Therapeutic potential of bone morphogenetic proteins

Bibliography

• VILJANEN V: Allogeneic and Xertogeneic Bone Morphogenetic Protein in Skeletal Reconstruction. Tampere: Acta Universitatis Tamperensis (1997).
   Google Scholar
• DUDLEY AT, LYONS KM, ROBERTSON EJ: A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev. (1995) 9:2795–2807.
   PubMed Web of Science ®Google Scholar
• JONES, CM, LYONS KM, HOGAN BL: Involvement of bone morphogenetic protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. Development (1991) 111:531–542.
   PubMed Web of Science ®Google Scholar
• LUO G, HOFMANN C, BRONCKERS AL, SOHOCKI M, BRADLEY A, KARSENTY G: Bmp-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev. (1995) 9:2808–2820.
   PubMed Web of Science ®Google Scholar
• SAKOU T: Bone morphogenetic proteins: from basic studies to clinical approaches. Bone (1998) 22:591–603.
   PubMed Web of Science ®Google Scholar
• ZHANG H, BRADLEY A: Mice deficient for bmp2 are nonviable and have defects in amnion/chorion and cardiac development. Development (1996) 122:2977–2986.
   PubMed Web of Science ®Google Scholar
• ZHANG D, MEHLER MF, SONG Q, KESSLER JA: Development of bone morphogenetic protein receptors in the nervous system and possible roles in regulating trkc expression. J. Neurosci. (1998) 18:3314–3326.
   PubMed Web of Science ®Google Scholar
• ZOU, H, NISWANDER, L: Requirement for bmp signaling in interdigital apoptosis and scale formation. Science (1996) 272:738–741.
   PubMed Web of Science ®Google Scholar
• OZKAYNAK E, RUEGER DC, DRIER EAet al: Op-1 Cdna Encodes an Osteogenic Protein in the Tgf-Beta Family. EMBO (1990) 9:2085–2093.
   PubMed Web of Science ®Google Scholar
• OZKAYNAK E, SCHNEGELSBERG PN, JIN DF et al.: Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis. I Biol. Chem. (1992) 267:25220–25227.
   Google Scholar
• WOZNEY JM: The bone morphogenetic protein family and osteogenesis. Md. Reprod. Dev. (1992) 32:160–167.
   PubMed Web of Science ®Google Scholar
• WOZNEY JM: Bone morphogenetic proteins. Prog. Growth Factor Res. (1989) 1:267–280.
   PubMedGoogle Scholar
• WOZNEY JM, ROSEN V, CELESTE AJ et al.: Novel regulators of bone formation: molecular clones and activities. Science (1988) 242:528–1534.
   Google Scholar
• URIST MR: Bone: formation by autoinduction. Science (1965) 1501:893–899.
   Google Scholar
• •One of the original Urist papers describing the concept of a factor in bone that could induce ectopic bone formation.
   Google Scholar
• URIST MR, STRATES BS: Bone morphogenetic protein. I Dent. Res. (1971) 50:1392–1406.
   PubMed Web of Science ®Google Scholar
• •One of the original Urist papers describing the concept of a factor in bone that could induce ectopic bone formation.
   Google Scholar
• URIST, MR, IWATA, H, STRATES, BS: Bone morphogenetic protein and proteinase in the guinea pig. Cliri Orthop (1972) 85:275–290.
   PubMedGoogle Scholar
• URIST MR, SATO K, BROWNELL et al.:Human bone morphogenetic protein (hBMP). Proc. Soc. Exp. Biol. Med. (1983) 173:194–199.
   PubMed Web of Science ®Google Scholar
• WANG EA, ROSEN V, CORDES P et al.: Purification and characterization of other distinct bone-inducing factors. Proc. Nati Acad. Sri. USA (1988) 85:9484–9488.
   PubMed Web of Science ®Google Scholar
• OTSUKA F, YAO Z, LEE T, YAMAMOTO S, ERICKSON GE SHIMASAKI S: Bone morphogenetic protein-15, identification of target cells and biological functions. I Biol. Chem. (2000) 275:39523–39528.
   Web of Science ®Google Scholar
• REDDI AH: Bmps: actions in flesh and bone. Nature Med. (1997) 3:837–839.
   PubMed Web of Science ®Google Scholar
• ••A key reference describing the BMPs inbone.
