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Journal of the International Society of Sports Nutrition Volume 11, 2014 - Issue 1
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Research Article

High-intensity interval training and β-hydroxy-β-methylbutyric free acid improves aerobic power and metabolic thresholds

Edward H Robinson IV1 Institute of Exercise Physiology & WellnessUniversity of Central Florida, 400032816OrlandoFLUSA;2 College of Education & Human Performance12494 University Boulevard32816OrlandoFLUSA
,
Jeffrey R Stout1 Institute of Exercise Physiology & WellnessUniversity of Central Florida, 400032816OrlandoFLUSA;2 College of Education & Human Performance12494 University Boulevard32816OrlandoFLUSACorrespondence[email protected]
,
Amelia A Miramonti1 Institute of Exercise Physiology & WellnessUniversity of Central Florida, 400032816OrlandoFLUSA;2 College of Education & Human Performance12494 University Boulevard32816OrlandoFLUSA
,
David H Fukuda1 Institute of Exercise Physiology & WellnessUniversity of Central Florida, 400032816OrlandoFLUSA;2 College of Education & Human Performance12494 University Boulevard32816OrlandoFLUSA
,
Ran Wang1 Institute of Exercise Physiology & WellnessUniversity of Central Florida, 400032816OrlandoFLUSA;2 College of Education & Human Performance12494 University Boulevard32816OrlandoFLUSA
,
Jeremy R Townsend1 Institute of Exercise Physiology & WellnessUniversity of Central Florida, 400032816OrlandoFLUSA;2 College of Education & Human Performance12494 University Boulevard32816OrlandoFLUSA
,
Gerald T Mangine1 Institute of Exercise Physiology & WellnessUniversity of Central Florida, 400032816OrlandoFLUSA;2 College of Education & Human Performance12494 University Boulevard32816OrlandoFLUSA
,
Maren S Fragala1 Institute of Exercise Physiology & WellnessUniversity of Central Florida, 400032816OrlandoFLUSA;2 College of Education & Human Performance12494 University Boulevard32816OrlandoFLUSA
&
Jay R Hoffman1 Institute of Exercise Physiology & WellnessUniversity of Central Florida, 400032816OrlandoFLUSA;2 College of Education & Human Performance12494 University Boulevard32816OrlandoFLUSA
 show all
Article: 16 | Published online: 01 Apr 2022

References

  • LaursenPBJenkinsDGThe scientific basis for high-intensity interval trainingSports Med200232 1 53 73 11772161
  • PerryCGRHeigenhauserGJFBonenASprietLLHigh-intensity aerobic interval training increases fat and carbohydrate metabolic capacities in human skeletal muscleAppl Physiol Nutr Metab200833 6 1112 1123 1:CAS:528:DC%2BD1cXhsFSmur%2FJ 19088769
  • LaursenPBShingCMPeakeJMCoombesJSJenkinsDGInfluence of high-intensity interval training on adaptations in well-trained cyclistsJ Strength Cond Res200519 3 527 533 16095414
  • JenkinsDGQuigleyBMThe influence of high-intensity exercise training on the Wlim-Tlim relationshipMed Sci Sports Exerc199325 2 275 282 1:STN:280:DyaK3s7ps1CmsA%3D%3D 8450733
  • JacobsRABoushelRWright‒ParadisCCalbetJARobachPGnaigerELundbyCMitochondrial function in human skeletal muscle following high‒altitude exposureExp Physiol201398 1 245 255 1:CAS:528:DC%2BC3sXjvVOmtr4%3D 22636256
  • HelgerudJHoydalKWangEKarlsenTBergPBjerkaasMSimonsenTHelgesenCHjorthNBachRAerobic High-Intensity Intervals Improve VO2max More Than Moderate TrainingMed Sci Sports Exerc200739 4 665 17414804
