TRPA1 modulators in preclinical development

Bibliography

• Venkatachalam K, Montell C. TRP channels. Annu Rev Biochem 2007;76:387-417
   PubMed Web of Science ®Google Scholar
• Pedersen SF, Owsianik G, Nilius B. TRP channels: an overview. Cell Calcium 2005;38:233-52
   PubMed Web of Science ®Google Scholar
• Ramsey IS, Delling M, Clapham DE. An introduction to trp channels. Annu Rev Physiol 2006;68:619-47
   PubMed Web of Science ®Google Scholar
• Clapham DE. TRP channels as cellular sensors. Nature 2003;426:517-24
   PubMed Web of Science ®Google Scholar
• Nilius B, Voets T. Diversity of TRP channel activation. Novartis Found Symp 2004;258:140-9
   PubMedGoogle Scholar
• Dhaka A, Viswanath V, Patapoutian A. Trp ion channels and temperature sensation. Annu Rev Neurosci 2006;29:135-61
   PubMed Web of Science ®Google Scholar
• Stucky CL, Dubin AE, Jeske NA, Roles of transient receptor potential channels in pain. Brain Res Rev 2009;60:2-23
   PubMed Web of Science ®Google Scholar
• Patapoutian A, Tate S, Woolf CJ. Transient receptor potential channels: targeting pain at the source. Nat Rev Drug Discov 2009;8:55-68
   PubMed Web of Science ®Google Scholar
• Story GM, Peier AM, Reeve AJ, ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 2003;112:819-29
   PubMed Web of Science ®Google Scholar
• Jaquemar D, Schenker T, Trueb B. An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts. J Biol Chem 1999;274:7325-33
   PubMed Web of Science ®Google Scholar
• Jordt SE, Bautista DM, Chuang HH, Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 2004;427:260-5
   PubMed Web of Science ®Google Scholar
• Obata K, Katsura H, Mizushima T, TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J Clin Invest 2005;115:2393-401
   PubMed Web of Science ®Google Scholar
• Fajardo O, Meseguer V, Belmonte C, Viana F. TRPA1 channels mediate cold temperature sensing in mammalian vagal sensory neurons: pharmacological and genetic evidence. J Neurosci 2008;28:7863-75
   PubMedGoogle Scholar
• Simons CT, Carstens MI, Carstens E. Oral irritation by mustard oil: self-desensitization and cross-desensitization with capsaicin. Chem Senses 2003;28:459-65
   PubMed Web of Science ®Google Scholar
• Handwerker HO, Forster C, Kirchhoff C. Discharge patterns of human C-fibers induced by itching and burning stimuli. J Neurophysiol 1991;66:307-15
   PubMed Web of Science ®Google Scholar
• Albin KC, Carstens MI, Carstens E. Modulation of oral heat and cold pain by irritant chemicals. Chem Senses 2007;32:811-16
   PubMed Web of Science ®Google Scholar
• Garcia-Anoveros J, Nagata K. TRPA1. Handb Exp Pharmacol 2007;179:347-362
   Google Scholar
• Peterlin Z, Chesler A, Firestein S. A painful trp can be a bonding experience. Neuron 2007;53:635-8
   PubMed Web of Science ®Google Scholar
• Bessac BF, Jordt SE. Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda) 2008;23:360-70
   PubMed Web of Science ®Google Scholar
• Macpherson LJ, Hwang SW, Miyamoto T, More than cool: promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci 2006;32:335-43
   PubMed Web of Science ®Google Scholar
• Bandell M, Story GM, Hwang SW, Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 2004;41:849-57
   PubMed Web of Science ®Google Scholar
• Macpherson LJ, Geierstanger BH, Viswanath V, The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr Biol 2005;15:929-34
   PubMed Web of Science ®Google Scholar
• Bautista DM, Movahed P, Hinman A, Pungent products from garlic activate the sensory ion channel TRPA1. Proc Natl Acad Sci USA 2005;102:12248-52
   PubMed Web of Science ®Google Scholar
