Fibromyalgia Syndrome: A Central Role for the Hippocampus—A Theoretical Construct

REFERENCES

• Hudson J I, Goldenberg D L, Pope H G, Jr., Keck P E, Jr., Schlesinger L. Comorbidity of fibromyalgia with medical and psychiatric disorders:. Am J Med 1992; 92(4)363–367
   PubMed Web of Science ®Google Scholar
• Demitrack M A, Crofford L J. Evidence for and pathophysiologic implications of hypothalamic-pituitary-adrenal axis dysregulation in fibromyalgia and chronic fatigue syndrome:. Ann NY Acad Sci 1998; 840: 684–697
   PubMed Web of Science ®Google Scholar
• McEwen B S. Effects of adverse experiences for brain structure and function. Biol Psychiatry 2000; 48(8)721–731
   PubMed Web of Science ®Google Scholar
• Riedel W, Layka H, Neeck G. Secretory pattern of GH, TSH, thyroid hormones, ACTH, cortisol, FSH, and LH in patients with fibromyalgia syndrome following systemic injection of the relevant hypothalamic-releasing hormones. Z Rheumatol 57 Suppl 1998; 2: 81–87
   Google Scholar
• Neeck G, Crofford L J. Neuroendocrine perturbations in fibromyalgia and chronic fatigue syndrome. Rheum Dis Clin North Am 2000; 26(4)989–1002
   PubMed Web of Science ®Google Scholar
• Riedel W, Schlapp U, Leck S, Netter P, Neeck G. Blunted ACTH and cortisol responses to systemic injection of corticotropin-releasing hormone [CRH] in fibromyalgia: Role of somatostatin and CRH-binding protein. Ann N Y Acad Sci 2002; 966: 483–490
   PubMed Web of Science ®Google Scholar
• Martinez-Lavin M, Hermosillo A G, Mendoza C, Ortiz R, Cajigas J C, Pineda C, Nava A, Vallejo M. Orthostatic sympathetic derangement in subjects with fibromyalgia. J Rheumatol 1997; 24(4)714–8
   PubMed Web of Science ®Google Scholar
• Cohen H, Neumann L, Alhosshle A, Kotler M, Abu-Shakra M, Buskila D. Abnormal sympathovagal balance in men with fibromyalgia. J Rheumatol. 2001; 28(3)581–9
   PubMed Web of Science ®Google Scholar
• Martinez-Lavin M, Hermosillo A G, Rosas M, Soto M E. Circadian studies of autonomic nervous balance in patients with fibromyalgia: A heart rate variability analysis. Arthritis Rheum 1998; 41(11)1966–71
   PubMed Web of Science ®Google Scholar
• Cohen H, Neumann L, Shore M, Amir M, Cassuto Y, Buskila D. Autonomic dysfunction in patients with fibromyalgia: Application of power spectral analysis of heart rate variability. Semin Arthritis Rheum 2000; 29(4)217–27
   PubMed Web of Science ®Google Scholar
• Martinez-Lavin M, Hermosillo A G. Autonomic nervous system dysfunction may explain the multisystem features of fibromyalgia. Semin Arthritis Rheum 2000; 29(4)197–9
   PubMed Web of Science ®Google Scholar
• Fisher L A. Corticotropin-releasing factor: Endocrine and autonomic integration of responses to stress. Trends Pharmacol Sci 1989; 10(5)189–93
   PubMed Web of Science ®Google Scholar
• Francis D D, Caldji C, Champagne F, Plotsky P M, Meaney M J. The role of corticotropin-releasing factor—norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress. Biol Psychiatry 1999; 46(9)1153–66
   PubMed Web of Science ®Google Scholar
• De Bellis M D, Chrousos G P, Dorn L D, Burke L, Helmers K, Kling M A, Trickett P K, Putnam F W. Hypothalamic-pituitary-adrenal axis dysregulation in sexually abused girls. J Clin Endocrinol Metab 1994; 78(2)249–55
   PubMed Web of Science ®Google Scholar
• Walker E A, Keegan D, Gardner G, Sullivan M, Bernstein D, Katon W J. Psychosocial factors in fibromyalgia compared with rheumatoid arthritis: II. Sexual, physical, and emotional abuse and neglect. Psychosom Med 1997; 59(6)572–7
