26117. Laurence D. J. R., Gusterson B. A. The epidermal growth factor. Tumor Biol 1990; 11: 229–261
   PubMed Web of Science ®Google Scholar
• Velu T. J., Beguinot L., Vass W. C., Willingham M. C. Epidermal growth factor-dependent transformation by a human EGF receptor proto-oncogene. Science 1987; 238: 1408–141018. Velu T. J., Beguinot L., Vass W. C., Willingham M. C. Epidermal growth factor-dependent transformation by a human EGF receptor proto-oncogene. Science 1987; 238: 1408–1410
   PubMed Web of Science ®Google Scholar
• Carpenter G. Properties of the receptor for epidermal growth factor. Cell 1984; 37: 357–35819. Carpenter G. Properties of the receptor for epidermal growth factor. Cell 1984; 37: 357–358
   PubMed Web of Science ®Google Scholar
• Downward J., Parker P., Waterfield M. D. Autophosphorylation sites on the epidermal growth factor receptor. Nature 1984; 311: 483–48520. Downward J., Parker P., Waterfield M. D. Autophosphorylation sites on the epidermal growth factor receptor. Nature 1984; 311: 483–485
   PubMed Web of Science ®Google Scholar
• Margolis B. L., Lax I., Kris R., Dombalagian M., Honegger A. M., Howk R., Givol D., Ullrich A., Schlessinger J. All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor. J. Biol. Chem. 1989; 264: 10667–1067121. Margolis B. L., Lax I., Kris R., Dombalagian M., Honegger A. M., Howk R., Givol D., Ullrich A., Schlessinger J. All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor. J. Biol. Chem. 1989; 264: 10667–10671
   PubMed Web of Science ®Google Scholar
• Russo M. W., Lukas T. J., Cohen S., Staros J. V. Identification of residues in the nucleotide binding site of the epidermal growth factor receptor/ kinase. J. Biol. Chem. 1985; 260: 5205–520822. Russo M. W., Lukas T. J., Cohen S., Staros J. V. Identification of residues in the nucleotide binding site of the epidermal growth factor receptor/ kinase. J. Biol. Chem. 1985; 260: 5205–5208
   PubMed Web of Science ®Google Scholar
• Gozes I., Littauer U. Z. Epidermal growth factor stimulates phosphorylation in membrane preparations, in vitro. Nature 1978; 276: 409–41023. Gozes I., Littauer U. Z. Epidermal growth factor stimulates phosphorylation in membrane preparations, in vitro. Nature 1978; 276: 409–410
   PubMed Web of Science ®Google Scholar
• Ushiro H., Cohen S. Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes. J. Biol. Chem. 1980; 255: 8363–836524. Ushiro H., Cohen S. Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes. J. Biol. Chem. 1980; 255: 8363–8365
   PubMed Web of Science ®Google Scholar
• Coffer P. J., Kruijer W. EGF receptor deletions define a region specifically mediating STAT transcription factor activation. Biochem. Biophys. Res. Commun. 1995; 210: 74–8125. Coffer P. J., Kruijer W. EGF receptor deletions define a region specifically mediating STAT transcription factor activation. Biochem. Biophys. Res. Commun. 1995; 210: 74–81
   PubMed Web of Science ®Google Scholar
• Spitzer E., Zschiesche W., Binas B., Grosse R., Erdmann B. EGF and TGF alpha modulate structural and functional differentiation of the mammary gland from pregnant mice in vitro: possible role of the arachidonic acid pathway. J. Cell. Biochem. 1995; 57: 495–50826. Spitzer E., Zschiesche W., Binas B., Grosse R., Erdmann B. EGF and TGF alpha modulate structural and functional differentiation of the mammary gland from pregnant mice in vitro: possible role of the arachidonic acid pathway. J. Cell. Biochem. 1995; 57: 495–508
   PubMed Web of Science ®Google Scholar
