64
Views
25
CrossRef citations to date
0
Altmetric
Miscellaneous

Virulence as a target for antimicrobial chemotherapy

Pages 1149-1159 | Published online: 24 Feb 2005

Bibliography

  • BUYSSE JM: The role of genomics in antibacterial target discovery. Carr: Med. Chem. (2001) 8(14):1713–1726.
  • BARRETT JF, HOCH JA: Two-component signal transduction as a target for microbial anti-infective therapy. Antimicrob. Agents Chemother. (1998) 42(7):1529–1536.
  • ALKSNE LE, PROJAN SJ: Bacterial virulence as a target for antimicrobial chemotherapy. Carr: Opin. Biotechnol (2000) 11(6):625–636.
  • FINCH RG, PRITCHARD DI, BYCROFT BW, WILLIAMS P, STEWART GS: Quorum sensing: a novel target for anti-infective therapy. Antimicrob. Chemother: (1998) 42(5):569–571.
  • KHAN MA, STEINER TS: Mechanisms of emerging diarrheagenic Escherichia coil infection. Carr: Infect. Dis. Rep. (2002) 4(2):112–117.
  • SEAL DV: Necrotizing fascfitis. Curt: Opin. Infect. Dis. (2001) 14(2):127–132.
  • HENWOOD CJ, TESS. G, WARNER M et al.: Antibiotic resistance among clinical isolates of Acinetobacterin the UK, and in vitro evaluation of tigecycline (GAR-936). .1. Antimicrob. Chemother: (2002) 49:479–487.
  • FREIJE M: Eight deadly blunders. Common mistakes in protecting against Legionella. Health Facility Management (2002) 3:35–38.
  • LEGNANI PP, LEONI E, CORRADINI N: Legionella contamination of hospital water supplies: monitoring of private healthcare facilities in Bologna, Italy. J. Hosp. Infect. (2002) 50:220–223.
  • TOMPKIN RB: Control of Listeria monocytogenesin the food-processing environment." Food Protection (2002) 65(4):709–725.
  • LEVIN BR, ANTIA R: Why we don't get sick: the within-host population dynamics of bacterial infections. Science (2001) 292(5519):1112–1115.
  • •This paper contains an excellent discussion of early events in colonisation and how commensalism differs from pathogenesis.
  • ARCHER GL, CLIMO MW: Staphylococcus aureus bacteremia-consider the source. N Engl. J. Med. (2001) 344(1):55–56.
  • GLUCK U: Nasal carriage of Staphyloccous aureus. N. Engl. J. Med. (2001) 344:1399–1401.
  • VON EIFF C, BECKER K, MACHKA K, STAMMER H, PETERS G: Nasal carriage as a source of Staphylococcus atoms bacteremia. N Engl. J. Med. (2001) 344:11–16.
  • •This paper describes an important study addressing this common source of nosocomial infection.
  • WEIST K, POLLEGE K, SCHULZ I, RUDEN H, GASTMEIER P: How many nosocomial infections are associated with cross-transmission? A prospective cohort study in a surgical intensive care unit. Infect. Control Hosp. Epidemiol (2002) 23(3):127–132.
  • FINLAY BB, FALKOW S: Common themes in microbial pathogenicity revisited. Microbial. Ma Biol. Rev (Washington, DC) (1997) 61(2):136–169.
  • JONES BD, FALKOW S: Salmonellosis: Host Immune Responses and Bacterial Virulence Determinants. Ann. Rev Immunol (1996) 14:533–561.
  • MILLER MB, BASSLER BL: Quorum sensing in bacteria. Ann. Rev Microbial. (2001) 55:165–199.
  • ••This article is a recent and thorough reviewof quorum sensing.
  • DEKIEVIT TR, IGLEWSKI BH: Bacterial quorum sensing in pathogenic relationships. Infect. Inman. (2000) 68(9):4839–4849.
  • LEHOUX DE, SANSCHAGRIN F, LEVESQUE RC: Discovering essential and infection-related genes. Curt: Opin. Microbial. (2001) 4:515–529.
  • •This contains a good overview of techniques used to identify genes essential in vivo, including some not discussed here.
  • CASADEVALL A, PIROFSKI L: Host-pathogen interactions: the attributes of virulence. J. Infect. Dis. (2001) 184(3):337–344.
  • ••A thought provoking discussion of howpathogenesis and virulence is defined in terms of both bacterium and host.
