608
Views
19
CrossRef citations to date
0
Altmetric
Reviews

Itk inhibitors: a patent review

Pages 459-469 | Published online: 11 Mar 2010

Bibliography

  • Smith CIE, Islam TC, Mattsson PT, The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species. Bioessays 2001;23:436-46
  • Forssell J, Sideras P, Eriksson C, Interleukin-2-inducible T cell kinase regulates mast cell degranulation and acute allergic responses. Am J Respir Cell Mol Biol 2005;32:511-20
  • Schaeffer EM, Yap GS, Lewis CM, Mutation of Tec family kinases alters T helper cell differentiation. Nat Immune 2001;2:1183-8
  • Schaeffer EM, Debnath J, Yap G, Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science 1999;284:638-41
  • Fowell DJ, Shinkai K, Liao XC, Impaired NFATc Translocation and Failure of Th2 Development in Itk-Deficient CD4+ T cells. Immunity 1999;11:399-409
  • Qian D, Weiss A. T cell antigen receptor signal transduction. Curr Opin Cell Biol 1997;9:205-12
  • Kanner SB, Perez-Villar JJ. Altering T-cell activation by targeting the multidomain tyrosine kinase Itk. Trends in Immunology 2003;24:249-53
  • Samelson LE. Signal transduction mediated by the T cell antigen seceptor: the role of adapter proteins. Annu Rev Immunol 2002;20:371-94
  • Mueller C, August A. Attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase ITK. J Immunol 2003;170:5056-63
  • Wong WS. Inhibitors of the tyrosine kinase signaling cascade for asthma. Curr Opin Pharmacol 2005;5:264-71
  • Lin T, McIntyre KW, Das J, Selective Itk inhibitors block T-cell activation and murine lung inflammation. Biochemistry 2004;43:11056-62
  • Matsumoto Y, Oshida T, Obayashi I, Identification of highly expressed genes in peripheral blood T cells from patients with atopic dermatitis. Int Arch Allergy Immunol 2002;129:327-40
  • Graves PE, Siroux V, Guerra S, Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain- IL-2-inducible T-cell kinase gene cluster in chromosome 5q33. J Allergy Clin Immunol 2005;116:650-6
  • Readlinger JA, Schiralli GM, Thomas JJ, Selective targeting of ITK blocks multiple steps of HIV replication. Proc Natl Acad Sci USA 2008;105:6684-9
  • Yu L, Mohanram V, Simonson OE, Proteasome inhibitors block HIV-1 replication by affecting both cellular and viral targets. Biochem Biophys Res Comm 2009;385:100-5
  • Brown K, Long JM, Vial SCM, Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors. J Biol Chem 2004;279:18727-32
  • Vertex Pharmaceuticals, Inc. Crystal structure of interleukin-2 tyrosine kinase (ITK) and binding pockets thereof. WO2005056785
  • Boehringer Ingelheim Pharmaceuticals, Inc. Crystal structure of the interleukin-2-inducible cell kinase (ITK) kinase domain. WO2005066335
  • Bristol-Myers Squibb Pharmaceuticals Research Institute. Thiazolyl inhibitors of Tec family tyrosine kinases. WO2002050071
  • Das J, Liu C, Moquin RV, Discovery and SAR of 2-amino-5-[thiomethyl)aryl]thiazoles as potent and selective Itk inhibitors. Bioorg Med Chem Lett 2006;16:2411-15
  • Das J, Furch JA, Liu C, Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors. Bioorg Med Chem Lett 2006;16:3706-12
  • Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzimidazole compounds. WO2004014905
  • Boehringer Ingelheim Pharmaceuticals, Inc. 1H-benzimidazol-2-yl-benzamide derivatives and related compounds as ITK inhibitors (interleukin-2-inducible T cell kinase) for the treatment of inflammation, immunological and allergic disorders. WO2005070420
  • Boehringer Ingelheim Pharmaceuticals, Inc. Thiophene-2-carboxylic acid-(1H-benzimidazol-2 yl)-amide derivatives and related compounds as inhibitors of the Tec kinase ITK (interleukin-2-inducible T cell kinase) for the treatment of inflammation, immunological and allergic disorders. WO2005079791