• Gilligan A., Prentki E., Knowles B. EGF receptor down-regulation attenuates ligand-induced second messenger formation. Exp. Cell. Res. 1990; 187: 134–14227. Gilligan A., Prentki E., Knowles B. EGF receptor down-regulation attenuates ligand-induced second messenger formation. Exp. Cell. Res. 1990; 187: 134–142
   PubMed Web of Science ®Google Scholar
• Johnson R. M., Garrison J. C. Epidermal growth factor and angiotensin II stimulate formation of inositol 1,4,5- and inositol 1,3,4-trisphosphate in hepatocytes. Differential inhibition by pertussis toxin and phorbol 12-myristate 13-acetate. J. Biol. Chem. 1987; 262: 17285–1729328. Johnson R. M., Garrison J. C. Epidermal growth factor and angiotensin II stimulate formation of inositol 1,4,5- and inositol 1,3,4-trisphosphate in hepatocytes. Differential inhibition by pertussis toxin and phorbol 12-myristate 13-acetate. J. Biol. Chem. 1987; 262: 17285–17293
   PubMed Web of Science ®Google Scholar
• Wahl M., Carpenter G. Regulation of epidermal growth factor-stimulated formation of inositol phosphates in A-431 cells by calcium and protein kinase C. J. Biol. Chem. 1988; 263: 7581–759029. Wahl M., Carpenter G. Regulation of epidermal growth factor-stimulated formation of inositol phosphates in A-431 cells by calcium and protein kinase C. J. Biol. Chem. 1988; 263: 7581–7590
   PubMed Web of Science ®Google Scholar
• Davis R. J. Independent mechanisms account for the regulation by protein kinase C of the epidermal growth factor receptor affinity and tyrosine-protein kinase activity. J. Biol. Chem. 1988; 263: 9462–946930. Davis R. J. Independent mechanisms account for the regulation by protein kinase C of the epidermal growth factor receptor affinity and tyrosine-protein kinase activity. J. Biol. Chem. 1988; 263: 9462–9469
   PubMed Web of Science ®Google Scholar
• Konturek J. W., Bielanski W., Konturek S. J., Bogdal J., Oleksy J. Distribution and release of epidermal growth factor in man. Gut 1989; 30: 1194–120031. Konturek J. W., Bielanski W., Konturek S. J., Bogdal J., Oleksy J. Distribution and release of epidermal growth factor in man. Gut 1989; 30: 1194–1200
   PubMed Web of Science ®Google Scholar
• Goldin F. G., Marcinkiewicz M., Zbroch T., Bityutskiy L. P., McCallum R. W., Sarosiek J. Esophagoprotective potential of cisapride. An additional benefit for gastroesophageal reflux disease. Dig. Dis. Sci. 1997; 42: 1362–136932. Goldin F. G., Marcinkiewicz M., Zbroch T., Bityutskiy L. P., McCallum R. W., Sarosiek J. Esophagoprotective potential of cisapride. An additional benefit for gastroesophageal reflux disease. Dig. Dis. Sci. 1997; 42: 1362–1369
   PubMed Web of Science ®Google Scholar
• Olsen Skov P., Kirkegaard P., Poulsen S. S., Nexo E. Adrenergic effects on exocrine secretion of rat submandibular epidermal growth factor. Gut 1984; 25: 1234–124033. Olsen Skov P., Kirkegaard P., Poulsen S. S., Nexo E. Adrenergic effects on exocrine secretion of rat submandibular epidermal growth factor. Gut 1984; 25: 1234–1240
   PubMed Web of Science ®Google Scholar
• Konturek P. Ch., Ernst H., Konturek J., Bobrzynski A., Kwiecien N., Faller G., Gedliczka O., Hahn E. G. Salivary and luminal release of epidermal growth factor under basal conditions and after pentagastrin stimulation in healthy subjects and in duodenal ulcer patients before and after eradication of, Helicobacter pylori. J. Physiol. Pharmacol. 1996; 47: 187–19434. Konturek P. Ch., Ernst H., Konturek J., Bobrzynski A., Kwiecien N., Faller G., Gedliczka O., Hahn E. G. Salivary and luminal release of epidermal growth factor under basal conditions and after pentagastrin stimulation in healthy subjects and in duodenal ulcer patients before and after eradication of, Helicobacter pylori. J. Physiol. Pharmacol. 1996; 47: 187–194
   PubMed Web of Science ®Google Scholar