   Google Scholar
• NISHITOH H, ICHIJO H, KIMURA M et al.: Identification of Type I and Type Ii serine/threonine kinase receptors for growth/differentiation factor-5. I Biol. Chem. (1996) 271:21345–21352.
   Web of Science ®Google Scholar
• HOGAN BL: Bone morphogenetic proteins in development. Curr. Opirr. Genet. Dev. (1996) 6:432–438.
   PubMed Web of Science ®Google Scholar
• KINGSLEY, DM: What do bmps do in mammals? clues from the mouse short-ear mutation. Trends Genet. (1994) 10:16–21.
   PubMed Web of Science ®Google Scholar
• KINGSLEY, DM: The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev. (1994) 8:133–146.
   PubMed Web of Science ®Google Scholar
• MASSAGUE, J: TGF-beta signal transduction. Ann. Rev Biochem. (1998) 67:753–791.
   PubMed Web of Science ®Google Scholar
• •An important review focussing on the signal transduction of TGF-P molecules.
   Google Scholar
• REDDI AH: Bone and cartilage morphogenesis: cell biology to clinical applications. Curr. Opirr. Cell Biol. (1994) 4:737–744.
   Google Scholar
• BURT DW, LAW AS: Evolution of the transforming growth factor-beta superfamily. Prog. Growth Factor Res. (1994) 5:99–118.
   PubMedGoogle Scholar
• BARR PJ: Mammalian subtilisins: the long-sought dibasic processing endoproteases. Cell (1991) 66:1–3.
   PubMed Web of Science ®Google Scholar
• CUI Y, JEAN E THOMAS G, CHRISTIAN JL: BMP-4 is proteolytically activated by furin and/or pc6 during vertebrate embryonic development. EMBO (1998) 17:4735–4743.
   PubMed Web of Science ®Google Scholar
• SCHLUNEGGER MP, GRUTTER MG: Refined crystal structure of human transforming growth factor beta 2 at 1.95 a resolution. j Md. Biol. (1993) 231:445–458.
   PubMed Web of Science ®Google Scholar
• SAHARINEN J, HYYTIAINEN M, TAIPALE J, KESKI-OJA J: Latent transforming growth factor-beta binding proteins (ltbps)-- structural extracellular matrix proteins for targeting TGF-beta action. Cytokirre Growth Factor Rev. (1999) 10:99–117.
   PubMed Web of Science ®Google Scholar
• ZIMMERMAN LB, DE JESUS-ESCOBAR JM, HARLAND RIVI: The spemann organizer signal noggin binds and inactivates bone morphogenetic Protein 4. Cell (1996) 86:599–606.
   PubMed Web of Science ®Google Scholar
• PICCOLO S, SASAI Y, LU B, DE ROBERTIS EM: Dorsoventral patterning in Xertapus: inhibition of ventral signals by direct binding of chordin to Bmp-4. Cell (1996) 86:589–598.
   PubMed Web of Science ®Google Scholar
• NAKAMURA T, TAKIO K, ETO Y, SHIBAI H, TITANI K, SUGINO H: Activin-binding protein from rat ovary is follistatin. Science (1990) 247:836–838.
   PubMed Web of Science ®Google Scholar
• HSU DR, ECONOMIDES AN, WANG X, EIMON PM, HARLAND RM: The Xerropus dorsalizing factor gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Ma. Cell (1998) 1:673–683.
   PubMed Web of Science ®Google Scholar
• KAWABATA M, IMAMURA T, MIYAZONO K: Signal transduction by bone morphogenetic proteins. Cytokirre Growth Factor Rev. (1998) 9:49–61.
   PubMed Web of Science ®Google Scholar
• LIU F, VENTURA F, DOODY J, MASSAGUE J: Human type H receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor Model to the Bmps. Md. Cell Biol. (1995) 15:3479–3486.
   Web of Science ®Google Scholar
• NOHNO T, ISHIKAWA T, SAITO T, HOSOKAWA K, NOJI S, WOLSING DH, ROSENBAUM JS: Identification of a human Type Ii receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein Type I receptors. j Biol. Chem. (1995) 270:22522–22526.
   PubMed Web of Science ®Google Scholar
• ROSENZWEIG BL, IMAMURA T, OKADOME T et al.: Cloning and characterization of a human type H receptor for bone morphogenetic proteins. Proc Natl Arad Sci USA (1995) 92:7632–7636.
