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Review

Therapeutic advances in ankylosing spondylitis

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Pages 21-29 | Published online: 24 Feb 2005

Bibliography

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  • •A report of two patients giving the favourable effects of thalidomide in the treatment of severe refractory AS.
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  • BRANDT J, HAIBEL H, CORNELY D et al: Successful treatment of active ankylosing spondylitis with the anti-tumor necrosis factor-a monoclonal antibody infliximab. Arthritis Rheum. (2000) 43 (6) :1346–1352.
  • •The first study to report the dramatic improvement of AS patients with refractory and severe disease with the mAb infliximab, suggesting the potential use of this biological agent and additionally, the involvement of TNF-a in AS pathophysiology.
  • VAN DER BOSCH F, KRUITHOF E, BAETEN D, DE KEYSER F, MIELANTS H, VEYS EM: Effects of a loading dose regimen of three infusions of chimeric monoclonal antibody to tumor necrosis factor-a (infliximab) in spondylarthropathy: an open pilot study. Ann. Rheum. Dis. (2000) 59(6):428–433.
  • ••A second open study with infliximab confirming the resultsby Brandt et al. and extending the treatment to the other spondylarthropathies (psoriatic arthritis and undifferenti-ated spondylarthropathy).

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