378
Views
72
CrossRef citations to date
0
Altmetric
Miscellaneous

ICE/Caspase-1 inhibitors as novel anti-inflammatory drugs

Pages 1207-1209 | Published online: 24 Feb 2005

Bibliography

  • DINARELLO CA: Biological basis for interleukin-1 in disease. Blood (1996) 87(6):2095–2147.
  • DINARELLO CA: IL-18: A T1-inducing, proinflammatory cytokine and new member of the IL-1 family. j Allergy CM]. Immurrol (1999) 103:11–24.
  • ENK AH, KATZ SI: Early molecular events in the induction phase of contact sensitivity. Proc. Natl. Acad. Li. USA (1992) 89:1398–1402.
  • NAIK SM, CANNON G, BURBACH GJ et al.: Human keratinocytes constitutively express interleukin-18 and secrete biologically active interleukin-18 after treatment with pro-inflammatory mediators and dinitrochlorobenzene. j Invest. Dermatol (1999) 113:766–772.
  • KUIDA K, LIPPKE JA, KU G et al: Altered cytokine export and apoptosis in mice deficient in interleukin-1I3 converting enzyme. Science (1995) 267: 2000-2003.
  • LIP, ALLEN H, BANERJEE S et al: Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell (1995) 80:401–411.
  • ANTONOPOULOS C, CUMBERBATCH M, DEARMAN RJ et al: Functional caspase-1 is required for Langerhans cell migration and optimal contact sensitization in mice. j Immurrol (2001) 166:3672–3677.
  • KU G, FAUST T, LAUFFER LL et al.: Interleukin-113 converting enzyme inhibition blocks progression of type II collagen-induced arthritis in mice. Cytolone (1996) 8:377–386.
  • KU G, FORD E RAYBUCK SA etal.: Selective interleukin-1I3 converting enzyme (ICE/Caspase-1) inhibition with pralnacasan (HMR 3480NX-740) reduces inflammation and joint destruction in murine type II collagen-induced arthritis (CIA). Am. Coll. Rheumatol (Abstracts) (Submitted, 2001).
  • MULLICAN M, HARBESON S, LAUFFER DJ et al: Structure-based design of an orally available, selective interleukin-113 converting enzyme (caspase-1) inhibitor, pralnacasan, that inhibits inflammation and joint destruction in murine collagen-induced arthritis. (Submitted, 2001).
  • LOHER F, BAUER C, SCHMALL K, etal.: The ICE inhibitor, pralnacasan, reduces DSS-induce murine colitis and Thl-cell activation. VIth International Symposium on Inflammatory Bowel Diseases Abstracts (Istanbul, Sept, 2001).
  • KU G, QADRI A, RANDLE JCR: Interleukin-113 converting enzyme (caspase-1) inhibition with VX-765 reduces inflammation and cytokine levels in murine oxazolone-induced dermatitis. j Invest. Dermatol (July 2001) (Society for Investigative Dermatology Abstracts, Washington, May 2001).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.