  • BRUMELL JH, PERRIN AJ, GOOSNEY DL, FINLAY BB: Microbial pathogenesis: new niches. Carr: Biol. (2002) 12:R15–R17.
  • FELTMAN H, SCHULERT G, KHAN S, JAIN M, PETERSON L, HAUSER AR: Prevalence of Type III secretion genes in clinical and environmental isolates of Pseudomonas aeruginosa. Microbiology (2001) 147(Pt 10):2659–2669.
  • KNODLER LA, CELLI J, FINLAY BB: Pathogenic trickery: deception of host cell processes. Nat. Rev Ma Cell Biol. (2001) 2 (8) :578–588.
  • HANDFIELD M, LEVESQUE RC: Strategies for isolation of in vivo expressed genes from bacteria. FEMS Microbiol Rev (1999) 23(1):69–91.
  • BLACK T, HARE R: Will genomics revolutionize antimicrobial drug discovery? Curr. Opin. Microbial. (2000) 3(5):522–527.
  • LOFERER H: Mining bacterial genomes for antimicrobial targets. Mol Med. Today (2000) 6(12):470–474.
  • MOXON R, TANG C: Challenge of investigating biologically relevant functions of virulence factors in bacterial pathogens. Philos. Trans. R. Soc. Lond. B Biol. Sci. (2000) 355(1397):643–656.
  • ROSAMOND J, ALLSOP A: Harnessing the power of the genome in the search for new antibiotics. Science (2000) 287(5460):1973–1976.
  • FINLAY BB, COSSART P: Exploitation of mammalian host cell functions by bacterial pathogens [published erratum appears in Science 1997 Oct 17;278(5337):373] [see comments]. Science (1997) 276(5313):718–725.
  • GALAN JE: Salmonella interactions with host cells: Type III secretion at work. Ann. Rev Cell Dev. Biol. (2001) 17:53–86.
  • •This review is an excellent source of background material on Type III secretion.
  • MARCUS SL, BRUMELL JH, PFEIFER CG, FINLAY BB: Salmonella pathogenicity islands: big virulence in small packages. Microbes Infect. (2000) 2(2):145–156.
  • DE SAIZIEU A, CERTA U, WARRINGTON J, GRAY C, KECK W, MOUS J: Bacterial transcript imaging by hybridization of total RNA to oligonucleotide arrays [see comments]. Nat. Biotechnol (1998) 16(1):45–48.
  • SEARLS DB: Bioinformatics tools for whole genomes. Ann. Rev Genomics Hum. Genet (2000) 1:251–279.
  • GRAVES PR, HAYSTEAD TA: Molecular biologist's guide to proteomics. Microbial. Mol Biol. Rev (2002) 66(1):39–63; table of contents.
  • SCHWEITZER B, KINGSM ORE SF: Measuring proteins on microarrays. Curc Opin. Biotechnol (2002) 13(1):14–19.
  • MAHAN MJ, SLAUCH JM, HANNA PC et al.: Selection for bacterial genes that are specifically induced in host tissues: the hunt for virulence factors. Infect. Agents Dis. (1993) 2(4):263–268.
  • •This paper, along with the next, describe the earliest uses of IVET.
  • CAMILLI A, BEATTIE DT, MEKALANOS JJ: Use of genetic recombination as a reporter of gene expression. Proc. Nat. Acad. ScL USA (1994) 91(7):2634–2638.
  • CHIANG SL, MEKALANOSJJ, HOLDEN DW: hi vivo genetic analysis of bacterial virulence. [Review] [71 refs]. Ann. Rev Microbiol (1999) 53:129–154.
  • VALDIVIA RH, FALKOW S: Bacterial genetics by flow cytometry: rapid isolation of Salmonella gphimurium acid-inducible promoters by differential fluorescence induction. MM. Microbiol (1996) 22(2):367–378.
  • •This paper describes a seminal use of differential fluorescent induction technology.
  • VALDIVIA RH, FALKOW S: Fluorescence-based isolation of bacterial genes expressed within host cells. Science (1997) 277(5334):2007–2011.
  • MARRA A, ASUNDI J, BARTILSON M et al.: Differential fluorescence induction analysis of Streptococcus pneumoniae identifies genes involved in pathogenesis. Infect. Immun. (2002) 70(3):1422–1433.
  • SCHNEIDER WP, HO SK, CHRISTINE J, YAO M, MARRA A, HROMOCKYJ AE: Virulence gene identification by differential fluorescence induction analysis of Staphylococcus aureus gene expression during infection-simulating culture. Infect. Inman. (2002) 70(3):1326–1333.