   PubMed Web of Science ®Google Scholar
• SCHMITT JM, HWANG K, WINN SR, HOLLINGER JO: Bone morphogenetic proteins: an update on basic biology and clinical relevance. I Orthop. Res. (1999) 17:269–278.
   PubMed Web of Science ®Google Scholar
• ••A key reference describing the BMPs inbone.
   Google Scholar
• SEKELSKY JJ, NEWFELD SJ, RAFTERYLA, CHARTOFF EH, GELBART WM: Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in drosophila melanogaster. Genetics (1995) 139:1347–1358.
   PubMed Web of Science ®Google Scholar
• SAVAGE C, DAS P, FINELLI AL etal.: Caeriorhabditis Elegaris genes Sma-2, Sma-3, and Sma-4 define a conserved family of transforming growth factor beta pathway components. Proc. Nail. Acad. Sri. USA (1996) 93:790–794.
   Google Scholar
• BAKER JC, HARLAND RIVI: From receptor to nucleus: the Smad pathway. Curr. Opirr. Genet. Dev. (1997) 7:467–473.
   PubMed Web of Science ®Google Scholar
• REDDI AH: Bone morphogenetic proteins: from basic science to clinical applications. Bone Joint Surg. Am. (2001) 83-A:S1–56.
   Google Scholar
• KRETZSCHMAR M, DOODY J, MASSAGUE J: Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smadl. Nature (1997) 389:618–622.
   PubMed Web of Science ®Google Scholar
• MARKER PC, SEUNG K, BLAND AE,RUSSELL LB, KINGSLEY DM: Spectrum of BMP5 mutations from germline mutagenesis experiments in mice. Genetics (1997) 145:435–443.
   PubMed Web of Science ®Google Scholar
• MONROE DG, JIN DF, SANDERS MM: Estrogen opposes the apoptotic effects of bone morphogenetic protein 7 on tissue remodeling. Mal. Cell Biol. (2000) 20:4626–4634.
   Web of Science ®Google Scholar
• JOHNSON EE, URIST MR: Distal Metaphyseal tibial nonunions associated with significant bowing deformity and cortical bone loss: treatment with human bone morphogenetic protein (H-Bmp) and internal fixation. Nippon Seikeigeka Gakkai Zasshi (1989) 63:613–620.
   PubMedGoogle Scholar
• GRAUER JN, PATEL TC, ERULKAR JS,TROIANO NW PANJABI MM, FRIEDLAENDER GE: 2000 Young investigator research award winner. evaluation of op-1 as a graft substitute for intertransverse process lumbar fusion. Spine (2001) 26:127–133.
   Google Scholar
• MAGIN MN, DELLING G: Improved lumbar vertebral interbody fusion using rhop-1: a comparison of autogenous bone graft, bovine hydroxylapatite (Bio-Oss), and Bmp-7 (Rhop-1) in Sheep. Spine (2001) 26:469–478.
   PubMed Web of Science ®Google Scholar
• DAVID SM, GRUBER HE, MEYER RA etal.: Lumbar spinal fusion using recombinant human bone morphogenetic protein in the canine, a comparison of three dosages and two carriers. Spine (1999) 241:1973–1979.
   Google Scholar
• BODEN SD, HAIR GA, VIGGESWARAPU M, LIU Y, TITUS L: Gene Therapy for Spine Fusion. Chia. Orthop. (2000) S225–233.
   Google Scholar
• TAKAHASHI K: [Bone Morphogenetic Protein (Bmp): From Basic Studies to Clinical Approaches]. Nippon Yakurigaku Zasshi (2000) 116:232–240.
   PubMedGoogle Scholar
• BALTZER AW, LATTERMANN C, WHALEN JD et al.: Potential Role of Direct Adenoviral Gene Transfer in Enhancing Fracture Repair. Chia. Orthop. (2000) S120–125.
   Google Scholar
• HELM GA, ALDEN TD, BERES EJ et al: Use of bone morphogenetic protein-9 gene therapy to induce spinal arthrodesis in the rodent. Neurosurg. (2000) 92:191–196.
   Web of Science ®Google Scholar
• FISCHGRUND JS, JAMES SB, CHABOT MC et al.: Augmentation of autograft using rhbmp-2 and different carrier media in the canine spinal fusion model. I Spinal. Disord. (1997) 10:467–472.