• Sarosiek J., Scheurich C. J., Marcinkiewicz M., McCallum R. W. Enhancement of salivary esophagoprotection: rationale for a physiological approach to gastroesophageal reflux disease. Gastroenterology 1996; 110: 675–68135. Sarosiek J., Scheurich C. J., Marcinkiewicz M., McCallum R. W. Enhancement of salivary esophagoprotection: rationale for a physiological approach to gastroesophageal reflux disease. Gastroenterology 1996; 110: 675–681
   PubMed Web of Science ®Google Scholar
• Marcinkiewicz M., Schriber J. P., Scheurich J., Edmunds M. C., McCallum R. W., Sarosiek J. Salivary bicarbonate and non-bicarbonate buffering capacity, mediated by esophago-salivary reflex, in patients with reflux esophagitis. Gastroenterology 1996; 110: A18636. Marcinkiewicz M., Schriber J. P., Scheurich J., Edmunds M. C., McCallum R. W., Sarosiek J. Salivary bicarbonate and non-bicarbonate buffering capacity, mediated by esophago-salivary reflex, in patients with reflux esophagitis. Gastroenterology 1996; 110: A186
   Web of Science ®Google Scholar
• Sarosiek J., McCallum R. W. What role do salivary inorganic components play in health and disease of the esophageal mucosa?. Digestion 1995; 56(Suppl 1)24–3137. Sarosiek J., McCallum R. W. What role do salivary inorganic components play in health and disease of the esophageal mucosa?. Digestion 1995; 56(Suppl 1)24–31
   PubMedGoogle Scholar
• Dutta S. K., Matossian H. B., Meirowitz R. F., Vaeth J. Modulation of salivary secretion by acid infusion in the distal esophagus in humans. Gastroenterology 1992; 103: 1833–184138. Dutta S. K., Matossian H. B., Meirowitz R. F., Vaeth J. Modulation of salivary secretion by acid infusion in the distal esophagus in humans. Gastroenterology 1992; 103: 1833–1841
   PubMed Web of Science ®Google Scholar
• Marcinkiewicz M., Sarosiek J., Scheurich J., McCallum R. W. Is human salivary bicarbonate secretion mediated by esophago-salivary reflex?. Am. J. Gastroenterol 1995; 90: 156439. Marcinkiewicz M., Sarosiek J., Scheurich J., McCallum R. W. Is human salivary bicarbonate secretion mediated by esophago-salivary reflex?. Am. J. Gastroenterol 1995; 90: 1564
   Google Scholar
• Marcinkiewicz M., Namiot Z., Sarosiek J., McCallum R. W. Modulation of salivary prostaglandin E2 secretion by intraesophageal mucosal changes in patients with reflux esophagitis. Gastroenterology 1995; 108: A 15840. Marcinkiewicz M., Namiot Z., Sarosiek J., McCallum R. W. Modulation of salivary prostaglandin E2 secretion by intraesophageal mucosal changes in patients with reflux esophagitis. Gastroenterology 1995; 108: A 158
   Google Scholar
• Marcinkiewicz M., Zbroch T., Scheurich J., Sarosiek J., McCallum R. W. Potential contribution of enhanced salivary epidermal growth factor output to the lower prevalence of reflux esophagitis and complications in African-Americans. Gastroenterology 1997; 112: A21141. Marcinkiewicz M., Zbroch T., Scheurich J., Sarosiek J., McCallum R. W. Potential contribution of enhanced salivary epidermal growth factor output to the lower prevalence of reflux esophagitis and complications in African-Americans. Gastroenterology 1997; 112: A211
   Web of Science ®Google Scholar
• Hradky M., Hybasek I., Cernoch V., Juran J. Esophageal abnormalities in Sjögren's syndrome. Scand. J. Gastroenterol 1967; 2: 200–20342. Hradky M., Hybasek I., Cernoch V., Juran J. Esophageal abnormalities in Sjögren's syndrome. Scand. J. Gastroenterol 1967; 2: 200–203
   PubMedGoogle Scholar
• Ramirez-Mata M., Pena-Ancira F. F., Alarcon-Segovia D. Abnormal esophageal motility in primary Sjogren's syndrome. J. Rheumatol. 1976; 3: 63–6943. Ramirez-Mata M., Pena-Ancira F. F., Alarcon-Segovia D. Abnormal esophageal motility in primary Sjogren's syndrome. J. Rheumatol. 1976; 3: 63–69
