Bibliography
- BRABEC V, KASPARKOVA J: Platinum-based drugs. In: Metallotherapeutic drugs and metal-based diagnostic agents. Gielen M, Tiekink ER (Eds). Wiley VC, Chichester (2005):489-506.
- DESOIZE B, MADOULET C: Particular aspects of platinum compounds used at present in cancer treatment. Crit. Rev. Oncol. Hematol. (2002) 42:317-325.
- McEVOY (Ed.). AHFS Drug Information, American Society of Heath–System Pharmacists, Bethesda (2000).
- BOULIKAS T, VOUGIOUKA M: Cisplatin and platinum drugs at the molecular level (Review). Oncol. Rep. (2003) 10:1663-1682.
- MARKMAN M: Toxicities of the platinum antineoplastic agents. Expert Opin. Drug Saf. (2003) 2:597-607.
- AKIYAMA S-I, CHEN Z-S, SUMIZAWA T, FURUKAWA T: Resistance to cisplatin. Anti-Cancer Drug Des. (1999) 14:143-151.
- GALANSKI M, JAKUPEC MA, KEPPLER BK: Update of the preclinical situation of anticancer platinum complexes: novel design strategies and innovative analytical approaches. Curr. Med. Chem. (2005) 12:2075-2094.
- RAYMOND E, FAIVRE S, CHANEY S, WOYNAROWSKI J, CVITKOVIC E: Cellular and molecular pharmacology of oxaliplatin. Mol. Cancer Ther. (2002) 1:227-235.
- BRABEC V, KASPARKOVA J: DNA interactions of platinum anticancer drugs. Recent advances and mechanisms of action. In: Metal Complexes in Cancer Chemotherapy. Perez JM, Fuertes MA, Alonso C (Eds). Research Signpost, Kerala (2005):187-218.
- BRABEC V, KASPARKOVA J: Modification of DNA by platinum complexes. Relation to resistance of tumors to platinum antitumor drugs. Drug Resist. Updates (2005) 8:131-146.
- MITKOVA E, UGRINOVA I, PASHEV IG, PASHEVA EA: The inhibitory effect of HMGB-1 protein on the repair of cisplatin-damaged DNA is accomplished through the acidic domain. Biochemistry (2005) 44:5893-5898.
- TORIGOE T, IZUMI H, ISHUGICHI H et al.: Cisplatin resistance and transcription factors. Curr. Med. Chem.- Anti-Cancer Agents (2005) 5:15-27.
- ZHANG L, HANIGAN M: Role of cysteine S-conjugate β-lyase in the metabolism of cisplatin. J. Pharmacol. Exp. Ther. (2003) 306:988-994.
- AMTMANN E, ZÖLLER M, WESCH H, SCHILLING G: Antitumoral activity of a sulphur-containing platinum complex with an acidic pH optimum. Cancer Chemother. Pharmacol. (2001) 47:461-466.
- FRIEBOLIN W, SCHILLING G, ZÖLLER M, AMTMANN E: Synthesis and structure–activity relationship of novel antitumoral platinum xanthate complexes. J. Med. Chem. (2004) 47:2256-2263.
- TANNOCK IF, ROTIN D: Acid pH in tumors and its potential for therapeutic exploitation. Cancer Res. (1989) 49:4373-4384.
- MARZANO C, TREVISAN A, GIOVAGNINI L, FREGONA D: Synthesis of a new platinum(II) complex: anticancer activity and nephrotoxicity in vitro. Toxicol. In Vitro (2002) 16:413-419.
- MARZANO C, BETTIO F, BACCICHETTI F, TREVISAN A, GIOVAGNINI L, FREGONA D: Antitumor activity of a new platinum(II) complex with low nephrotoxicity and genotoxicity. Chem. Biol. Interact. (2004) 148:37-48.