   PubMed Web of Science ®Google Scholar
• Imbierowicz K, Egle U T. Childhood adversities in patients with fibromyalgia and somatoform pain disorder. Eur J Pain, 7(2)113–9, 2003
   PubMed Web of Science ®Google Scholar
• Eichenbaum H. The hippocampus and declarative memory: Cognitive mechanisms and neural codes. Behav Brain Res 2001; 127(1–2)199–207
   PubMed Web of Science ®Google Scholar
• Sapolsky R M. Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry 2000; 57(10)925–35
   PubMed Web of Science ®Google Scholar
• Carlson L E, Sherwin B B. Relationships among cortisol [CRT], dehydroepiandrosterone-sulfate [DHEAS], and memory in a longitudinal study of healthy elderly men and women. Neurobiol Aging 1999; 20(3)315–24
   PubMed Web of Science ®Google Scholar
• Chrousos G P. Stressors, stress, and neuroendocrine integration of the adaptive response. The 1997 Hans Selye Memorial Lecture. Ann NY Acad Sci 30; 1998; 851: 311–35
   PubMed Web of Science ®Google Scholar
• Lopez J F, Akil H, Watson S J. Neural circuits mediating stress. Biol Psychiatry 1999; 46(11)1461–71
   PubMed Web of Science ®Google Scholar
• Kaufman J, Plotsky P M, Nemeroff C B, Charney D S. Effects of early adverse experiences on brain structure and function: Clinical implications. Biol Psychiatry 2000; 48(8)778–90
   PubMed Web of Science ®Google Scholar
• Herman J P, Schafer M K, Young E A, Thompson R, Douglass J, Akil H, Watson S J. Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis. J Neurosci 1989; 9(9)3072–82
   PubMed Web of Science ®Google Scholar
• Herman J P, Cullinan W E, Young E A, Akil H, Watson S J. Selective forebrain fiber tract lesions implicate ventral hippocampal structures in tonic regulation of paraventricular nucleus corticotropin-releasing hormone [CRH] and arginine vasopressin (AVP) mRNA expression. Brain Res 1992; 592(1–2)228–38
   PubMed Web of Science ®Google Scholar
• Owens M J, Nemeroff C B. Physiology and pharmacology of corticotropin-releasing factor. Pharmacol Rev 1991; 43(4)425–73
   PubMed Web of Science ®Google Scholar
• McEwen B S. Plasticity of the hippocampus: Adaptation to chronic stress and allostatic load. Ann NY Acad Sci 2001; 933: 265–77
   PubMed Web of Science ®Google Scholar
• Bingel U, Quante M, Knab R, Bromm B, Weiller C, Buchel C. Subcortical structures involved in pain processing: Evidence from single-trial fMRI. Pain 2002; 99(1–2)313–21
   PubMed Web of Science ®Google Scholar
• Dutar P, Lamour Y, Jobert A. Activation of identified septo-hippocampal neurons by noxious peripheral stimulation. Brain Res 1985; 328(1)15–21
   PubMed Web of Science ®Google Scholar
• Zheng F, Khanna S. Hippocampal field CA1 interneuronal nociceptive responses: Modulation by medial septal region and morphine. Neuroscience 1999; 93(1)45–55
   PubMed Web of Science ®Google Scholar
• Sinnamon H M, Schwartzbaum J S. Dorsal hippocampal unit and egg responses to rewarding and aversive brain stimulation in rats. Brain Res 1973; 56: 183–202
   PubMed Web of Science ®Google Scholar
• McKenna J E, Melzack R. Analgesia produced by lidocaine micro injection into the dentate gyrus. Pain 1992; 49(1)105–12
   PubMed Web of Science ®Google Scholar
• McKenna J E, Melzack R. Blocking NMDA receptors in the hippocampal dentate gyrus with AP5 produces analgesia in the formalin pain test. Exp Neurol 2001; 172(1)92–9
   PubMed Web of Science ®Google Scholar
• Wei F, Xu Z C, Qu Z, Milbrandt J, Zhuo M. Role of EGR1 in hippocampal synaptic enhancement induced by tetanic stimulation and amputation. J Cell Biol 2000; 149(7)1325–34