   PubMed Web of Science ®Google Scholar
• Simila S., Kokkonen J., Kaski M. Achalasia Sicca-Juvenile Sjögren's syndrome with achalasia and gastric hyposecretion. Eur. J. Pediatr. 1978; 175: 175–18144. Simila S., Kokkonen J., Kaski M. Achalasia Sicca-Juvenile Sjögren's syndrome with achalasia and gastric hyposecretion. Eur. J. Pediatr. 1978; 175: 175–181
   Google Scholar
• McGurk M., Hanford L., Justice S., Metcalf R. A. The secretory characteristics of epidermal growth factor in human saliva. Arch. Oral. Biol. 1990; 35: 653–65945. McGurk M., Hanford L., Justice S., Metcalf R. A. The secretory characteristics of epidermal growth factor in human saliva. Arch. Oral. Biol. 1990; 35: 653–659
   PubMed Web of Science ®Google Scholar
• Tuchman D. N., Dutta S. K., Vengurlekar S. M., Gottal R., Bidani J. A., Dutta D. Reduction of salivary epidermal growth factor (EGF) secretion and alteration in EGF receptor expression in esophageal mucosa in pediatric patients with reflux esophagitis. Gastroenterology 1992; 102: A18246. Tuchman D. N., Dutta S. K., Vengurlekar S. M., Gottal R., Bidani J. A., Dutta D. Reduction of salivary epidermal growth factor (EGF) secretion and alteration in EGF receptor expression in esophageal mucosa in pediatric patients with reflux esophagitis. Gastroenterology 1992; 102: A182
   Google Scholar
• Gray M. R., Donnelly R. J., Kingsnorth A. N. Role of salivary epidermal growth factor in the pathogenesis of Barrett's columnar lined oesophagus. Br. J. Surg. 1991; 78: 1461–146647. Gray M. R., Donnelly R. J., Kingsnorth A. N. Role of salivary epidermal growth factor in the pathogenesis of Barrett's columnar lined oesophagus. Br. J. Surg. 1991; 78: 1461–1466
   PubMed Web of Science ®Google Scholar
• Sakai Y., Nelson K. G., Snedeker S., Bossert N. L., Walker M. P., McLachlan J., Di Augustine R. P. Expression of epidermal growth factor in suprabasal cells of stratified squamous epithelia: implications for a role in differentiation. Cell. Growth. Differ. 1994; 5: 527–53548. Sakai Y., Nelson K. G., Snedeker S., Bossert N. L., Walker M. P., McLachlan J., Di Augustine R. P. Expression of epidermal growth factor in suprabasal cells of stratified squamous epithelia: implications for a role in differentiation. Cell. Growth. Differ. 1994; 5: 527–535
   PubMedGoogle Scholar
• Hamilton B. H., Orlando R. C. In vivo alkaline secretion by mammalian esophagus. Gastroenterology 1989; 97: 640–64849. Hamilton B. H., Orlando R. C. In vivo alkaline secretion by mammalian esophagus. Gastroenterology 1989; 97: 640–648
   PubMed Web of Science ®Google Scholar
• Sarosiek J., Hetzel D. P., Yu Z., Piascik R., Li L., Rourk R. M., McCallum R. W. Evidence on secretion of epidermal growth factor by the esophageal mucosa in humans. Am. J. Gastroenterol. 1993; 188: 1081–108750. Sarosiek J., Hetzel D. P., Yu Z., Piascik R., Li L., Rourk R. M., McCallum R. W. Evidence on secretion of epidermal growth factor by the esophageal mucosa in humans. Am. J. Gastroenterol. 1993; 188: 1081–1087
   Google Scholar
• Marcinkiewicz M., Sarosiek J., Edmunds M., Scheurich J., Weiss P., McCallum R. W. Monophasic luminal release of prostaglandin E2 in patients with reflux esophagitis under the impact of acid and acid/pepsin solutions. Its potential pathogenetic significance. J. Clin. Gastroenterol 1995; 21: 268–27451. Marcinkiewicz M., Sarosiek J., Edmunds M., Scheurich J., Weiss P., McCallum R. W. Monophasic luminal release of prostaglandin E2 in patients with reflux esophagitis under the impact of acid and acid/pepsin solutions. Its potential pathogenetic significance. J. Clin. Gastroenterol 1995; 21: 268–274
