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Review

Therapeutic strategies in Huntington’s disease

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Pages 449-465 | Published online: 02 Mar 2005

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  • •First study showing neuroprotective effects of GDNF on striatal projection neurons in the quinolinic acid model of HD.
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  • •This paper shows that cortical neurons activate an endogenous trophic mechanism after the loss of the striatum in a rat model of HD.
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