   PubMed Web of Science ®Google Scholar
• Lee E H, Lee C P, Wang H I, Lin W R. Hippocampal CRF, NE, and NMDA system interactions in memory processing in the rat. Synapse 1993; 14(2)144–53
   PubMed Web of Science ®Google Scholar
• Radulovic J, Fischer A, Katerkamp U, Spiess J. Role of regional neurotransmitter receptors in corticotropin-releasing factor [CRF]-mediated modulation of fear conditioning. Neuropharmacology 2000; 39(4)707–10
   PubMed Web of Science ®Google Scholar
• Wang H L, Wayner M J, Chai C Y, Lee E H. Corticotrophin-releasing factor produces a long-lasting enhancement of synaptic efficacy in the hippocampus. Eur J Neurosci 1998; 10(11)3428–37
   PubMed Web of Science ®Google Scholar
• Radulovic J, Ruhmann A, Liepold T, Spiess J. Modulation of learning and anxiety by corticotropin-releasing factor [CRF] and stress: Differential roles of CRF receptors 1 and 2. J Neurosci 1999; 19(12)5016–25
   PubMed Web of Science ®Google Scholar
• Blank T, Nijholt I, Eckart K, Spiess J. Priming of long-term potentiation in mouse hippocampus by corticotropin-releasing factor and acute stress: Implications for hippocampus-dependent learning. J Neurosci 2002; 22(9)3788–94
   PubMed Web of Science ®Google Scholar
• Takahashi T, Kimoto T, Tanabe N, Hattori T A, Yasumatsu N, Kawato S. Corticosterone acutely prolonged N-methyl-d-aspartate receptor-mediated Ca2+ elevation in cultured rat hippocampal neurons. J Neurochem 2002; 83(6)1441–51
   PubMed Web of Science ®Google Scholar
• Kerr D S, Campbell L W, Thibault O, Landfield P W. Hippocampal glucocorticoid receptor activation enhances voltage-dependent Ca2+ conductances: Relevance to brain aging. Proc Natl Acad Sci USA 1992; 89(18)8527–31
   PubMed Web of Science ®Google Scholar
• Bremner J D, Krystal J H, Southwick S M, Charney D S. Noradrenergic mechanisms in stress and anxiety: I. Preclinical studies. Synapse 1996; 23(1)28–38
   PubMed Web of Science ®Google Scholar
• Sarvey J M, Burgard E C, Decker G. Long-term potentiation: Studies in the hippocampal slice. J Neurosci Methods 1989; 28(1–2)109–24
   PubMed Web of Science ®Google Scholar
• Hu L A, Tang Y, Miller W E, Cong M, Lau A G, Lefkowitz R J, Hall R A. Beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors. J Biol Chem 2000; 275(49)38659–66
   PubMed Web of Science ®Google Scholar
• Garry E M, Moss A, Delaney A, O'Neill F, Blakemore J, Bowen J, Husi H, Mitchell R, Grant S G, Fleetwood-Walker S M. Neuropathic Sensitization of Behavioral Reflexes and Spinal NMDA Receptor/CaM Kinase II Interactions Are Disrupted in PSD-95 Mutant Mice. Curr Biol, 13(4)321–8, 2003
   PubMed Web of Science ®Google Scholar
• Carrasco G A, Van de Kar L D. Neuroendocrine pharmacology of stress. Eur J Pharmacol, 463(1–3)235–72, 2003
   PubMed Web of Science ®Google Scholar
• Lieberman D N, Mody I. Substance P enhances NMDA channel function in hippocampal dentate gyrus granule cells. J Neurophysiol 1998; 80(1)113–9
   PubMed Web of Science ®Google Scholar
• Zhou Q, Le Greves P, Ragnar F, Nyberg F. Intracerebroventricular injection of the N-terminal substance P fragment SP(1–7) regulates the expression of the N-methyl-D-aspartate receptor NR1, NR2A and NR2B subunit mRNAs in the rat brain. Neurosci Lett 2000; 291(2)109–12
   PubMed Web of Science ®Google Scholar
• Liu H, Mazarati A M, Katsumori H, Sankar R, Wasterlain C G. Substance P is expressed in hippocampal principal neurons during status epilepticus and plays a critical role in the maintenance of status epilepticus. Proc Natl Acad Sci USA 1999; 96(9)5286–91