  • SmithAEWalterAAGraefJLKendallKLMoonJRLockwoodCMFukudaDHBeckTWCramerJTStoutJREffects of β-alanine supplementation and high-intensity interval training on endurance performance and body composition in men; a double-blind trialJ Int Soc Sports Nutr20096 1 1 9
  • Churchward-VenneTABreenLDi DonatoDMHectorAJMitchellCJMooreDRStellingwerffTBreuilleDOffordEABakerSKPhillipsSMLeucine supplementation of a low-protein mixed macronutrient beverage enhances myofibrillar protein synthesis in young men: a double-blind, randomized trialAm J Clin Nutr201499 2 276 286 1:CAS:528:DC%2BC2cXhs1WlsLk%3D 24284442
  • NortonLELaymanDKLeucine regulates translation initiation of protein synthesis in skeletal muscle after exerciseJ Nutr2006136 2 533S 537S 1:CAS:528:DC%2BD28XhtFGhu78%3D 16424142
  • KatsanosCSKobayashiHSheffield-MooreMAarslandAWolfeRRA high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderlyAm J Physiol Endocrinol Metab2006291 2 E381 E387 1:CAS:528:DC%2BD28XovVWgtLw%3D 16507602
  • CarboneJWMcClungJPPasiakosSMSkeletal muscle responses to negative energy balance: effects of dietary proteinAdv Nutr20123 2 119 126 3648712 1:CAS:528:DC%2BC38XmtVGrsrY%3D 22516719
  • WilkinsonDJHossainTHillDSPhillipsBECrosslandHWilliamsJLoughnaPChurchward-VenneTABreenLPhillipsSMEffects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolismJ Physiol Lond2013591 11 2911 2923 3690694 1:CAS:528:DC%2BC3sXhtVWmtrbJ 23551944
  • WilsonGJWilsonJMManninenAHEffects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: a reviewNutr Metab (Lond)20085 1
  • StoutJRSmith-RyanAEFukudaDHKendallKLMoonJRHoffmanJRWilsonJMOliverJSMustadVAEffect of calcium β-hydroxy-β-methylbutyrate (CaHMB) with and without resistance training in men and women 65 yrs: A randomized, double-blind pilot trialExp Gerontol201348 11 1303 1310 1:CAS:528:DC%2BC3sXhs1Wit7fN 23981904
  • NissenSSharpRRayMRathmacherJARiceDFullerJCJrConnellyASAbumradNEffect of leucine metabolite β-hydroxy-β-methylbutyrate on muscle metabolism during resistance-exercise trainingJ Appl Physiol (1985)199681 5 2095 2104 1:CAS:528:DyaK2sXjs1KqsA%3D%3D
  • FlakollPSharpRBaierSLevenhagenDCarrCNissenSEffect of β-hydroxy-β-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly womenNutrition200420 5 445 1:CAS:528:DC%2BD2cXjsVeltL8%3D 15105032
  • KnitterAPantonLRathmacherJPetersenASharpREffects of β-hydroxy-β-methylbutyrate on muscle damage after a prolonged runJ Appl Physiol200089 4 1340 1344 1:CAS:528:DC%2BD3cXotlyltbg%3D 11007567
  • VukovichMDDreifortGDEffect of [beta]-Hydroxy-[beta]-Methylbutyrate on the Onset of Blood Lactate Accumulation and VO2peak in Endurance-Trained CyclistsJ Strength Cond Res200115 4 491 497 1:STN:280:DC%2BD38%2FivVOitg%3D%3D 11726262
  • LamboleyCRRoyerDDionneIJEffects of beta-hydroxy-beta-methylbutyrate on aerobic-performance components and body composition in college studentsInt J Sport Nutr Exerc Metab200717 1 56 69 1:CAS:528:DC%2BD2sXjsFeks7Y%3D 17469236
  • WilsonJMLoweryRPJoyJMWaltersJABaierSMFullerJCStoutJRNortonLESikorskiEMWilsonSβ-Hydroxy-β-methylbutyrate free acid reduces markers of exercise-induced muscle damage and improves recovery in resistance-trained menBr J Nutr20131 1 1 7
  • KollerAMairJSchobersbergerWWohlfarterTHaidCMayrMVilligerBFreyWPuschendorfBEffects of prolonged strenuous endurance exercise on plasma myosin heavy chain fragments and other muscular proteins. Cycling vs runningJ Sports Med Phys Fitness199838 1 10 17 1:CAS:528:DyaK1cXjsF2jurs%3D 9638026
  • GravettierFJWallnauLB Statistics for the Behavioral Sciences1996 St. Paul, MN West Publishing Co.