- FREGONA D, GIOVAGNINI L, RONCONI L et al.: Pt(II) and Pd(II) derivatives of ter-butylsarcosinedithio- carbamate. Synthesis, chemical and biological characterization and in vitro nephrotoxicity. J. Inorg. Biochem. (2003) 93:181-189.
- HOLFORD J, RAYNAUD F, MURRER BA et al.: Chemical, biochemical and pharmacological activity of the novel sterically hindered platinum co-ordination complex cis[amminedichloro(2-methyl- pyridine)]platinum(II) (AMD473). Anticancer Drug Des. (1998) 13:366-373.
- HOLFORD J, SHARP SY, MURRER BA et al.: In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473. Br. J. Cancer. (1998) 77:1-18.
- GELMON KA, STEWART D, CHI KN et al.: A Phase I study of AMD473 and docetaxel given once every 3 weeks in patients with advanced refractory cancer: a National Cancer Institute of Canada-Clinical Trials Group trial, IND 131. Annal. Oncol. (2004) 15:1115-1122.
- MUNK VP, DIAKOS CI, ELLIS LT, FENTON RR, MESSERLE BA, HAMBLEY TW: Investigations into the interactions between DNA and conformationally constrained pyridylamineplatinum(II) analogues of AMD473. Inorg Chem. (2003) 42:3582-3590.
- CONRAD ML, ENMAN JE, SCALES SJ et al.: Synthesis, characterization, and cytotoxicities of platinum(II) complexes bearing pyridinecarboxaldimines containing bulky aromatic groups. Inorg. Chim. Acta. (2005) 358:3-69.
- OKADA T, EL-MEHASSEB IM, KODAKA M, TOMOHIRO T, OKAMOTO K, OKUNO H: Mononuclear platinum(II) complex with 2-phenylpyridine ligands showing high cytotoxicity against mouse sarcoma 180 cells acquiring high cisplatin resistance. J. Med. Chem. (2001) 44:4661-4667.
- HALL MD, HAMBLEY TW: Platinum(IV) coordination compounds: their bioinorganic chemistry. Coord. Chem. Rev. (2002) 232:49-67.
- KWON YE, WHANG KJ, PARK YJ et al.: Synthesis, characterization and antitumor activity of novel octahedral Pt(IV) complexes. Bioorg. Med. Chem. (2003) 11:1669-1676.
- KWON YE, KIM K-H: Octahedral Pt(IV) complex K101 induces apoptosis via ERK1/2 activation and the p53 pathway in human colon cancer cells. Anticancer Drugs (2006) 17:553-558.
- ZAK F, TURANEK J, KROUTIL A et al.: Platinum(IV) complex with adamantylamine as nonleaving group: synthesis, characterization, and in vitro antitumor activity against a panel of cisplatin-resistant cell lines. J. Med. Chem. (2004) 47:761-763.
- HORVATH V, BLANAROVA O, SVIHALKOVA-SINDLEROVA L et al.: Platinum(IV) complex with adamantylamine overcomes intrinsic resistance to cisplatin in ovarian cancer cells. Gynecol. Oncol. (2006)102(1):32-40.
- JEON YJ, KIM S-Y, KO YH, SAKAMOTO S, YAMAGUCHI K, KIM K: Novel molecular drug carrier: encapsulation of oxaliplatin in cucurbit[7]uril and its effects on stability and reactivity of the drug. Org. Biomol. Chem. (2005) 3:2122-2125.
- WHEATE NJ, DAY AI, BLANCH RJ, ARNOLD AP, CULLINANE C, COLLINS JG: Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment. Chem. Commun. (Camb.). (2004) 2004:1424-1425.
- WHEATE NJ, BUCK DP, DAY AI, COLLINS JG: Cucurbit[n]uril binding of platinum anticancer complexes. Dalton Trans. (2006) 2006:451-458.
