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Therapeutic applications of the gaseous mediators carbon monoxide and hydrogen sulfide

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Pages 663-682 | Published online: 06 May 2009

Bibliography

  • Wu L, Wang R. Carbon monoxide: endogenous production, physiological functions, and pharmacological applications. Pharmacol Rev 2005;57:585-630
  • Kamoun P. Endogenous production of hydrogen sulfide in mammals. Amino acids 2004;26:243-5
  • Ignarro L. Endothelium-derived nitric oxide: actions and properties. FASEB J 1989;3:31-6
  • Moncada S, Higgs A. The L-arginine-nitric oxide pathway. NEJM 1993;329:2002-12
  • Sjöstrand T. Endogenous formation of carbon monoxide: the CO concentration in the inspired and expired air of hospital patients. Acta Physiol. Scand 1951;22(2-3):137-141
  • Verma A, Hirsch DJ, Glatt CE, et al. Carbon monoxide: a putative neural messenger. Science 1993;259:381-4
  • Li L, Moore PK. An overview of the biological significance of endogenous gases: new roles for old molecules. Biochem Soc Trans 2007;35:1138-41
  • Ryter SW, Alam J, Choi AM. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev 2006;86(2):583-650
  • Dore S. Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimer's disease. Free Radic Biol Med 2002;32(12):1276-82
  • Lin Q, Weis S, Yang G, et al. Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress. J. Biol. Chem 2007;282(28):20621-33
  • Lin QS, Weis S, Yang G, et al. Catalytic inactive heme oxygenase-1 protein regulates its own expression in oxidative stress. Free Radic Biol Med 2008;44(5):847-55
  • Motterlini R, Clark JE, Foresti R, et al. Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities. Circ Res 2002;90(2):E17-24
  • Clark JE, Naughton P, Shurey S, et al. Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Circ Res 2003;93(2):e2-8
  • Motterlini R, Sawle P, Hammad J, et al. CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule. FASEB J 2005;19:284-6
  • Otterbein LE, Bach FH, Alam J, et al. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med 2000;6(4):422-8
  • Chora AA, Fontoura P, Cunha A, et al. Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation. J Clin Invest 2007;117(2):438-47
  • Ott MC, Scott JR, Bihari A, et al. Inhalation of carbon monoxide prevents liver injury and inflammation following hind limb ischemia/reperfusion. FASEB J 2005;19(1):106-8
  • Mishra S, Fujita T, Lama VN, et al. Carbon monoxide rescues ischemic lungs by interrupting MAPK-driven expression of early growth response 1 gene and its downstream target genes. Proc Natl Acad Sci USA 2006;103(13):5191-6
  • Sawle P, Foresti R, Mann BE, et al. Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages. Br J Pharmacol 2005;145(6):800-10
  • Chin BY, Jiang G, Wegiel B, et al. Hypoxia-inducible factor 1α stabilization by carbon monoxide results in cytoprotective preconditioning. Proc Natl Acad Sci USA 2007;104(12):5109-14
  • Brouard S, Otterbein LE, Anrather J, et al. Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis. J Exp Med 2000;192(7):1015-26
  • Brouard S, Berberat PO, Tobiasch E, et al. Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-κB to protect endothelial cells from tumor necrosis factor-alpha-mediated apoptosis. J Biol Chem 2002;277(20):17950-61
  • Zhang X, Shan P, Otterbein LE, et al. Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. J Biol Chem 2003;278(2):1248-58
  • Zhang X, Shan P, Alam J, et al. Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury. J Biol Chem 2003;278(24):22061-70
  • Vieira HLA, Queiroga CSF, Alves PM. Preconditioning induced by carbon monoxide provides neuronal protection against apoptosis. J Neurochem 2008;107:375-84
  • Liu XM, Chapman GB, Peyton KJ, et al. Antiapoptotic action of carbon monoxide on cultured vascular smooth muscle cells. Exp Biol Med 2003;228(5):572-5