• Xu H, Delling M, Jun JC, Clapham DE. Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci 2006;9:628-35
   PubMed Web of Science ®Google Scholar
• McNamara CR, Mandel-Brehm J, Bautista DM, TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci USA 2007;104:13525-30
   PubMed Web of Science ®Google Scholar
• Escalera J, von Hehn CA, Bessac BF, TRPA1 mediates the noxious effects of natural sesquiterpene deterrents. J Biol Chem 2008;283:24136-44
   PubMed Web of Science ®Google Scholar
• Bautista DM, Jordt SE, Nikai T, TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 2006;124:1269-82
   PubMed Web of Science ®Google Scholar
• Bessac BF, Sivula M, von Hehn CA, Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J 2009;23:1102-14
   PubMed Web of Science ®Google Scholar
• Andersson DA, Gentry C, Moss S, Bevan S. Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J Neurosci 2008;28:2485-94
   PubMed Web of Science ®Google Scholar
• Bessac BF, Sivula M, von Hehn CA, TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin Invest 2008;118:1899-910
   PubMed Web of Science ®Google Scholar
• Kwan KY, Allchorne AJ, Vollrath MA, TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron 2006;50:277-89
   PubMed Web of Science ®Google Scholar
• Tracey WD Jr, Wilson RI, Laurent G, Benzer S. Painless, a Drosophila gene essential for nociception. Cell 2003;113:261-73
   PubMed Web of Science ®Google Scholar
• Kindt KS, Viswanath V, Macpherson L, Caenorhabditis elegans TRPA-1 functions in mechanosensation. Nat Neurosci 2007;10:568-77
   Google Scholar
• Corey DP, Garcia-Anoveros J, Holt JR, TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature 2004;432:723-30
   PubMed Web of Science ®Google Scholar
• Nagata K, Duggan A, Kumar G, Garcia-Anoveros J. Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J Neurosci 2005;25:4052-61
   PubMed Web of Science ®Google Scholar
• Kwan KY, Glazer JM, Corey DP, TRPA1 modulates mechanotransduction in cutaneous sensory neurons. J Neurosci 2009;29:4808-19
   PubMed Web of Science ®Google Scholar
• Kerstein PC, del Camino D, Moran MM, Stucky CL. Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors. Mol Pain 2009;5:19
   PubMed Web of Science ®Google Scholar
• Belmonte C, Viana F. Molecular and cellular limits to somatosensory specificity. Mol Pain 2008;4:14
   PubMed Web of Science ®Google Scholar
• Hill K, Schaefer M. TRPA1 is differentially modulated by the amphipathic molecules trinitrophenol and chlorpromazine. J Biol Chem 2007;282:7145-53
   PubMed Web of Science ®Google Scholar
• Brierley SM, Hughes PA, Page AJ, The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology 2009. [Epub ahead of print]
   PubMed Web of Science ®Google Scholar
• Kwan KY, Corey DP. Burning cold: involvement of TRPA1 in noxious cold sensation. J Gen Physiol 2009;133:251-6
   Google Scholar
• Madrid R, de la PE, Donovan-Rodriguez T, Variable threshold of trigeminal cold-thermosensitive neurons is determined by a balance between TRPM8 and Kv1 potassium channels. J Neurosci 2009;29:3120-31
   PubMed Web of Science ®Google Scholar
• Karashima Y, Talavera K, Everaerts W, TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci USA 2009;106:1273-8
   PubMed Web of Science ®Google Scholar
• Sawada Y, Hosokawa H, Hori A, Cold sensitivity of recombinant TRPA1 channels. Brain Res 2007;1160:39-46
   PubMed Web of Science ®Google Scholar
• Hinman A, Chuang HH, Bautista DM, Julius D. TRP channel activation by reversible covalent modification. Proc Natl Acad Sci USA 2006;103:19564-8