- FARELL N, QU Y, BIERBACH U, VALSECCHI M, MENTA E: Structure–activity relationships within di- and trinuclear platinum Phase-I clinical anticancer agents. In: Cisplatin–Chemistry and Biochemistry of a Leading Anticancer Drug. Lippert B (Ed.) Verlag Helvetica Chimica Acta, Zürich (1999):479-496.
- SERVIDEI T, FERLINI C, RICCARDI A et al.: The novel trinuclear platinum complex BBR3464 induces a cellular response different from cisplatin. Eur. J. Cancer (2001) 37:930-938.
- QU Y, SCARSDALE NJ, TRAN M, FARELL NP: Cooperative effects in long-range 1,4 DNA-DNA interstrand cross-links formed by polynuclear platinum complexes: an unexpected syn orientation of adenine bases outside the binding sites. J. Biol. Inorg. Chem. (2003) 8:19-28.
- HARRIS AL, YANG X, HEGMANS A et al.: Synthesis, characterization and cytotoxicity of a novel highly charged trinuclear platinum compound. Enhancement of cellular uptake with charge. Inor. Chem. (2005) 44:9598-9600.
- TEIXEIRA LJ, SEABRA M, REIS E et al.: Cytotoxic activity of metal complexes of biogenic polyamines: polynuclear platinum(II) chelates. J. Med. Chem. (2004) 47:2917-2925.
- KOMEDA S, LUTZ M, SPEK AL, CHIKUMA M, REEDIJK J: New antitumor-active azole-bridged dinuclear platinum(II) complexes: synthesis, characterization, crystal structures, and cytotoxic studies. Inorg. Chem. (2000) 39:4230-4236.
- TELETCHEA S, KOMEDA S, TEUBEN JM, ELIZONDO-RIOJAS MA, REEDIJK J, KOZELKA J: A pyrazolato-bridged dinuclear platinum(II) complex induces only minor distortions upon DNA-binding. Chemistry (2006) 12:3741-3753.
- KOMEDA S, KALAYDA GV, LUTZ M et al.: New isomeric azine-bridged dinuclear platinum(II) complexes circumvent cross-resistance to cisplatin. J. Med. Chem. (2003) 46:1210-1219.
- XIN ZHANG C, LIPPARD SJ: New metal complexes as potential therapeutics. Curr. Opin. Chem. Biol. (2003) 7:481-489.
- MOMEKOV G, BAKALOVA A, KONSTANTINOV S, TODOROV D, KARAIVANOVA M: Comparative assessment of the cytotoxic effects of carboxylato-bridged dinuclear platinum(II) complexes against human tumor cell lines. Neoplasma (2005) 52:469-475.
- MOMEKOV G, FERDINANDOV D, BAKALOVA A, ZAHARIEVA M, KONSTANTINOV S, KARAIVANOVA M: In vitro toxicological evaluation of a dinuclear platinum(II) complex with acetate ligands. Arch. Toxicol. (2006) 80(9):555-560
- RADULOVIC S, TESIC Z, MANIC S: Trans-platinum complexes as anticancer drugs: recent developments and future prospects. Curr. Med. Chem. (2002) 9:1611-1618.
- NAJAJREH Y, PEREZ JM, NAVARRO-RANNINGER C, GIBSON D: Novel soluble cationic trans-diamminedichloroplatinum(II) complexes that are active against cisplatin resistant ovarian cancer cell lines. J. Med. Chem. (2002) 45:5189-5195.
- PROKOP R, KASPARKOVA J, NOVAKOVA O et al.: DNA interactions of new antitumor platinum complexes with trans-geometry activated by a 2-methylamine or sec-butylamine ligand. Biochem. Pharmacol. (2004) 67:1097-1104.
- VAN ZUTPHEN S, REEDIJK J: Targeting platinum anti-tumour drugs: overview of strategies employed to reduce systemic toxicity. Coord. Chem. Rev. (2005) 249:2845-2853.
