91
Views
16
CrossRef citations to date
0
Altmetric
Review

Advances in anti-obesity therapeutics

Pages 243-250 | Published online: 22 Apr 2005

Bibliography

  • GLAZER G: Long-term pharmacotherapy of obesity 2000: a review of efficacy and safety. Arch. Intern. Med. (2001) 161:1814–1824.
  • ••Efficacy comparison of existing anti-obesity drugs.
  • HALPERN A, MANCINI MC: Treatment of obesity: an update on anti-obesity medications. Obes. Rev (2003) 4:25–42.
  • ••Efficacy comparison of existing anti-obesity drugs.
  • FARRIGAN C, PANG K: Obesity market overview. Nat. Rev Drug Discov. (2002) 1:257–258.
  • BARSH GS, SCHWARTZ MW: Genetic approaches to studying energy balance: Perception and integration. Nat. Rev Genet. (2002) 3:589–600.
  • FRIEDMAN JM: Modern science versus the stigma of obesity. Nat. Med. (2004) 10:563–569.
  • CONE RD, COWLEY MA, BUTLER AA et al.: The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis. Int. J. Obes. Relat. Metab. Disord. (2001) 25\(Suppl. 5):563–567.
  • SMITH GP: Dopamine and food reward. Frog. Psychobiol Physic] Psycho] (1995) 16:83–144.
  • SCHULTZ W: Getting formal with dopamine and reward. Neuron (2002) 36:241–263.
  • SCISLOWSKI PW, TOZZO E, ZHANG Y et al: Biochemical mechanisms responsible for the attenuation of diabetic and obese conditions in obiob mice treated with dopaminergic agonists. Int. J. Obes. Relat. Metab. Disord. (1999) 23:425–431.
  • GOLDMAN-RAKIC PS, MULY ECR, WILLIAMS GV: D1 receptors in prefrontal cells and circuits. Brain Res. Rev. (2000) 31:295–301.
  • VAN REE JM, NIESINK RJ, VAN WOLFSWINKEL L et al.: Endogenous opioids and reward. Eur. Pharmacol (2000) 405:89–101.
  • GARDNER EL, VOREL SR: Cannabinoid transmission and reward-related events. Neurobiol Dis. (1998) 5:502–533.
  • BERRY EM, MECHOULAM R: Tetrahydrocannabinol and endocannabinoids in feeding and appetite. Pharmacol Ther. (2002) 95:185–190.
  • BREIVOGEL CS, CHILDERS SR: The functional neuroanatomy of brain cannabinoid receptors. Neurobiol Dis. (1998) 5:417–431.
  • KISHI T, ASCHKENASI CJ, LEE CE et al: Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J. Comp. Neurol (2003) 457:213–235.
  • PECKYS D, LANDWEHRMEYER GB: Expression of 14-, lc-, and 8-opioid receptor messenger RNA in the human CNS: a 33P in situ hybridisation study. Neuroscience (1999) 88:1093–1135.
  • WIRTSHAFTER D, DAVID JD: Set points, settling points and the control of body weight. Physic] Behav. (1977) 19:75–78.
  • •An early review on the theory of body weight control.
  • BERRIDGE KC: Motivation concepts in behavioral neuroscience. Physic] Behav. (2004) 81:179–209.
  • ••Review on motivational aspects of feedingcontrol.
  • BERTHOUD HR: Multiple neural systems controlling food intake and body weight. Neurosci. Biobehav. Rev (2002) 26:393-428. Review on redundancy of feeding control.
  • HAGAN MM, RUSHING PA, BENOIT SC, WOODS SC, SEELEY RJ: Opioid receptor involvement in the effect of AgRP-(83-132) on food intake and food selection. Am. Physiol Regul Integr. Comp. Physic] (2001) 280:R814–R821.
  • OLSZEWSKI PK, WIRTH MM, GRACE MK, LEVINE AS, GIRAUDO SQ: Evidence of interactions between melanocortin and opioid systems in regulation of feeding. Neuroreport (2001) 12:1727–1730.