  • HENSEL M, SHEA JE, GLEESON C, JONES MD, DALTON E, HOLDEN DW: Simultaneous identification of bacterial virulence genes by negative selection. Science (1995) 269(5222):400–403.
  • •This reports the earliest use of signature tagged mutagenesis.
  • CHIANG SL, MEKALANOS JJ: Use of signature-tagged transposon mutagenesis to identify Vibrio cholerae genes critical for colonization. MM. Microbiol (1998) 27(4):797–805.
  • PERRY RD: Signature-tagged mutagenesis and the hunt for virulence factors. Trends Microbiol (1999) 7(10):385–388; discussion 388–389.
  • HANDFIELD M, BRADY LJ, PROGULSKE-FOX A, HILLMAN JD: MAT: a novel method to identify microbial genes expressed specifically during human infections. Trends Microbiol (2000) 8(7):336–339.
  • ENGEBRECHT J, NEALSON K, SILVERMAN M: Bacterial bioluminescence: isolation and genetic analysis of functions from Vibrio fischeri Cell (1983) 32(3):773–781.
  • •This important paper describes early analysis of quorum sensing.
  • KLEEREBEZEM M, QUADRI LE: Peptide pheromone-dependent regulation of antimicrobial peptide production in Gram-positive bacteria: a case of multicellular behavior. Peptides (2001) 22(10):1579–1596.
  • PARSEK MR, GREENBERG EP: Acyl-homoserine lactone quorum sensing in Gram-negative bacteria: a signaling mechanism involved in associations with higher organisms. Proc. Nat. Acad. Sci. USA (2000) 97(16):8789–8793.
  • MAGNUSON R, SOLOMON J, GROSSMAN AD: Biochemical and genetic characterization of a competence pheromone from B. subtilis. Cell (1994) 77(2):207–216.
  • HAVARSTEIN LS, COOMARASWAMY G, MORRISON DA: An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae. Proc. Nat. Acad. ScL USA (1995) 92(24):11140–11144.
  • SOLOMON JM, LAZAZZERA BA, GROSSMAN AD: Purification and characterization of an extracellular peptide factor that affects two different developmental pathways in Bacillus subtilis. Genes Dev. (1996) 10(16):2014–2024.
  • LAZAZZERA BA, SOLOMON JM, GROSSMAN AD: An exported peptide functions intracellularly to contribute to cell density signaling in B. subtilis. Cell (1997) 89(6):917–925.
  • DAVIES DG, PARSEK MR, PEARSON JP, IGLEWSKI BH, COSTERTON JW, GREENBERG EP: The involvement of cell-to-cell signals in the development of a bacterial biofilm [see comments]. Science (1998) 280(5361):295–298.
  • NOVICK RP, MUIR TW: Virulence gene regulation by peptides in staphylococci and other Gram-positive bacteria. Curr: Opin. Microbiol (1999) 2(1):40–45.
  • •This is an excellent overview of virulence gene regulation in Gram-positive bacteria.
  • SPERANDIO V, MELLIES JL, NGUYEN W, SHIN S, KAPER JB: Quorum sensing controls expression of the Type III secretion gene transcription and protein secretion in enterohemorrhagic and enteropathogenic Escherichia coll. Proc. Nat. Acad. ScL USA (1999) 96(26):15196–15201.
  • SURETTE MG, MILLER MB, BASSLER BL: Quorum sensing in Escherichia coil, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production. Proc. Nat. Acad. Sci. USA (1999) 96(4):1639–1644.
  • WINSON MK, CAMARA M, LATIFI A et al.: Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa. Proc. Nat. Acad. ScL USA (1995) 92(20):9427–9431.
  • BASSLER BL, WRIGHT M, SHOWALTER RE, SILVERMAN MR: Intercellular signalling in Vibrio harveyi: sequence and function of genes regulating expression of luminescence. MM. Microbiol (1993) 9(4):773–786.
  • BASSLER BL, WRIGHT M, SILVERMAN MR: Multiple signalling systems controlling expression of luminescence in Vibrio harveyl. sequence and function of genes encoding a second sensory pathway. Ma Microbiol (1994) 13:273–286.
  • BASSLER BL: How bacteria talk to each other: regulation of gene expression by quorum sensing. Curt: Opin. Microbiol (1999) 2(6):582–587.