   PubMedGoogle Scholar
• SANDHU HS: Anterior lumbar interbody fusion with osteoinductive growth factors. Orthop. (2000) 56–60.
   Google Scholar
• RIPAMONTI U, MA SS, CUNNINGHAM NS, YEATES L, REDDI AH: Reconstruction of the bone--bone marrow organ by osteogenin, a bone morphogenetic protein, and demineralized bone matrix in calvarial defects of adult primates. Plash Recomm Surg. (1993) 91:27–36.
   PubMed Web of Science ®Google Scholar
• MARDEN LJ, HOLLINGER JO, CHAUDHARI A, TUREK T, SCHAUB RG, RON E: Recombinant human bone morphogenetic protein-2 is superior to demineralized bone matrix in repairing craniotomy defects in rats. I Biomed. Mater Res. (1994) 28:1127–1138.
   PubMed Web of Science ®Google Scholar
• KHOURI RK, BROWN, DM, KOUDSI B et al.: Repair of calvarial defects with flap tissue: role of bone morphogenetic proteins and competent responding tissues. Plash Recomm Surg. (1996) 98:103–109.
   PubMed Web of Science ®Google Scholar
• TORIUMI DM, KOTLER HS, LUXENBERG DP, HOLTROP ME, WANG EA: Mandibular Reconstruction with a Recombinant Bone-Inducing Factor. Functional, Histologic, and Biomechanical Evaluation. Arch. Otalaryrtgal Head Neck Surg. (1991) 117:1101–1112.
   PubMed Web of Science ®Google Scholar
• KHOURI RK, KOUDSI B, REDDI H: Tissue transformation into bone in vivo. a potential practical application. farm (1991) 266:1953–1955.
   Google Scholar
• BOYNE PJ, MARX RE, NEVINS M et al: A feasibility study evaluating rhbmp-2/ absorbable collagen sponge for maxillary sinus floor augmentation. Irm I Periodontics Restorative Dent. (1997) 17:11–25.
   PubMed Web of Science ®Google Scholar
• HOWELL TH, FIORELLINI J, JONES A et al.: A Feasibility study evaluating rhbmp-2/absorbable collagen sponge device for local alveolar ridge preservation or augmentation. Int. I Periodontics Restorative Dent. (1997) 17:124–139.
   PubMed Web of Science ®Google Scholar
• COCHRAN DL, JONES AA, LILLY LC, FIORELLINI JP, HOWELL H: Evaluation of recombinant human bone morphogenetic protein-2 in oral applications including the use of endosseous implants: 3-year results of a pilot study in humans. j Periodontal (2000) 71:1241–1257.
   PubMed Web of Science ®Google Scholar
• LYONS KM, PELTON RW, HOGAN BL: Patterns of expression of murine vgr-1 and bmp-2a ma suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development. Genes Dev. (1989) 31:1657–1668.
   Web of Science ®Google Scholar
• EBENDAL T, BENGTSSON H, SODERSTROM S: Bone morphogenetic proteins and their receptors: potential functions in the brain. j Neurosch Res. (1998) 51:139–146.
   PubMed Web of Science ®Google Scholar
• DEWULF N, VERSCHUEREN K, LONNOY OP et al.: Distinct Spatial and Temporal Expression Patterns of Two Type I Receptors for Bone Morphogenetic Proteins During Mouse Embryogenesis. Endocrinology (1995) 136:2652–2663.
   PubMed Web of Science ®Google Scholar
• HELM GA, ALDEN TD, SHEEHAN JP, KALLMES D: Bone Morphogenetic Proteins and Bone Morphogenetic Protein Gene Therapy in Neurological Surgery: A Review. Neurosurgery (2000) 46:1213–1222.
   PubMed Web of Science ®Google Scholar
• ARKELL R, BEDDINGTON RS: Bmp-7 Influences Pattern and Growth of the Developing Hindbrain of Mouse Embryos. Development (1997) 124:1–12.
   PubMed Web of Science ®Google Scholar
• RAJAN, P, MCKAY, RD: Multiple routes toastrocytic differentiation in the cns. Neurosci. (1998) 18:3620–3629.