   PubMed Web of Science ®Google Scholar
• van der Hart M G, Czeh B, de Biurrun G, Michaelis T, Watanabe T, Natt O, Frahm J, Fuchs E. Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume. Mol Psychiatry 2002; 7(9)933–41
   PubMed Web of Science ®Google Scholar
• Sapolsky R M. Stress, Glucocorticoids, and Damage to the Nervous System: The Current State of Confusion. Stress Jul; 1996; 1(1)1–19
   PubMedGoogle Scholar
• DeVries A C, Joh H D, Bernard O, Hattori K, Hurn P D, Traystman R J, Alkayed N J. Social stress exacerbates stroke outcome by suppressing Bc1–2 expression. Proc Natl Acad Sci USA 2001; 98(20)11824–8
   PubMed Web of Science ®Google Scholar
• Starkman M N, Gebarski S S, Berent S, Schteingart D E. Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome. Biol Psychiatry 1992; 32(9)756–65
   PubMed Web of Science ®Google Scholar
• Sheline Y I, Wang P W, Gado M H, Csernansky J G, Vannier M W. Hippocampal atrophy in recurrent major depression. Proc Natl Acad Sci USA 1996; 93(9)3908–13
   PubMed Web of Science ®Google Scholar
• Urban M O, Gebhart G F. The glutamate synapse: A target in the pharmacological management of hyperalgesic pain states. Prog Brain Res 1998; 116: 407–20
   PubMed Web of Science ®Google Scholar
• Svendsen F, Tjolsen A, Hole K. LTP of spinal A beta and C-fibre evoked responses after electrical sciatic nerve stimulation. Neuroreport 1997; 8(16)3427–30
   PubMed Web of Science ®Google Scholar
• Liu X G, Sandkuhler J. Activation of spinal N-methyl-D-aspartate or neurokinin receptors induces long-term potentiation of spinal C-fibre-evoked potentials. Neuroscience 1998; 86(4)1209–16
   PubMed Web of Science ®Google Scholar
• Urban M O, Gebhart G F. Supraspinal contributions to hyperalgesia. Proc Natl Acad Sci USA 1999; 96(14)7687–92
   PubMed Web of Science ®Google Scholar
• Yunus M B. Towards a model of pathophysiology of fibromyalgia: Aberrant central pain mechanisms with peripheral modulation. J Rheumatol 1992; 19(6)846–50
   PubMed Web of Science ®Google Scholar
• Staud R, Vierck C J, Cannon R L, Mauderli A P, Price D D. Abnormal sensitization and temporal summation of second pain (wind-up) in patients with fibromyalgia syndrome. Pain 2001; 91(1–2)165–75
   PubMed Web of Science ®Google Scholar
• Bennett R M. The rational management of fibromyalgia patients. Rheum Dis Clin North Am 2002; 28(2)181–99
   PubMed Web of Science ®Google Scholar
• Graven-Nielsen T, Aspegren Kendall S, Henriksson K G, Bengtsson M, Sorensen J, Johnson A, Gerdle B, Arendt-Nielsen L. Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients. Pain 2000; 85(3)483–91
   PubMed Web of Science ®Google Scholar
• Grace G M, Nielson W R, Hopkins M, Berg M A. Concentration and memory deficits in patients with fibro-myalgia syndrome. J Clin Exp Neuropsychol 1999; 21(4)477–87
   PubMed Web of Science ®Google Scholar
• Park D C, Glass J M, Minear M, Crofford L J. Cognitive function in fibromyalgia patients. Arthritis Rheum 2001; 44(9)2125–33
   PubMed Web of Science ®Google Scholar
• Sapolsky R M. Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry 2000; 57(10)925–35
   PubMed Web of Science ®Google Scholar
• Carlson L E, Sherwin B B. Relationships among cortisol [CRT], dehydroepiandrosterone-sulfate [DHEAS], and memory in a longitudinal study of healthy elderly men and women. Neurobiol Aging 1999; 20(3)315–24
   PubMed Web of Science ®Google Scholar