  • Sarady JK, Zuckerbraun BS, Bilban M, et al. Carbon monoxide protection against endotoxic shock involves reciprocal effects on iNOS in the lung and liver. FASEB J 2004;18(7):854-6
  • Morita T, Perrella MA, Lee ME, Kourembanas S. Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP. Proc Natl Acad Sci USA 1995;92(5):1475-9
  • Otterbein LE, Zuckerbraun BS, Haga M, et al. Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nat Med 2003;9(2):183-90
  • Song R, Mahidhara RS, Liu F, et al. Carbon monoxide inhibits human airway smooth muscle cell proliferation via mitogen-activated protein kinase pathway. Am J Respir Cell Mol Biol 2002;27(5):603-10
  • Ameredes BT, Otterbein LE, Kohut LK, et al. Low-dose carbon monoxide reduces airway hyperresponsiveness in mice. Am J Physiol Lung Cell Mol Physiol 2003;285(6):L1270-6
  • Song R, Mahidhara RS, Zhou Z, et al. Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway. J Immunol 2004;172(2):1220-12266
  • Graser T, Vedernikov YP, Li DS. Study on the mechanism of carbon monoxide induced endothelium-independent relaxation in porcine coronary artery and vein. Biomed Biochim Acta 1990;49(4):293-6
  • Hussain AS, Marks GS, Brien JF, Nakatsu K. The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-alpha] quinoxalin-1-one (ODQ) inhibits relaxation of rabbit aortic rings induced by carbon monoxide, nitric oxide, and glyceryl trinitrate. Can J Physiol Pharmacol 1997;75:1034-7
  • Christodoulides N, Durante W, Kroll MH, Schafer AI. Vascular smooth muscle cell heme oxygenases generate guanylyl cyclase-stimulatory carbon monoxide. Circulation 1995;91(9):2306-9
  • Cardell LO, Ueki IF, Stjärne P, et al. Bronchodilatation in vivo by carbon monoxide, a cyclic GMP related messenger. Br J Pharmacol 1998;124(6):1065-8
  • Kaide JI, Zhang F, Wei Y, et al. Carbon monoxide of vascular origin attenuates the sensitivity of renal arterial vessels to vasoconstrictors. J Clin Invest 2001;107(9):1163-71
  • Jaggar JH, Leffler CW, Cheranov SY, et al. Carbon monoxide dilates cerebral arterioles by enhancing the coupling of Ca2+ sparks to Ca2+-activated K+ channels. Circ Res 2002;91(7):610-7
  • Zhang F, Kaide J, Wei Y, et al. Carbon monoxide produced by isolated arterioles attenuates pressure-induced vasoconstriction. Am J Physiol Heart Circ Physiol 2001;281(1):H350-8
  • Li A, Xi Q, Umstot ES, et al. Astrocyte-derived CO is a diffusible messenger that mediates glutamate-induced cerebral arteriolar dilation by activating smooth muscle cell KCa channels. Circ Res 2008;102(2):234-41
  • Motterlini R, Foresti R, Grenn CJ. Studies on the development of carbon monoxide releasing molecules: potential applications for the treatment of cardiovascular dysfunction. In: Wang R, editor, CRC Press, Boca Raton, Florida, USA, 2002. p. 149-271
  • Mann BE, Motterlini R. CO and NO in medicine. Chem Commun 2007;(41):4197-208
  • Motterlini R, Mann BE, Foresti R. Therapeutic applications of carbon monoxide-releasing molecules. Expert Opin Investig Drugs 2005;14:1305-18
  • Dominy JE, Stipanuk MH. New roles for cysteine and transsulfuration enzymes: production of H2S, a neuromodulator and smooth muscle relaxant. Nutr Rev 2004;62:348-53
  • Abe K, Kimura H. The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci 1996;16:1066-71
  • Hosoki R, Matsuki N, Kimura H. The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochem Biophys Res Commun 1997;237:527-31
  • Zhao W, Zhang J, Lu Y, Wang R. The vasorelaxant effect of H2S as a novel endogenous gaseous K(ATP) channel opener. EMBO J 2001;20:6008-16
  • Shibuya N, Tanaka M,Yoshida M, et al. 3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain. Antioxid Redox Signal 2008 In press
  • Ishikami M, Hiraki K, Umemura K, et al. A source of hydrogen sulfide and a mechanism of release in brain. Antioxid Redox Signal 2009;11:1-10
