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Drug Evaluation

Ibutilide – recent molecular insights and accumulating evidence for use in atrial flutter and fibrillation

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Pages 655-669 | Published online: 31 May 2005

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  • •Early study of ibutilide in animal model of atrial flutter.
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  • •Major clinical trial demonstrating the efficacy of ibutilide in atrial flutter and fibrillation.
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  • •Interesting electrophysiological study of ibutilide in humans.
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  • •Interesting study of the relationship of gender with drug-induced QT prolongation.
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  • ••Describes the development of ibutilideanalogues including trecetilide.
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