  • Snow RJ, Abeywardane A, Campbell S, Hit-to-Lead studies on benzimidazole inhibitors of ITK: discovery of a novel class of kinase inhibitors. Bioorg Med Chem Lett 2007;17:3660-5
  • Moriarty KJ, Winters M, Qiao L, Itk kinase inhibitors: initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead. Bioorg Med Chem Lett 2008;18:5537-40
  • Winters MP, Robinson DJ, Khine HH, 5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk). Bioorg Med Chem Lett 2008;18:5541-4
  • Moriarty KJ, Takahashi H, Pullen SS, Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk). Bioorg Med Chem Lett 2008;18:5545-9
  • Lo HY, Bentzien J, Fleck RW, 2-Aminobenzimidazoles as potent ITK antagonists: trans-stilbene-like moieties targeting the kinase specificity pocket. Bioorg Med Chem Lett 2008;18:6218-21
  • Lo HY, Bentzien J, White A, 2-Aminobenzimidazoles as potent ITK antagonists: de novo design of a pyrrole system targeting additional hydrogen bonding interaction. Tetrahedron Lett 2008;49:7337-40
  • Cook BN, Bentzien J, White A, Discovery of potent inhibitors of interleukin-2 inducible T-cell kinase (ITK) through structure-based drug design. Bioorg Med Chem Lett 2009;19:773-7
  • Riether D, Zindell R, Kowalski JA, 5-Aminomethylbenzimidazoles as potent ITK antagonists. Bioorg Med Chem Lett 2009;19:1588-91
  • Boehringer Ingelheim Pharmaceuticals, Inc. Tec kinase inhibitors. WO2007076228
  • Boehringer Ingelheim Pharmaceuticals, Inc. Tec kinase inhibitors. WO2007058832
  • Astrazeneca AB. Substituted pyrrolopyridines. WO2004016610, US20050266331
  • Astrazeneca AB. Use of and some novel imidazopyridine. WO2004016611, US20050261333
  • Astrazeneca AB. Novel use of benzothiazole derivatives. WO2004016600, US20060106015
  • Astrazeneca AB. Pyrazolo (4, 3c) cinnoline compounds as inhibitors of ITK kinase activity. WO2004016615
  • Sanofi-aventis. Thienopyrazoles. WO2005026175, US20070254937
  • Vertex Pharmaceuticals, Inc. Pyrid-2-ones useful as inhibitors of TEC family protein kinases for the treatment of inflammatory, proliferative and immunologically-mediated diseases. WO2006065946, US20060183911
  • Vertex Pharmaceuticals, Inc. 3,5-disubstituted pyrid-2-ones useful as inhibitors of Tec kinase family of non-receptor tyrosine kinases. WO2007027594, CA2620269
  • Vertex Pharmaceuticals, Inc. 3,5-disubstituted pyrid-2-ones useful as inhibitors of Tec kinase family of non-receptor tyrosine kinases. WO2007027729, CA2620352
  • Bayer Schering Pharma AG. Sulfoximine-substituted pyrimidines, their preparation and use as drugs. WO2007017455, US20070232632
  • Cellzome. Aminopyridine derivates as kinase inhibitors. WO2008025820, EP1900727
  • Cellzome. Diazolodiazine derivatives as kinase inhibitors. WO2008025822, EP1900739
  • Cellzome. Triazole derivatives as kinase inhibitors. WO2008025821, EP1894931
  • Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002;296:1655-7
  • San Diego State University Research Foundation. Compositions and methods for inhibiting inducible T cell kinase (ITK) and treating asthma and bronchial inflammations. WO2008144351
  • Jansen PM, Jan Danser AH, Imholz BP, Aldosterone-receptor antagonism in hypertension. J Hypertens 2009;6:80-691
  • Brugts JJ, Ferrari R, Simoons ML. Angiotensin-converting enzyme inhibition by perindopril in the treatment of cardiovascular disease. Expert Rev Cardiovasc Ther 2009;7:345-60
  • Huck K, Feyen O, Niehues T, Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation. J Clin Invest 2009;119:1350-8

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.