- BARUAH H, BARRY CG, BIERBACH U: Platinum-intercalator conjugates: from DNA-targeted cisplatin derivatives to adenine binding complexes as potential modulators of gene regulation. Curr. Topics Med. Chem. (2004) 4:1537-1549.
- BOULIKAS T: Low toxicity and anticancer activity of a novel liposomal cisplatin (lipoplatin) in mouse xenografts. Oncol. Rep. (2004) 12:3-12.
- BOULIKAS T, STATHOPOULOS GP, VOLAKAKIS N, VOUGIOUKA M: Systemic lipoplatin infusion results in preferential tumor uptake in human studies. Anticancer Res. (2005) 25:3031-3039.
- FEDIER A, POYET C, PERUCCHINI D, BOULIKAS T, FINK D: LH1-deficient tumor cells are resistant to lipoplatin, but retain activity to lipoxal. Anticancer Drugs (2006) 17:315-323.
- IINUMA H, MARUYAMA K, OKINAGA K et al.: Intracellular targeting therapy of cisplatin-encapsulated transferrin-polyethylene glycol liposome on peritoneal dissemination of gastric cancer. Int. J. Cancer (2002) 99:130-137.
- GENG L, OSUSKY K, KONJETI S, FU A, HALLAHAN D: Radiation-guided drug delivery to tumor blood vessels results in improved tumor growth delay. J. Control Release (2004) 99:369-381.
- ANDRESEN TL, JENSEN SS, KAASGAARD T, JORGENSEN K: Triggered activation and release of liposomal prodrugs and drugs in cancer tissue by secretory phospholipase A2. Curr. Drug Deliv. (2005) 2:353-362.
- APV: Drug Delivery Focus Group Newsletter (2006) 2006:1-10.
- LU C, PEREZ-SOLER R, PIPERDI B et al.: Phase II study of a liposome-entrapped cisplatin analog (L-NDDP) administered intrapleurally and pathologic response rates in patients with malignant pleural mesothelioma. J. Clin. Oncol. (2005) 23:3495-3501.
- HAN I, KIM OJ, LEE GY et al.: Enhanced antitumor activity of trans(+/-)-1,2-di- aminocyclo-hexaneglutamatoplatinum(II) formulated with stealth liposome. Bioorg. Med. Chem. (2003) 11:5443-5447.
- RADEMAKER-LAKHAI JM, TERRET C, HOWELL SB et al.: A Phase I and pharmacological study of the platinum polymer AP5280 given as an intravenous infusion once every 3 weeks in patients with solid tumors. Clin. Cancer Res. (2004) 10:3386-3395.
- NISHIYAMA N, OKAZAKI S, CABRAL H et al.: Novel cisplatin- incorporated polymeric micelles can eradicate solid tumors in mice. Cancer Res. (2003) 63:8977-8983.
- ARONOV O, HOROWITZ AT, GABIZON A, GIBSON D: Folate-targeted PEG as a potential carrier for carboplatin analogs. Synthesis and in vitro studies. Bioconjug. Chem. (2003) 14:563-574.
- ARONOV O, HOROWITZ AT, GABIZON A, FUERTES MA, PEREZ JM, GIBSON D: Nuclear localization signal-targeted poly(ethylene glycol) conjugates as potential carriers and nuclear localizing agents for carboplatin analogues. Bioconjug Chem. (2004) 15:814-823.
- JUN YJ, KIM JI, JUN MJ, SOHN YS: Selective tumor targeting by enhanced permeability and retention effect. Synthesis and antitumor activity of polyphosphazene-platinum(II) conjugates. J. Inorg. Biochem. (2005) 99:1593-1601.
- CASSINO C, GABANO E, RAVERA M et al.: Platinum(II) and technecium(I) complexes anchored to ethynylestradiol: a way to drug targeting and delivery. Inorg. Chim. Acta (2004) 357:2157-2166.