   PubMed Web of Science ®Google Scholar
• GROSS RE, MEHLER MF, MABIE PC, ZANG Z, SANTSCHI L, KESSLER JA: Bone morphogenetic proteins promote astroglial lineage commitment by mammalian subventricular zone progenitor cells. Neuron (1996) 17:595–606.
   PubMed Web of Science ®Google Scholar
• SODERSTROM S, BENGTSSON H, EBENDAL T: Expression of Serine/ Threonine Kinase Receptors Including the Bone Morphogenetic Factor Type Ii Receptor in the Developing and Adult Rat Brain. Cell Tissue Res. (1996) 286:269–279.
   PubMed Web of Science ®Google Scholar
• SCHLUESENER HJ, MEYERMANN R: Expression of Bmp-6, a Tgf-Beta Related Morphogenetic Cytokine, in Rat Radial Glial Cells. Glia (1994) 12:161–164.
   PubMed Web of Science ®Google Scholar
• FURUTA Y, PISTON DW, HOGAN BL: Bone morphogenetic proteins (bmps) as regulators of dorsal forebrain development. Development (1997) 124:2203–2212.
   PubMed Web of Science ®Google Scholar
• KRIEGLSTEIN K, SUTER- CRAZZOLARA C, HOTTEN G, POHL J, UNSICKER, K: Trophic and protective effects of growth/differentiation factor 5, a member of the transforming growth factor-beta superfamily, on midbrain dopaminergic neurons. I Neurosci. Res. (1995) 42:724–732.
   PubMed Web of Science ®Google Scholar
• JORDAN J, BOTTNER M, SCHLUESENER HJ, UNSICKER K, KRIEGLSTEIN K: Bone morphogenetic proteins: neurotrophic roles for midbrain dopaminergic neurons and implications of astroglial cells. Eur. I Neurosci. (1997) 9:1699–1709.
   PubMed Web of Science ®Google Scholar
• LEWEN A, SODERSTROM S, HILLERED L, EBENDAL T: Expression of serine/threonine kinase receptors in traumatic brain injury. Neuroreport (1997) 8:475–479.
   PubMed Web of Science ®Google Scholar
• LEIN P, JOHNSON M, GUO X, RUEGER D, HIGGINS D: Osteogenic protein-1 induces dendritic growth in rat sympathetic neurons. Neuron (1995) 15:597–605.
   PubMed Web of Science ®Google Scholar
• KAWAMATA T, REN J, CHAN, TC, CHARETTE, M, FINKLESTEIN, SP: Intracisternal osteogenic protein-1 enhances functional recovery following focal stroke. Neuroreport (1998) 9:1441–1445.
   PubMed Web of Science ®Google Scholar
• PERIDES G, JENSEN FE, EDGECOMB P, RUEGER DC, CHARNESS ME: Neuroprotective effect of human osteogenic protein-1 in a rat model of cerebral hypoxia/ ischemia. Neurosci Lett. (1995) 187:21–24.
   PubMed Web of Science ®Google Scholar
• IWASAKI S, TSURUOKA N, HATTORI A, SATO M, TSUJIMOTO M, KOHNO M: Distribution and characterization of specific cellular binding proteins for bone morphogenetic protein-2. j Biol. Chem. (1995) 270:5476–5482.
   PubMed Web of Science ®Google Scholar
• SONG JJ, CELESTE AJ, KONG FM, JIRTLE RL, ROSEN V, THIES RS: Bone morphogenetic protein-9 binds to liver cells and stimulates proliferation. Endocrinology (1995) 136:4293–4297.
   PubMed Web of Science ®Google Scholar
• KNITTEL T, FELLMER P, MULLER L, RAMADORI G: Bone morphogenetic protein-6 is expressed in nonparenchymal liver cells and upregulated by transforming growth factor-beta 1. Exp. Cell Res. (1997) 232:263–269.
   PubMed Web of Science ®Google Scholar
• DUDLEY AT, ROBERTSON EJ: Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in bmp7 deficient embryos. Dev. Dpi. (1997) 208:349–362.
   PubMed Web of Science ®Google Scholar
• LYONS KM, HOGAN BL, ROBERTSON EJ: Colocalization of bmp land bmp 2 rnas suggests that these factors cooperatively mediate tissue interactions during murine development. Mech. Dev. (1995) 50:71–83.
