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The therapeutic potential of vasopressin receptor antagonists in congestive heart failure

GHEORGHIADE M, GATTIS WA, O’CONNER C et al.: Effects of tolvaptan vasopressin antagonist, in patients hospitalized with worsening heart failure. JAMA (2004) 291(16):1963-1971.

Pages 687-691 | Published online: 31 May 2005

Bibliography

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  • ••The ACTIV in CHF study is the firstrandomised trial to evaluate both the acute and chronic effects of the V2 antagonist tolvaptan in patients hospitalised with CHF.
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  • ••This recent paper provides a comprehensive review of the potential role for vasopressin antagonists as therapeutic agents in patients with CHE
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  • ••This article summarises the relevant dataof the AVP antagonists for the treatment of heart failure, and reviews the role of AVP in both normal physiology and the pathogenesis of heart failure.
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  • •In this earlier study in patients with CHF taking furosemide, tolvaptan was associated with a reduction in body weight compared with placebo, as well as increases In urine volumes and reductions in urine osmolality and sodium concentrations.
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