- GABANO E, CASSINO C, BONETTI S et al.: Synthesis and characterisation of estrogenic carriers for cytotoxic Pt(II) fragments: biological activity of the resulting complexes. Org. Biomol. Chem. (2005) 3:3531-3539.
- DOMINGUEZ MF, MACIAS RIR, IZCO-BASURKO I et al.: Low in vivo toxicity of a novel cisplatin-ursodeoxycholic derivative (Bamet-UD2) with enhanced cytostatic activity versus liver tumors. J. Pharmacol. Exp. Ther. (2001) 297:1106-1112.
- MONTE MJ, BALLESTERO MR, BRIZ O, PEREZ MJ, MARIN JJ: Proapoptotic effect on normal and tumor intestinal cells of cytostatic drugs with enterohepatic organotropism. J. Pharmacol. Exp. Ther. (2005) 315:24-35.
- POTTIER RH, KENNEDY JC: The possible role of ionic species in selective biodistribution of photochemotherapeutic agents toward neoplastic tissue. J. Photochem. Photobiol. B. (1990) 8:1-16.
- KORBELIK M, HUNG J: Cellular delivery and retention of Photofrin II: the effects of interaction with human plasma proteins. Photochem. Photobiol. (1991) 53:501-510.
- BRUNNER H, ARNDT MR, TREITTINGER B: Porphyrin platinum conjugates – new aims. Inorg. Chim. Acta. (2004) 357:1649-1669.
- ALI H, VAN LIER JE: Metal complexes as photo- and radiosensitizers. Chem. Rev. (1999) 99:2379-2450.
- BERJOT M, THEOPHANIDES T: Excitation profiles of soret-excited resonance raman spectra of platinum-hematoporphyrin complexes. Inorg. Chim. Acta, (1980) 46:281-284.
- LOTTNER C, BART K-C, BERNHARDT G, BRUNNER H: Hematoporphyrin-derived soluble porphyrin-platinum conjugates with combined cytotoxic and phototoxic antitumor activity. J. Med. Chem. (2002) 45:2064-2078.
- LOTTNER C, BART K-C, BERNHARDT G, BRUNNER H: Soluble tetraarylporphyrin-platinum conjugates as cytotoxic and phototoxic antitumor agents. J. Med. Chem. (2002) 45:2079-2089.
- LOTTNER C, KNUECHEL R, BERNHARDT, BRUNNER H: Combined chemotherapeutic and photodynamic treatment on human bladder cells by hematoporphyrin-platinum(II) conjugates. Cancer Lett. (2004) 203:171-180.
- LOTTNER C, KNUECHEL R, BERNHARDT, BRUNNER H: Distribution and subcellular localization of a water-soluble hematoporphyrin- platinum(II) complex in human bladder cancer cells. Cancer Lett. (2004) 215:167-177.
- BRUNNER H, SCHELLERER K-M: Double porphyrin platinum conjugates. Z. Naturforsch. (2002) 57b:751-756.
- KLENER T, WINGEN F, KEPPLER BK, KREMPIEN B, SCHMAHL D: Anticancer agent-linked phosphonates with antiosteolytic and antineoplastic properties: a promising perspective in the treatment of bone-related malignancies? J. Cancer. Res. Clin. Oncol. (1990) 116:341-350.
- BLOEMINK MJ, DIEDEREN JJ, DORENBOS JP, HEETEBRIJ RJ, KEPPLER BK, REEDIJK J: Calcium ions do accelerate the DNA binding of new antitumor-active platinum aminophosphonate complexes. Eur. J. Inorg. Chem. (1999) 1999:1655-1657.
- LAFORGIA M, CERAZINO L, MARGIOTTA et al.: Synthesis and characterization of platinum(II) complexes of diethyl[(methylsulfinyl)methyl] phosphonate: potential drugs against bone tumors. Eur. J. Inorg. Chem. (2004) 2004:3445-3452.
