Isoforms of human B7-H3 co-signalling molecule for T cell activation as potential immunoregulatory agents

Bibliography

• FRAUWIRTH KA, THOMPSON CB: Activation and inhibition of lymphocytes by costimulation. j Clin. Invest. (2002) 109:295–299.
   PubMed Web of Science ®Google Scholar
• CARRENO BM, COLLINS M: The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Ann. Rev. Immunol (2002) 20:29–53.
   PubMed Web of Science ®Google Scholar
• WANG S, CHEN L: Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses. Microbes Infect. (2004) 6:759–766.
   PubMed Web of Science ®Google Scholar
• • Review of the role of B7-CD28 family molecules in the control of T-cell-mediated immune response and tolerance.
   Google Scholar
• GREEN WALD RJ, FREEMAN GJ, SHARPE AH: The B7 family revisited. Ann. Rev. Immunol (2005) 23:515–548.
   PubMedGoogle Scholar
• • Up-to-date review of B7 family members, their roles in regulating immune responses and their therapeutic potential.
   Google Scholar
• RILEY JL, JUNE CH: The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation. Blood (2005) 105:13–21.
   PubMed Web of Science ®Google Scholar
• STUART RW, RACKE MK: Targeting T cell costimulation in autoimmune disease. Expert Opin. Ther. Targets (2002) 6:275–289.
   PubMedGoogle Scholar
• EVANS DE, WEINBERG AD: Boosting T cell costimulation in cancer: the possibilities seem endless. Int. Rev. Immunol. (2003) 22:173–194.
   PubMed Web of Science ®Google Scholar
• DUMONT FJ: CTLA4-Ig fusion proteins: promise for improved therapy of transplant rejection and autoimmune diseases. Therapy (2004) 1:289–304
   Google Scholar
• CHAPOVAL Al, NI J, LAU JS et al: B7-H3: a costimulatory molecule for T cell activation and IFN-y production. Nat. Immunol (2001) 2:269–274.
   PubMed Web of Science ®Google Scholar
• •• Initial description of human B7-H3 VC asa costimulatory molecule that enhances TCR-induced T cell proliferation and IFN-y production.
   Google Scholar
• SUH WK, GAJEWSKA BU, OKADA H et al: The B7 family member B7-H3 preferentially down-regulates T helper Type 1-mediated immune responses. Nat. Immunol (2003) 4:899–906.
   PubMed Web of Science ®Google Scholar
• •• First evidence that mouse B7-H3 has anegative regulatory function in T cell-mediated immune responses both in vitro and in vivo.
   Google Scholar
• LING V, WU PW, SPAULDING V et ed.: Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss. Genomics (2003) 82:365–377.
   Google Scholar
• •• This paper by the Wyeth Research teamreports the same data as in the patent application discussed here.
   Google Scholar
• SUN M, RICHARDS S, PRASAD DV et al: Characterization of mouse and human B7-H3 genes. J. Immunol (2002) 168:6294–6297.
   PubMed Web of Science ®Google Scholar
• STEINBERGER P, MAJDIC 0, DERDAK SV et al: Molecular characterization of human 41g-B7-H3, a member of the B7 family with four Ig-like domains. J. Immunol (2004) 172:2352–2359.
   PubMed Web of Science ®Google Scholar
• • Shows that B7-H3 VCVC is the principal B7-H3 isoform expressed on human DCs and that it does not function as a costimulatory molecule for T cell activation.
   Google Scholar
• PRASAD DV, NGUYEN T, LIZ et al: Murine B7-H3 is a negative regulator of T cells. J. Immunol. (2004) 173:2500–2506.
   PubMed Web of Science ®Google Scholar
• SUN X, VALE M, LEUNG E et al.: Mouse B7-H3 induces antitumor immunity. Gene Ther. (2003) 10:1728–1734.
   PubMed Web of Science ®Google Scholar
• LUO L, CHAPOVAL AI, FLIES DB et al: B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CDS cytolytic T cells. Immunol (2004) 173:5445–5450.
   Google Scholar
• WANG L, FRASER CC, KIKLY K et al: B7-H3 promotes acute and chronic allograft rejection. Eur. J. Immunol (2005) 35:428–438.
   PubMed Web of Science ®Google Scholar
• BROWN JA, DORFMAN DM, MA FR et al: Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. Immunol (2003) 170:1257–1266.
   Web of Science ®Google Scholar
• SUBUDHI SK, ALEGRE ML, FU YX: The balance of immune responses: costimulation verse coinhibition. j MoL Med. (2005) 83:193–202.
   PubMed Web of Science ®Google Scholar
• SAATIAN B, YU XY, LANE AP et al: Expression of genes for B7-H3 and other T cell ligands by nasal epithelial cells during differentiation and activation. Am. J. Physiol. Lung Cell Md. Physiol (2004) 287:L217–L225.
   Google Scholar
• CASTRICONI R, DONDERO A, AUGUGLIARO R et al: Identification of 41g-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis. Proc. Natl. Acad. Sci. USA (2004) 101:12640–12645.
   PubMed Web of Science ®Google Scholar
• • Demonstrates that B7-H3 VCVC is expressed on neuroblatoma cells and inhibits NK cell-mediated cytolysis.
   Google Scholar
• SUH WK, WANG SX, JHEON AH et al: The immune regulatory protein B7-H3 promotes osteoblast differentiation and bone mineralization. Proc. Natl. Acad. Sci. USA (2004) 101:12969–12973.
   PubMed Web of Science ®Google Scholar
• • This paper shows that mouse B7-H3 is expressed in developing bones and plays a positive regulatory role in bone formation.
   Google Scholar