  • ALVARO JD, TATRO JB, QUILLAN JM et al.: Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction. Mol. Pharmacol (1996) 50:583–591.
  • DRYDEN S, FRANKISH H, WANG Q, WILLIAMS G: Neuropeptide Y and energy balance: one way ahead for the treatment of obesity? Eur.j Clin. Invest. (1994) 24:293–308.
  • HEISLER LK, COWLEY MA, TECOTT LH et al: Activation of central melanocortin pathways by fenfluramine. Science (2002) 297:609–611.
  • WADDEN TA, BERKOWITZ RI, WOMBLE LG et al: Effects of sibutramine plus orlistat in obese women following 1 year of treatment by sibutramine alone: a placebo-controlled trial. Obes. Res. (2000) 8:431–437.
  • ARNONE M, MARUANI J, CHAPERON F et al: Selective inhibition of sucrose and ethanol intake by SR-141716, an antagonist of central cannabinoid (CBI) receptors. Psychopharmacology (1997) 132:104–106.
  • SIMIAD J, KEANE M, KEANE PE, SOUBRIE P: SR-141716, a CBI cannabinoid receptor antagonist, selectively reduces sweet food intake in marmoset. Behav. Pharmacol (1998) 9:179–181.
  • COLOMBO G, AGABIO R, DIAZ G et al.: Appetite suppression and weight loss after the cannabinoid antagonist SR-141716. Life Sci. (1998) 63:113–117.
  • VERTY AN, McGREGOR IS, MALLET PE: Consumption of high carbohydrate, high fat, and normal chow is equally suppressed by a cannabinoid receptor antagonist in non-deprived rats. Neurosci. Lett. (2004) 354:217–220.
  • PERIO A, BARNOUIN MC, PONCELET M, SOUBRIE P: Activity of SR-141716 on post-reinforcement pauses in operant responding for sucrose reward in rats. Behav. Pharmacol. (2001) 12:641–645.
  • DAVIDSON MH, HAUPTMAN J, DIGIROLAMO M et al.: Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: a randomised controlled trial. JAMA (1999) 281:235–242.
  • JAMES WP, ASTRUP A, FINER N et al:Effect of sibutramine on weight maintenance after weight loss: a randomised trial. STORM Study Group. Sibutramine Trial of Obesity Reduction and Maintenance. Lancet (2000) 356:2119–2125.
  • BATKAI S, PACHER P, OSEI-HYIAMAN D et al.: Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. Circulation (2004) 110: 1996-2002.
  • RANDALL MD, KENDALL DA, O'SULLIVAN S: The complexities of the cardiovascular actions of cannabinoids. Br. J. Pharmacol. (2004) 142:20–26.
  • MENDIZABAL VE, ADLER- GRASCHINSKY E: Cannabinoid system as a potential target for drug development in the treatment of cardiovascular disease. Curr. Vasc. Pharmacol. (2003) 1:301–313.
  • BATKAI S, PACHER P, JARAI Z, WAGNER JA, KUNOS G: Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CBI or CB2 receptors. Am..]: Physiol. Heart Circ. Physiol. (2004) 287(2):H595–H600.
  • SLEEMAN MW, ANDERSON KD, LAMBERT PD, YANCOPOULOS GD, WIEGAND SJ: The ciliary neurotropic factor and its receptor, CNTFR a. Pharm. Acta Hely. (2000) 74:265–272.
  • STAHL N, YANCOPOULOS GD: The tripartite CNTF receptor complex: activation and signaling involves components shared with other cytokines. Neurobiol. (1994) 25:1454–1466.
  • GLOAGUEN I, COSTA P, DEMARTIS A et al.: Ciliary neurotropic factor corrects obesity and diabetes associated with leptin deficiency and resistance. Proc. Natl. Acad. Sri. USA (1997) 94:6456–6461.
  • LAMBERT PD, ANDERSON KD, SLEEMAN MW et al.: Ciliary neurotropic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. Proc. Natl. Acad. Li. USA (2001) 98:4652–4657.
  • MARSH DJ, HOLLOPETER G, HUSZAR D et al.: Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat. Genet. (1999) 21:119–122.