   PubMed Web of Science ®Google Scholar
• Macpherson LJ, Dubin AE, Evans MJ, Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 2007;445:541-5
   PubMed Web of Science ®Google Scholar
• Meseguer V, Karashima Y, Talavera K, Transient receptor potential channels in sensory neurons are targets of the antimycotic agent clotrimazole. J Neurosci 2008;28:576-86
   PubMed Web of Science ®Google Scholar
• Fajardo O, Meseguer V, Belmonte C, Viana F. TRPA1 channels: novel targets of 1,4-dihydropyridines. Channels (Austin) 2008;2:429-38
   PubMed Web of Science ®Google Scholar
• Karashima Y, Damann N, Prenen J, Bimodal action of menthol on the transient receptor potential channel TRPA1. J Neurosci 2007;27:9874-84
   PubMed Web of Science ®Google Scholar
• Xiao B, Dubin AE, Bursulaya B, Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. J Neurosci 2008;28:9640-51
   PubMed Web of Science ®Google Scholar
• Wang YY, Chang RB, Waters HN, The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions. J Biol Chem 2008;283:32691-703
   PubMed Web of Science ®Google Scholar
• Hu H, Bandell M, Petrus MJ, Zinc activates damage-sensing TRPA1 ion channels. Nat Chem Biol 2009;5:183-90
   PubMed Web of Science ®Google Scholar
• Madrid R, Donovan-Rodriguez T, Meseguer V, Contribution of TRPM8 channels to cold transduction in primary sensory neurons and peripheral nerve terminals. J Neurosci 2006;26:12512-25
   PubMed Web of Science ®Google Scholar
• Nagatomo K, Kubo Y. Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels. Proc Natl Acad Sci USA 2008;105:17373-8
   PubMed Web of Science ®Google Scholar
• Chuang HH, Neuhausser WM, Julius D. The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron 2004;43:859-69
   PubMed Web of Science ®Google Scholar
• Chen J, Kym PR. TRPA1: the species difference. J Gen Physiol 2009;133:623-5
   PubMed Web of Science ®Google Scholar
• Klionsky L, Tamir R, Gao B, Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists. Mol Pain 2007;3:39
   PubMed Web of Science ®Google Scholar
• Chen J, Zhang XF, Kort ME, Molecular determinants of species-specific activation or blockade of TRPA1 channels. J Neurosci 2008;28:5063-71
   PubMed Web of Science ®Google Scholar
• Doerner JF, Gisselmann G, Hatt H, Wetzel CH. Transient receptor potential channel A1 is directly gated by calcium ions. J Biol Chem 2007;282:13180-9
   PubMed Web of Science ®Google Scholar
• Zurborg S, Yurgionas B, Jira JA, Direct activation of the ion channel TRPA1 by Ca(2+). Nat Neurosci 2007;10:277-9
   PubMed Web of Science ®Google Scholar
• Cavanaugh EJ, Simkin D, Kim D. Activation of transient receptor potential A1 channels by mustard oil, tetrahydrocannabinol and Ca2+ reveals different functional channel states. Neuroscience 2008;154:1467-76
   PubMed Web of Science ®Google Scholar
• Benedikt J, Samad A, Ettrich R, Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel. Biochim Biophys Acta 2009;1793:1279-88
   PubMed Web of Science ®Google Scholar
• Andersson DA, Gentry C, Moss S, Bevan S. Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+. Proc Natl Acad Sci USA 2009;106:8374-9
   PubMed Web of Science ®Google Scholar
• Kim D, Cavanaugh EJ. Requirement of a soluble intracellular factor for activation of transient receptor potential A1 by pungent chemicals: role of inorganic polyphosphates. J Neurosci 2007;27:6500-9
   PubMed Web of Science ®Google Scholar
• Wang S, Dai Y, Fukuoka T, Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain. Brain 2008;131:1241-51
   PubMed Web of Science ®Google Scholar
