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Review

The glutamatergic system outside the CNS and in cancer biology

, &
Pages 1487-1496 | Published online: 25 Nov 2005

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  • ••Excellent review article about theGlu system in cutaneous squamous cell carcinomas, which lack expression of the NMDAR.
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  • MOLLOY TJ, WANG Y, HORNER A, SKERRY TM, MURRELL GA: Microarray analysis of healing rat Achilles tendon: Evidence for glutamate signalling mechanisms and embryonic gene expression in healing tendon tissue. J. Orthop. Res. (2005) (In Press).
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  • ••Evidence for the antiproliferative effect ofGlu antagonists on cancer cells.
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  • Involvement of metabotropic glutamate receptor 1, a G protein coupled receptor, in melanoma development.(12 Part 1):4176-4184.
  • ••Important article documenting thesynergistic effect of the mGluR4 antagonist MAP4 and 5-FU, a chemotherapeutic agent, in patients with advanced colorectal cancer.
  • CHANG HJ, Y00 BC, LIM SB et al.: Metabotropic glutamate receptor 4 expression in colorectal carcinoma and its prognostic significance. Clin. Cancer Res. (2005) 11(9):3288–3295.
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  • CHOI SW, PARK SY, HONG SP et al.: The expression of NMDA receptor 1 is associated with clinicopathological parameters and prognosis in the oral squamous cell carcinoma. J. Oral Pathol Med. (2004) 33(9):533–537.
  • ••Evidence that the overexpression ofNMDAR1 in OSCC may be a useful marker for determining the prognosis of OSCC.
  • POLLOCK PM, COHEN-SOLAL K, SOOD R et al.: Melanoma mouse model implicates metabotropic glutamate signaling melanocytic neoplasia. Nat. Genet. (2003) 34(1):108–112.
  • ••The expression of mGluR1 is detectableonly in melanoma and not in melanocytes.
  • MARIN YE, CHEN S: Involvement of metabotropic glutamate receptor 1, a G protein coupled receptor, in melanoma development. J. Mol Med. (2004) 82(11):735–749.
  • SADZUKA Y, YAMASHITA Y, SONOBE T: Effects of glutamate transporter inhibitors on the antitumor activity of doxorubicin. Clin. Cancer Res. (2002) 8(12):3943–3947.
  • ••The synergistic effect of the GLASTantagonist and antitumor agent (DOX) in M5076 ovarian sarcoma cells.
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  • ••Osteosarcoma cells have Glu componentsand react by GluR antagonists in the same manner in both normal and cancer bone cells.
  • KALARITI N, LEMBESSIS P, KOUTSILIERIS M: Characterization of the glutametergic system in MG-63-like osteosarcoma cells. Anti-Cancer Res. (2004) 24(6):3923–3929. Identification of NMDAR, mGluRs, EAAT1 and GS in MG-63 osteoblast-like osteosarcoma cells.
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  • GENEVER PG, SKERRY TM: Regulation of spontaneous glutamate release activity in osteoblastic cells and its role in differentiation and survival: evidence for intrinsic glutamatergic signaling in bone. FASEB J. (2001) 15(9):1586–1588.
  • OLKKU A. BODINE PV, LINNALA-KANKKUNEN A, MAHONEN A: Glucocorticoick induce glutamine synthetase expression in human osteoblastic cells: a novel observation in bone. Bone (2004) 34(2):320–329.

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