  • TAGA ME, SEMMELHACK JL, BASSLER BL: The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella gphimurium. Mol Microbiol (2001) 42(3):777–793.
  • CHEN X, SCHAUDER S, POTIER N et al.: Structural identification of a bacterial quorum-sensing signal containing boron. Nature (2002) 415(6871):545–549.
  • ••This recent paper describes the elucidationof the structure of AI-2 autoinducer.
  • DAY WA JR., MAURELLI AT: Shigella flexneri LtixS quorum-sensing system modulates virB expression but is not essential for virulence. Infect. Inman. (2001) 69(1):15–23.
  • GOV Y, BITLER A, DELL'ACQUA G, TORRES JV, BALABAN N: RNAIII inhibiting peptide (RIP), a global inhibitor of Staphylococcus aureuspathogenesis: structure and function analysis. Peptides (2001) 22(10):1609–1620.
  • VIEIRA-DA-MOTTA 0, RIBEIRO PD, DIAS DA SILVA W, MEDINA-ACOSTA E: RNAIII inhibiting peptide (RIP) inhibits agr-regulated toxin production. Peptides (2001) 22(10):1621–1627.
  • MAYVILLE P, JI G, BEAVIS R et al.: Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureusresponsible for virulence. Proc. Nat. Acad. Sci. USA (1999) 96(4):1218–1223.
  • •This report describes the structure of and variability among autoinducing thiolactones.
  • DONG YH, WANG LH, XU JL, ZHANG HB, ZHANG XF, ZHANG LH: Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase. Nature (2001) 411(6839):813–817.
  • STOCK AM, ROBINSON VL, GOUDREAU PN: Two-component signal transduction. Ann. Rev Biochem. (2000) 69:183–215.
  • THROUP JP, KORETKE KK, BRYANT AP et al.: A genomic analysis of two-component signal transduction in Streptococcus pneumoniae. Mol Microbiol (2000) 35(3):566–576.
  • BARRETT JF, GOLDSCHMIDT RIVI, LAWRENCE LE, et al: Antibacterial agents that inhibit two-component signal transduction systems. Proc. Nat. Acad. Sci. USA (1998) 95(9):5317–5322.
  • MACIELAG MJ, DEMERS JP, FRAGA-SPANO SA et al.: Substituted salicylanilides as inhibitors of two-component regulatory systems in bacteria. Med. Chem. (1998) 41(16):2939–2945.
  • KANOJIA RIVI, MURRAY W, BERNSTEIN J et al.: 6-oxa isosteres of anacardic acids as potent inhibitors of bacterial histidine protein kinase (HPK)-mediated two-component regulatory systems. Bioorg. Med. Chem. Lett. (1999) 9(20):2947–2952.
  • WEIDNER-WELLS MA, OHEMENG KA, NGUYEN VN et al: Amidino benzimidazole inhibitors of bacterial two-component systems. Bioorg. Med. Chem. Lett. (2001) 11(12):1545–1548.
  • TREW SJ, WRIGLEY SK, PAIRET L et al:Novel streptopyrroles from Smeptomyces rimosus with bacterial protein histidine kinase inhibitory and antimicrobial activities. Antibiot. (2000) 53(1):1–11.
  • ROYCHOUDHURY S, BLONDELLE SE, COLLINS SM et al.: Use of combinatorial library screening to identify inhibitors of a bacterial two-component signal transduction kinase. Ma Diversity (1998) 4(3):173–182.
  • HILLIARD JJ, GOLDSCHMIDT R, LICATA L, BAUM EZ, BUSH K: Multiple mechanisms of action for inhibitors of histidine protein kinases from bacterial two-component systems. Antimicrob. Agents Chemother. (1999) 43:1693–1699.
  • VOLZ K: Structural and functional conservation in response regulators. In: Two-component signal transduction. Hoch JA, Silhavy TJ (Eds), American Society for Microbiology, Washington, D.C., USA (1995):53–64.
  • FOSTER TJ, HOOK M: Surface protein adhesins of Staphylococcus aureus [see comments]. Trends Microbiol (1998) 6(12):484–488.
  • PROJAN SJ, NOVICK RP: The Molecular Basis of Pathogenicity. In The Staphylocci in Human Disease, Archer G, Crossley K (Ed). Churchill Livingstone, New York, USA (1997):55–81.
  • TON-THAT H, MAZMANIAN SK, ALKSNE L, SCHNEEWIND 0: Anchoring of surface proteins to the cell wall of Staphylococcus aureus. Biolog. Chem. (2002) 277(9):7447–7452.