• Karashima Y, Prenen J, Meseguer V, Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators. Pflugers Arch 2008;457:77-89
   PubMed Web of Science ®Google Scholar
• Dai Y, Wang S, Tominaga M, Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. J Clin Invest 2007;117:1979-87
   PubMed Web of Science ®Google Scholar
• Kim D, Cavanaugh EJ, Simkin D. Inhibition of transient receptor potential A1 channel by phosphatidylinositol-4,5-bisphosphate. Am J Physiol Cell Physiol 2008;295:C92-9
   PubMed Web of Science ®Google Scholar
• Andre E, Campi B, Materazzi S, Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest 2008;118:2574-82
   PubMed Web of Science ®Google Scholar
• Nassenstein C, Kwong K, Taylor-Clark T, Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. J Physiol 2008;586:1595-604
   PubMed Web of Science ®Google Scholar
• Colsoul B, Nilius B, Vennekens R. On the putative role of transient receptor potential cation channels in asthma. Clin Exp Allergy 2009. [Epub ahead of print]
   PubMed Web of Science ®Google Scholar
• Taylor-Clark TE, Nassenstein C, McAlexander MA, Undem BJ. TRPA1: a potential target for anti-tussive therapy. Pulm Pharmacol Ther 2009;22:71-4
   PubMed Web of Science ®Google Scholar
• Caceres AI, Brackmann M, Elia MD, A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proc Natl Acad Sci USA 2009;106:9099-104
   PubMed Web of Science ®Google Scholar
• Trevisani M, Siemens J, Materazzi S, 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci USA 2007;104:13519-24
   PubMed Web of Science ®Google Scholar
• Taylor-Clark TE, McAlexander MA, Nassenstein C, Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal. J Physiol 2008;586:3447-59
   Google Scholar
• Cruz-Orengo L, Dhaka A, Heuermann RJ, Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1. Mol Pain 2008;4:30
   PubMed Web of Science ®Google Scholar
• Taylor-Clark TE, Undem BJ, MacGlashan DW Jr, Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1). Mol Pharmacol 2008;73:274-81
   PubMed Web of Science ®Google Scholar
• Taylor-Clark TE, Ghatta S, Bettner W, Undem BJ. Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1. Mol Pharmacol 2009;75:820-9
   PubMed Web of Science ®Google Scholar
• Sun B, Li Q, Dong L, Rong W. Ion channel and receptor mechanisms of bladder afferent nerve sensitivity. Auton Neurosci 2009. [Epub ahead of print]
   PubMed Web of Science ®Google Scholar
• Kullmann FA, Shah MA, Birder LA, De Groat WC. Functional TRP and ASIC-like channels in cultured urothelial cells from the rat. Am J Physiol Renal Physiol 2009;296:F892-901
   Web of Science ®Google Scholar
• Everaerts W, Gevaert T, Nilius B, De Ridder D. On the origin of bladder sensing: Tr(i)ps in urology. Neurourol Urodyn 2008;27:264-73
   PubMed Web of Science ®Google Scholar
• Patacchini R, Maggi CA, Meli A. Capsaicin-like activity of some natural pungent substances on peripheral endings of visceral primary afferents. Naunyn Schmiedebergs Arch Pharmacol 1990;342:72-7
   PubMed Web of Science ®Google Scholar
• Streng T, Axelsson HE, Hedlund P, Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. Eur Urol 2008;53:391-9
   PubMed Web of Science ®Google Scholar
• Du S, Araki I, Kobayashi H, Differential expression profile of cold (TRPA1) and cool (TRPM8) receptors in human urogenital organs. Urology 2008;72:450-5
   PubMed Web of Science ®Google Scholar
• Zygmunt PM, Andersson DA, Hogestatt ED. Delta 9-tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-independent mechanism. J Neurosci 2002;22:4720-7
   PubMed Web of Science ®Google Scholar
• Zygmunt PM, Petersson J, Andersson DA, Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 1999;400:452-7