  • NissenSVan KoeveringMWebbDAnalysis of β-hydroxy-β-methylbutyrate in plasma by gas chromatography and mass spectrometryAnal Biochem1990188 1 17 19 1:CAS:528:DyaK3cXltFWqs7c%3D 2221358
  • BergstromHCHoushTJZunigaJMTraylorDACamicCLLewisRWJrSchmidtRJJohnsonGOThe Relationships Among Critical Power Determined From a 3-Min All-Out Test, Respiratory Compensation Point, Gas Exchange Threshold, and Ventilatory ThresholdRes Q Exerc Sport201384 2 232 238 23930549
  • DayJRRossiterHBCoatsEMSkasickAWhippBJThe maximally attainable VO2 during exercise in humans: the peak vs. maximum issueJ Appl Physiol (1985)200395 5 1901 1907 1:STN:280:DC%2BD3svnslGgtA%3D%3D
  • BeaverWLWassermanKWhippBJA new method for detecting anaerobic threshold by gas exchangeJ Appl Physiol (1985)198660 6 2020 2027 1:STN:280:DyaL283ltVCrug%3D%3D
  • GaskillSERubyBCWalkerAJSanchezOASerfassRCLeonASValidity and reliability of combining three methods to determine ventilatory thresholdMed Sci Sports Exerc200133 11 1841 1848 1:STN:280:DC%2BD3MnltFajsw%3D%3D 11689733
  • WassermanKWhippBKoyalSBeaverWAnaerobic threshold and respiratory gas exchange during exerciseJ Appl Physiol197335 2 236 243 1:CAS:528:DyaE3sXkslKmt7o%3D 4723033
  • CaiozzoVJDavisJAEllisJFAzusJLVandagriffRPriettoCMcMasterWA comparison of gas exchange indices used to detect the anaerobic thresholdJ Appl Physiol198253 5 1184 1189 1:STN:280:DyaL3s%2Fot1amsA%3D%3D 7174412
  • HuckSWMcLeanRAUsing a repeated measures ANOVA to analyze the data from a pretest-posttest design: A potentially confusing taskPsychol Bull197582 4 511
  • GreenSSalkindNAkeyTMethods for controlling type I error across multiple hypothesis testsUsing SPSS for Windows: Analysing and Understanding Data2000 2 New Jersey Prentice-Hall 395 396
  • DuffieldREdgeJBishopDEffects of high-intensity interval training on the response during severe exerciseJ Sci Med Sport20069 3 249 255 16690353
  • TalanianJLGallowaySDHeigenhauserGJBonenASprietLLTwo weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in womenJ Appl Physiol2007102 4 1439 1447 1:CAS:528:DC%2BD2sXlt1antr0%3D 17170203
  • JourkeshMAhmaidiSKeikhaBSadriIOjagiAEffects of six weeks sodium bicarbonate supplementation and high-intensity interval training on endurance performance and body compositionAnn Biol Res20112 2 403 404 1:CAS:528:DC%2BC3MXlsFemsrc%3D 413
  • ZanchiNGerlinger-RomeroFGuimarães-FerreiraLde Siqueira FilhoMFelittiVLiraFSeelaenderMLanchaAHMB supplementation: clinical and athletic performance-related effects and mechanisms of actionAmino Acids201140 4 1015 1025 1:CAS:528:DC%2BC3MXjsFGjtL0%3D 20607321
  • StoutJCramerJZoellerRTorokDCostaPHoffmanJHarrisRO’kroyJEffects of β-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in womenAmino Acids200732 3 381 386 1:CAS:528:DC%2BD2sXjvFanu7c%3D 17136505