  • Furne J, Saeed A, Levitt MD. Whole tissue hydrogen sulfide concentrations are orders of magnitude lower than presently accepted values. Am J Physiol Regul Integr Comp Physiol 2008;295:R1479-85
  • Cheng Y, Ndisang JF, Tang G, et al. Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats. Am J Physiol Heart Circ Physiol 2004;287:H2316-23
  • Geng B, Cui Y, Zhao J, et al. Hydrogen sulfide downregulates the aortic L-arginine/nitric oxide pathway in rats. Am J Physiol Regul Integr Comp Physiol 2007;293:R1608-11618
  • Kubo S, Doe I, Kurokawa Y, et al. Direct inhibition of endothelial nitric oxide synthase by hydrogen sulfide: contribution to dual modulation of vascular tension. Toxicol 2007;232:138-46
  • Ali MY, Ping CY, Mok YY, et al. Regulation of vascular nitric oxide in vitro and in vivo; a new role for endogenous hydrogen sulphide? Br J Pharmacol 2006;149:625-34
  • Lim JJ, Liu Y, Khin ES, Bian JS. Vasoconstrictive effect of hydrogen sulfide involves downregulation of cAMP in vascular smooth muscle cells. Am J Physiol Cell Physiol 2008;295:C1261-70
  • Koenitzer JR, Isbell TS, Patel HD, et al. Hydrogen sulfide mediates vasoactivity in an O2-dependent manner. Am J Physiol Heart Circ Physiol 2007;292:H1953-60
  • Yang G, Wu L, Jiang B, et al. H2S as a physiological vasorelaxant: hypertension of mice with deletion of cystathionine-γ-lyase. Science 2008;322:587-90
  • Distrutti E, Mencarelli A, Santucci L, et al. The methionine connection: homocysteine and hydrogen sulfide exert opposite effects on hepatic microcirculation in rats. Hepatol 2008;47:659-67
  • Mok YY, Atan MS, Yoke Ping C, et al. Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis. Br J Pharmacol 2004;143:881-9
  • Du J, Yan H, Tang C. Endogenous H2S is involved in the development of spontaneous hypertension (article in chinese). Beijing Da Xue Xue Bao 2003;35:102
  • Olson KR. Hydrogen sulfide and oxygen sensing: implications in cardiorespiratory control. J Exp Biol 2008;211:2727-34
  • Teague B, Asiedu S, Moore PK. The smooth muscle relaxant effect of hydrogen sulphide in vitro: evidence for a physiological role to control intestinal contractility. Br J Pharmacol 2002;137:139-45
  • Kimura H. Hydrogen sulfide as a neuromodulator. Mol Neurobiol 2002;26:13-9
  • Zhao WWR. H2S-induced vasorelaxation and underlying cellular and molecular mechanisms. Am J Physiol Heart Circ Physiol 2002;283:474-80
  • Matsunami M, Tarui T, Mitani K, et al. Luminal hydrogen sulfide plays a pro-nociceptive role in mouse colon. Gut 2008 In press
  • Eto K, Asada T, Arima K, et al. Brain hydrogen sulfide is severely decreased in Alzheimer's disease. Biochem Biophys Res Commun 2002;293(5):1485-8
  • Kamoun P. Endogenous hydrogen sulfide overproduction in Down syndrome. Am J Med Genet A 2003;116A(3):310-1
  • Fiorucci S, Antonelli E, Distrutti E, et al. Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs. Gastroenterol 2005;129:1210-24
  • Zanardo RC, Brancaleone V, Distrutti E, et al. Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation. FASEB J 2006;20:2118-20
  • Sidhapuriwala J, Li L, Sparatore A, et al. Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat. Eur J Pharmacol 2007;569:149-54
  • Zhang H, Zhi L, Moochhala SM, et al. Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis. J Leukoc Biol 2007;82:894-905
  • Kawabata A. Hydrogen sulfide as a novel nociceptive messenger. Pain 2007;132:74-81
  • Distrutti E, Sediari L, Mencarelli A, et al. 5-Amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-[1,2]dithiol-3yl)-phenyl ester (ATB-429), a hydrogen sulfide-releasing derivative of mesalamine, exerts antinociceptive effects in a model of postinflammatory hypersensitivity. J Pharmacol Exp Ther 2006;316:325-35
  • Li L, Moore PK. Putative biological roles of hydrogen sulfide in health and disease: a breath of not so fresh air? Trends Pharmacol Sci 2008;29:84-90