   PubMed Web of Science ®Google Scholar
• Kawasaki H, Takasaki K, Saito A, Goto K. Calcitonin gene-related peptide acts as a novel vasodilator neurotransmitter in mesenteric resistance vessels of the rat. Nature 1988;335:164-7
   PubMed Web of Science ®Google Scholar
• Triggle DJ. 1,4-Dihydropyridines as calcium channel ligands and privileged structures. Cell Mol Neurobiol 2003;23:293-303
   PubMed Web of Science ®Google Scholar
• Johnson CD, Melanaphy D, Purse A, Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone. Am J Physiol Heart Circ Physiol 2009;296:H1868-77
   PubMed Web of Science ®Google Scholar
• Baron R. Neuropathic pain: a clinical perspective. Handb Exp Pharmacol 2009;194:3-30
   PubMedGoogle Scholar
• Campbell JN, Meyer RA. Mechanisms of neuropathic pain. Neuron 2006;52:77-92
   PubMed Web of Science ®Google Scholar
• Zimmermann M. Pathobiology of neuropathic pain. Eur J Pharmacol 2001;429:23-37
   PubMed Web of Science ®Google Scholar
• Yu S, Ouyang A. TRPA1 in bradykinin-induced mechanical hypersensitivity of vagal C fibers in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol 2009;296:G255-65
   Web of Science ®Google Scholar
• Yang J, Li Y, Zuo X, Transient receptor potential ankyin-1 participates in visceral hyperalgesia following experimental colitis. Neurosci 2008;440:237-41
   Web of Science ®Google Scholar
• Kondo T, Obata K, Miyoshi K, Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats. Gut 2009. [Epub ahead of print]
   PubMed Web of Science ®Google Scholar
• Katsura H, Obata K, Mizushima T, Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats. Exp Neurol 2006;200:112-23
   PubMed Web of Science ®Google Scholar
• McKemy DD, Neuhausser WM, Julius D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 2002;416:52-8
   PubMed Web of Science ®Google Scholar
• Peier AM, Moqrich A, Hergarden AC, A TRP channel that senses cold stimuli and menthol. Cell 2002;108:705-15
   PubMed Web of Science ®Google Scholar
• Colburn RW, Lubin ML, Stone DJ Jr, Attenuated cold sensitivity in trpm8 null mice. Neuron 2007;54:379-86
   PubMed Web of Science ®Google Scholar
• Gauchan P, Andoh T, Kato A, Kuraishi Y. Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice. Neurosci Lett 2009;458:93-5
   PubMed Web of Science ®Google Scholar
• Petrus M, Peier AM, Bandell M, A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol Pain 2007;3:40
   PubMed Web of Science ®Google Scholar
• Redpoint Bio Corp. Screnning assay for inhibitors of TRPA1 by a lower alkyl phenol. WO2008013861, 2008
   Google Scholar
• IRM LLC and The Scripps Research Institute. Methods and compositions for treating hyperalgesia. WO2007098252, 2007
   Google Scholar
• Abbot laboratories. TRPA1 antagonists. WO2009089082, 2009
   Google Scholar
• Abbot laboratories. TRPA1 antagonists. WO2009089083, 2009
   Google Scholar
• Eid SR, Crown ED, Moore EL, HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain 2008;4:48
   PubMed Web of Science ®Google Scholar
• Hydra Biosciences, Inc. TRPA1 inhibitors for treating pain. WO2007073505, 2007
   Google Scholar
• Wei H, Hamalainen MM, Saarnilehto M, Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology 2009;111:147-54
   PubMed Web of Science ®Google Scholar
• Gavva NR. Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1. Trends Pharmacol Sci 2008;29:550-7
   PubMed Web of Science ®Google Scholar
• Chen J, Kim D, Bianchi BR, Pore dilation occurs in TRPA1 but not in TRPM8 channels. Mol Pain 2009;5:3
   PubMed Web of Science ®Google Scholar