  • ZoellerRStoutJO’kroyJTorokDMielkeMEffects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustionAmino Acids200733 3 505 510 1:CAS:528:DC%2BD2sXpvVahu74%3D 16953366
  • GaesserGAPooleDCThe slow component of oxygen uptake kinetics in humansExerc Sport Sci Rev199624 1 35 70 1:STN:280:DyaK28zltlKntw%3D%3D 8744246
  • WassermanKBeaverWLWhippBJGas exchange theory and the lactic acidosis (anaerobic) thresholdCirculation199081 1 Suppl II14 II30 1:STN:280:DyaK3c7gs12ntw%3D%3D 2403868
  • PatersonDJFriedlandJSBascomDAClementIDCunninghamDAPainterRRobbinsPAChanges in arterial K + and ventilation during exercise in normal subjects and subjects with McArdle’s syndromeJ Physiol1990429 339 348 1181703 1:STN:280:DyaK3M7hs1Gntw%3D%3D 2277352
  • BergerNJCampbellITWilkersonDPJonesAMInfluence of acute plasma volume expansion on VO2 kinetics, VO2 peak, and performance during high-intensity cycle exerciseJ Appl Physiol (1985)2006101 3 707 714
  • EddyDOSparksKLAdeliziDAThe effects of continuous and interval training in women and menEur J Appl Physiol Occup Physiol197737 2 83 92 1:CAS:528:DyaE1cXjsFWitA%3D%3D 902658
  • HeckHMaderAHessGMuckeSMullerRHollmannWJustification of the 4-mmol/l lactate thresholdInt J Sports Med19856 3 117 130 1:STN:280:DyaL2M3oslOktQ%3D%3D 4030186
  • EdgeJBishopDGoodmanCThe effects of training intensity on muscle buffer capacity in femalesEur J Appl Physiol200696 1 97 105 1:CAS:528:DC%2BD2MXht1OisrnM 16283370
  • WestonSBZhouSWeatherbyRPRobertsonSJDoes exogenous coenzyme Q10 affect aerobic capacity in endurance athletes?Int J Sport Nutr19977 3 197 1:CAS:528:DyaK2sXmt1Wlu7Y%3D 9286743
  • HenrikssonJEffects of physical training on the metabolism of skeletal muscleDiabetes Care199215 11 1701 1711 1:STN:280:DyaK3s7gsFOqsg%3D%3D 1468304
  • KrustrupPSöderlundKMohrMBangsboJThe slow component of oxygen uptake during intense, sub-maximal exercise in man is associated with additional fibre recruitmentPflugers Arch2004447 6 855 866 1:CAS:528:DC%2BD2cXhvFCntbY%3D 14758477
  • BruckbauerAZemelMBThorpeTAkulaMRStuckeyACOsborneDMartinEBKennelSWallJSSynergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and miceNutr Metab (Lond)20129 1 77 1:CAS:528:DC%2BC3sXlsVCmug%3D%3D
  • PinheiroCGerlinger-RomeroFGuimarães-FerreiraLSouza-JrAVitzelKNachbarRNunesMCuriRMetabolic and functional effects of beta-hydroxy-beta-methylbutyrate (HMB) supplementation in skeletal muscleEur J Appl Physiol2012112 7 2531 2537 1:CAS:528:DC%2BC38XosFCku7w%3D 22075640
  • VerdinEHirscheyMDFinleyLWHaigisMCSirtuin regulation of mitochondria: energy production, apoptosis, and signalingTrends Biochem Sci201035 12 669 675 2992946 1:CAS:528:DC%2BC3cXhsVGnsrjE 20863707
  • HardieDGSakamotoKAMPK: a key sensor of fuel and energy status in skeletal musclePhysiology (Bethesda)200621 1 48 60 1:CAS:528:DC%2BD28XitVWlsrk%3D

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