  • TON-THAT HM, SK FAULL, KF, SCHNEEWIND, 0: Anchoring of surface proteins to the cell wall of Staphylococcus aureus. Sortase catalyzed M vitro transpeptidation reaction using LPXTG peptide and NH(2)-Gly(3) substrates. Biolog. Chem. (2000) 275(13):9876–9881.
  • MAZMANIAN SK, LIU G, TON-THAT H, SCHNEEWIND 0: Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall. Science (1999) 285(5428):760–763.
  • ••This describes the cloning of the sortaseenzyme.
  • TON-THAT HL, G. MAZMANIAN, S. K. FAULL, K. F. SCHNEEWIND, 0.: Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of Staphylococcus aureus at the LPXTG motif. Proc. Nat. Acad. ScLUSA (1999) 96(22):12424–12429.
  • •This report describes early analysis of sortase.
  • PALLEN MJ, LAM AC, ANTONIO M, DUNBAR K: An embarrassment of sortases - a richness of substrates? Trends Microbiol (2001) 9(3):97–101.
  • TON-THAT H, MAZMANIAN SK, SCHNEEWIND 0: An embarrassment of sortases - a richness of substrates? Response. Trends Microbiol (2001) 9(3):101–102.
  • GARANDEAU C, REGLIER-POUPET H, DUBAIL I, BERETTI JL, BERCHE P, CHARBIT A: The sortase SrtA of Listeria monocytogenes is involved in processing of internalin and in virulence. Infect. Immun. (2002) 70(3):1382–1390.
  • JOHNSSON IM, MAZMANIAN SK, SCHNEEWIND 0, VERDRENGH M, BREMELL T, TARKOWSKI A: On the role of Staphylococcus aureus sortase and sortase-catalyzed surface protein anchoring in murine septic arthritis. I Infect. Dis. (2002) 185:1417–1424.
  • BOLKEN TC, FRANKE CA, JONES KF et al.: Inactivation of the srtA gene in Streptococcus gordonii inhibits cell wall anchoring of surface proteins and decreases M vitro and in vivo adhesion. Infect. Immun. (2001) 69(1):75–80.
  • MAZMANIAN SK, LIU G, JENSEN ER, LENOY E, SCHNEEWIND 0: Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections [see comments]. Proc. Nat. Acad. ScL USA (2000) 97(10):5510–5515.
  • SOTO GE, DODSON KW, OGG D et al: Periplasmic chaperone recognition motif of subunits mediates quaternary interactions in the pilus. bubo,/ (1998) 17(21):6155–6167.
  • LEE VT, SCHNEEWIND 0: Protein secretion and the pathogenesis of bacterial infections. Genes Dev. (2001) 15(14):1725–1752.
  • ••This is an excellent and thorough review ofsecretion systems in bacteria and their function in pathogenesis.
  • LOW DA, WEYAND NJ, MAHAN MJ: Roles of DNA adenine methylation in regulating bacterial gene expression and virulence. Infect. Immun. (2001) 69(12):7197–7204.
  • JONES CH, BOLKEN TC, JONES KF, ZELLER GO, HRUBY DE: Conserved DegP protease in Gram-positive bacteria is essential for thermal and oxidative tolerance and full virulence in Streptococcus pyogerres. Infect. Inman. (2001) 69(9):5538–5545.
  • ALLSOP AE: New antibiotic discovery, novel screens, novel targets and impact of microbial genomics. Curt: Opin. Microbiol (1998) 1(5):530–534.
  • CLIMO MW, ISRAEL DS, WONG ES, WILLIAMS D, COUDRON P, MARKOWITZ SM: Hospital-wide restriction of clindamycin: effect on the incidence of Clostridium di/Bede-associated diarrhea and cost. Ann. Intern. Med. (1998) 128(12 Pt 1):989–995.
  • SALYERS AA, SHOEMAKER NB: Resistance gene transfer in anaerobes: new insights, new problems. Clin. Infect. Dis. (1996) 23\(Suppl. 1):536–543.
  • ••This is an insightful discussion of mechanisms of antibiotic resistance maintenance and gene transfer.
  • http://www.cdc.gov/ncidod/hip/ SURVEILL/NNIS.HTM
  • http:/www.quorex.com
  • http:/www.fda. gov/c der/guidance/ index.htm
  • http://library.dialog.com/bluesheets/html/ b10465.html

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.