   PubMed Web of Science ®Google Scholar
• Jankowski J., Coghill G., Tregaskis B., Hopwood D., Wormsley K. G. Epidermal growth factor in the oesophagus. Gut 1992; 33: 1448–145352. Jankowski J., Coghill G., Tregaskis B., Hopwood D., Wormsley K. G. Epidermal growth factor in the oesophagus. Gut 1992; 33: 1448–1453
   Google Scholar
• Oka Y., Orth D. N. Human plasma epidermal growth factor/beta urogastrone is associated with blood platelets. J. Clin. Invest. 1983; 72: 249–25953. Oka Y., Orth D. N. Human plasma epidermal growth factor/beta urogastrone is associated with blood platelets. J. Clin. Invest. 1983; 72: 249–259
   PubMed Web of Science ®Google Scholar
• Livstone E., Sheahan S., Behar J. Studies of esophageal cell proliferation in patients with reflux esophagitis. Gastroenterology 1977; 73: 1315–131954. Livstone E., Sheahan S., Behar J. Studies of esophageal cell proliferation in patients with reflux esophagitis. Gastroenterology 1977; 73: 1315–1319
   PubMed Web of Science ®Google Scholar
• Jankowski J., McMennemin R., Hopwood D., Penston J. G., Wormsley K. G. Abnormal expression of growth regulatory peptides in Barrett's oesophagus. Clin. Scl 1991; 81: 663–66855. Jankowski J., McMennemin R., Hopwood D., Penston J. G., Wormsley K. G. Abnormal expression of growth regulatory peptides in Barrett's oesophagus. Clin. Scl 1991; 81: 663–668
   PubMed Web of Science ®Google Scholar
• Dutta S. K., Meirowitz R. F., Vengurlekar S., Resau J. Localization and characterization of epidermal growth factor receptors in human oesophageal epithelium. Gastroenterology 1990; 98: A3856. Dutta S. K., Meirowitz R. F., Vengurlekar S., Resau J. Localization and characterization of epidermal growth factor receptors in human oesophageal epithelium. Gastroenterology 1990; 98: A38
   Google Scholar
• Jankowski J., Murphy S., Coghill G., Grant A., Hopwood D., Wormsley K. G. Expression of epidermal growth factor receptors in oesophageal mucosa. Gut 1992; 33: 439–44357. Jankowski J., Murphy S., Coghill G., Grant A., Hopwood D., Wormsley K. G. Expression of epidermal growth factor receptors in oesophageal mucosa. Gut 1992; 33: 439–443
   PubMed Web of Science ®Google Scholar
• Hsuan J. J., Totty N., Waterfield M. D. Identification of a novel auto-phosphorylation site (P4) on the epidermal growth factor receptor. Biochem. J. 1989; 262: 659–66358. Hsuan J. J., Totty N., Waterfield M. D. Identification of a novel auto-phosphorylation site (P4) on the epidermal growth factor receptor. Biochem. J. 1989; 262: 659–663
   PubMed Web of Science ®Google Scholar
• Fehlman E. J., Anres D., Grossman M. I. Epidermal growth factor stimulates ornithine decarboxylase activity in the digestive tract of mouse. Proc. Soc. Exp. Biol. Med. 1978; 159: 400–40259. Fehlman E. J., Anres D., Grossman M. I. Epidermal growth factor stimulates ornithine decarboxylase activity in the digestive tract of mouse. Proc. Soc. Exp. Biol. Med. 1978; 159: 400–402
   PubMed Web of Science ®Google Scholar
• Konturek S. J., Radecki T., Brzozowski T., Piastucki I., Dembinski A., Dembinska-Kiec A., Zmuda A., Gryglewski R., Gregory H. Gastric cytoprotection by epidermal growth factor: Role of endogenous prostaglandins and DNA synthesis. Gastroenterology 1981; 81: 438–44360. Konturek S. J., Radecki T., Brzozowski T., Piastucki I., Dembinski A., Dembinska-Kiec A., Zmuda A., Gryglewski R., Gregory H. Gastric cytoprotection by epidermal growth factor: Role of endogenous prostaglandins and DNA synthesis. Gastroenterology 1981; 81: 438–443
   PubMed Web of Science ®Google Scholar
