10
Views
19
CrossRef citations to date
0
Altmetric
Original Article

Nutritional Supplement (NT Factor™) Restores Mitochondrial Function and Reduces Moderately Severe Fatigue in Aged Subjects

, , , , , & show all
Pages 23-36 | Published online: 04 Dec 2011

References

  • Kroenke K, Wood DR, Mangelsdorff AD, Meier NJ, Powell JB. Chronic fa-tigue in primary care. Prevalence, patient characteristics, and outcome. JAMA 1988; 260:929–934.
  • Morrison JD. Fatigue as a presenting complaint in family practice. J Family Pract 1980; 10:795–801.
  • McDonald E, David AS, Pelosi AJ, Mann AH. Chronic fatigue in primary care attendees. Psychol Med 1993; 23:987–998.
  • Piper BF, Linsey AM, Dodd MJ. Fatigue mechanism in cancer. Oncol Nursing Forum 1987; 14:17–23.
  • Richter C, Par JW, Ames B. Normal oxidative damage to mitochondrial and nu-clear DNA is extensive. Proc Nat Acad Sci USA 1998; 85:6465–6467.
  • Wei YH, Lee HC. Oxidative stress, mitochondria' DNA mutation and impair-ment of antioxidant enzymes in aging. Exp Biol Med 2002; 227:671–682.
  • Spector AA, Yorek MA. Membrane lipid composition and cellular function. J Lipid Res 1985; 26:10105.
  • Harman D. Aging: A theory based on free radical and radiation chemistry. J Gerontol 1956; 2:298–300.
  • Xu D, Finkel T. A role for mitochondria as potential regulators of cellular life span. Biochem Biophysics Res Commun 2002; 294:245–248.
  • Colodny L, Lynch K, Farber C, Papish S, et al. Results of a study to evaluate the use of Protax to reduce adverse effects of chemotherapy. JANA 2000; 2:17–25.
  • Seidman M, Khan MJ, Tang WX, Quirk WS. Influence of lecithin on mitochon-dria' DNA and age-related hearing loss. Otolaryngol Head Neck Surg 2002; 127: 138–144.
  • Ellithorpe RR, Settineri R, Nicolson GL. Pilot Study: Reduction of fatigue by use of a dietary supplement containing glycophospholipids. JANA 2003; in press.
  • Kim MJ, Cooper DD, Hayes SF, Spangrude GJ. Rhodamine-123 staining in hematopoietic stem cells of young mice indicates mitochondria' activation rather than dye efflux. Blood 1998; 91: 4106–4117.
  • Nunnally JC. 1978. Psychometric Theory (2nd ed.) New York: McGraw-Hill, pp. 117–123.
  • Zeisel SH, In Hanin I, Popell G (eds.) 1996. Phospholipids, biochemical phar-maceutical and analytical considerations. New York: Plenum Press, pp. 219–231.
  • Conlay LA, Wurtman RJ, Blusztajn K, et al. Decreased plasma choline concen-trations in marathon runners. N Engl J Med 1986; 315:892.
  • Johns DR. Seminars in medicine of Beth Israel Hospital, Boston: Mitochondria' DNA and Disease. N Engl J Med 1995; 333: 638–644.
  • Kowald A. The mitochondrial theory of aging: do damaged mitochondria accu-mulate by delayed degradation? Exp Gerontol 1999; 34:605–612.
  • Paradies G, Petrosillo G, Pistolese M, Ruggiero F. Reactive oxygen species af-fect mitochondria' electron transport complex I activity through oxidative cardiolipin damage. Gene 2002; 286:135–141.
  • Lin M, Simon D, Ahn C, Lauren K, Beal MF. High aggregrate burden of so-matic mtDNA point mutations in aging and Alzheimer's disease brain. Human Mol Genet 2002; 11:133–145.
  • Koboska J, Coskun P, Esposito L, Wallace DC. Increased mitochondria' oxida-tive stress in the Sod2(+/- ) mouse results in age-related decline of mitochondria' func-tion culminating in increased apoptosis. Proc Nat Acad Sci USA 2001; 98:2278–2283.
  • Biagini G, Pallotti F, Carraro S, et al. Mitochondria' DNA in platelets from aged subjects. Mech Ageing Dev 1998; 101:269–275.
  • Meissner C, Mohamed SA, Klueter H, Hamann K, von Wurmb N, Oehmichen M. Quantification of mitochondria' DNA in human blood cells using an automated de-tection system. Forensic Sci Int 2000; 113:109–112.
  • Lee HC, Oang CY, Hsu HS, Wei YH. Deletion in blood mitochondrial DNA in Kearns-Sayre syndrome. Biochim Biophys Acta 1994; 1226:37–43.
  • Poulton J, Deadman ME, Ramacharan S, Gardiner RM. Germ-line deletions of mtDNA in mitochondrial myopathy. Am J Hum Genet 1991; 90:649–653.
  • Smith OP, Hamm MJ, Woodward CE, Brockington M. Pearson's marrow/pan-creas syndrome: haematological features associated with deletion and duplication of mitochondrial DNA. Br J Haemotol 1995; 90:469–472.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.