- GALANSKI M, SLABY S, JAKUPEC MA, KEPPLER BK: Synthesis, characterization, and in vitro antitumor activity of osteotropic diam(m)ineplatinum(II) complexes bearing a N,N-bis(phos- phonomethyl)glycine ligand. J. Med. Chem. (2003) 46:4946-4951.
- BAKALOVA A, BUYUKLIEV R, TCHOLAKOVA I, MOMEKOV G, KONSTANTINOV S, KARAIVANOVA M: Synthesis, physicochemical investigation and cytotoxic activity of new Pt(II) complexes with hydantoin ligands. Eur. J. Med. Chem. (2003) 38:627-632.
- BAKALOVA A, BUYUKLIEV R, MOMEKOV G et al.: Synthesis, physicochemical and in vitro pharmacological investigation of new platinum(II) complexes with some cycloalkanespiro-5′-hydantoins. Eur. J. Med. Chem. (2005) 40:590-596.
- WHITAKKER J, McFADYEN WD, WICKHAM G, WAKELIN GL, MURRAY V: The interaction of DNA-targeted platinum phenanthridinium complexes with DNA. Nucleic Acids Res. (1998) 26:3933-3939.
- WHITAKKER J, MCFADYEN WD, BAGULEY BC, MURRAY V: The interaction of DNA-targeted platinum phenanthridinium complexes with DNA in human cells. Anticancer Drug Des. (2001) 16:81-89.
- TEMPLE MD, RECABARREN R, McFADYEN WD, HOLMES RJ, DENNY WA, MURRAY V: The interaction of DNA-targeted 9-aminoacridine-4-carboxamide platinum complexes with DNA in intact human cells. Biochi. Biophys. Acta. (2002) 1574:223-230.
- BROW JM, PLEATMAN CR, BIERBACH U: Cytotoxic acridinylthiourea and its platinum conjugate produce enzyme-mediated DNA strand breaks. Bioorg. Med. Chem. Lett.. (2002) 12:2953-2955.
- HESS SM, MOUNCE AM, SEQUEIRA RC, AUGUSTUS TM, ACKLEY MC, BIERBACH U: Platinum-acridinylthiourea conjugates show cell line-specific cytotoxic enhancement in H460 lung carcinoma cells compared to cisplatin. Cancer Chemother. Pharmacol. (2005) 56:337-343.
- ALDERDEN RA, MELLOR HR, MODOK S, HAMBLEY TW, CALLAGHAN R: Cytotoxic efficacy of an anthraquinone linked platinum anticancer drug. Biochem. Pharmacol. (2006) 71:1136-1145.
- LOSKOTOVA H, BRABEC V: DNA interactions of cisplatin tethered to the DNA minor groove binder distamycin. Eur. J. Biochem. (1999) 266:392-402.
- KRUSZEWSKI M, BOUZYK E, ODLAK T et al.: Differential toxic effects of cis-platinum(II) and palladium(II) chlorides complexed with methyl-3,4-diamine- 2,3,4,6-tetradeoxy-α-L-lyxo-hexapyranoside in mouse lymphoma cell lines differing in DSB and NER repair ability. Teratogen. Carcinogen. Mutagen. (2003) (Suppl.1):1-11.
- GANGOPADHYAY SB, ROEDIGS A, BILL KANGARLOO S, KREBS B, WOLFF JE: Cellular accumulation determines the activity of three novel tricyclic platinum agents. Anticancer Res. (2001) 21:2039-2044.
- MA D-L, CHE C-M: A bifunctional platinum(II) complex capable of intercalation and hydrogen-bonding interactions with DNA: binding studies and cytotoxicity. Chem. Eur. J. (2003) 9:6133-6144.
- BRODIE C, COLLINS JG, ALDRICH-WRIGHT JR: DNA binding and biological activity of some platinum(II) intercalating compounds containing methyl-substituted 1,10-phenanthrolines. Dalton Trans. (2004) 8:1145-1152.