• Chen L. B., Gudor R. C., Sun T. T. Control of a cell surface major glycoprotein by epidermal growth factor. Science 1977; 197: 776–77861. Chen L. B., Gudor R. C., Sun T. T. Control of a cell surface major glycoprotein by epidermal growth factor. Science 1977; 197: 776–778
   PubMed Web of Science ®Google Scholar
• Van Dyke R. C., Ives H. E. Na+/K+ exchange: What, where and why?. Hepatology 1988; 8: 960–96562. Van Dyke R. C., Ives H. E. Na+/K+ exchange: What, where and why?. Hepatology 1988; 8: 960–965
   PubMed Web of Science ®Google Scholar
• Gullick W. J., Lemoine N. R. EGF receptor antibody 29.1.1. J. Pathol 1990; 162: 275–27663. Gullick W. J., Lemoine N. R. EGF receptor antibody 29.1.1. J. Pathol 1990; 162: 275–276
   PubMed Web of Science ®Google Scholar
• Benamouzig R., Ferriere F., Guettier C., Amouroux J., Coste T., Rautureau J. Role of salivary and seric epidermal growth factor in pathogenesis of reflux esophagitis in chronic alcoholics and nondrinkers. Dig. Dis. Sci 1996; 41: 1595–159964. Benamouzig R., Ferriere F., Guettier C., Amouroux J., Coste T., Rautureau J. Role of salivary and seric epidermal growth factor in pathogenesis of reflux esophagitis in chronic alcoholics and nondrinkers. Dig. Dis. Sci 1996; 41: 1595–1599
   PubMed Web of Science ®Google Scholar
• Korelz K., Schlag P., Moller P. Expression of epidermal growth factor receptor in normal colorectal mucosa. Adenoma and carcinoma. Virchows Arch. A. Pathol. Anal. Histopathol 1990; 416: 343–34965. Korelz K., Schlag P., Moller P. Expression of epidermal growth factor receptor in normal colorectal mucosa. Adenoma and carcinoma. Virchows Arch. A. Pathol. Anal. Histopathol 1990; 416: 343–349
   PubMed Web of Science ®Google Scholar
• Vinter-Jensen L., Juhl Orlof C., Eika B., Gregersen H., Dajani E. Z. Epidermal growth factor attenuates the sclerotherapy-induced biomechanical properties of the oesophagus. Scand. J. Gastroenterol 1995; 30: 614–61966. Vinter-Jensen L., Juhl Orlof C., Eika B., Gregersen H., Dajani E. Z. Epidermal growth factor attenuates the sclerotherapy-induced biomechanical properties of the oesophagus. Scand. J. Gastroenterol 1995; 30: 614–619
   PubMed Web of Science ®Google Scholar
• Edmunds M. C., Namiot Z., Sarosiek J., Rourk R. M., Yu Z., McCallum R. W. Esophageal epidermal growth factor impairment persists despite healing of endoscopic changes in patients with reflux esophagitis. Gastroenterology 1994; 106: A7367. Edmunds M. C., Namiot Z., Sarosiek J., Rourk R. M., Yu Z., McCallum R. W. Esophageal epidermal growth factor impairment persists despite healing of endoscopic changes in patients with reflux esophagitis. Gastroenterology 1994; 106: A73
   PubMed Web of Science ®Google Scholar
• Sarosiek J., Edmunds M. C., Namiot Z., Marcinkiewicz M., McCallum R. W. Secretory profile of Barrett's esophagus in humans: Its significantly modified protective potential. Gastroenterol. 1994; 106: A17368. Sarosiek J., Edmunds M. C., Namiot Z., Marcinkiewicz M., McCallum R. W. Secretory profile of Barrett's esophagus in humans: Its significantly modified protective potential. Gastroenterol. 1994; 106: A173
   Web of Science ®Google Scholar
• Gilchrist W., Burkhalter E., Eaton C., Schaudies P. R., Maydonovitch C., Andrada F., Maged A. R., Roy K. H., Wong R. K. H. The effect of indomethacin on the secretion of human salivary epidermal growth factor. Am. J. Gastroenterol. 1994; 89: 97–10069. Gilchrist W., Burkhalter E., Eaton C., Schaudies P. R., Maydonovitch C., Andrada F., Maged A. R., Roy K. H., Wong R. K. H. The effect of indomethacin on the secretion of human salivary epidermal growth factor. Am. J. Gastroenterol. 1994; 89: 97–100
   PubMed Web of Science ®Google Scholar