  • ZIOTOPOULOU M, ERANI DM, HILEMAN SM, BJORBAEK C, MANTZOROS CS: Unlike leptin, ciliary neurotropic factor does not reverse the starvation-induced changes of serum corticosterone and hypothalamic neuropeptide levels but induces expression of hypothalamic inhibitors of leptin signaling. Diabetes (2000) 49:1890–1896.
  • XU B, DUBE MG, KALRA PS et al: Anorectic effects of the cytokine, ciliary neurotropic factor, are mediated by hypothalamic neuropeptide Y: comparison with leptin. Endocrinology (1998) 139:466–473.
  • ROWLAND NE, MARSHALL M, ROTH JD: Comparison of either norepinephrine-uptake inhibitors or phentermine combined with serotonergic agents on food intake in rats. Psychopharmacology (2000) 149:77–83.
  • GEHLERT DR, DRESHFIELD L, TINSLEY F et al: The selective norepinephrine reuptake inhibitor, LY368975, reduces food consumption in animal models of feeding. J. Pharmacol. Exp. Ther. (1998) 287:122–127.
  • ANDERSON JW, GREENWAY FL, FUJIOKA K et al: Bupropion SR enhances weight loss: a 48-week double-blind, placebo-controlled trial. Obes. Res. (2002) 10:633–641.
  • RITTER RC, COVASA M, MATSON CA:Cholecystokinin: proofs and prospects for involvement in control of food intake and body weight. Neuropeptides (1999) 33:387–399.
  • REIDELBERGER RD, HERNANDEZ J, FRITZSCH B, HULCE M: Abdominal vagal mediation of the satiety effects of CCK in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2004) 286:R1005–R1012.
  • MATSON CA, RITTER RC: Long-termCCK-leptin synergy suggests a role for CCK in the regulation of body weight. Am. J. Physiol. (1999) 276:R1038–R1045.
  • BICKEL M, GOSSEL M, GEISEN K et al: Analysis of the anorectic efficacy of HMR1426 in rodents and its effects on gastric emptying in rats. Int. J. Obes. Relat. Metab. Disord. (2004) 28:211–221.
  • McCALLUM RW, SOYKAN I, SRIDHAR KR et al.: 8-9-tetrahydrocannabinol delays the gastric emptying of solid food in humans: a double-blind, randomized study. Aliment. Pharmacol. Ther. (1999) 13:77–80.
  • ISHIGUCHI T, AMANO T, MATSUBAYASHI H et al: Centrally administered neuropeptide Y delays gastric emptying via Y2 receptors in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2001) 281:R1522–R1530.
  • MOLLER DM, KAUFMAN KD: Metabolic syndrome - a clinical and molecular perspective. Ann. Rev Med. (2005) 56:45–62.
  • FONG TM: Targeting metabolic syndrome. Expert Opin. Investig. Drugs (2004) 13:1203–1206.
  • VAN DER PLOEG LH: Obesity: an epidemic in need of therapeutics. Curr. Opin. Chem. Biol. (2000) 4:452–460.
  • SPANSWICK D, LEE K: Emerging antiobesity drugs. Expert Opin. Emerg. Drugs (2003) 8:217–237.
  • FAROOQI IS, KEOGH JM, YEO GS et al: Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Eng]. I Med. (2003) 348:1085–1095.
  • HUSZAR D, LYNCH CA, FAIR-HUNTRESS V et al.: Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell (1997) 88:131–141.
  • VAN DER PLOEG LHT, MARTIN WJ, HOWARD AD et al.: A role for the melanocortin 4 receptor in sexual function. Proc. Nati Acad. Sci. USA (2002) 99:11381–11386.
  • GANTZ I, FONG TM: The melanocortin system. Am. J. Physiol. Endocrinol. Metab. (2003) 284:E468–E474.
  • LINDBLOM J, KASK A, HAGG E et al: Chronic infusion of a melanocortin receptor agonist modulates dopamine receptor binding in the rat brain. Pharmacol. Res. (2002) 45:119–124.
