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- ••First study describing endothelin.
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- •Interesting findings.
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- •Important findings.
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- •Important findings.
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- •Important findings.
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- •Important findings.
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- •Interesting findings.
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- •Interesting findings.
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- ACTELION LTD: Actelion shows accelerated growth for second quarter. Press
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- ••
- ••54.Release (2000) August 8.
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- ••ET antagonism in acute heart failure.
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- ••Currently largest trial examining ETantagonism in heart failure.
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- GENENTECH INC: Genentech, Inc. announces that Phase III trial of intravenous endothelin receptor antagonist tezosentan for acute heart failure shows positive hemodynamic results. Press Release (2001) February 13
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- •Interesting findings.
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- TEXAS BIOTECHNOLOGY CORP: Texas Biotechnology reports positive Phase IIa trial results of endothelin receptor antagonist in CHF Press Release (1998) February 11.
- TEXAS BIOTECHNOLOGY CORP: Texas Biotechnology reports additional positive Phase IIA trial results in congestive heart failure Press Release (1998) July 21.
- GLAXOSMITHKLINE PLC: Product development pipeline: February 2001 Company Brochure (2001) .
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- •Important findings. LERMAN A, HOLMES DR JR, BELL MR, GARRATT KN, NISHIMURA RA, BURNETT JC JR: Endothelin in coronary endothelial dysfunction and early atherosclerosis in humans. Circulation (1995) 92:2426-2431. Important findings.
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- •Prognostic value of ET in acute myocardial infarction. WENZEL RR, FLEISH M, SHAW S et al: Hemodynamic and coronary effects of the endothelin antagonist bosentan in patients with coronary artery disease. Circulation (1998) 98(21): 2235–2240. Important findings. KINLAY S, BEHRENDT D, WAINSTEIN M et al:Role of Endothelin-1 in the active constriction of human atherosclerotic coronary arteries. Circulation (2001) 104:1114-1118. Interesting findings.
- KNOLL AG: Knoll and Hoechst Marion Roussel announce alliance to codevelop compound for chronic heart failure and high blood pressure Press Release (1998) December 22.
- ABBOT LABORATORIES: Drug development pipeline-Abbott Laboratories. From a presentation by Miles D White CEO of Abbott at the Merrill Lynch Global Healthcare Conference. February 6–8, 2001. Company World Wide Web site (2001).
- CANNAN CR, BURNETT JR JC, BRANDT RR, LERMAN A: Endothelin at pathophysiological concentrations mediates coronary vasoconstriction via the endothelin-A receptor. Circulation (1995) 92:3312–3317Important findings.
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- DOUGLAS SA, VICKERYCLARK LM, LOUDEN C, OHLSTEIN EH: Selective ET(A) receptor antagonism with BQ-123 is insufficient to inhibit angioplasty induced neointima formation in the rat. Cardiovascular Research (1995) 29(5):641–646.
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- •Important findings.
- KOWALA MC, ROSE PM, STEIN PD et al.: Selective blockade of the endothelin subtype A receptor decreases early atherosclerosis in hamsters fed cholesterol. Pathol (1995) 146:819–826.
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- ••ET-A/B receptor antagonism in patientswith arterial hypertension.
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- •Interesting findings.
- NAKOV R, PFARR E, EBERLE S (on behalf of the HEAT-2 investigators): HEAT-2 (Hypertension: Endothelin Antagonist Treatment) presented during the European Society of Cardiology meeting (2001).
- ••ET-A receptor antagonism in patients witharterial hypertension.
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- •Excellent review.
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- •Important findings.
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- •Important findings.
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- ••Effects of ET antagonism in pulmonaryhypertension.
- ACTELION LTD: Oral endothelin receptor antagonist Tracleer meets primary endpoint in pulmonary arterial hypertension study. Press Release (2001) May 2.
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- TEXAS BIOTECHNOLOGY CORP: ICOS Corporation and Texas Biotechnology Corporation initiate a pivotal trial in pulmonary arterial hypertension. Press Release ( 2001) May 30.
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- BARST RJ, RUBIN LJ, MCGOON MD, CALDWELL EJ, LONG WA, LEVY PS: Survival in primary pulmonary hypertension with long-term continuous intravenous prostacyclin. Ann. Intern. Med. (1994) 121:409–415.
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