   PubMed Web of Science ®Google Scholar
• PISCIONE TD, PHAN T, ROSENBLUM ND: Bmp7 Controls collecting tubule cell proliferation and apoptosis via smadl-dependent and -independent pathways. Am Physiol. Renal Physiol. (2001) 280:F19–33.
   PubMed Web of Science ®Google Scholar
• ALMANZAR MM, FRAZIER KS, DUBE PH et al.: Osteogenic protein-1 mrna expression is selectively modulated after acute ischemic renal Injury. I Am. Soc. Nephrol. (1998) 9:1456–1463.
   PubMed Web of Science ®Google Scholar
• SIMON M, MARESH JG, HARRIS, SE, HERNANDEZ JD et al.: Expression of bone morphogenetic protein-7 mrna in normal and ischemic adult rat kidney. Am. Physiol. (1999) 276:F382–389.
   PubMed Web of Science ®Google Scholar
• KELLY KJ, BONVENTRE JV: Osteogenic protein-1 protects the rat kidney from ischemic injury (Abstract). j Am. Soc. Nephrol. (1996) 7:1827.
   Google Scholar
• VUKICEVIC S, GRGIC M, STAVIJENIC A, SAMPATH TK: Recombinant human Op-1 (Bmp-7) Prevents rapid loss of glomerular function and improves mortality associated with chronic renal failure (Abstract).1 Am. Soc. Nephrol. (1996) 7:1867.
   Google Scholar
• VUKICEVIC S, KOPP JB, LUYTEN FP, SAMPATH TK: Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7). Proc. Nati Acad. Sri. USA (1996) 93:9021–9026.
   PubMed Web of Science ®Google Scholar
• BUTTERWITH SC: Regulators of adipocyte precursor cells. Pou/t. Set (1997) 76:118–123.
   PubMed Web of Science ®Google Scholar
• SOTTILE V, SEMEN K: Bone Morphogenetic Protein-2 Stimulates Adipogenic Differentiation of Mesenchymal Precursor Cells in Synergy with Brl 49653 (Rosiglitazone). FEBS Lett (2000) 475:201–204.
   PubMed Web of Science ®Google Scholar
• JI X, CHEN D, XU C, HARRIS SE, MUNDY GR, YONEDA T: Patterns of gene expression associated with bmp-2-induced osteoblast and adipocyte differentiation of mesenchymal progenitor cell 3t3-F442a. j Bone Miner. Metab. (2000) 18:132–139.
   PubMed Web of Science ®Google Scholar
• ASAHINA I, SAMPATH TK, HAUSCHKA PV: Human osteogenic protein-1 induces chondroblastic, osteoblastic, and/or adipocytic differentiation of clonal murine target cells. Esp. Cell Res. (1996) 222:38–47.
   PubMed Web of Science ®Google Scholar
• FRIEDLAENDER GE, PERRY CR, COLE JD et al.: Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. j Bone Joint Surg. Am. (2001) 83-A:S151–158.
   Google Scholar
• •A key reference describing the BMPs in bone.
   Google Scholar
• BODEN SD: Biology of lumbar spine fusion and use of bone graft substitutes: present, future, and next generation. Tissue Eng. (2000) 6:383–399.
   PubMedGoogle Scholar
• ZLOTOLOW DA, VACCARO AR, SALAMON ML, ALBERT TJ: The role of human bone morphogenetic proteins in spinal fusion. j Am. Acad. Orthop. Surg. (2000) 8:3–9.
   PubMedGoogle Scholar
• JEPPSSON C, SAVELAND H, RYDHOLM U, ASPENBERG P: Op-1 for cervical spine fusion: bridging bone in only 1 of 4 rheumatoid patients but prednisolone did not inhibit bone induction in rats. Acta Orthop. Land. (1999) 70:559–563.
   PubMed Web of Science ®Google Scholar
• PARAMORE CG, LAURYSSEN C, RAUZZINO MJ et al.: The safety of op-1 for lumbar fusion with decompression-- a canine study. Neurosurgery (1999) 44:1151-1155; Discussion 1155–1156.
   Google Scholar
• ITOH T, MOCHIZUKI M, NISHIMURA R et al.: Repair of ulnar segmental defect by recombinant human bone morphogenetic protein-2 in Dogs. Vet. Med. Sci. (1998) 60:451–458.
   PubMed Web of Science ®Google Scholar