  • CABEZA DE VACA S, KIM G, CARR KD: The melanocortin receptor agonist MTII augments the rewatding effect of amphetamine in ad-libitum-fed and food-restricted rats. Psychopharmacology (2002) 161:77–85.
  • SEBHAT I, YE Z, BEDNAREK M et al: Melanocortin-4 receptor agonists and antagonists: chemistry and potential therapeutic utilities. Ann. Rep. Med. Chem. (2003) 38:31–40.
  • SAILER AW, SANO H, ZENG Z et al: Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc. Nati Acad. Sci. USA (2001) 98:7564–7569.
  • SAITO Y, NOTHACKER HP, WANG Z et al.: Molecular characterization of the melanin-concentrating-hormone receptor. Nature (1999) 400:265–269.
  • SHIMADA M, TRITOS NA, LOWELL BB, FLIER JS, MARATOS-FLIER E: Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature (1998) 396:670–674.
  • MARSH DJ, WEINGARTH DT, NOVI DE et al.: Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive and hyperphagic and have altered metabolism. Proc. Natl. Acad. Sci. USA (2002) 99:3240–3245.
  • CHEN Y, HU C, HSU CK et al: Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity. Endocrinology (2002) 143:2469–2477.
  • KOWALSKI TJ, McBRIAR MD: Therapeutic potential of melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity. Expert Opin. Investig. Drugs (2004) 13:1113–1122.
  • SHAW WN: Long-term treatment of obese Zucker rats with LY255582 and other appetite suppressants. Pharmacol Biochem. Behav. (1993) 46:653–659.
  • GLASS M, BILLINGTON CJ, LEVINE AS: Opioids and food intake: distributed functional neural pathways? Neuropeptides (1999) 33:360–368.
  • STATNICK MA, TINSLEY FC, EASTWOOD BJ et al.: Peptides that regulate food intake: antagonism of opioid receptors reduces body fat in obese rats by decreasing food intake and stimulating lipid utilization. Am. I Physiol Regul Integr. Comp. Physiol (2003) 284:R1399–R1408.
  • BODNAR RJ: Endogenous opioids and feeding behavior: a 30-year historical perspective. Peptides (2004) 25:697–725.
  • DREWNOWSKI A: Metabolic determinants of binge eating. Addictive Behav. (1995) 20:733–745.
  • DE ZWAAN M, MITCHELL JE: Opiate antagonists and eating behaviour in humans: a review. J. Clin. Pharmacol (1992) 32:1060–1072.
  • KIM S, WAGNER HN, VILLEMAGNE VL et al.: Longer occupancy of opioid receptors by nalmefene compared to naloxone as measured in vivo by a dual-detector system. I Nuc. Med. (1997) 38:1726–1731.
  • CHEN RZ, HUANG RR, SHEN CP, MACNEIL DJ, FONG TM: Chronic administration of nalmefene leads to increased food intake and body weight gain in mice. Eur. Pharmacol (2004) 495:63–66.
  • HAWKINS MF, CUBIC B, BAUMEISTER AA, BARTON C: Microinjection of opioid antagonists into the substantia nigra reduces stress-induced eating in rats. Brain Res. (1992) 584:261–265.
  • BRUGMAN S, CLEGG DJ, WOODS SC, SEELEY RJ: Combined blockade of both µ-and x-opioid receptors prevents the acute orexigenic action of agouti-related protein. Endocrinology (2002) 143:4265–4270.
  • SETOLA V, HUFEISEN SJ, GRANDE-ALLEN KJ et al: 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro. Mol. Pharmacol (2003) 63:1223–1229.
  • LEIBEL RL, ROSENBAUM M, HIRSCH J: Changes in energy expenditure resulting from altered body weight. N Engl. J. Med. (1995) 332:621–628.
  • ••Pivotal study demonstrating thecompensatory reduction of metabolic rate in response to dieting.

Websites

  • http://www.theheart.org Website for highlights from the ACC 2004, ESC 2004 and AHA 2004 scientific sessions.
  • http://www.regeneron.com REGENERON-PHARMACEUTICALS: Press release.
  • http://www.iddb3.com Database for investigational drugs.
  • http://www.alizyme.com ALIZYME.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.