- McCLUSKEY A, ACKLAND SP, GARDINER E, WALKOM CC, SAKOFF JA: The inhibition of protein phosphatases 1 and 2A: a new target for rational anti-cancer drug design? Anticancer Drug Des. (2001) 16:291-303.
- TO KK, HO YP, AU-YEUNG SC: Synergistic interaction between platinum-based antitumor agents and demethylcantharidin. Cancer Lett. (2005) 223:227-237.
- TO KK, HO YP, AU-YEUNG SC: In vitro and in vivo suppression of growth of hepatocellular carcinoma cells by novel traditional Chinese medicine-platinum anti-cancer agents. Anticancer Drugs. (2005) 16:825-835.
- BLAGLOW JE, MILLER RA: The thioredoxin reductase/thioredoxin system: novel redox targets for cancer therapy. Cancer Biol. Ther. (2005) 4:6-13.
- MILLET R, URIG S, JACOB J et al.: Synthesis of 5-nitro-2-furancarbohydrazides and their cis-diamminedichloroplatinum complexes as bitopic and irreversible human thioredoxin reductase inhibitors. J. Med. Chem. (2005) 48:7024-7039.
Patents
- SUNKYONG IND. LTD: US5395947 (1995).
- ASTA MEDICA AG: HR920573 (1996).
- DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OEFFENTLICHEN RECHTS ET AL.: WO2005058307 (2005).
- SONUS PHARMACEUTICALS INC.: WO2004006859 (2004).
- TEXAS AM UNIVERSITY SYSTEM: WO2004024062 (2004).
- PLIVA LACHEMA AS: WO2004087126 (2004).
- KAY H, PALMER JW, STANKO JA, SEBTI SM: US20050288365 (2005).
- ISAACS L, LAGONA JA: US2005080068 (2005).
- UNISEARCH LTD; WHEATE NJ, DAY AI, BLANCH RJ, COLLINS JG: WO2005068469 (2005).
- NOVUSPHARMA SPA: US6596889 (2003).
- BOEHRINGER MANNHEIM ITALIA: US5744497 (1998).
- VIRGINIA COMMONWEALTH UNIVERSITY: WO03018594 (2003).
- CHOLAKOVA JF, BAKALOVA AG, KONSTANTINOV SM, KARAIVANOVA MH: BG64022 (2003).
- SONUS PHARMACEUTICALS INC.: US20050209321 (2005).
- HEBREW UNIVERSITY: WO03017998 (2003).
- SEQUUS PHARM. INC.: HK1021320 (2004).
- REGULON INC: DE60027039D (2006).
- LIPLASOME PHARMA AS, JOERGENSEN K, ANDRESEN T: WO2006048017 (2006).
- ARONEX PHARMACEUTICALS INC.: WO2004103344 (2004).
- ARONEX PHARMACEUTICALS INC.: WO2004103382 (2004).
- ARONEX PHARMACEUTICALS INC.: WO2004098524 (2004).
- EWHA WOMEN’S UNIVERSITY: WO2004074299 (2004).
- ACCESS PHARMACEUTICALS INC.: WO2005079396 (2005).
- TRUSTEES EWHA WOMANS UNIVERSITY: WO2004096820 (2004).
- SOHN YS, SONG S-C, LEE, SANG BL: AUO781233 (2005).
- BERUBE G: US20040006051 (2004).
- ICE SRL: WO3095462 (2003).
- ICE SRL: WO0309547 (2003).
- ZENTARIS GMBH: MXPA04007443 (2004).
- ZENTARIS GMBH: PL373346 (2005).
- CHOLAKOVA JF, BAKALOVA AG, ALEKSIEV BV ET AL.: BG61482 (1995).
Websites
- http://www.fda.gov/orphan/designat/alldes.rtfUS FDA. Cumulative list of orphan products designated through 2006 (2006).
- http://www.antigenics.com/products/cancer/aroplatinAroplatin™ liposomal platinum agent – an investigational product (2006).