  • Yale University. WO03094932A1; 2003
  • Beth Israel Hospital. WO03000114; 2003
  • Beth Israel Deaconess Medical Center Inc. & University of Pittsburgh. WO03072024A2; 2003
  • University of Pittsburgh. WO03088923A2; 2003
  • University of Pittsburgh. WO03088981A1; 2003
  • Yale University & University of Pittsburgh. WO0309677;2003
  • Yale University & University of Pittsburgh. WO03103585A2; 2003
  • University of Pittsburgh & Yale University. WO2004043341; 2004
  • Beth Israel Deaconess Medical Center Inc. WO2008008513; 2008
  • University of Pittsburgh. WO2004000368; 2004
  • The General Hospital Corporation. US5885621; 1997
  • Air Liquide santé© International. FR2816212; 2002
  • Air Liquide santé© International. WO0209731; 2002
  • Aga AB. WO2005067945; 2005
  • Lohmann Therapie Systems lts. WO9535105; 1995
  • University Maryland Biotechnology Institute. US5670664; 1997
  • Sangstat Medical Corporation. WO02078684; 2002
  • Northwick Park Institute for Medical Research & University of Sheffield. WO02092075A3; 2002
  • Northwick Park Institute for Medical Research & University of Sheffield. WO20040405598; 2004
  • Northwick Park Institute for Medical Research & University of Sheffield. WO20040405599; 2004
  • Foresti R, Hammad J, Clark JE, et al. Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br J Pharmacol 2004;142:453-60
  • Hemocorm Ltd. WO20070065485; 2007
  • Hemocorm Ltd. WO2007085806A2; 2007
  • Hemocorm Ltd. WO2008003953A2; 2008
  • Alfama Inc. WO2003066067A3; 2003
  • Alfama Inc. WO2007073225; 2007
  • Alfama Inc. US20080026984A1; 2008
  • Antibe Therapeutics Inc. WO2006085127A1; 2006
  • Antibe Therapeutics Inc. WO2008009118A1; 2008
  • Antibe Therapeutics Inc. WO2006125295; 2006
  • Antibe Therapeutics Inc. WO2007140611A1; 2007
  • Fuso Pharmaceutical Ind. & University Kinki. JP2007063167; 2007
  • Wallace JL, Dicay M, McKnight W, Martin GR. Hydrogen sulfide enhances ulcer healing in rats. FASEB J 2007;21:4070-6
  • Antibe Therapeutics Inc. WO 2008009127A1; 2008
  • Wallace JLCG, Santagada V, Cirino G, Fiorucci S. Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat. Gastroenterol 2007;132:261-71
  • Expotrend Company S.A. EP1630164A1; 2006
  • Turko IVS, Ballard SA, Francis SH, Corbin JD. Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (type 5) by sildenafil and related compounds. Mol Pharmacol 1999;56:124-30
  • Metabono S.A. WO2006066894A1; 2006
  • Fudan University, China. CN101011413A; 2007
  • Volpato GP, Searles R, Yu B, et al. Inhaled hydrogen sulfide: a rapidly reversible inhibitor of cardiac and metabolic function in the mouse. Anesthesiol 2008;108:659-68
  • Szabo C. Hydrogen sulphide and its therapeutic potential. Nat Rev Drug Discov 2007;6:917-35
  • Ikaria Inc. 2008
  • Hybernation Therapeutics Limited. WO2008011670A1; 2008
  • Ikaria Inc. WO2008079993A2; 2008
  • Ikaria Inc. WO2008043081A2; 2008
  • Gosudartvennoe ObschcheobrazovatelL'noe uchrezhdenie vysshego professional'nogo obrazovanija Kazanskij gosudarstvennij meditsinkij universitet (RU). RU2304967; 2007
  • Federal'noe G, Uchrezhdenie PJA. Pjatigorskij GNIK Rosdrava, Russia. RU2321386; 2008
  • CTG Pharma S.R.L. EP1886681A2; 2008
  • Duenas-González A, Candelaria M, Pé©rez-Plasencia C, et al. Valproic acid as epigenetic cancer drug: preclinical, clinical and transcriptional effects on solid tumors. Cancer Treat Rev 2008;34:206-22
  • Taiyo Kagaku KK. JP2007099672A; 2007
  • Levine J, Ellis CJ, Furne JK, et al. Fecal hydrogen sulfide production in ulcerative colitis. Am J Gastroenterol 1998;93:83-7
  • Fuso Pharmaceutical Ind. & University Kinki. JP2007112735; 2007
  • Hulsman N, Medema JP, Bos C, et al. Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin. J Med Chem 2007;50:2424-31

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